Can the outside-in half-tunnel technique reduce femoral tunnel widening in anterior cruciate ligament reconstruction? A CT study

There are different techniques for drilling the femoral tunnel in the anterior cruciate ligament reconstruction (ACLR), but their influence in the bone tunnel enlargement in unknown. The purpose of this study was to compare two different surgical techniques for evaluating femoral tunnel enlargement in ACLR. The hypothesis was that tunnel placement using the outside-in technique leads to less tunnel enlargement compared to the transtibial technique. METHODS: Forty-four patients treated for ACLR between March 2013 and March 2014 were prospectively enrolled in this study. According to the surgical technique, subjects were assigned to Group A (Out-in) or Group B (Transtibial). All patients underwent CT examination in order to evaluate the femoral tunnel enlargement at four different levels. Moreover, all patients were evaluated with the Lachman test and pivot shift test, and the KT1000 arthrometer was used to measure the anterior laxity of the knee. A subjective evaluation was performed using the 2000 International Knee Documentation Committee Subjective Knee score, Lysholm knee score and Tegner activity scale. All patients were assessed after 24 months of follow-up. RESULTS: At the final follow-up, there were statistically significant differences (p 0.05). CONCLUSIONS: In ACLR with a suspension system, the outside-in technique leads to less enlargement of the femoral tunnel lower than the transtibial technique. KEYWORDS: Anterior cruciate ligament reconstruction; CT imaging; Drilling technique; Femoral tunnel enlargement PMID: 28389757 DOI: 10.1007/s00590-017-1950-8 Share on FacebookShare on TwitterShare on Google+ LinkOut - more resource

Data sonification of volcano seismograms and Sound/Timbre reconstruction of ancient musical instruments with Grid infrastructures

n/

Actuation and Control of a Steerable Catheter for Mitral Valve Repair

In the field of Structural Heart Diseases, Mitral Regurgitation's incidence is rising because of an aging population worldwide, and it has reached an annual mortality rate near 34%. The procedures of Structural Intervention Cardiology have enlarged the number of treated patients, since their minimally invasive and trans-catheter approach. To provide a forward step-change in this procedure, the aim of this work is to improve the use of the commercially available MitraClip system®, suggesting an innovative robot-assisted platform with autonomous control for the aforementioned system. The presented methodology is constituted of two phases: in the first one, we design, in the Solidworks® environment, 3D print and integrate the mechanical support with electrical motors and micro-controller devoted to catheter's steering. In the second phase, we develop the closed-loop position control to improve the accuracy in the autonomous positioning of the catheter. The described approach was tested to demonstrate its feasibility and dexterity: a position accuracy of 1.1±0.54 mm in following a given optimal trajectory was obtained

Viscosity, Boson Peak and Elastic Moduli in the Na2O-SiO2 System

The temperature and chemical dependence of the melt viscosity are ubiquitous in the model development of the volcanic dynamics, as well as in the glass production and design. We focussed on the yet-explored relationship between the bulk and shear moduli ratio and boson peak with the melt fragility of their parental glasses. Here, we explored the extension of the observed trend by testing the conventional binary system Na2O-SiO2, thus providing new evidence supporting the link between the flow of melts and supercooled liquids and the vibrational dynamics of their parental glasses. This was accomplished by integrating new low-frequency Raman measurements and integrating data from the literature on Brillouin light scattering and viscometry. This approach allows us to feed the MYEGA equation with reliable input parameters to quantitatively predict the viscosity of the Na2O-SiO2 system from the liquid up to the glass transition

Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration?

Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration

Ages of the bulge globular clusters NGC 6522 and NGC 6626 (M28) from HST proper-motion-cleaned color–magnitude diagrams

Bulge globular clusters (GCs) with metallicities [Fe/H]−1.0 and blue horizontal branches are candidates to harbor the oldest populations in the Galaxy. Based on the analysis of HST proper-motion-cleaned color–magnitude diagrams in filters F435W and F625W, we determine physical parameters for the old bulge GCs NGC 6522 and NGC 6626 (M28), both with well-defined blue horizontal branches. We compare these results with similar data for the inner halo cluster NGC 6362. These clusters have similar metallicities (−1.3[Fe/H]−1.0) obtained from high-resolution spectroscopy. We derive ages, distance moduli, and reddening values by means of statistical comparisons between observed and synthetic fiducial lines employing likelihood statistics and the Markov chain Monte Carlo method. The synthetic fiducial lines were generated using α-enhanced BaSTI and Dartmouth stellar evolutionary models, adopting both canonical (Y∼0.25) and enhanced (Y∼0.30–0.33) helium abundances. RR Lyrae stars were employed to determine the HB magnitude level, providing an independent indicator to constrain the apparent distance modulus and the helium enhancement. The shape of the observed fiducial line could be compatible with some helium enhancement for NGC 6522 and NGC 6626, but the average magnitudes of RR Lyrae stars tend to rule out this hypothesis. Assuming canonical helium abundances, BaSTI and Dartmouth models indicate that all three clusters are coeval, with ages between ∼12.5 and 13.0 Gyr. The present study also reveals that NGC 6522 has at least two stellar populations, since its CMD shows a significantly wide subgiant branch compatible with 14%±2% and 86%±5% for first and second generations, respectively

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling

Intracellular neurofibrillary tangles (NFT) composed by tau and extracellular amyloid beta (A\u3b2) plaques accumulate in Alzheimer's disease (AD) and contribute to neuronal dysfunction. Mitochondrial dysfunction and neurodegeneration are increasingly considered two faces of the same coin and an early pathological event in AD. Compelling evidence indicates that tau and mitochondria are closely linked and suggests that tau-dependent modulation of mitochondrial functions might be a trigger for the neurodegeneration process; however, whether this occurs either directly or indirectly is not clear. Furthermore, whether tau influences cellular Ca2+ handling and ER-mitochondria cross-talk is yet to be explored. Here, by focusing on wt tau, either full-length (2N4R) or the caspase 3-cleaved form truncated at the C-terminus (2N4R\u394C20), we examined the above-mentioned aspects. Using new genetically encoded split-GFP-based tools and organelle-targeted aequorin probes, we assessed: i) tau distribution within the mitochondrial sub-compartments; ii) the effect of tau on the short- (8-10\u202fnm) and the long- (40-50\u202fnm) range ER-mitochondria interactions; and iii) the effect of tau on cytosolic, ER and mitochondrial Ca2+ homeostasis. Our results indicate that a fraction of tau is found at the outer mitochondrial membrane (OMM) and within the inner mitochondrial space (IMS), suggesting a potential tau-dependent regulation of mitochondrial functions. The ER Ca2+ content and the short-range ER-mitochondria interactions were selectively affected by the expression of the caspase 3-cleaved 2N4R\u394C20 tau, indicating that Ca2+ mis-handling and defects in the ER-mitochondria communications might be an important pathological event in tau-related dysfunction and thereby contributing to neurodegeneration. Finally, our data provide new insights into the molecular mechanisms underlying tauopathies

Evidence for mitochondrial Lonp1 expression in the nucleus

The coordinated communication between the mitochondria and nucleus is essential for cellular activities. Nonetheless, the pathways involved in this crosstalk are scarcely understood. The protease Lonp1 was previously believed to be exclusively located in the mitochondria, with an important role in mitochondrial morphology, mtDNA maintenance, and cellular metabolism, in both normal and neoplastic cells. However, we recently detected Lonp1 in the nuclear, where as much as 22% of all cellular Lonp1 can be found. Nuclear localization is detectable under all conditions, but the amount is dependent on a response to heat shock (HS). Lonp1 in the nucleus interacts with heat shock factor 1 (HSF1) and modulates the HS response. These findings reveal a novel extramitochondrial function for Lonp1 in response to stress