PC-based Multiple Information System Interface (PC/MISI) design plan

The general design plan for the implementation of a common user interface to multiple remote information systems within a microcomputer-based environment is presented. The intent is to provide a framework for the development of detailed specifications which will be used as guidelines for the actual development of the system

Design criteria for a PC-based common user interface to remote information systems

A set of design criteria are presented which will allow the implementation of an interface to multiple remote information systems on a microcomputer. The focus of the design description is on providing the user with the functionality required to retrieve, store and manipulate data residing in remote information systems through the utilization of a standardized interface system. The intent is to spare the user from learning the details of retrieval from specific systems while retaining the full capabilities of each system. The system design includes multi-level capabilities to enhance usability by a wide range of users and utilizes microcomputer graphics capabilities where applicable. A data collection subsystem for evaluation purposes is also described

PC-based Multiple Information System Interface (PC/MISI) detailed design and implementation plan

The design plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intended to be used as a blueprint for the implementation of the system. Each component is described in the detail necessary to allow programmers to implement the system. A description of the system data flow and system file structures is given

IBM PC/IX operating system evaluation plan

An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included

The USL NASA PC R and D project: Detailed specifications of objects

The specifications for a number of projects which are to be implemented within the University of Southwestern Louisiana NASA PC R and D Project are discussed. The goals and objectives of the PC development project and the interrelationships of the various components are discussed. Six projects are described. They are a NASA/RECON simulator, a user interface to multiple remote information systems, evaluation of various personal computer systems, statistical analysis software development, interactive presentation system development, and the development of a distributed processing environment. The relationships of these projects to one another and to the goals and objectives of the overall project are discussed

A report on the USL NASA/RECON project. Part 2: PC-based R and D in support of IS and R applications

This Working Paper Series entry describes the PC R and D development effort initiated as part of the NASA/RECON Project at the University of Southwestern Louisiana. This effort involves the development of a PC-based environment for the prototyping and evaluation of various tools designed to enhance the interaction between scientists and engineers and remote information systems. The design of PC-based tools for the enhancement of the NASA/RECON university-level courses is described as well as the design of a multi-functional PC-based workstation to support access to and processing of information from local, distributed, and remote sources. Course preparation activities are described in a companion report entitled A Report on the USL NASA/RECON Project: Part 1, the Development of a Transportable, University-Level, IS and R Educational Program, by Suzy Gallagher and Martin Granier, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-7

The design of PC/MISI, a PC-based common user interface to remote information storage and retrieval systems. Presentation visuals

This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-15. The paper discusses the following: problem definition; the PC solution; the goals of system design; the design description; future considerations, the research environment; conclusions

Enzyme replacement therapy with taliglucerase alfa: 36-month safety and efficacy results in adult patients with Gaucher disease previously treated with imiglucerase.

Taliglucerase alfa is the first available plant cell-expressed human recombinant therapeutic protein. It is indicated for treatment of patients with type 1 Gaucher disease (GD) in adult and pediatric patients in several countries. Study PB-06-002 examined the safety and efficacy of taliglucerase alfa for 9 months in patients who previously received imiglucerase. The results of adult patients from Study PB-06-002 who continued receiving taliglucerase alfa in extension Study PB-06-003 for up to 36 months are reported here. Eighteen patients received at least one dose of taliglucerase alfa in Study PB-06-003; 10 patients completed 36 total months of therapy, and four patients who transitioned to commercial drug completed 30-33 months of treatment. In patients who completed 36 total months of treatment, mean percent (±standard error) changes from baseline/time of switch to taliglucerase alfa to 36 months were as follows: hemoglobin concentration, -1.0% (±1.9%; n = 10); platelet count, +9.3% (±9.8%; n = 10); spleen volume measured in multiples of normal (MN), -19.8% (±9.9%; n = 7); liver volume measured in MN, +0.9% (±5.4%; n = 8); chitotriosidase activity, -51.5% (±8.1%; n = 10); and CCL18 concentration, -36.5 (±8.0%; n = 10). Four patients developed antidrug antibodies, including one with evidence of neutralizing activity in vitro. All treatment-related adverse events were mild or moderate and transient. The 36-month results of switching from imiglucerase to taliglucerase alfa treatment in adults with GD provide further data on the clinical safety and efficacy of taliglucerase alfa beyond the initial 9 months of the original study. www.clinicaltrials.gov identifier NCT00705939. Am. J. Hematol. 91:661-665, 2016. © 2016 Wiley Periodicals, Inc

Reversible Lysine Acetylation Regulates Activity of Human Glycine N-Acyltransferase-like 2 (hGLYATL2): Implications for Production of Glycine-conjugated Signaling Molecules

Background: Lysine acetylation is a major post-translational modification of proteins. Results: Human glycine N-acyltransferase-like 2 is regulated by acetylation/deacetylation of lysine 19. Conclusion: Reversible lysine acetylation is important in regulating the activity and function of human glycine N-acyltransferases. Significance: Our study links post-translational modification of proteins with the production of lipid signaling molecules, the N-acyl glycines