Predictors and moderators of outcomes of HIV/STD sex risk reduction interventions in substance abuse treatment programs: a pooled analysis of two randomized controlled trials

BACKGROUND: The objective of the current study was to examine predictors and moderators of response to two HIV sexual risk interventions of different content and duration for individuals in substance abuse treatment programs. METHODS: Participants were recruited from community drug treatment programs participating in the National Institute on Drug Abuse Clinical Trials Network (CTN). Data were pooled from two parallel randomized controlled CTN studies (one with men and one with women) each examining the impact of a multi-session motivational and skills training program, in comparison to a single-session HIV education intervention, on the degree of reduction in unprotected sex from baseline to 3- and 6- month follow-ups. The findings were analyzed using a zero-inflated negative binomial (ZINB) model. RESULTS: Severity of drug use (p < .01), gender (p < .001), and age (p < .001) were significant main effect predictors of number of unprotected sexual occasions (USOs) at follow-up in the non-zero portion of the ZINB model (men, younger participants, and those with greater severity of drug/alcohol abuse have more USOs). Monogamous relationship status (p < .001) and race/ethnicity (p < .001) were significant predictors of having at least one USO vs. none (monogamous individuals and African Americans were more likely to have at least one USO). Significant moderators of intervention effectiveness included recent sex under the influence of drugs/alcohol (p < .01 in non-zero portion of model), duration of abuse of primary drug (p < .05 in non-zero portion of model), and Hispanic ethnicity (p < .01 in the zero portion, p < .05 in the non-zero portion of model). CONCLUSION: These predictor and moderator findings point to ways in which patients may be selected for the different HIV sexual risk reduction interventions and suggest potential avenues for further development of the interventions for increasing their effectiveness within certain subgroups

Substance Use Disorders and HIV/AIDS Prevention and Treatment Intervention: Research and Practice Considerations

Faithful Falcons / Aida Barrera -- Fathers of the Valley–1800 / Dorothy McWhorter -- Hidalgo\u27s Two Musketeers-1905 / Shirley Ann Wallace -- Royal Salt Mine-1730 / Dorothy Burnett -- Citrus King Of Texas-1892 / Jackie Lee Carter -- Edinburg Gets County Seat-1908 / Vilma Gorena -- Legend Of Juan Grande-1820 / Frances Garza -- Valley Terminology-1802 / Joyce Jean Turner -- Martyr of Hidalgo-1854 / Sara S. Weaver -- El Mesquite-1528 / Mary K. Elliott -- First Commissioners\u27 Meeting-1852 / Morgan Groves -- Texas Mustang-1785 / Wanda Davis -- Oil In The Valley-1910 / Otto Woods -- Early Hidalgo Transportation / Dora Mae Kelley -- Better Roads Worst Need-1852 / Morgan Groves -- County Land Grants-1798 -- White Gold Of Bagdad-1840 / Margaret Looney -- A Trip To La Coma Ranch-1903 / Hidalgo Advance -- First Commissioner\u27s Meeting-1852 -- Edinburgh-Circa 1893 / W. H. Chatfield -- A. Y. Baker, Political Ruler-1920 / Allan Engleman -- Border Patrol-1924 -- Battle of Ojo De Agua [Ojo de Agua Raid]-1915 / Louis Consler -- Vegetable and Citrus-1902 / W. H. Friend -- County Agriculture Statistics-1890 / W. H. Chatfield.https://scholarworks.utrgv.edu/lrgv/1003/thumbnail.jp

Temporal Relationship of Sex Risk Behaviors and Substance Use Severity Among Men in Substance Use Treatment

Sex risk behaviors and substance use are intertwined. Many men continue to engage in high-risk sexual behaviors even when enrolled in substance use disorder (SUD) treatment. We hypothesized that changes in sex risk behaviors would coincide with changes in drug/alcohol use severity among men in SUD treatment. During an HIV risk-reduction trial, men in methadone maintenance and outpatient drug-free treatment (N&nbsp;=&nbsp;359) completed assessments at baseline and six&nbsp;months after. We assessed changes in sex risk and substance use severity, using the Addiction Severity Index-Lite (ASI-Lite), controlling for treatment condition. In multinomial logistic regressions, decreased alcohol severity was significantly associated with decreases in reported sex partners, and increased alcohol severity was significantly associated with increases in reported sex partners. Increasing drug use severity was significantly associated with maintaining and initiating sex with a high-risk partner, while decreasing alcohol use severity was significantly associated with discontinuing sex under the influence. However, changes in drug/alcohol use severity were not associated with changes in unprotected sex. Substance use reductions may decrease HIV risk behaviors among male substance users. Our findings highlight the importance of integrating interventions in SUD treatment settings that address the intersection of sex risk behaviors and substance use