Origin and stability of the dipolar response in a family of tetragonal tungsten bronze relaxors

A new family of relaxor dielectrics with the tetragonal tungsten bronze structure (nominal composition Ba6M3+Nb9O30, M3+ = Ga, Sc or In) were studied using dielectric spectroscopy to probe the dynamic dipole response and correlate this with the crystal structure as determined from powder neutron diffraction. Independent analyses of real and imaginary parts of the complex dielectric function were used to determine characteristic temperature parameters, TVF, and TUDR, respectively. In each composition both these temperatures correlated with the temperature of maximum crystallographic strain, Tc/a determined from diffraction data. The overall behaviour is consistent with dipole freezing and the data indicate that the dipole stability increases with increasing M3+ cation size as a result of increased tetragonality of the unit cell. Crystallographic data suggests that these materials are uniaxial relaxors with the dipole moment predominantly restricted to the B1 cation site in the structure. Possible origins of the relaxor behaviour are discussed.Comment: Main article 32 pages, 8 figures; Supplementary data 24 pages, 4 figure

Comorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project

Background. Patients with SCD now usually live well into adulthood. Whereas transitions into adulthood are now often studied, little is published about aging beyond the transition period. We therefore studied age-associated SCD differences in utilization, pain, and psychosocial variables. Methods. Subjects were 232 adults in the Pain in Sickle Cell Epidemiology Study (PiSCES). Data included demographics, comorbidity, and psychosocial measures. SCD-related pain and health care utilization were recorded in diaries. We compared 3 age groups: 16–25 (transition), 26–36 (younger adults), and 37–64 (older adults) years. Results. Compared to the 2 adult groups, the transition group reported fewer physical challenges via comorbidities, somatic complaints, and pain frequency, though pain intensity did not differ on crisis or noncrisis pain days. The transition group utilized opioids less often, made fewer ambulatory visits, and had better quality of life, but these differences disappeared after adjusting for pain and comorbidities. However, the transition group reported more use of behavioral coping strategies. Conclusion. We found fewer biological challenges, visits, and better quality of life, in transition-aged versus older adults with SCD, but more behavioral coping. Further study is required to determine whether age-appropriate health care, behavioral, or other interventions could improve age-specific life challenges of patients with SCD

Signs And Voices: Deaf Culture, Identity, Language, And Arts

This collection, carefully chosen from the recent Signs and Voices Conference, the Presidential Forum on American Sign Language at the Modern Language Association Convention, and other sources, addresses all of the factors now changing the cultural landscape for deaf people. Taken together, the essays in this book and the accompanying DVD point to new directions in a broad range of fields, including cognitive science, deaf studies, disability studies, education, linguistics, literary criticism, philosophy, and psychology. This showcase of innovative and rigorous cross-disciplinary study will prove invaluable to everyone interested in the current state of the Deaf community

Transforming Equity-oriented Leaders: Principal Residency Network Program Evaluation

After 12 years focused on developing school leaders who act as change agents for educational equity, the Principal Residency Network (PRN) partnered with Johnson and Wales University’s Center for Research and Evaluation to conduct a utilization-focused (Patton, 2002) program evaluation funded by a grant from the Rhode Island Foundation. The PRN is a principal preparation program of the non-profit organization, the Center for Leadership and Educational Equity. This sequential explanatory mixed methods study explored PRN graduates’ outcomes and perceptions of the program, with an overarching purpose of creating a coherent data collection and inquiry process to be used by program staff on an ongoing basis. Following the development of an evaluation framework, Phase I of the study consisted of collecting assessment data and feedback from current PRN participants, as well as administering a survey questionnaire to recent graduates of the program (N=14), previously administered in 2005 (N=21) and 2009 (N=6). Phase II of this evaluation was designed to further explore recent graduates’ perceptions of the nature and relevancy of the program in developing their commitment and skill to lead for equity in order to recommend program improvements; N=7 participated in a 90 minute focus group. Findings indicated four conclusions from which recommendations were drawn: the program is achieving strong results, participants perceive the program to have an interconnected and coherent focus on preparing them to be equity-oriented leaders, the mentor is a critical component, and modeling the cycle of inquiry created through this evaluative study is important

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis

The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage. Although direct activation of the Activin-A and/or Bmp pathways with growth factors yields context-dependent success, recent studies have shown that induction of Wnt signaling using low molecular weight molecules such as CHIR, which in turn induces the Activin-A and Bmp pathways, is widely effective. To further enhance the reproducibility of CHIR-induced cardiomyogenesis, and to ultimately promote myocyte maturation, we are using exogenous growth factors to optimize cardiomyogenic signaling downstream of CHIR induction. As indicated by RNA-seq, induction with CHIR during Day 1 (Days 0–1) was followed by immediate expression of Nodal ligands and receptors, followed later by Bmp ligands and receptors. Co-induction with CHIR and high levels of the Nodal mimetic Activin-A (50–100 ng/ml) during Day 0–1 efficiently induced definitive endoderm, whereas CHIR supplemented with Activin-A at low levels (10 ng/ml) consistently improved cardiomyogenic efficiency, even when CHIR alone was ineffective. Moreover, co-induction using CHIR and low levels of Activin-A apparently increased the rate of cardiomyogenesis, as indicated by the initial appearance of rhythmically beating cells by Day 6 instead of Day 8. By contrast, co-induction with CHIR plus low levels (3–10 ng/ml) of Bmp4 during Day 0–1 consistently and strongly inhibited cardiomyogenesis. These findings, which demonstrate that cardiomyogenic efficacy is improved by optimizing levels of CHIR-induced growth factors when applied in accord with their sequence of endogenous expression, are consistent with the idea that Nodal (Activin-A) levels toggle the entry of cells into the endodermal or mesodermal lineages, while Bmp levels regulate subsequent allocation into mesodermal cell types

Lessons learned from adapting a remote area health placement from physical to virtual: a COVID-19-driven innovation

Objectives: To investigate the acceptability and the effectiveness of a virtual adaptation of a well-established, mandatory, community-based pre-clinical remote area health placement in which medical students learn about the social and environmental determinants of health in remote Australia; and make recommendations to guide the delivery of future learning experiences. Methods: A mixed-methods convergent design was used. All 99 students, 36 placement hosts and 10 staff were invited to complete an online survey and 27(27%), 12(33%) and 10(100%), respectively, contributed data. Qualitative data were collected via semi-structured interviews from four students, four hosts and six staff. Survey data were analysed using descriptive statistics (frequency and percentage) and open-ended responses summarised to provide supporting contextual evidence. Interview transcripts were analysed and coded independently, then corroborated to identify and summarise common themes using thematic analysis. Results: Survey and interview data indicated that the virtual placement was acceptable to students and hosts and enabled students to achieve intended learning objectives. Virtual activities enabled students and hosts to develop authentic, genuine interpersonal relationships, which in turn were facilitated when hosts and students had practiced videoconferencing beforehand with good high-speed internet connections via mobile devices. Pastoral care and access to IT support were essential. Conclusions: Virtual placements can be used in combination with and are an option for students and hosts who cannot attend/courses that cannot fund physical placements. Careful design and further research is required to ensure that virtual placements enable "head, heart and hands" learning and do not create/reinforce inequities

Millennial Alumni Perceptions of Communications: A Look at One Land Grant University’s Media Use

An important aspect of higher education is alumni relationship cultivation, because it keeps alma maters connected to graduates. To assess this relationship, researchers sought to describe Millennial alumni perceptions of media distributed by the Dale Bumpers College of Agricultural, Food, and Life Sciences (Bumpers College) from 2012 through 2014. Assessed media included alumni magazines, an e-newsletter, key event invitations, College website, and social media presences. Active and inactive alumni responses were gathered via telephone interviews and qualitatively analyzed for emergent themes. Researchers identified Building the Professional and Interest in Giving Back as themes related to respondents’ connection to Bumpers College. Five additional themes emerged related to assessed media and included Message Relationship, Specialized Content, Communications Medium, Message Barriers, and Need for Promotion. No alumni were dissatisfied with their collegiate experience and favored monetary donations for its convenience. Alumni sought a personable-angle communications media and were drawn by updates about the College’s research and global impacts. Respondents consumed print and digital media differently with engagement based on personal preference and flexibility. Subthemes emerged related to Message Barriers and included time, distance, vague messages, too much information, non-relatable subject matter, technical errors, and outdated information. Finally, there was little brand recognition between Bumpers College and University messaging, and most alumni were unaware of the College’s social media presences

Access: Multiple Avenues For Deaf People

The companion to Signs and Voices: Deaf Culture, Identity, Language, and Arts, this volume presents an accomplished group of contributors who address the major technological, institutional, and societal advances in access for deaf people, as well as the remaining hurdles

Lack of nAChR Activity Depresses Cochlear Maturation and Up-Regulates GABA System Components: Temporal Profiling of Gene Expression in α9 Null Mice

It has previously been shown that deletion of chrna9, the gene encoding the alpha9 nicotinic acetylcholine receptor (nAChR) subunit, results in abnormal synaptic terminal structure. Additionally, all nAChR-mediated cochlear activity is lost, as characterized by a failure of the descending efferent system to suppress cochlear responses to sound. In an effort to characterize the molecular mechanisms underlying the structural and functional consequences following loss of alpha9 subunit expression, we performed whole-transcriptome gene expression analyses on cochleae of wild type and alpha9 knockout (alpha9(-/-)) mice during postnatal days spanning critical periods of synapse formation and maturation.Data revealed that loss of alpha9 receptor subunit expression leads to an up-regulation of genes involved in synaptic transmission and ion channel activity. Unexpectedly, loss of alpha9 receptor subunit expression also resulted in an increased expression of genes encoding GABA receptor subunits and the GABA synthetic enzyme, glutamic acid decarboxylase. These data suggest the existence of a previously unrecognized association between the nicotinic cholinergic and GABAergic systems in the cochlea. Computational analyses have highlighted differential expression of several gene sets upon loss of nicotinic cholinergic activity in the cochlea. Time-series analysis of whole transcriptome patterns, represented as self-organizing maps, revealed a disparate pattern of gene expression between alpha9(-/-) and wild type cochleae at the onset of hearing (P13), with knockout samples resembling immature postnatal ages.We have taken a systems biology approach to provide insight into molecular programs influenced by the loss of nicotinic receptor-based cholinergic activity in the cochlea and to identify candidate genes that may be involved in nicotinic cholinergic synapse formation, stabilization or function within the inner ear. Additionally, our data indicate a change in the GABAergic system upon loss of alpha9 nicotinic receptor subunit within the cochlea

Millennial Alumni Perceptions of Communications: A Look at One Land Grant University’s Media Use

An important aspect of higher education is alumni relationship cultivation, because it keeps alma maters connected to graduates. To assess this relationship, researchers sought to describe Millennial alumni perceptions of media distributed by the Dale Bumpers College of Agricultural, Food, and Life Sciences (Bumpers College) from 2012 through 2014. Assessed media included alumni magazines, an e-newsletter, key event invitations, College website, and social media presences. Active and inactive alumni responses were gathered via telephone interviews and qualitatively analyzed for emergent themes. Researchers identified Building the Professional and Interest in Giving Back as themes related to respondents’ connection to Bumpers College. Five additional themes emerged related to assessed media and included Message Relationship, Specialized Content, Communications Medium, Message Barriers, and Need for Promotion. No alumni were dissatisfied with their collegiate experience and favored monetary donations for its convenience. Alumni sought a personable-angle communications media and were drawn by updates about the College’s research and global impacts. Respondents consumed print and digital media differently with engagement based on personal preference and flexibility. Subthemes emerged related to Message Barriers and included time, distance, vague messages, too much information, non-relatable subject matter, technical errors, and outdated information. Finally, there was little brand recognition between Bumpers College and University messaging, and most alumni were unaware of the College’s social media presences