The option on the table : Obama's rhetoric and the case for military conflict with Iran

The following analysis seeks to demonstrate how the Obama administration, through its rhetoric, is attempting to build public support for a potential military conflict with Iran. Further, the study seeks to show how the language of the Obama administration rhetorically creates the reality of the foreign policy relationship between Iran and the United States. The study begins with a brief overview of the US-Iran foreign policy relationship over the course of President Obama’s first term. The analysis then focuses on three primary areas: the political myth of the inevitability of military conflict with Iran, the Just War rhetoric of the Obama administration, and the relationship between official-level rhetoric, the media, and public opinion. Finally, future possibilities of peace and military conflict are considered. The study analyzes official-level speeches, addresses, debates, and press briefings delivered between January 2012 and March 2013. The study of political rhetoric exposes the ways in which language informs foreign and military policy. Understanding the rhetorical construction of foreign policy relationships and exploring how public support for military conflict is acquired may offer insights into how military conflict could be prevented in the future

Proteomic Changes Resulting from Gene Copy Number Variations in Cancer Cells

Along the transformation process, cells accumulate DNA aberrations, including mutations, translocations, amplifications, and deletions. Despite numerous studies, the overall effects of amplifications and deletions on the end point of gene expression—the level of proteins—is generally unknown. Here we use large-scale and high-resolution proteomics combined with gene copy number analysis to investigate in a global manner to what extent these genomic changes have a proteomic output and therefore the ability to affect cellular transformation. We accurately measure expression levels of 6,735 proteins and directly compare them to the gene copy number. We find that the average effect of these alterations on the protein expression is only a few percent. Nevertheless, by using a novel algorithm, we find the combined impact that many of these regional chromosomal aberrations have at the protein level. We show that proteins encoded by amplified oncogenes are often overexpressed, while adjacent amplified genes, which presumably do not promote growth and survival, are attenuated. Furthermore, regulation of biological processes and molecular complexes is independent of general copy number changes. By connecting the primary genome alteration to their proteomic consequences, this approach helps to interpret the data from large-scale cancer genomics efforts

Synthesising practice guidelines for the development of community-based exercise programmes after stroke

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Multiple guidelines are often available to inform practice in complex interventions. Guidance implementation may be facilitated if it is tailored to particular clinical issues and contexts. It should also aim to specify all elements of interventions that may mediate and modify effectiveness, including both their content and delivery. We conducted a focused synthesis of recommendations from stroke practice guidelines to produce a structured and comprehensive account to facilitate the development of community-based exercise programmes after stroke.National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsul

Mount Peake - Lander River, Northern Territory : combined explanatory notes

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Tennant Creek, Northern Territory : explanatory notes

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Short Range, Northern Territory : explanatory notes

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