Gentisic Acid, Salicylic Acid, Total Phenolic Content and Cholinesterase Inhibitory Activities of Red Wines Made from Various Grape Varieties

Alzheimer’s disease is characterised by a decrease in acetylcholine (ACh) levels in the brain due to the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). As a result, disorders in cholinergic transmission are observed, leading to cognitive impairment. In this work, the inhibition of AChE and BChE activities by red wines made of various grape varieties was determined for the first time.  There was no significant difference in the polyphenol content between the grape varieties; nevertheless, there were significant differences in the content of gentisic acid and salicylic acid, and in the inhibition of AChE and BChE between the wine samples. A statistically significant correlation between AChE inhibitory activity and salicylic acid, as well as between BChE inhibitory activity and total phenolic content, was recorded. In model solution studies, it was shown that salicylic acid effectively inhibited BChE activity at concentrations similar to the maximum concentrations found in the test wines. Hierarchical cluster analysis (HCA) revealed that the wines could be divided into three groups. Cabernet Sauvignon and Syrah wines had the highest content of salicylic acid and AChE inhibitory activity, as well as low BChE inhibitory activity. Pinot noir, Tempranillo, Regent and Rondo wines showed the lowest content of salicylic acid and low AChE inhibitory activity. Garnacha tinta, Merlot, Montepulciano and Negroamaro wines had a medium content of salicylic acid, and the highest or medium BChE inhibitory activity. This work is important for both the wine industry and for health protection

Application of Volatile Compounds Analysis for Distinguishing between Red Wines from Poland and from Other European Countries

Authenticity and the geographical origin of wines are terms of great importance for consumers and producers. This work is focused on distinguishing between red wines from Poland and from other European countries, notably France, Italy and Spain. To achieve this goal, we determined aroma compounds in wines from different countries by headspace solid-phase microextraction/gas chromatography-mass spectrometry. The content of hexan-1-ol in Polish wines was significantly higher (about twice as high) than in French, Italian and Spanish wines.  Linear discriminant analysis (LDA) showed that 3-(methylsulfanyl) propane-1-ol, hexan-1-ol, ethyl phenylacetate and ethyl 2-hydroxy-4-methylpentanoate were the most discriminant variables for distinguishing between wines from Poland and from other European countries.  Hierarchical cluster analysis (HCA) revealed that Polish wines were separated thoroughly from the other wines based on ethyl phenylacetate, hexan-1-ol, ethyl 2-hydroxy-4-methylpentanoate, (E)-3-hexen-1-ol, 2-phenylethanol and 3-(methylsulfanyl)propan-1-ol, which is important for preventing possible frauds

A case of elongated styloid process in a modern-age skull from Puerto Cabello, Venezuela

Background: The styloid process (SP) arises from cartilage of the second branchial arch and tends to calcify during later life. If the length of the SP is more than 30 mm, it can be considered abnormally elongated. Clinical symptoms associated with elongation of this type are defined as Eagle’s syndrome. The paper presents a case of an elongated SP in a modern skull from Puerto Cabello, Venezuela, obtained from a series of skulls of African slaves kept at the Department of Anthropology, Polish Academy of Sciences in Wroclaw. Materials and methods: The skull belonged to a male individual, aged ca. 55 years at death (maturus). In terms of basic anthropometric features it had slightly greater facial width parameters in comparison to the cerebral part, and a shorter length of neurocranium when compared to average values of morphological features in African skulls from Uganda. Results: Further macroscopic analysis revealed the presence of an elongated SP (ca. 70.1 mm) with secondary lesions remaining after a healed fracture. Imaging of the bone structure of the elongated SP was carried out using a computed to­mography scan, with multilevel image analysis without contrast. The elongation and calcification of the left ligament in anterior orientation could have caused irritation to the structure of cranial nerves, running within the parapharyngeal space, and to sympathetic fibres running in the wall of cervical arteries. Conclusions: Analyses of craniological materials recovered during excavations or as part of old osteological collections are rare due to the fragility of this bone structure, and for that reason they may be a valuable source of information on the health status of historic human populations

A study of educational leadership preparation concerning the assistant principal : perspectives of Missouri principals and assistant principals

Abstract from short.pdf file.Dissertation supervisor: Dr. Cynthia MacGregor.Includes vita.It is unclear if the initial preparation of educational leaders, in relation to the role of assistant principals (APs), has kept pace with growing demands associated with the position. Little research exists specifically addressing the initial developmental preparation of APs. Elements of a needs assessment and program evaluation combine to build infrastructure for a conceptual framework to guide this study. A mixed method design for this study was determined to be the best method in which to provide answers concerning the proposed research questions. Participants consisted of lead and assistant principals from school districts across Missouri. Quantitative and qualitative data was analyzed for trends. Quantitative and qualitative data was compared to one another in order to attain a thorough and comprehensive examination of collected data.Includes bibliographical references (pages 149-161)

Inflationary scalar spectrum in loop quantum cosmology

In the context of loop quantum cosmology, we consider an inflationary era driven by a canonical scalar field and occurring in the semiclassical regime, where spacetime is a continuum but quantum gravitational effects are important. The spectral amplitude and index of scalar perturbations on an unperturbed de Sitter background are computed at lowest order in the slow-roll parameters. The scalar spectrum can be blue-tilted and far from scale invariance, and tuning of the quantization ambiguities is necessary for agreement with observations. The results are extended to a generalized quantization scheme including those proposed in the literature. Quantization of the matter field at sub-horizon scales can provide a consistency check of such schemes.Comment: 29 pages, 2 figures. v2: typos corrected, discussion improved and extended, new section added. Conclusions are unchange

Spin-Foams for All Loop Quantum Gravity

The simplicial framework of Engle-Pereira-Rovelli-Livine spin-foam models is generalized to match the diffeomorphism invariant framework of loop quantum gravity. The simplicial spin-foams are generalized to arbitrary linear 2-cell spin-foams. The resulting framework admits all the spin-network states of loop quantum gravity, not only those defined by triangulations (or cubulations). In particular the notion of embedded spin-foam we use allows to consider knotting or linking spin-foam histories. Also the main tools as the vertex structure and the vertex amplitude are naturally generalized to arbitrary valency case. The correspondence between all the SU(2) intertwiners and the SU(2)$\times$SU(2) EPRL intertwiners is proved to be 1-1 in the case of the Barbero-Immirzi parameter $|\gamma|\ge 1$, unless the co-domain of the EPRL map is trivial and the domain is non-trivial.Comment: RevTex4, 23 pages, 8 figures; important references added; minor corrections, version published in Class.Quant.Grav; theorem of injectivity of EPRL map correcte

Quantum gravity from the point of view of locally covariant quantum field theory

We construct perturbative quantum gravity in a generally covariant way. In particular our construction is background independent. It is based on the locally covariant approach to quantum field theory and the renormalized Batalin-Vilkovisky formalism. We do not touch the problem of nonrenormalizability and interpret the theory as an effective theory at large length scales