6,843 research outputs found
Checking the internal pedagogical consistency of a game learning situation: the Leclercq’s triple consistency triangle
Leclercq’s triangle is a conceptual tool used for securing the pedagogical validity of learning situations. It materializes the sound pedagogy principle which commands to establish a triple consistency between objectives, methods and evaluation in any given learning situation. The ELEKTRA adventure game provides a practical illustration of its relevance.Peer reviewe
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Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles.
Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs. An understudied phenomenon is the nucleolar localization of Rev phosphoprotein, which completes nucleocytoplasmic transport of unspliced/partially spliced HIV mRNA through multimerization with intronic cis-acting targets-the Rev-response element (RRE). Rev contains a nucleolar localization signal (NoLS) comprising the COOH terminus of the arginine-rich motif for accumulation within nucleoli-speculated as the interaction ground for Rev with cellular proteins mediating mRNA-independent nuclear export and splicing. Functionality of Rev nucleolar access during HIV-1 production and infection was investigated in the context of deletion and single-point mutations within Rev-NoLS. Mutations induced upon Rev-NoLS are hypothesized to inactivate the HIV-1 infectious cycle. HIV-1HXB2 replication ceased with Rev mutations lacking nucleolar access due to loss or replacement of multiple arginine residues. Rev mutations missing single arginine residues remained strictly nucleolar in pattern and participated in proviral production, however, with reduced efficiency. Viral RNA packaging also decreased in efficiency after expression of nucleolar-localizing mutations. These results were observed during propagation of variant HIV-1NL4-3 containing nucleolar-localizing mutations within the viral backbone (M4, M5, and M6). Lentiviral particles produced with Rev single-point mutations were transducible at extremely low frequency. Similarly, HIV-1NL4-3 Rev-NoLS variants lost infectivity, unlike virulent WT (wild type) HIV-1NL4-3. HIV-1NL4-3 variants were capable of CD4+ host entry and reverse transcription as WT HIV-1NL4-3, but lacked ability to complete a full infectious cycle. We currently reveal that viral integration is deregulated in the presence of Rev-NoLS mutations
Spin Needlets for Cosmic Microwave Background Polarization Data Analysis
Scalar wavelets have been used extensively in the analysis of Cosmic
Microwave Background (CMB) temperature maps. Spin needlets are a new form of
(spin) wavelets which were introduced in the mathematical literature by Geller
and Marinucci (2008) as a tool for the analysis of spin random fields. Here we
adopt the spin needlet approach for the analysis of CMB polarization
measurements. The outcome of experiments measuring the polarization of the CMB
are maps of the Stokes Q and U parameters which are spin 2 quantities. Here we
discuss how to transform these spin 2 maps into spin 2 needlet coefficients and
outline briefly how these coefficients can be used in the analysis of CMB
polarization data. We review the most important properties of spin needlets,
such as localization in pixel and harmonic space and asymptotic uncorrelation.
We discuss several statistical applications, including the relation of angular
power spectra to the needlet coefficients, testing for non-Gaussianity on
polarization data, and reconstruction of the E and B scalar maps.Comment: Accepted for publication in Phys. Rev.
An accurate equation of state for the one component plasma in the low coupling regime
An accurate equation of state of the one component plasma is obtained in the
low coupling regime . The accuracy results from a smooth
combination of the well-known hypernetted chain integral equation, Monte Carlo
simulations and asymptotic analytical expressions of the excess internal energy
. In particular, special attention has been brought to describe and take
advantage of finite size effects on Monte Carlo results to get the
thermodynamic limit of . This combined approach reproduces very accurately
the different plasma correlation regimes encountered in this range of values of
. This paper extends to low 's an earlier Monte Carlo
simulation study devoted to strongly coupled systems for ({J.-M. Caillol}, {J. Chem. Phys.} \textbf{111}, 6538 (1999)). Analytical
fits of in the range are provided with a
precision that we claim to be not smaller than . HNC equation and
exact asymptotic expressions are shown to give reliable results for
only in narrow intervals, i.e. and respectively
Many-body Anderson localization in one dimensional systems
We show, using quasi-exact numerical simulations, that Anderson localization
of one-dimensional particles in a disordered potential survives in the presence
of attractive interaction between particles. The localization length of the
composite particle can be computed analytically for weak disorder and is in
good agreement with the quasi-exact numerical observations using Time Evolving
Block Decimation. Our approach allows for simulation of the entire experiment
including the final measurement of all atom positions.Comment: 12pp, 5 fig, version accepted in NJ
Liquid-vapor transition of systems with mean field universality class
We have considered a system where the interaction, v(r) = v_IS(r) + xi^2
v_MF(r), is given as a linear combination of two potentials, each of which
being characterized with a well-defined critical behavior: for v_IS(r) we have
chosen the potential of the restricted primitive model which is known to belong
to the Ising 3D (IS) universality class, while for v_MF(r) we have considered a
long-range interaction in the Kac-limit, displaying mean field (MF) behavior.
We study the performance of two theoretical approaches and of computer
simulations in the critical region for this particular system and give a
detailed comparison between theories and simulation of the critical region and
the location of the critical point. Both, theory and simulation give evidence
that the system belongs to the MF universality class for any positive value of
xi and that it shows only non-classical behavior for xi=0. While in this
limiting case theoretical approaches are known to fail, we find good agreement
for the critical properties between the theoretical approaches and the
simulations for xi^2 larger than 0.05.Comment: 9 pages, 11 figures, 3 table
Time delays in quasi-periodic pulsations observed during the X2.2 solar flare on 2011 February 15
We report observations of quasi-periodic pulsations (QPPs) during the X2.2
flare of 2011 February 15, observed simultaneously in several wavebands. We
focus on fluctuations on time scale 1-30 s and find different time lags between
different wavebands. During the impulsive phase, the Reuven Ramaty High Energy
Solar Spectroscopic Imager (RHESSI) channels in the range 25-100 keV lead all
the other channels. They are followed by the Nobeyama RadioPolarimeters at 9
and 17 GHz and the Extreme Ultra-Violet (EUV) channels of the Euv
SpectroPhotometer (ESP) onboard the Solar Dynamic Observatory (SDO). The
Zirconium and Aluminum filter channels of the Large Yield Radiometer (LYRA)
onboard the Project for On-Board Autonomy (PROBA2) satellite and the SXR
channel of ESP follow. The largest lags occur in observations from the
Geostationary Operational Environmental Satellite (GOES), where the channel at
1-8 {\AA} leads the 0.5-4 {\AA} channel by several seconds. The time lags
between the first and last channels is up to 9 s. We identified at least two
distinct time intervals during the flare impulsive phase, during which the QPPs
were associated with two different sources in the Nobeyama RadioHeliograph at
17 GHz. The radio as well as the hard X-ray channels showed different lags
during these two intervals. To our knowledge, this is the first time that time
lags are reported between EUV and SXR fluctuations on these time scales. We
discuss possible emission mechanisms and interpretations, including flare
electron trapping
Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017
During 2013–2017, 620 cases of Candida auris were reported in the European Union/European Economic Area – 466 (75.2%) colonisations, 110 (17.7%) bloodstream infections, 40 (6.5%) other infections and four cases (0.6%) of unknown colonisation/infection status – the majority from four large outbreaks. Survey results showed that several countries lacked laboratory capacity and/or information on the occurrence of cases at national level. To prevent further spread, adequate laboratory capacity and infection control preparedness is required in Europe.</jats:p
Quantum measurements without macroscopic superpositions
We study a class of quantum measurement models. A microscopic object is
entangled with a macroscopic pointer such that each eigenvalue of the measured
object observable is tied up with a specific pointer deflection. Different
pointer positions mutually decohere under the influence of a bath.
Object-pointer entanglement and decoherence of distinct pointer readouts
proceed simultaneously. Mixtures of macroscopically distinct object-pointer
states may then arise without intervening macroscopic superpositions.
Initially, object and apparatus are statistically independent while the latter
has pointer and bath correlated according to a metastable local thermal
equilibrium. We obtain explicit results for the object-pointer dynamics with
temporal coherence decay in general neither exponential nor Gaussian. The
decoherence time does not depend on details of the pointer-bath coupling if it
is smaller than the bath correlation time, whereas in the opposite Markov
regime the decay depends strongly on whether that coupling is Ohmic or
super-Ohmic.Comment: 50 pages, 5 figures, changed conten
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