1,417 research outputs found
Chapter 9: Aquatic Macroinvertebrates, Section A: Aquatic Macroinvertebrates (Exclusive of Mosquitoes)
Final Report. Excerpt (Chapter 9, Section A) from The Des Plaines River Wetlands
Demonstration Project, Volume II, Baseline Survey, edited by Donald L. Hey and Nancy S.
PhilippiReport issued on: October 1985INHS Technical Report prepared for Wetlands Research, Inc
Controlling changes in vocal tract resistance
There is some evidence that speech aerodynamics follows the rules of a regulating system. The purpose of the present study was to assess how the speech system manages perturbations that produce "errors" within the system. Three experimental approaches were used to evaluate the physiological responses to an imposed change in airway resistance. The first involved subjects with varying degrees of velopharyngeal inadequacy. The second and third approaches involved noncleft subjects whose airway was perturbed by bleed valves and bite blocks during consonant productions. The pressure-flow technique was used to measure aerodynamic variables associated with the production of test consonants. The results of this study provide additional evidence that the speech system actively responds to perturbations in ways that tend to minimize a change in consonant speech pressures. The degree of success in stabilizing pressures appears to reflect the capability of the system to use whatever articulatory and respiratory responses are available
Perception and Respiratory Responses of the Upper Airway Mechanism to Added Resistance With Aging
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141059/1/lio2123_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141059/2/lio2123.pd
Effect of Vehicle on the Nasal Absorption of Epinephrine During Cardiopulmonary Resuscitation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90174/1/j.1875-9114.1996.tb03030.x.pd
Lifespan extension and the doctrine of double effect
Recent developments in biogerontology—the study of the biology of ageing—suggest that it may eventually be possible to intervene in the human ageing process. This, in turn, offers the prospect of significantly postponing the onset of age-related diseases. The biogerontological project, however, has met with strong resistance, especially by deontologists. They consider the act of intervening in the ageing process impermissible on the grounds that it would (most probably) bring about an extended maximum lifespan—a state of affairs that they deem intrinsically bad. In a bid to convince their deontological opponents of the permissibility of this act, proponents of biogerontology invoke an argument which is grounded in the doctrine of double effect. Surprisingly, their argument, which we refer to as the ‘double effect argument’, has gone unnoticed. This article exposes and critically evaluates this ‘double effect argument’. To this end, we first review a series of excerpts from the ethical debate on biogerontology in order to substantiate the presence of double effect reasoning. Next, we attempt to determine the role that the ‘double effect argument’ is meant to fulfil within this debate. Finally, we assess whether the act of intervening in ageing actually can be justified using double effect reasoning
A FUSE Survey of Interstellar Molecular Hydrogen in the Small and Large Magellanic Clouds
We describe a moderate-resolution FUSE survey of H2 along 70 sight lines to
the Small and Large Magellanic Clouds, using hot stars as background sources.
FUSE spectra of 67% of observed Magellanic Cloud sources (52% of LMC and 92% of
SMC) exhibit absorption lines from the H2 Lyman and Werner bands between 912
and 1120 A. Our survey is sensitive to N(H2) >= 10^14 cm^-2; the highest column
densities are log N(H2) = 19.9 in the LMC and 20.6 in the SMC. We find reduced
H2 abundances in the Magellanic Clouds relative to the Milky Way, with average
molecular fractions = 0.010 (+0.005, -0.002) for the SMC and =
0.012 (+0.006, -0.003) for the LMC, compared with = 0.095 for the
Galactic disk over a similar range of reddening. The dominant uncertainty in
this measurement results from the systematic differences between 21 cm radio
emission and Lya in pencil-beam sight lines as measures of N(HI). These results
imply that the diffuse H2 masses of the LMC and SMC are 8 x 10^6 Msun and 2 x
10^6 Msun, respectively, 2% and 0.5% of the H I masses derived from 21 cm
emission measurements. The LMC and SMC abundance patterns can be reproduced in
ensembles of model clouds with a reduced H2 formation rate coefficient, R ~ 3 x
10^-18 cm^3 s^-1, and incident radiation fields ranging from 10 - 100 times the
Galactic mean value. We find that these high-radiation, low-formation-rate
models can also explain the enhanced N(4)/N(2) and N(5)/N(3) rotational
excitation ratios in the Clouds. We use H2 column densities in low rotational
states (J = 0 and 1) to derive a mean kinetic and/or rotational temperature
= 82 +/- 21 K for clouds with N(H2) >= 10^16 cm^-2, similar to Galactic
gas. We discuss the implications of this work for theories of star formation in
low-metallicity environments. [Abstract abridged]Comment: 30 pages emulateapj, 14 figures (7 color), 7 tables, accepted for
publication in the Astrophysical Journal, figures 11 and 12 compressed at
slight loss of quality, see http://casa.colorado.edu/~tumlinso/h2/ for full
version
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.0 × 10-8). No SNPs were associated with thoracic aortic calcification at the genome-wide threshold. Increased expression of HDAC9 in human aortic smooth muscle cells promoted calcification and reduced contractility, while inhibition of HDAC9 in human aortic smooth muscle cells inhibited calcification and enhanced cell contractility. In matrix Gla protein-deficient mice, a model of human vascular calcification, mice lacking HDAC9 had a 40% reduction in aortic calcification and improved survival. This translational genomic study identifies the first genetic risk locus associated with calcification of the abdominal aorta and describes a previously unknown role for HDAC9 in the development of vascular calcification
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