Investigation into the functional role of chromoproteins in the physiology and ecology of the Hawaiian stony coral Montipora flabellata in Kāne‘ohe Bay, O‘ahu

Ph.D

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

The Hawaiian Koʻa card: Coral health and bleaching assessment color reference card for Hawaiian corals

Coral reefs are the foundation to our social, cultural, and economic life; however, reefs around the world are currently being threatened by many local and global impacts. Ongoing increases in seawater temperature pose significant threats to the integrity of these valuable ecosystems through extensive coral bleaching events. Therefore, we developed a coral health reference card, the Hawaiian Koʻa (coral) Card, to assess and quantify coral bleaching and to educate the community about its impacts in Hawaii. To accurately quantify the change in coral color during bleaching, controlled laboratory studies followed by Feld validations and surveys were conducted. Colors presented on the Hawaiian Koʻa Card have been linked to physiological state and health (e.g., symbiont density, chlorophyll levels, photosynthetic performance) of common coral species in Hawaii due to bleaching. The Hawaiian Koʻa Card provides a technical solution to inform and improve management of our nearshore resources through collaborative monitoring efforts by community members, educators, researchers, and managers on a state-wide scale, which will assist in determining management efficacy, identifying regions and species of resilience, establishing baselines and focus areas, and developing and executing rapid response plans

Health Risks of Genetically Modified Foods

As genetically modified (GM) foods are starting to intrude in our diet concerns have been expressed regarding GM food safety. These concerns as well as the limitations of the procedures followed in the evaluation of their safety are presented. Animal toxicity studies with certain GM foods have shown that they may toxically affect several organs and systems. The review of these studies should not be conducted separately for each GM food, but according to the effects exerted on certain organs it may help us create a better picture of the possible health effects on human beings. The results of most studies with GM foods indicate that they may cause some common toxic effects such as hepatic, pancreatic, renal, or reproductive effects and may alter the hematological, biochemical, and immunologic parameters. However, many years of research with animals and clinical trials are required for this assessment. The use of recombinant GH or its expression in animals should be re-examined since it has been shown that it increases IGF-1 which may promote cancer