Effects of Perioperative Psychological Intervention on Rehabilitation Process of Patients with Total Knee Arthroplasty

Background: This study focuses on evaluating the effects of perioperative psychological intervention on rehabilitation process of patients with total knee arthroplasty (TKA). Method: We selected 40 patients randomly which all need to receive total knee arthroplasty in Nanjing Drum Tower Hospital during the period from January 2022 to March 2022. The patients were randomly assigned to two Groups (20 in each group): an intervention group (Psychological intervention combined with routine nursing, drug and rehabilitation therapy) and a control group (routine nursing, drug rehabilitation therapy). During each patients’ perioperative TKA surgeries, three scales (including VAS, ROM and ADL) are used to assess two groups. Result: After one week of psychological intervention, the pain score of the intervention group was lower than that of control group, the knee motion was greater than that of control group, and the ADL score was higher than that of control group. There was a significant difference in the treatment recovery between the two groups (P<0.05) Conclusions: Perioperative psychological intervention can promote the rehabilitation process of TKA patients, It can significantly improve pain, joint activity limitation, disuse muscle atrophy and other problems in a short period of time after surgery. Besides, it will effectively help patients to overcome the fear of movement, anxiety and improve patients' confidence, rehabilitation cooperation and prevention of complications, make patients adapt to the later rehabilitation life

Binder-free and carbon-free 3D porous air electrode for Li-O2 batteries with high efficiency, high capacity, and long life

Pt-Gd alloy polycrystalline thin film is deposited on 3D nickel foam by pulsed laser deposition method serving as a whole binder/carbon-free air electrode, showing great catalytic activity enhancement as an efficient bifunctional catalyst for the oxygen reduction and evolution reactions in lithium oxygen batteries. The porous structure can facilitate rapid O2 and electrolyte diffusion, as well as forming a continuous conductive network throughout the whole energy conversion process. It shows a favorable cycle performance in the full discharge/charge model, owing to the high catalytic activity of the Pt-Gd alloy composite and 3D porous nickel foam structure. Specially, excellent cycling performance under capacity limited mode is also demonstrated, in which the terminal discharge voltage is higher than 2.5 V and the terminal charge voltage is lower than 3.7 V after 100 cycles at a current density of 0.1 mA cm−2. Therefore, this electrocatalyst is a promising bifunctional electrocatalyst for lithium oxygen batteries and this depositing high-efficient electrocatalyst on porous substrate with polycrystalline thin film by pulsed laser deposition is also a promising technique in the future lithium oxygen batteries research

Changes and driving forces analysis of alpine wetlands in the first meander of the Yellow River based on long-term time series remote sensing data

IntroductionAs a vital component of the ecosystem of the Qinghai-Tibet Plateau, alpine wetlands coexist with their vulnerability, sensitivity, and abundant biodiversity, propelling the material cycle and energy flux of the entire plateau ecosystem. In recent decades, climate change and human activities have significantly altered the regional landscape. Monitoring and assessing changes in the alpine wetlands on the Qinghai-Tibet Plateau requires the efficient and accurate collection of long-term information.MethodsHere, we interpreted the remote sensing data of the first meander of the Yellow River of alpine wetlands from 1990 to 2020 based on Google Earth Engine (GEE) platform, using geographic information system (GIS) and landscape pattern index to analyze the spatial and temporal evolution of wetland landscape patterns, and the primary drivers of changes in wetland area were explored by GeoDetector.ResultsOur result showed that most wetland areas were found in regions with gradients less than 12° and elevations between 3315 and 3600 m. From 1990 to 2010, the area of alpine wetland in the study area decreased by 25.43%. During the period between 2010 and 2020 to the 1990s, the wetland area decreased by 322.9 km2. Conversion to and from grassland was the primary form of wetland transfer out and in, respectively. The overall migration of the wetland centroid in the study area was to the southwest between 1990 and 2010 and to the north between 2010 and 2020. The geometry of the wetland landscape was relatively simple, the landscape was relatively intact, and patches retained a high level of agglomeration and connectivity. However, their level of agglomeration and connectivity was disrupted. A quantitative analysis of the factor detector in GeoDetector revealed that the DEM, slope, and evaporation were the most important driving factors influencing the change of wetland area, with socioeconomic development also influencing changes in the wetland area to a lesser extent.DiscussionUsing interaction detectors, it was discovered that the interaction of various driving factors could better explain the long-term variations in wetland areas, with a greater degree of explanation than that of each driving factor alone

Core-shell Co/CoO integrated on 3D nitrogen doped reduced graphene oxide aerogel as an enhanced electrocatalyst for the oxygen reduction reaction

Here, we demonstrate that Cobalt/cobalt oxide core-shell nanoparticles integrated on nitrogen-doped (N-doped) three-dimensional reduced graphene oxide aerogel-based architecture (Co/CoO-NGA) were synthesized through a facile hydrothermal method followed by annealing treatment. The unique endurable porous structure could provide sufficient mass transfer channels and ample active sites on Co/CoO-NGA to facilitate the catalytic reaction. The synthesized Co/CoO-NGA was explored as an electrocatalyst for the oxygen reduction reaction, showing comparable oxygen reduction performance with excellent methanol resistance and better durability compared with Pt/C

Core-shell Co/CoO integrated on 3D nitrogen doped reduced graphene oxide aerogel as an enhanced electrocatalyst for the oxygen reduction reaction

Here, we demonstrate that Cobalt/cobalt oxide core-shell nanoparticles integrated on nitrogen-doped (N-doped) three-dimensional reduced graphene oxide aerogel-based architecture (Co/CoO-NGA) were synthesized through a facile hydrothermal method followed by annealing treatment. The unique endurable porous structure could provide sufficient mass transfer channels and ample active sites on Co/CoO-NGA to facilitate the catalytic reaction. The synthesized Co/CoO-NGA was explored as an electrocatalyst for the oxygen reduction reaction, showing comparable oxygen reduction performance with excellent methanol resistance and better durability compared with Pt/C

The transcriptome sequencing analysis reveals immune mechanisms of soybean fermented powder on the loach (Misgurnus anguillicaudatus) in response to Lipopolysaccharide (LPS) infection

The loach (Misgurnus anguillicaudatus), a small commercial fish that is widely cultivated for its high-quality protein, vitamins, minerals, and essential amino acid, is a member of the genus Misgurnus and the family Cyprinidae. In this study, we gave the LPS-injected loach fermented soybean meal and used transcriptome sequencing to investigate the impact of the fermented soybean powder on the loach’s immune system. 3384 up-regulated genes and 12116 down-regulated genes were found among the 15500 differentially expressed genes, according to the results. The differentially expressed genes were shown to be involved in cellular processes, metabolic processes, cellular anatomical entities, and binding, according to the Go functional annotation. Meanwhile, the KEGG enrichment analysis indicated that the soybean fermented powder treated groups showed significant differences in DNA replication, Nucleotide excision repair, Fanconi anemia pathway, and Base excision repair pathways, suggesting that these pathways are closely related to the enhancement of the immune function of loach by soybean fermented powder. The particular conclusions not exclusively can provide a new conception for the rational utilization of soybean fermented powder but also can provide theoretical guidance for the subsequent healthy breeding of loach

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

BackgroundMitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network. Moreover, MFN2 is essential for mitophagy. In Ang II-induced cardiac remodeling, the combined effects of MFN2-mediated mitochondrial fusion and mitophagy are unclear. This study was designed to explore a novel strategy for preventing cardiomyocyte injury via modulation of mitochondrial dynamics.MethodsWe studied the function of MFN2 in mitochondrial fusion and mitophagy in Ang II-stimulated cardiomyocyte injury. Cardiomyocyte injury experiments, including reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), and apoptosis rate of cardiomyocytes were performed. The mitochondrial morphology in cardiomyocytes was examined via transmission electron microscopy (TEM) and confocal microscopy. Autophagic levels in response to Ang II were examined by immunoblotting of autophagy-related proteins. Moreover, PINK1/MFN2/Parkin pathway-related proteins were examined.ResultsWith stimulation by Ang II, MFN2 expression was progressively reduced. MFN2 deficiency impaired mitochondrial quality, resulting in exacerbated mitochondrial damage induced by Ang II. The Ang II-induced increases in ROS production and apoptosis rate were alleviated by MFN2 overexpression. Moreover, MFN2 alleviated the Ang II-induced reduction in MMP. MFN2 promoted mitochondrial fusion, and MFN2 promoted Parkin translocation and phosphorylation, leading to mitochondrial autophagy. The effects of MFN2 overexpression were reversed by autophagy inhibitors.ConclusionMitofusin 2 promotes Parkin translocation and phosphorylation, leading to mitophagy to clear damaged mitochondria. However, the beneficial effects of MFN2 were reversed by autophagy inhibitors. Additionally, MFN2 participates in mitochondrial fusion to maintain mitochondrial quality. Thus, MFN2 participated in mitophagy and mitochondrial fusion against Ang II-induced cardiomyocyte injury

Cold-Season Surface Energy Balance on East Rongbuk Glacier, Northern Slope of Mt. Qomolangma (Everest)

As the highest peak on the earth, Mt. Qomolangma provides an unparalleled platform to study glacier-atmosphere interaction. Although glacier surface energy balance (SEB) on Mt. Qomolangma was examined during warm season, relevant knowledge during cold season is still unknown, which prevents a complete understanding of all-season glacier SEB on it. Based on an in-situ observation from October 2007 to January 2008, this study presents a cold-season glacier SEB result at 6,523 m above sea level on Mt. Qomolangma and identifies its atmospheric control. Our results show that the observational period experienced strong winds and deficient clouds. Near-surface wind speeds usually exceeded 10 m s−1, resulting in a substantial sensible heat transport toward glacier and thus enhancing outgoing longwave radiation, which, under the combined effect of deficient clouds, eventually caused an increase in longwave radiative loss. The large solar zenith angle and relatively high albedo of the glacier surface led to a small absorption of solar irradiance, which, in combination with the strong longwave radiation loss, resulted in a semi-permanent surface radiative loss. Uncommon over the highly reflective glacier surface, clouds decreased the incident solar radiation more than increased the longwave radiation, demonstrating that the clouds' shading effect surpassed its greenhouse effect. As a vital heat sink, the turbulent latent heat induced an average sublimation rate of 0.8 mm water equivalent per day. This study provides valuable insights into the atmospheric control on the cold-season glacier-atmosphere interaction at high altitudes on Mt. Qomolangma when meteorological variables are subject to the westerlies