Percepción de la salud podológica en una muestra de personas con diabetes

[Resumen] Objetivo: Analizar el grado de conocimiento que tiene la población diabética de la podología como profesión y su salud podológica. Metodología: 152 personas con diabetes mellitus, con una media de edad de 65,99 años participaron en el estudio. Los participantes fueron invitados a completar un cuestionario anónimo en línea de diecisiete preguntas, previa invitación por correo electrónico a través del Website Google Docs. Resultados: Un 84,2% y un 80,1% saben que los podólogos realizan tratamientos quiropodológicos frente a sólo un 40,1% presentan un total conocimiento de las competencias de la profesión podológica. Sólo un 50% saben que el podólogo evalúa y controla el cuidado del pie diabético. Un 93,5% considera que es importante o muy importante el cuidado del pie, sin embargo sólo un 60,5% acude a algún centro podológico. La fuente más importante de información sobre el podólogo con un 44% es a través de su médico, seguido con un 27,3% por familia o amigos y sólo un 0,7% por su enfermera. Conclusiones: Sólo un 40,1% presentan un total conocimiento de las competencias del podólogo y ponen de manifiesto la necesidad de educación sanitaria para la salud del pie y de seguir investigando en esta condición común e incapacitante en la búsqueda de mejorar la calidad de vida y el bienestar de las personas con diabetes.Traballo fin de grao (UDC.FEP). Podoloxía. Curso 2014/201

Predictors of right atrial dilatation and long-term function after right ventricular outflow tract surgical repair: Quantification of restrictive physiology matters

Right diastolic dysfunction; Right atrium function; Restrictive physiologyDisfunción diastólica derecha; Función de la aurícula derecha; Fisiología restrictivaDisfunció diastòlica dreta; Funció de l'aurícula dreta; Fisiologia restrictivaRight ventricular (RV) diastolic dysfunction in patients with a surgically-repaired RV outflow tract (RVOT) obstruction merits further studies. Right atrial (RA) dilation and function may be related to (RV) diastolic dysfunction in this setting. The end-diastolic forward flow (EDFF) in the pulmonary artery (PA) has been suggested as a non-invasive marker of poor RV compliance, however, there is controversy regarding its true significance; EDFF quantification may help elucidate this controversy. Objective to study predictors of RA enlargement and dysfunction in patients with a surgically-repaired RVOT obstruction and its relationship with quantitative EDFF. Methods In 81 consecutive patients (mean age: 37.5 (±7) years), transthoracic echocardiography (Echo) and cardiac magnetic resonance (CMR) were performed. Echo parameters: RA size (indexed RA area (iRAA)), RA function (RA global strain (RAGS)) and maximum EDFF velocity-time integral (VTI-EDFF) obtained during a whole respiratory cycle. CMR-indexed RA area (imRAA) was also obtained. Patients were divided into three groups according to iRAA, imRAA and RAGS; bivariate analysis was performed. A multivariate model was then applied using variables that were found to be statistically significant in the bivariate analysis. Results Upon multivariate analysis, higher VTI-EDFF values and the presence of significant tricuspid regurgitation proved to be independent factors associated with increased iRAA and imRAA and lower RAGS, whereas RV volumes, function and pulmonary regurgitant fraction were not. Conclusion VTI-EDFF linearly correlated with the degree of RA dilation and deformation; EDFF quantification as against qualitative assessment may be considered a non-invasive tool for diastolic RV dysfunction

Seroprevalence of canine Leishmania infantum infection in the Mediterranean region and identification of risk factors : The example of North-Eastern and Pyrenean areas of Spain

This project received funding from the European Union's Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement nº 642609 and by Ministerio de Ciencia e Innovación, Spain (CG12010-22368-CO2-01).Altres ajuts: RICET/RD12/0018/0010The Mediterranean basin is an endemic region for canine leishmaniosis (CanL), where it represents a major veterinary problem and raises human health concerns. However, the distribution of the disease is heterogeneous and not all countries and locations have been equally studied and characterized. This work describes the situation of CanL in Girona province (Catalonia, Spain), for which no data has been previously reported, and presents a relevant study to exemplify other areas with similar characteristics across the region. Four cross-sectional seroprevalence surveys were performed from 2012 to 2016 throughout the province, including 36 sampling stations in 26 localities and a total of 593 dogs. For each animal, individual and location variables were also collected. Additionally, each dog owner answered a questionnaire about their knowledge of CanL and preventive methods used. Blood samples were analysed by an in-house ELISA and a mixed logistic regression model was used to assess the relationship between pre-determined variables and dog seropositivity. A Spearman's correlation was used to assess the association between dog owners' perceived risk of CanL and Leishmania infantum seropositivity in dogs at a given location. The overall true seroprevalence estimated for Girona province was 19.5% (95%CI: 15.5-23.5), of which only 6.8% (10/146) were considered symptomatic. Age of the dog [OR = 1.21 (95%CI: 1.11-1.31); p < 0.001] and altitude [OR = 0.02 (95%CI: 0.001-0.19); p = 0.001] were identified as risk factors for the infection. The results obtained in this study are expected to aid in the implementation of directed control programmes in CanL endemic areas throughout Europe, as well as to provide suitable data for the design of better risk assessment maps of the disease

Dating of Archaeological Gold by Means of Solid State Electrochemistry

This is the peer reviewed version of the following article: Doménech Carbó, Antonio, Scholz, Fritz , Domenech Carbo, Mª Teresa, Piquero-Cilla, Juan , Montoya, Noemí, Pasies -Oviedo, Trinidad, Gozalbes, Manuel , Melchor Montserrat, José Manuel , Oliver, Arturo . (2018). Dating of Archaeological Gold by Means of Solid State Electrochemistry.ChemElectroChem, 5, 15, 2113-2117. DOI: 10.1002/celc.201800435 , which has been published in final form at http://doi.org/10.1002/celc.201800435. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving[EN] In archaeology and history of art, age determination is a fundamental analytical problem. While several techniques for age determination of various materials, like radiocarbon dating, are established, these methods cannot be applied for metals, for which new techniques have to be developed. For the first time a dating method for archaeological gold objects is described which is based on a corrosion clock and electrochemical measurements, using the voltammetry of immobilized particles. Samples are prepared by one touch' with a graphite pencil, only transferring a few nanograms of the archaeological gold. The method has been calibrated with the help of a series of well-documented gold specimen from different prehistory museums covering the last 2600years. Our results prove that this corrosion clock is going on a constant pace, practically independent of the environment, making it most attractive for applications in archaeometry.Projects CTQ2014-53736-C3-1-P and CTQ2014-53736-C3-2-P, which are supported with Ministerio de Economia, Industria y Competitividad (MINECO) and Fondo Europeo de Desarrollo Regional (ERDF) funds, as well as project CTQ2017-85317-C2-1-P supported with funds from, MINECO, ERDF and Agencia Estatal de Investigacion (AEI) are gratefully acknowledged. The authors also wish to thank Dr. Jose Luis Moya Lopez, Mrs. Alicia Nuez Inbernon and Mr. Manuel Planes Insausti (Microscopy Service of the Universitat Politecnica de Valencia) and M. Teresa Minguez and Clara Yebenes (Seccion de Microscopia del SCSIE, Universitat deValencia) for technical support.Doménech Carbó, A.; Scholz, F.; Domenech Carbo, MT.; Piquero-Cilla, J.; Montoya, N.; Pasies -Oviedo, T.; Gozalbes, M.... (2018). Dating of Archaeological Gold by Means of Solid State Electrochemistry. ChemElectroChem. 5(15):2113-2117. https://doi.org/10.1002/celc.201800435S2113211751

Reposición de lagunas en cerámica arqueológica. Comparación de la escayola y un producto comercial ante ensayos de envejecimiento acelerado

lo largo de la historia se han venido empleando variados materiales en la elaboración de masillas para la reposición de faltantes en cerámica arqueológica. En la actualidad, la investigación de nuevos materiales ofrece al campo de la restauración innumerables productos, siendo los tradicionales sustituidos. En este trabajo se realiza el estudio comparativo de dos tipos de materiales: uno tradicional como la escayola y un producto comercial en polvo utilizado desde hace dos décadas en sustitución del anterior. Tras preparar distintas probetas, éstas han sido sometidas a condiciones de envejecimiento acelerado (humedad-desecación, luz ultravioleta y atmósfera saturada con SO2, siendo analizadas mediante distintos ensayos físico-químicos. De los resultados obtenidos se concluye que ambos materiales tienen el mismo comportamiento, por lo que su elección estará determinada por la manejabilidad y aplicación del producto y no por su envejecimiento a largo plazo o incompatibilidad con la cerámica.Lastras Pérez, M.; Domenech Carbo, MT.; Carrascosa Moliner, MB.; Yusa Marco, DJ. (2007). Reposición de lagunas en cerámica arqueológica. Comparación de la escayola y un producto comercial ante ensayos de envejecimiento acelerado. Arché. (2):89-98. http://hdl.handle.net/10251/321888998

Fragmented condensation in Bose-Hubbard trimers with tunable tunnelling

We consider a Bose-Hubbard trimer, i.e. an ultracold Bose gas populating three quantum states. The latter can be either di erent sites of a triple-well potential or three internal states of the atoms. The bosons can tunnel between di erent states with variable tunnelling strength between two of them. This will allow us to study; i) di erent geometrical con gurations, i.e. from a closed triangle to three aligned wells and ii) a triangular con guration with a -phase, i.e. by setting one of the tunnellings negative. By solving the corresponding three-site Bose-Hubbard Hamiltonian we obtain the ground state of the system as a function of the trap topology. We characterise the di erent ground states by means of the coherence and entanglement properties. For small repulsive interactions, fragmented condensates are found for the -phase case. These are found to be robust against small variations of the tunnelling in the small interaction regime. A low-energy e ective many-body Hamiltonian restricted to the degenerate manifold provides a compelling description of the -phase degeneration and explains the low-energy spectrum as excitations of discrete semi uxon states

Robustness of discrete semifluxons in closed Bose-Hubbard chains

We present the properties of the ground state and low-energy excitations of Bose-Hubbard chains with a geometry that varies from open to closed and with a tunable twisted link. In the vicinity of the symmetric π-flux case the system behaves as an interacting gas of discrete semifluxons for finite chains and interactions in the Josephson regime. The energy spectrum of the system is studied by direct diagonalization and by solving the corresponding Bogoliubov-de Gennes equations. The atom-atom interactions are found to enhance the presence of strongly correlated macroscopic superpositions of semifluxons

Development and validation of a simple high-performance liquid chromatography analytical method for simultaneous determination of phytosterols, cholesterol, and squalene in parenteral lipid emulsions.

A simple analytical method for simultaneous determination of phytosterols, cholesterol and squalene in lipid emulsions was developed owing to increased interest in their clinical effects. Method development was based on commonly used stationary (C18 , C8 and phenyl) and mobile phases (mixtures of acetonitrile, methanol and water) under isocratic conditions. Differences in stationary phases resulted in peak overlapping or coelution of different peaks. The best separation of all analyzed compounds was achieved on Zorbax Eclipse XDB C8 (150 × 4.6 mm, 5 μm; Agilent) and ACN-H2 O-MeOH, 80:19.5:0.5 (v/v/v). In order to achieve a shorter time of analysis, the method was further optimized and gradient separation was established. The optimized analytical method was validated and tested for routine use in lipid emulsion analyses

Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: association with insulin resistance and weight loss in a population with metabolic syndrome

Background: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and their precursor fatty acids, and to analyze the interplay between changes in eCBs or NAEs ratios, insulin resistance and the achievement of clinically meaningful weight reductions. Methods: Prospective cohort study in a subsample of N = 105 participants (54.3% women; 65.6 ± 4.6 years) with overweight or obesity and metabolic syndrome that underwent a 3-years MedDiet intervention (PREDIMED-Plus study). Plasma eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), fatty acids, diet, glycemic homeostasis (including the assessment of insulin resistance-HOMA-IR), and cardiovascular risk markers were monitored (at 0-6-12-36 months). Results: Mediterranean diet adherence increased in both sexes and remained high during the 3 years of follow-up. Reductions in body weight, glycemic and cardiovascular parameters were larger in men than in women. Women presented higher concentrations of NAEs than men throughout the study. In both sexes, AEA and other NAEs (including OEA, and PEA) decreased after 6 months (for AEA: -4.9%), whereas the ratio OEA/AEA increased after 1 year (+5.8%). Changes in 2-AG (-3.9%) and the ratio OEA/PEA (+8.2%) persisted over the 3 years of follow-up. In women, 6-months changes in AEA (OR = 0.65) and the ratio OEA/AEA (OR = 3.28) were associated with the achievement of 8% weight reductions and correlated with HOMA-IR changes (r = 0.29 and r = -0.34). In men, OEA/PEA changes were associated with 8% weight reductions (OR = 2.62) and correlated with HOMA-IR changes (r = -0.32). Conclusion: A 3-years MedDiet intervention modulated plasma concentrations of eCBs and NAEs. Changes in AEA and in the relative abundance of NAEs were associated with clinically meaningful weight reductions. However, marked sex differences were identified in eCBs and NAEs, as well as in the efficacy of the intervention in terms of glycemic and cardiovascular parameters, which could be related to post-menopause alterations in glucose metabolism. These findings support a sex-balanced research strategy for a better understanding of the mechanisms underlying the regulation of body weight loss