Background: This study focuses on evaluating the effects of perioperative psychological intervention on rehabilitation process of patients with total knee arthroplasty (TKA). Method: We selected 40 patients randomly which all need to receive total knee arthroplasty in Nanjing Drum Tower Hospital during the period from January 2022 to March 2022. The patients were randomly assigned to two Groups (20 in each group): an intervention group (Psychological intervention combined with routine nursing, drug and rehabilitation therapy) and a control group (routine nursing, drug rehabilitation therapy). During each patients’ perioperative TKA surgeries, three scales (including VAS, ROM and ADL) are used to assess two groups. Result: After one week of psychological intervention, the pain score of the intervention group was lower than that of control group, the knee motion was greater than that of control group, and the ADL score was higher than that of control group. There was a significant difference in the treatment recovery between the two groups (P<0.05) Conclusions: Perioperative psychological intervention can promote the rehabilitation process of TKA patients, It can significantly improve pain, joint activity limitation, disuse muscle atrophy and other problems in a short period of time after surgery. Besides, it will effectively help patients to overcome the fear of movement, anxiety and improve patients' confidence, rehabilitation cooperation and prevention of complications, make patients adapt to the later rehabilitation life
