Compounded Apixaban Suspensions for Enteral Feeding Tubes

Objective: There is limited information on compounded apixaban formulations for administration via enteral feeding tubes. This study was designed to identify a suitable apixaban suspension formulation that is easy to prepare in a pharmacy setting, is compatible with commonly used feeding tubes, and has a beyond-use date of seven days. Methods: Apixaban suspensions were prepared from commercially available 5 mg Eliquis® tablets. Several vehicles and compounding methods were screened for ease of preparation, dosage accuracy, and tube compatibility. Two tubing types, polyurethane and polyvinyl chloride (PVC), with varying lengths and diameters, were included in the study. They were mounted on a peg board during evaluation to mimic the patient body position. A seven-day stability study of the selected formulation was also conducted. Results: Vehicles containing 40-60% Ora-Plus® in water all exhibited satisfactory flowability through the tubes. The mortar/pestle compounding method was found to produce more accurate and consistent apixaban suspensions than the pill crusher or crushing syringe method. The selected formulation, 0.25 mg/mL apixaban in 50:50 Ora-Plus®:water, was compatible with both tubing types, retaining \u3e 98% drug in post-tube samples. The stability study also confirmed that this formulation was stable physically and chemically over seven days of storage at room temperature. Conclusions: A suitable apixaban suspension formulation was identified for administration via enteral feeding tubes. The formulation consisted of 0.25 mg/mL apixaban in 50:50 Ora-Plus®:water. The stability study results supported a beyond-use date of seven days at room temperature

Quasi Periodic Oscillations (QPOs) and frequencies in an accretion disk and comparison with the numerical results from non-rotating black hole computed by the GRH code

The shocked wave created on the accretion disk after different physical phenomena (accretion flows with pressure gradients, star-disk interaction etc.) may be responsible observed Quasi Periodic Oscillations (QPOs) in $X-$ray binaries. We present the set of characteristics frequencies associated with accretion disk around the rotating and non-rotating black holes for one particle case. These persistent frequencies are results of the rotating pattern in an accretion disk. We compare the frequency's from two different numerical results for fluid flow around the non-rotating black hole with one particle case. The numerical results are taken from our papers Refs.\refcite{Donmez2} and \refcite{Donmez3} using fully general relativistic hydrodynamical code with non-selfgravitating disk. While the first numerical result has a relativistic tori around the black hole, the second one includes one-armed spiral shock wave produced from star-disk interaction. Some physical modes presented in the QPOs can be excited in numerical simulation of relativistic tori and spiral waves on the accretion disk. The results of these different dynamical structures on the accretion disk responsible for QPOs are discussed in detail.Comment: 13 figures, added reference, accepted for publication in Modern Physics Letters

Optimization of Single-Sided Charge-Sharing Strip Detectors

Simulation of the charge sharing properties of single-sided CZT strip detectors with small anode pads are presented. The effect of initial event size, carrier repulsion, diffusion, drift, trapping and detrapping are considered. These simulations indicate that such a detector with a 150 µm pitch will provide good charge sharing between neighboring pads. This is supported by a comparison of simulations and measurements for a similar detector with a coarser pitch of 225 µm that could not provide sufficient sharing. The performance of such a detector used as a gamma-ray imager is discussed

Continued Studies of Single-Sided Charge-Sharing CZT Strip Detectors

In this paper, we report progress in the study of thick single-sided charge-sharing cadmium zinc telluride (CZT) strip detector modules designed to perform gammaray spectroscopy and 3-D imaging. We report on continuing laboratory and simulation measurements of prototype detectors with 11×11 unit cells (15×15×7.5mm3 ). We report preliminary measurements of the 3-D spatial resolution. Our studies are aimed at developing compact, efficient, detector modules for 0.05 to 1 MeV gamma measurements while minimizing the number and complexity of the electronic readout channels. This is particularly important in space-based coded aperture and Compton telescope instruments that require large area, large volume detector arrays. Such arrays will be required for the NASA’s Black Hole Finder Probe (BHFP) and Advanced Compton Telescope (ACT). This design requires an anode pattern with contacts whose dimensions and spacing are roughly the size of the ionization charge cloud. The first prototype devices have 125µm anode contacts on 225µm pitch. Our studies conclude that finer pitch contacts will be required to improve imaging efficiency

Further studies of single-sided charge-sharing CZT strip detectors

We report progress in the study of a thick CZT strip detector module designed to perform gamma-ray spectroscopy and 3-D imaging. We report preliminary performance measurements of 7.5 mm thick single-sided charge-sharing strip detector prototype devices. This design features both row and column contacts on the anode surface. This electron-only approach addresses problems associated with poor hole transport in CZT that limit the thickness and energy range of double-sided strip detectors. This work includes laboratory and simulation studies aimed at developing compact, efficient, detector modules for 0.05 to 1 MeV gamma measurements while minimizing the number and complexity of the electronic readout channels. This is particularly important in space-based coded aperture and Compton telescope instruments that require large area, large volume detector arrays. Such arrays will be required for the NASA Black Hole Finder Probe (BHFP)and Advanced Compton Telescope (ACT). This new design requires an anode pattern with contacts whose dimensions and spacing are roughly the size of the ionization charge cloud. The first prototype devices have 125 μm anode contacts on 225 μm pitch. Our results demonstrate the principle of operation but suggest that even finer anode contact feature sizes will be necessary to achieve the desired performance

Single-sided CZT strip detectors

We report progress in the study of thick CZT strip detectors for 3-d imaging and spectroscopy and discuss two approaches to device design. We present the spectroscopic, imaging, detection efficiency and response uniformity performance of prototype devices. Unlike double-sided strip detectors, these devices feature both row and column contacts implemented on the anode surface. This electron-only approach circumvents problems associated with poor hole transport in CZT that normally limit the thickness and energy range of double-sided strip detectors. These devices can achieve similar performance to pixel detectors. The work includes laboratory and simulation studies aimed at developing compact, efficient, detector modules for 0.05 to 1 MeV gamma radiation measurements. The low channel count strip detector approach can significantly reduce the complexity and power requirements of the readout electronics. This is particularly important in space-based coded aperture or Compton telescope instruments requiring large area, large volume detector arrays. Such arrays will be required for NASA\u27s Black Hole Finder Probe (BHFP) and Advanced Compton Telescope (ACT)

Polymer-inorganic core-shell nanofibers by electrospinning and atomic layer deposition: flexible nylon-znO core-shell nanofiber mats and their photocatalytic activity

Cataloged from PDF version of article.Polymer-inorganic core-shell nanofibers were produced by two-step approach; electrospinning and atomic layer deposition (ALD). First, nylon 6,6 (polymeric core) nanofibers were obtained by electrospinning, and then zinc oxide (ZnO) (inorganic shell) with precise thickness control was deposited onto electrospun nylon 6,6 nanofibers using ALD technique. The bead-free and uniform nylon 6,6 nanofibers having different average fiber diameters (∼80, ∼240 and ∼650 nm) were achieved by using two different solvent systems and polymer concentrations. ZnO layer about 90 nm, having uniform thickness around the fiber structure, was successfully deposited onto the nylon 6,6 nanofibers. Because of the low deposition temperature utilized (200 °C), ALD process did not deform the polymeric fiber structure, and highly conformal ZnO layer with precise thickness and composition over a large scale were accomplished regardless of the differences in fiber diameters. ZnO shell layer was found to have a polycrystalline nature with hexagonal wurtzite structure. The core-shell nylon 6,6-ZnO nanofiber mats were flexible because of the polymeric core component. Photocatalytic activity of the core-shell nylon 6,6-ZnO nanofiber mats were tested by following the photocatalytic decomposition of rhodamine-B dye. The nylon 6,6-ZnO nanofiber mat, having thinner fiber diameter, has shown better photocatalytic efficiency due to higher surface area of this sample. These nylon 6,6-ZnO nanofiber mats have also shown structural stability and kept their photocatalytic activity for the second cycle test. Our findings suggest that core-shell nylon 6,6-ZnO nanofiber mat can be a very good candidate as a filter material for water purification and organic waste treatment because of their photocatalytic properties along with structural flexibility and stability. © 2012 American Chemical Society

Template-based synthesis of aluminum nitride hollow Nanofibers via plasma-enhanced atomic layer deposition

Cataloged from PDF version of article.Aluminum nitride (AlN) hollow nanofibers were synthesized via plasma-enhanced atomic layer deposition using sacrificial electrospun polymeric nanofiber templates having different average fiber diameters (~70, ~330, and ~740 nm). Depositions were carried out at 200°C using trimethylaluminum and ammonia precursors. AlN-coated nanofibers were calcined subsequently at 500°C for 2 h to remove the sacrificial polymeric nanofiber template. SEM studies have shown that there is a critical wall thickness value depending on the template's average fiber diameter for AlN hollow nanofibers to preserve their shapes after the template has been removed by calcination. Best morphologies were observed for AlN hollow nanofibers prepared by depositing 800 cycles (corresponding to ~69 nm) on nanofiber templates having ~330 nm average fiber diameter. TEM images indicated uniform wall thicknesses of ~65 nm along the fiber axes for samples prepared using templates having ~70 and ~330 nm average fiber diameters. Synthesized AlN hollow nanofibers were polycrystalline with a hexagonal crystal structure as determined by high-resolution TEM and selected area electron diffraction. Chemical compositions of coated and calcined samples were studied using X-ray photoelectron spectroscopy (XPS). High-resolution XPS spectra confirmed the presence of AlN. © 2012 The American Ceramic Societ

Size-controlled conformal nanofabrication of biotemplated three-dimensional TiO2 and ZnO nanonetworks

Cataloged from PDF version of article.A solvent-free fabrication of TiO2 and ZnO nanonetworks is demonstrated by using supramolecular nanotemplates with high coating conformity, uniformity, and atomic scale size control. Deposition of TiO2 and ZnO on three-dimensional nanofibrous network template is accomplished. Ultrafine control over nanotube diameter allows robust and systematic evaluation of the electrochemical properties of TiO2 and ZnO nanonetworks in terms of size-function relationship. We observe hypsochromic shift in UV absorbance maxima correlated with decrease in wall thickness of the nanotubes. Photocatalytic activities of anatase TiO2 and hexagonal wurtzite ZnO nanonetworks are found to be dependent on both the wall thickness and total surface area per unit of mass. Wall thickness has effect on photoexcitation properties of both TiO2 and ZnO due to band gap energies and total surface area per unit of mass. The present work is a successful example that concentrates on nanofabrication of intact three-dimensional semiconductor nanonetworks with controlled band gap energies