OpenAdaptxt: an open source enabling technology for high quality text entry

Modern text entry systems, especially for touch screen phones and novel devices, rely on complex underlying technologies such as error correction and word suggestion. Furthermore, for global deployment a vast number of languages have to be supported. Together this has raised the entry bar for new text entry techniques, which makes developing and testing a longer process thus stifling innovation. For example, testing a new feedback mechanism in comparison to a stock keyboard now requires the researchers to support at least slip correction and probably word suggestion. This paper introduces OpenAdaptxt: an open source community driven text input platform to enable development of higher quality text input solutions. It is the first commercial-grade open source enabling technology for modern text entry that supports both multiple platforms and dictionary support for over 50 spoken languages

Architecture and performance of the KM3NeT front-end firmware

The KM3NeT infrastructure consists of two deep-sea neutrino telescopes being deployed in the Mediterranean Sea. The telescopes will detect extraterrestrial and atmospheric neutrinos by means of the incident photons induced by the passage of relativistic charged particles through the seawater as a consequence of a neutrino interaction. The telescopes are configured in a three-dimensional grid of digital optical modules, each hosting 31 photomultipliers. The photomultiplier signals produced by the incident Cherenkov photons are converted into digital information consisting of the integrated pulse duration and the time at which it surpasses a chosen threshold. The digitization is done by means of time to digital converters (TDCs) embedded in the field programmable gate array of the central logic board. Subsequently, a state machine formats the acquired data for its transmission to shore. We present the architecture and performance of the front-end firmware consisting of the TDCs and the state machine

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Recomendaciones para prevención y control de infecciones por SARS-CoV-2 en odontología

According to the World Health Organization (WHO), the new pandemic of coronavirus pneumonia COVID-19 or SARS-CoV-2, in a short period of time, has spread to all regions of the world where the number of confirmed cases and deaths continues to rise. Along with the Severe Acute Respiratory Syndrome coronavirus (SARS) and the Middle East Respiratory Syndrome coronavirus (MERS), this is the third highly pathogenic human coronavirus that has emerged in the past two decades. Faced with this Public Health emergency, attempts have been made to control the global spread; however, in the vast majority of countries the capacity of their health systems has been overwhelmed. Appropriate measures have been found to reduce the risk of infection and effectively prevent the spread of the epidemic. In dentistry, due to the special nature of its procedures, the risk of cross infection is high and strict prevention and control measures are important, particularly due to possible care for asymptomatic patients capable of transmitting the virus. Given the urgent need to establish strict and effective infection control protocols, a review of the scientific evidence was carried out to analyze the epidemiological and infectious characteristics of SARS-CoV-2 and to recommend prevention and control measures in relation to professionals and students of dentistry to block person-to-person transmission routes in dental clinics and hospitals.Según la Organización Mundial de la Salud (OMS), la nueva pandemia de neumonía por coronavirus COVID-19 o SARS-CoV-2, en un corto período de tiempo, se ha extendido a todas las regiones del mundo donde el número de casos confirmados y muertes sigue aumentando. Junto con el coronavirus del Síndrome Respiratorio Agudo Severo (SARS) y el coronavirus del Síndrome Respiratorio del Medio Oriente (MERS), este es el tercer coronavirus humano altamente patógeno que ha surgido en las últimas dos décadas. Frente a esta emergencia de Salud Pública, se ha intentado controlar la propagación global, sin embargo, en la gran mayoría de países se ha visto desbordada la capacidad de sus sistemas de salud. Se ha observado que medidas adecuadas pueden reducir el riesgo de infección y prevenir efectivamente la propagación de la epidemia. En odontología, debido a la naturaleza especial de sus procedimientos, el riesgo de infección cruzada es alto y las medidas estrictas de prevención y control son importantes, particularmente por la posible atención a pacientes asintomáticos capaces de transmitir el virus. Ante la urgente necesidad de establecer protocolos de control de infecciones estrictos y efectivos, se realizó una revisión de la evidencia científica para analizar las características epidemiológicas e infecciosas de SARS-CoV-2 y recomendar medidas de prevención y control en relación a los profesionales y estudiantes de la odontología a fin de bloquear las rutas de transmisión de persona a persona en clínicas y hospitales dentales

LIPCAR Is Increased in Chronic Symptomatic HF Patients. A Sub-Study of the GISSI-HF Trial

International audienceAbstract Background The long noncoding RNA LIPCAR (Long Intergenic noncoding RNA Predicting CARdiac remodeling) has emerged as a promising biomarker in cardiac disease and cardiac remodeling. To determine whether LIPCAR levels help for a molecular phenotyping of chronic heart failure (HF) patients, this study assessed the association of LIPCAR with severity of the disease and its progression, and with risk of death or hospitalization in HF patients. Methods LIPCAR was measured in plasma of 967 HF patients with symptomatic heart failure participating in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca - Heart Failure (GISSI-HF) biohumoral sub-study. Results Plasma levels of LIPCAR were significantly associated with functional impairment as assessed by the New York Heart Association (NYHA) class, kidney function as reflected by estimated glomerular filtration rate, and creatinine, hemoglobin and mitral insufficiency. In females, these associations were more marked as compared to males. LIPCAR plasma levels were significantly related to the two cardiac markers, N-terminal pro-B type natriuretic peptide and high-sensitivity cardiac troponin T, but not to inflammatory markers such as high sensitivity C-reactive protein and pentraxin-3, nor to patient reported outcomes such as depression and quality of life. HF patients with high LIPCAR levels univariately showed significantly higher incidence of cardiovascular hospitalizations but not of death; after adjusting for covariates, no significant effects of LIPCAR were found for cardiovascular hospitalizations. Conclusion The circulating long noncoding RNA LIPCAR was increased in HF patients with higher NYHA class, impaired kidney function, and lower hemoglobin, which are indicators of patients’ overall state

Safety of mRNA BNT162b2 COVID-19 (Pfizer-BioNtech) vaccine in children aged 5-11 years: Results from an active pharmacovigilance study in central Italy

This survey investigated on adverse events after vaccination with mRNA BNT162b2 (Comirnaty, Pfizer-BioNTech) vaccine in children aged 5–11 years in central Italy through active surveillance reporting. During December 2021–January 2022, parents of children who undergone vaccination were interviewed using a structured questionnaire. 197 out of 208 contacted parents participated (94.7% response rate), of whom 166 (84.3%) had one child. Of the 229 children, the mean age was 8.9 years, 50.7% were female. 193 (84.3%) had at least one adverse event after the first dose (mean age 9.1 years; 54.4% female), and 146 (73.4%) of 199 after the second (mean age 8.9 years; 54.8% female), which was not administered to 30 children due to previous COVID-19 history. Local symptoms after the first and second dose occurred in 183 (94.8%) and 141 (96.6%) recipients (p = .435), respectively, while systemic reactions in 62 (32.1%) and 34 (23.3%) (p = .074). Mild events were reported by 81.7% and 69.8% children after the first and second dose, followed by moderate (3.9% and 10.6%) and severe (1.3% and 0.5%). After each dose, injection site reactions (79.5% and 68.8%) were the most frequent, followed by headache (13.1%) and lymphadenopathy (8.5%) after the first and second dose, respectively. The adverse events were reported to pediatricians only for 5.7% and 3.9% of children and treated for 17.6% and 15.8%. This is the first report about safety profile through active surveillance of mRNA BNT162b2 among children in Italy, revealing temporary and mild-to-moderate symptoms with no serious events after each vaccine dose