PK11195 Increases Anxiety Like Behaviors in the Open Field

Anxiety is one of the most common mental illnesses in the US. Signaling between regions of the brain can be corrupted causing stress related behaviors. Medications that help treat these behaviors target GABA receptors in an inhibitory manner. However, these medications only work for a period of time. The likelihood of being free of these medications becomes uncertain. Another approach is a protein called translocator protein. TSPO, once known as peripheral benzodiazepine receptor is known to mediate anxiety related behaviors through the synthesis of neurosteriods. While TSPO may mediate these behaviors, its mechanism is not well known. Ligand PK11195 was used to evaluate behaviors in animal models using the open field task

Ultradian Cycles of Mood in Normal and Depressed Subjects

Objective: To study ultradian cycles of mood in four inpatient groups. Method: We assessed the mood of depressed and nondepressed subjects, on an hourly basis, between 7:00 a.m. and 10:00 p.m. for two consecutive days using a visual analog scale of mood. Hourly mood scores for each group were plotted against time. Results: We found ultradian cycles with mean lengths of 3-4 hours in all groups. The major depressive episode and adjustment disorder depression groups, however, had ultradian cycles of significantly greater amplitude than ward staff. Conclusions: Depressed patients demonstrate greater amplitude in ultradian cycles of mood than nondepressed subjects

Key Biofouling Organisms in Tidal Habitats Targeted by the Offshore Renewable Energy Sector in the North Atlantic Include the Massive Barnacle Chirona hameri

Marine habitats are being targeted for the extraction of offshore renewable energy (ORE) as part of the drive to decarbonise electricity generation. Unmanaged biofouling impacts ORE devices and infrastructure by elevating drag forces, increasing weight, and accelerating corrosion, leading to decreased performance and survivability, and extending costly periods of maintenance. ORE deployments in high tidal flow locations are providing opportunities to study the biofouling unique to these habitats. In this study, surveys of numerous devices and associated infrastructure deployed at the European Marine Energy Centre in Scotland identified high tidal flow fouling assemblages. Substrate orientation relative to tidal flow appears to affect the abundance of key fouling species, including the massive barnacle Chirona hameri. This species is shown to recruit to a wide range of artificial substrates, over a prolonged period from mid-spring to mid-summer, and in maximum current speeds from 0.4–4.0 m/s. For the first time, C. hameri is reported in near-surface depths, on uncoated components of a floating tidal device. The highly gregarious settlement behaviour and rapid growth exhibited by this species may have important implications for managing fouling in the ORE industry, especially in ‘niche’ areas. Anti-fouling strategies and maintenance scheduling applicable to ORE and other marine industries are discussed

Evaluating Alternatives for Communicating About Food Risk

This article describes the development and preliminary evaluation of model materials designed as one-step in helping consumers understand how scientists assess food risk, how that information is used in food safety policy decisions and what individuals can do to protect themselves from residual risks

APOGEE Kinematics I: Overview of the Kinematics of the Galactic Bulge as Mapped by APOGEE

We present the stellar kinematics across the Galactic bulge and into the disk at positive longitudes from the SDSS-III APOGEE spectroscopic survey of the Milky Way. APOGEE includes extensive coverage of the stellar populations of the bulge along the mid-plane and near-plane regions. From these data, we have produced kinematic maps of 10,000 stars across longitudes 0 deg < l < 65 deg, and primarily across latitudes of |b| < 5 deg in the bulge region. The APOGEE data reveal that the bulge is cylindrically rotating across all latitudes and is kinematically hottest at the very centre of the bulge, with the smallest gradients in both kinematic and chemical space inside the inner-most region (l,|b|) < (5,5) deg. The results from APOGEE show good agreement with data from other surveys at higher latitudes and a remarkable similarity to the rotation and dispersion maps of barred galaxies viewed edge on. The thin bar that is reported to be present in the inner disk within a narrow latitude range of |b| < 2 deg appears to have a corresponding signature in [Fe/H] and [alpha/Fe]. Stars with [Fe/H] > -0.5 have dispersion and rotation profiles that are similar to that of N-body models of boxy/peanut bulges. There is a smooth kinematic transition from the thin bar and boxy bulge (l,|b|) < (15,12) deg out into the disk for stars with [Fe/H] > -1.0, and the chemodynamics across (l,b) suggests the stars in the inner Galaxy with [Fe/H] > -1.0 have an origin in the disk.Comment: Accepted by ApJ 15 December 201

The Sloan Digital Sky Survey Reverberation Mapping Project: Ensemble Spectroscopic Variability of Quasar Broad Emission Lines

We explore the variability of quasars in the MgII and Hbeta broad emission lines and UV/optical continuum emission using the Sloan Digital Sky Survey Reverberation Mapping project (SDSS-RM). This is the largest spectroscopic study of quasar variability to date: our study includes 29 spectroscopic epochs from SDSS-RM over $6$ months, containing 357 quasars with MgII and 41 quasars with Hbeta . On longer timescales, the study is also supplemented with two-epoch data from SDSS-I/II. The SDSS-I/II data include an additional $2854$ quasars with MgII and 572 quasars with Hbeta. The MgII emission line is significantly variable ($\Delta f/f$ 10% on 100-day timescales), a necessary prerequisite for its use for reverberation mapping studies. The data also confirm that continuum variability increases with timescale and decreases with luminosity, and the continuum light curves are consistent with a damped random-walk model on rest-frame timescales of $\gtrsim 5$ days. We compare the emission-line and continuum variability to investigate the structure of the broad-line region. Broad-line variability shows a shallower increase with timescale compared to the continuum emission, demonstrating that the broad-line transfer function is not a $\delta$-function. Hbeta is more variable than MgII (roughly by a factor of $1.5$), suggesting different excitation mechanisms, optical depths and/or geometrical configuration for each emission line. The ensemble spectroscopic variability measurements enabled by the SDSS-RM project have important consequences for future studies of reverberation mapping and black hole mass estimation of $1<z<2$ quasars.Comment: 20 pages, 25 figures. ApJ accepted: minor revisions following referee repor

Aquilegia, Vol. 32 No. 3, Fall 2008, Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1125/thumbnail.jp