Modeling an Aquifer: Numerical Solution to the Groundwater Flow Equation

We present a model of groundwater dynamics under stationary flow and governed by Darcy's Law of water motion through porous media, we apply it to study a 2D aquifer with water table of constant slope comprised of an homogeneous and isotropic media, the more realistic case of an homogeneous anisotropic soil is also considered. Taking into account some geophysical parameters we develop a computational routine, in the Finite Difference Method, that solves the resulting elliptic partial equation, both in a homogeneous isotropic and homogeneous anisotropic media. After calibration of the numerical model, this routine is used to begin a study of the Ayamonte-Huelva aquifer in Spain, a modest analysis of the system is given, we compute the average discharge vector as well as its root mean square as a first predictive approximation of the flux in this system, providing us a signal of the location of best exploitation; long term goal is to develop a complete computational tool for the analysis of groundwater dynamics.Comment: 13 pages and 12 figure

Investigación de impacto sobre la formación en mediación y educación en museos: análisis de la Web of Science

Educational mediation in non-formal education and cultural industries contexts is increasingly important, especially when institutions of heritage, art and creativity try to reach effectively the public and citizenship. Specifically, museums require training and instruction in mediation and the educational role. This work, based on a bibliographic review of articles in impact journals, analyses the scientific publications on the Web of Science (WOS) linked to the training of educators in museums. The quantitative and qualitative analysis of the main characteristics of these contents leads us to affirm that education on museums and heritage is an emerging line of research. Although it is a sector in which there are some difficulties translating the richness and diversity of education in museums to the academic and researcher world. In particular, the WOS does not have a prominent content in the general theme of mediation in museums and, in particular, the training of these professionals. In the final 51 articles selected, the publications coming from Spanish universities or institutions have an outstanding weight. In summary, it is necessary to support the presence of the professional reality of museums in academic research circuits, improving reflection and analysis on the preparation and training of these professionals.La mediación educativa en el ámbito de la Educación No Formal y de las industrias culturales es, cada vez más importante, especialmente a la hora de llegar con eficacia a los públicos y la ciudadanía por parte de las instituciones vinculadas al patrimonio, el arte y la creatividad. De forma específica, los museos requieren de una formación y capacitación en la función mediadora y educativa. Este trabajo, basado en una revisión bibliográfica de artículos en revistas de impacto, analiza las publicaciones científicas en la Web of Science (WOS) vinculadas a la formación de educadores en museos. El análisis cuantitativo y cualitativo de las características principales de estos contenidos nos lleva a afirmar que la educación en museos y patrimonio es una línea emergente de investigación, aunque se trata de un sector en el que existen dificultades para trasladar al mundo académico e investigador la riqueza y diversidad de la educación en museos. En concreto, la WOS no cuenta con un contenido destacado en la temática general de mediación en museos y, particularmente, de la formación de ese colectivo profesional. En la selección final de 51 artículos, las publicaciones procedentes de universidades o instituciones españolas tienen un peso destacado. En resumen, es imprescindible apostar por la presencia de la realidad profesional de los museos en los circuitos de investigación, mejorando la reflexión y el análisis sobre la preparación y capacitación de estos profesionales

Auditoría Administrativa Auditoría de Recursos Humanos

El presente documento tiene por tema general auditoria administrativa, derivándose el subtema auditoria de recursos humanos, las empresas utilizan la auditoría administrativa como una herramienta de evaluación, con el fin que se pretende al realizarla es el de analizar y escudriñar la empresa en su totalidad o en áreas específicas en donde se requieran un estudio más profundo, así poder tomar acciones para subsanar deficiencias, superar obstáculos, establecer un marco para definir objetivos congruentes encaminados a resultados específicos. En el primer capítulo desarrollado se puede comprender a una auditoria administrativa por medio de sus generalidades en su acepción más amplia, significa verificar que la información financiera, administrativa y operacional que se genera sea confiable, veraz y oportuna teniendo por objetivo ser una herramienta fundamental para impulsar el crecimiento de las organizaciones ya que permite detectar en qué áreas hay deficiencias y poder realizar un análisis de mayor cohesión al funcionamiento de dichas áreas. En el segundo capítulo desarrollado el control de recursos humanos se puede comprender el control como una herramienta administrativa cíclico y repetitivo que sirve a los gerentes para monitorear si las metas establecidas se están logrando de forma eficiente ,la palabra control tiene significados y connotaciones que dependen de su función o del terreno especifico en que se aplique. En el tercer capítulo tres se desarrolla el tema sistemas de información de recursos humanos, estos sistemas están integrados por subsistemas que incluyen el hadware, software y almacenamientos de datos (base de datos), el sistema de información de recursos humanos es un procedimiento sistemático que sirve para reunir, almacenar, combinar y validar datos, con relación a sus recursos humanos. En el cuarto y último capítulo se aborda el tema “auditoria de recursos humanos”para completar la gestión de recursos humanos es necesario revisar si lo anterior se está cumpliendo de acuerdo a las normas y políticas establecidas de la empresa atra vez de la auditoria de recursos humanos, la auditoria es un término ligado al control que permite revisar y comprobar el cumplimiento de la aplicación de normas, políticas, y procedimientos de recursos humanos. Para desarrollar este trabajo investigativo se recopiló información mediante literatura bibliográfica de diversos autores especialistas en la auditoría administrativa, entre ellos: Alfredo Amador Sotomayor, Enrique Franklin, William Leonard, Idalberto Chiavenato, etc., de igual manera se aplicaron las normas APA versión números seis, con las orientaciones metodológicas del tutor de seminario de graduación

Growth Dynamics and Water Potential Components of Three Summer Squash (Cucurbita pepo L.) Cultivars

Summer squash fruit is a horticultural crop that possesses a very short postharvest life due to its high rates of metabolism and transpiration along with a low cuticle resistance exhibited mainly when the fruit is harvested at horticultural maturity. This research was realized following the fruit growth of the summer squash cultivars: ‘Enterprise’, ‘Pascola’ and ‘Hurakan F1’, whose seeds were germinated in polystyrene trays and their seedlings were subsequently transferred to pots for optimum growth under greenhouse conditions. Fruits were sampled at 3, 5, 7 and 9 days after anthesis (DAA). Physical (weight, diameter, and length of fruit), chemical (pH, titratable acidity and total soluble solids), hydric status (water, osmotic and pressure potentials), and histological analysis were done. The highest number of fruits having marketing quality were shown in both ‘Pascola’ and ‘Hurakan F1’ cultivars at 7 DAA, whereas, in ‘Enterprise’ was shown at 9 DAA. Marketing quality fruits from the three cultivars showed similarities on pH (about 6.6), titratable acidity (TA) decreases in ‘Enterprise’ and ‘Hurakan F1’, whereas total soluble solids (TSS) decreases in ‘Pascola’ and ‘Hurakan F1’ (pJ 0.5). From 3 to 9 DAA, in all cultivars, the water potential was close to -1.0 MPa, the osmotic potential showed an increasing pattern ranging between -1.59 and -1.15 MPa, and the pressure potential remained in the positive range. Tissue water stability was histologically related to a well-defined parenchyma tissue showing thin-walled, polygonal, intact and turgid cells during fruit growth

Bioavailability and systemic transport of oleanolic acid in humans, formulated as a functional olive oil

14 Páginas.-- 6 Figuras.-- 2 TablasEvidence of the pharmacological activity of oleanolic acid (OA) suggests its potential therapeutic application. However, its use in functional foods, dietary supplements, or nutraceuticals is hindered by limited human bioavailability studies. The BIO-OLTRAD trial is a double-blind, randomized controlled study with 22 participants that received a single dose of 30 mg OA formulated as a functional olive oil. The study revealed that the maximum serum concentration of OA ranged from 500 to 600 ng mL-1, with an AUC0-∞ value of 2862.50 ± 174.50 ng h mL-1. Furthermore, we discovered a physiological association of OA with serum albumin and triglyceride-rich lipoproteins (TRL). UV absorption spectra showed conformational changes in serum albumin due to the formation of an adduct with OA. Additionally, we demonstrated that TRL incorporate OA, reaching a maximum concentration of 140 ng mL-1 after 2-4 hours. We conjecture that both are efficient carriers to reach target tissues and to yield high bioavailability.This research is part of the R+D+i project PID2019-107837RB-I00, funded by the Spanish Ministry of Science and Innovation/Spanish National Research Agency, grant number MCIN/AEI/10.13039/501100011033/. A. G.-G. is grateful for funding received from the “Next Generation EU” funds, the European Union through the Recovery, Transformation and Resilience Plan and by the Ministry of Universities, in the framework of the Margarita Salas, Maria Zambrano grants for the Requalification of the Spanish University System 2021–2023, organized by the Pablo de Olavide University, Seville. J. J. R.-M. obtained an Erasmus+ scholarship (No. 2021-1-IT02-KA131-HED-000008483) from the University of Sassari (ITALY), for a stay at the Department of Food and Health of the Instituto de la Grasa-CSIC. The authors especially thank the ACESUR Group (Dos Hermanas, Seville, Spain), which donated the commercial olive oil for the trial. This collaborator had no role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication.Peer reviewe

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis