Assessment of the uncertainty associated with synchronization error in analog to digital conversion with dither and CAV

Peer Reviewe

Globalizing Hayden White

This conversation originated in a plenary session organized by Ewa Domańska and María Inés La Greca under the same title of ‘Globalizing Hayden White’ at the III International Network for Theory of History Conference ‘Place and Displacement: The Spacing of History’ held at Södertörn University, Stockholm, in August 2018. In order to pay homage to Hayden White’s life work 5 months after his passing we knew that what was needed–and what he himself would have wanted–was a vibrant intellectual exchange. Our ‘celebration by discussion’ contains elaborated and revised versions of the presentations by scholars from China (Xin Chen), Latin America (María Inés La Greca, Veronica Tozzi Thompson), United States (Paul Roth), Western (Kalle Pihlainen) and East-Central Europe (Ewa Domańska). We took this opportunity of gathering scholars who represent different parts of the world, different cultures and approaches to reflect on White’s ideas in a global context. Our interest was in discussing how his work has been read and used (or even misread and misused) and how it has influenced theoretical discussions in different parts of the globe. Rather than just offering an account as experts, we mainly wanted to reflect on the current state of our field and the ways that White’s inheritance might and should be carried forward in the future.Fil: Domanska, Ewa. Adam Mickiewicz University in Poznań; PoloniaFil: la Greca, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tres de Febrero. Departamento de Metodología, Estadística y Matemáticas; Argentina. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Departamento de Filosofía; ArgentinaFil: Roth, Paul A.. University of California at Santa Cruz; Estados UnidosFil: Chen, Xin. Zhejiang University; ChinaFil: Tozzi, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tres de Febrero. Departamento de Metodología, Estadística y Matemáticas; Argentina. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Departamento de Filosofía; ArgentinaFil: Pihlainen, Kalle. Tallinn University; Estoni

The human cancer cell active toxin Cry41Aa from Bacillus thuringiensis acts like its insecticidal counterparts

Understanding how certain protein toxins from the normally insecticidal bacterium Bacillus thuringiensis (Bt) target human cell lines has implications for both the risk assessment of products containing these toxins and potentially for cancer therapy. This understanding requires knowledge of whether the human cell active toxins work by the same mechanism as their insecticidal counterparts or by alternative ones. The Bt Cry41Aa (also known as Parasporin3) toxin is structurally related to the toxins synthesised by commercially produced transgenic insect-resistant plants, with the notable exception of an additional C-terminal β-trefoil ricin domain. To better understand its mechanism of action, we developed an efficient expression system for the toxin and created mutations in regions potentially involved in the toxic mechanism. Deletion of the ricin domain did not significantly affect the activity of the toxin against the human HepG2 cell line, suggesting that this region was not responsible for the mammalian specificity of Cry41Aa. Various biochemical assays suggested that unlike some other human cell active toxins from Bt Cry41Aa did not induce apoptosis, but that its mechanism of action was consistent with that of a pore-forming toxin. The toxin induced a rapid and significant decrease in metabolic activity. Adenosine triphosphate depletion, cell swelling and membrane damage were also observed. An exposed loop region believed to be involved in receptor binding of insecticidal Cry toxins was shown to be important for the activity of Cry41Aa against HepG2 cells

Genetic characterization of parvoviruses circulating in turkey and chicken flocks in Poland

Between 2008 and 2011, commercial turkey and chicken flocks in Poland were examined for the presence of turkey parvovirus (TuPV) and chicken parvovirus (ChPV). Clinical samples (10 individual faecal swabs/flock) from 197 turkey flocks (turkeys aged 1 to 19 weeks) and 45 chicken flocks (chickens aged 3 to 17 weeks) were collected in different regions of the country and tested using a PCR assay that targeted the NS1 gene (3’ORF). The prevalence of TuPV was 29.4 % in the flocks tested, while ChPV infections were found in 22.2 % of the studied flocks. Phylogenetic analysis revealed a clear division into three groups: ChPV-like, TuPV-like and a third, previously unrecognized and distinct subgroup, TuPV-LUB, containing exclusively three Polish isolates from turkeys. The isolates from the novel group showed as little as 50.6-64.5 % of nucleotide sequence identity to the prototype chicken and turkey parvovirus strains. Genetic analysis of a ChPV isolate that was classified in the TuPV group strongly suggests a recombination event between chicken and turkey parvoviruses

Chris Lorenz's idea of conceptual inversion

The text deals with Chris Lorenz’s idea of conceptual inversion, understood as an epistemological blockade that stands as a barrier to the development of a proper theory of humanities and social sciences. According to Lorenz, the methodological and theoretical views of scientific programmes embody negations (i.e. inversions) of the views being criticized by them. Because of this process of “turning upside down”, many of the conceptual problems connected with the criticized positions survive. The author asks two questions: first, about the relation between Lorenz’s idea of conceptual inversion and Imre Lakatos’ idea of reconfigurations of research programmes, and, second, about possible common ground on which Lorenz’s interest in empiricism emerging out of his criticism of narrativism, and Ewa Domanska’s interest in new empiricism related to posthumanism (also critical of textual constructivism), could meet

Assessment of the uncertainty associated with synchronization error in analog to digital conversion with dither and CAV

Peer Reviewe

Chris Lorenz's idea of conceptual inversion

The text deals with Chris Lorenz’s idea of conceptual inversion, understood as an epistemological blockade that stands as a barrier to the development of a proper theory of humanities and social sciences. According to Lorenz, the methodological and theoretical views of scientific programmes embody negations (i.e. inversions) of the views being criticized by them. Because of this process of “turning upside down”, many of the conceptual problems connected with the criticized positions survive. The author asks two questions: first, about the relation between Lorenz’s idea of conceptual inversion and Imre Lakatos’ idea of reconfigurations of research programmes, and, second, about possible common ground on which Lorenz’s interest in empiricism emerging out of his criticism of narrativism, and Ewa Domanska’s interest in new empiricism related to posthumanism (also critical of textual constructivism), could meet

Beyond Anthropocentrism in Historical Studies

no abstrac