153 research outputs found
ΠΠ½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π΅ΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π΄Π΅ΡΠ°Π»Π΅ΠΉ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎΠ»ΠΎΡΠ°
Distribution of load between the cutting elements of the roller cutter drill bit depends on several factors, among them on the stiffness of the drilling-bit assembly. To deduce the dependencies of the stiffness of the drilling-bit assembly on the drill bit design and the point of application of the external load, the scheme of static interaction of the rolling cutter drill bit with the non-deformable bottom hole is considered. The calculation results allow to conclude, that the vertical stiffness of the drilling bit assembly has a maximum value at the contact with the bottom hole of the middle teeth rows of the roller cutters. For verification of the results of the analytical calculations the experimental measurements of the vertical movements of the rolling cutters of the roller cutter drill bit at the contact of those with bottom hole with the teeth of the different teeth rows have been made. The proposed methodology can be used to optimize the design of the roller cutter drill bits at the blueprint stage.La distribuciΓ³n de la carga entre los elementos de un armamento de broca de rodillo depende de varios factores, incluida la rigidez del nudo de rodillo. Para obtener las dependencias de la rigidez de una junta de rodillo en el diseΓ±o de la broca y el punto de aplicaciΓ³n de una carga externa, se considera un esquema de interacciΓ³n estΓ‘tica de una broca de rodillo con una cara no deformable. Los resultados del cΓ‘lculo nos permiten concluir que la rigidez vertical del nudo del rodillo tiene un valor mΓ‘ximo en contacto con la parte inferior de los bordes centrales del cono del rodillo. Para verificar los resultados de los cΓ‘lculos analΓticos, se realizaron mediciones experimentales del movimiento vertical de los conos de bits cuando estaban en contacto con los dientes de varias coronas. La tΓ©cnica propuesta se puede utilizar para optimizar el diseΓ±o de las brocas de rodillo en la etapa de diseΓ±o.Π Π°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΏΠΎ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ°ΠΌ Π²ΠΎΠΎΡΡΠΆΠ΅Π½ΠΈΡ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎΠ»ΠΎΡΠ° Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΡΠ΄Π° ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΎΡ ΠΆΠ΅ΡΡΠΊΠΎΡΡΠΈ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ·Π»Π°. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠ΅ΠΉ ΠΆΠ΅ΡΡΠΊΠΎΡΡΠΈ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ·Π»Π° ΠΎΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ Π΄ΠΎΠ»ΠΎΡΠ° ΠΈ ΡΠΎΡΠΊΠΈ ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π²Π½Π΅ΡΠ½Π΅ΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΡ
Π΅ΠΌΠ° ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎΠ»ΠΎΡΠ° Ρ Π½Π΅Π΄Π΅ΡΠΎΡΠΌΠΈΡΡΠ΅ΠΌΡΠΌ Π·Π°Π±ΠΎΠ΅ΠΌ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ΄Π΅Π»Π°ΡΡ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½Π°Ρ ΠΆΠ΅ΡΡΠΊΠΎΡΡΡ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ·Π»Π° ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ΅ Ρ Π·Π°Π±ΠΎΠ΅ΠΌ ΡΡΠ΅Π΄Π½ΠΈΡ
Π²Π΅Π½ΡΠΎΠ² ΡΠ°ΡΠΎΡΠΊΠΈ. Π‘ ΡΠ΅Π»ΡΡ ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΡΠΎΡΠ΅ΠΊ Π΄ΠΎΠ»ΠΎΡΠ° ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠ΅ ΠΈΡ
Ρ Π·Π°Π±ΠΎΠ΅ΠΌ Π·ΡΠ±ΠΊΠ°ΠΌΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π²Π΅Π½ΡΠΎΠ². ΠΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΠ°Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΌΠΎΠΆΠ΅Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡΡΡ Π΄Π»Ρ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΡΠ°ΡΠΎΡΠ΅ΡΠ½ΡΡ
Π΄ΠΎΠ»ΠΎΡ Π½Π° ΡΡΠ°Π΄ΠΈΠΈ ΠΈΡ
ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ
Neutrophil granulocytes: participation in homeostatic and reparative processes. Part II
A supportive homeostatic function of neutrophilic granulocytes is accomplished in the physiology of diverse tissues and body systems. Neutrophils are found along the entire female reproductive tract (FRT), gradually declining in numbers from the upper parts towards the vagina. At the same time, both quantity and activity of FRT mucosal neutrophils are controlled by hormonal changes at different phases of menstrual cycle. Tissue neutrophils serve as an important source of broad-spectrum proteolytic enzymes such as matrix metalloproteinases and elastase necessary for extracellular matrix remodeling as well as vascular endothelial growth factor (VEGF) required for physiological FRT angiogenesis. During pregnancy, decidual neutrophils play a prominent role in vascular remodeling in pregnant uterus as well as development of maternal-fetal immune tolerance. The influx of neutrophils into the intestinal mucosa due to its trauma or infection not only ensures defense against pathogens, but also leads to increased proliferation of intestinal epithelial cells. Neutrophilic granulocytes elicit signals and events protective for the epithelium by marking them with a βhypoxic signatureβ to trigger transcription of the gene set responsible for production of mucins, mucin-modifying peptides, antimicrobial proteins, Π²-defensins, ultimately contributing to lesion healing and recovery of epithelial barrier function. βInflammatory hypoxiaβ initiated by neutrophils and subsequent stabilization of the transcription factor hypoxia-induced factor (HIF) in intestinal epithelial cells trigger mechanisms of self-limited and resolved inflammation, which prevent excessive accumulation of neutrophils in the intestinal lumen and development of chronic inflammatory process. Neutrophilic granulocytes dominate in the oral cavity mucosa and comprise more than 95% of total leukocyte population recruited into the gingival sulcus and gingival fluid. Neutrophils maintain physiological amount and stability of symbiotic microflora composition in dental and gingival biofilms, counteracting pathogenic bacteria via phagocytosis, degranulation and extracellular trap formation, thereby ensuring healthy state in periodontal structures. Finally, similar to some other congenital disorders affecting neutrophil quantity and functions it was shown that in case of leukocyte adhesion deficiency type 1 (LAD-1) pathogenesis of periodontitis may not only be associated with a defect in their protective effector activity, but also with altered immunoregulatory function of tissue neutrophils
Neutrophil granulocytes: participation in homeostatic and reparative processes. Part I
After exiting from the bone marrow (BM) into the circulation, mature neutrophil granulocytes undergo a set of sequential phenotypic and physiological changes collectively called βagingβ in the absence of inflammation, by constitutively sensing prime signals from commensal microbiota and acquiring higher functional alertness in case of activation upon tissue damage or pathogen invasion. Physiological aging of blood neutrophils and their subsequent return to the BM result in signals modulating size and function of the hematopoietic niche. Circadian physiological infiltration of BM by neutrophils contributes to maintaining baseline level of circulating hematopoietic progenitor cells capable of regeneration and immune surveillance. Apart from the BM, neutrophils actively enter other healthy tissues, probably exerting some effects on their baseline physiologic state. Using lung tissue, it has been shown that neutrophils can βgovernβ action of gene set regulating cell growth, migration, proliferation, differentiation, and carcinogenesis. Neutrophils participate in destruction of endometrial tissues during desquamation phase as well as subsequent repair and physiological angiogenesis during proliferative phase of the menstrual cycle; promote wall rupture of the preovulatory ovarian follicle and oocyte exit; contribute to degradation and resorption of the corpus luteum in pregnancy failure; play an important physiological role in vascular remodeling in pregnant uterus and developing maternal immune tolerance to semi-allogeneic fetus. Neutrophils actively migrating to the surface of intestinal epithelium during local infection and/or damage stimulate epithelial restitution and recovery of its barrier function. On the other hand, neutrophils recruited into the oral cavity regulate quantitative and qualitative composition of microbial communities in oral biofilms, and ensure healthy state of periodontal structures. Being a major player and regulator in healing of skin wounds at early stage, inflammation, neutrophils not only destroy potential pathogens, but also participate in cleansing wounds from cell debris, produce cytokines, enzymes, and growth factors affecting further stages in repair process. Both apoptosis and NETosis underlying neutrophil death greatly contribute to wound healing. However, dysregulation and imbalance in both apoptosis and NETosis may lead to unfavorable consequences as well as developing chronic non-healing wounds
The correlation of the CD-lymphocyte level content in peripheral blood of sportsmen with the size of geomagnetic activity Ap-index
Diagnosis of Epilepsy: from the Beginning to the New Hybrid PET/MR Technique
The problem of diagnosis and treatment of epilepsy concerns medical society for a several thousands of years. The understanding of the causes and pathological mechanisms of this condition underwent numerous and substantial changes during this time, that allowed reaching significant advances in both the diagnosis or treatment. At the present time, there is a wide spectrum of diagnostic methods that allow localizing the epileptogenic focus, that is essential for planning the surgical treatment in patients with pharmacoresistant epilepsy. The results of the surgical treatment are strongly dependent on the diagnostic accuracy in the detection of one or several epileptogenic foci and on the prognosis of their resection. In this connection, the research on the possibilities and perfection of new diagnostic methods hold the potential to improve the results of the surgical treatment and the life quality in patients with pharmacoresistant epilepsy. This review presents a detailed description of the evolution of epilepsy diagnostics from the first implementation of electroencephalography in the 1920-s to the modern hybrid methods such as SISCOM (Subtraction Ictal SPECT Co-Registered to MRI) and PET-MRI
Π Π°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ ΡΡΠ±ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ Π’-ΠΊΠ»Π΅ΡΠΎΠΊ
Regulatory T-lymphocytes play a central role in the immunological tolerance system. To date, existence of manyΒ different subpopulations of regulatory T-cells have been described. However, a number of questions related to theΒ function, differentiation, and homeostasis of these subpopulations in a body remain unclear. Interactions betweenΒ the previously discovered pairs of helper and regulatory T-lymphocytes require further study. The main topic isΒ identification and establishment of the functions of regulatory memory cells. Interstitial migration of activatedΒ regulatory T-lymphocytes is also a promising direction. In this review, we summarized the main findings in multiple subsets of regulatory T-lymphocytes, discussed unclear data that will require further studies, andΒ showedΒ an application for regulatory T-lymphocytes in medicine.Π Π΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΡΠ²Π»ΡΡΡΡΡ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΠ»Π΅ΡΠ°Π½ΡΠ½ΠΎΡΡΠΈ.Β Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΎΠΏΠΈΡΠ°Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ±ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Β Π’-ΠΊΠ»Π΅ΡΠΎΠΊ (Treg), ΠΎΠ΄Π½Π°ΠΊΠΎ Π±ΠΎΠ»ΡΡΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π²ΠΎΠΏΡΠΎΡΠΎΠ², ΠΊΠ°ΡΠ°ΡΡΠΈΡ
ΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ,Β ΠΏΡΡΠ΅ΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΈ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° ΡΡΠΈΡ
ΡΡΠ±ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅, ΠΎΡΡΠ°ΡΡΡΡ Π½Π΅ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠΌΠΈ.Β ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠ°Π½Π΅Π΅ ΠΏΠ°ΡΡ Ρ
Π΅Π»ΠΏΠ΅ΡΠΎΠ² ΠΈ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΈΠΌ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΡΠ΅Π±ΡΡΡΒ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ
Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ. ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΎΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈΒ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ. Π’ΠΊΠ°Π½Π΅Π²Π°Ρ ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Β Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ°ΠΊΠΆΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ. Π ΡΡΠΎΠΌ ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠΎΠ±ΡΠ°Π½Ρ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΡΒ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ±ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ Π΄Π°Π½Π½ΠΎΠΉΒ ΡΠ΅ΠΌΠ°ΡΠΈΠΊΠΈ, ΡΡΠ΅Π±ΡΡΡΠΈΠ΅ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Π·Π°ΡΡΠΎΠ½ΡΡΡ ΠΏΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΠ±Π»Π°ΡΡΠΈ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉΒ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅
Evaluation of the metabolism properties of choline kinase alpha in neoplasms of the parathyroid glands. A pilot study
BACKGROUND: Primary hyperparathyroidism (PHPT) is a widespread endocrine disease characterized by excessive production of parathyroid hormone (PTH) due to parathyroid gland hyperplasia (PGH) or tumor lesions (adenoma or cancer of the parathyroid gland (PG) in 80% and 1–5% of cases respectively). Choline kinase α–alpha (XKα) overexpression is described in tumors of different localization, but there is no data on its expression in PG tumors. AIMS: To study the character of XKα expression in PG neoplasms and its relationship with clinical, laboratory, and visualization characteristics (positron emission tomography combined with computed tomography (PET/CT) with 18F–fluorocholine (18F–FC)). MATERIALS AND METHODS: The material for the study was based on tissue samples from 10 patients of 34–70 years old (Me = 61.5; [48; 66]), with a laboratory–confirmed diagnosis of PHT. An immunohistochemical study (IHC) was carried out on materials from 2 patients with hyperplasia of the main cells, from 5 patients with adenoma of PG, from 1 patient with atypical adenoma and 1 with carcinoma of PG; in 1 case the metastasis of cancer of the neck with lymph node was examined. RESULTS: The expression of XKα is spotted in all types of PG cells (chief cells: active and inactive forms), transitional forms between the chief cells and oxyphil; oxyphil cells, but it was most intense in active chief cells. The expression of XKα was observed in neoplasms of PG of various degrees of malignancy. In the most numerous group of PG formations with a favorable prognosis (11 samples from 7 patients), no statistically significant correlation (p> 0.05) was obtained between the intensity expression of the XKα, of the PTH and the proliferative activity index Ki–67, the level of radiopharmaceutical accumulation in PET/CT with 18F–FC (SUVmax) and laboratory data (PTH, Ca, Ca++). CONCLUSIONS: In the majority of investigated cases, moderate and intensive expression of the XKα was detected in PG cells. A small amount of studied cases does not allow us to identify the connection between the intensity of XKα expression and the malignant potential for the formation of PG
The formation process of extracellular DNA - additional diagnostic criterion for definition grade of breast carcinoma
Neutrophil granulocytes, being a permanent structure in the palette of the Β«microenvironmentΒ» tumors lay a different role in oncogenes. In response to tumor cells incentives neutrophils actively shape in the extracellular space setuptable structure consisting of nucleic acids and enzymes - neutrophil extracellular nets. It was noticed, that in the tumor tissue, breast carcinoma near the tumor cells is diffuse and clusters distributed free cell DNA.lt has been shown that neutrophils when meeting with tumor cells become activated and begin to form a free cell extracellular DNA around themwith various level proliferation activity.ΠΠ΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΠ΅ Π³ΡΠ°Π½ΡΠ»ΠΎΡΠΈΡΡ, ΡΠ²Π»ΡΡΡΡ ΠΏΠΎΡΡΠΎΡΠ½Π½ΡΠΌΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠΌ Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΌΠΈΠΊΡΠΎΠΎΠΊΡΡΠΆΠ΅Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ, ΠΈΠ³ΡΠ°ΡΡ Π½Π΅ΠΎΠ΄Π½ΠΎΠ·Π½Π°ΡΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΎΠ½ΠΊΠΎΠ³Π΅Π½Π΅Π·Π΅. Π ΠΎΡΠ²Π΅Ρ Π½Π° ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠΎΡΠΌΠΈΡΡΡΡ Π²ΠΎ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅ ΡΠ΅ΡΠ΅ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΡΡΡΡΠΊΡΡΡΡ, ΡΠΎΡΡΠΎΡΡΠΈΠ΅ ΠΈΠ· Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² - Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΠ΅ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π»ΠΎΠ²ΡΡΠΊΠΈ. ΠΠ°ΠΌΠΈ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΡΠΊΠ°Π½ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΡΡΠ΄ΠΎΠΌ Ρ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π΄ΠΈΡΡΡΠ·Π½ΠΎ ΠΈ ΡΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡΠΌΠΈ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ ΠΠΠ.Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»Ρ ΠΏΡΠΈ Π²ΡΡΡΠ΅ΡΠ΅ Ρ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΡΡ ΠΈΠ½Π°ΡΠΈΠ½Π°ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°ΡΡΠ²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΡΠ΅ΡΠΈ ΠΠΠΠ²ΠΎΠΊΡΡΠ³Π½ΠΈΡ
Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΡΠΎΠ²Π½Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ
Possible climate-related signals in high-resolution topography of lobate debris aprons in Tempe Terra, Mars
Lobate debris aprons are common features in the midlatitudes of Mars that are assumed to be the result of the flow of ice-rich material. We produce high-resolution digital elevation models of two of these features in the Tempe Terra region of Mars using HiRISE stereo images. We identify two main topographic features of different wavelength using a power spectrum analysis approach. Short wavelength features, between approximately 10 and 20 m in length, correspond to a polygonal surface texture present throughout our study area. Long wavelength features, between approximately 700 and 1800 m in length, correspond to broad ridges that are up to 20 m in amplitude. We interpret both topographic signals to be the likely result of climate change affecting the debris contribution and/or the flow regime of the lobate debris aprons. The apparent surface age of about 300 Ma could be evidence of an astronomical forcing mechanism recorded in these lobate debris aprons at this time in Mars' history. Citation: Grindrod, P. M., and S. A. Fawcett (2011), Possible climate-related signals in high-resolution topography of lobate debris aprons in Tempe Terra, Mars, Geophys. Res. Lett., 38, L19201, doi: 10.1029/2011GL049295
Clinical immunological characteristics of the patients with chronic generalized parodontitis
Clinical immunological study of 99 patients with CHGP and 25 clinically healthy persons with intact paradont was carried out. A number ot disorders of cellular and humoral immunity and functional neutrophils activity of peripheral blood is revealed among the patients with chronic generalized parodontitis. The intensity of immune disorders depends on the severity of parodontitis. The interrelation of inflammatory destructive processes in parodontium tissues and disorders in cellular and humoral immunity chains as well as functional neutrophils activity is proved by the correlation relationship.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ 99 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π₯ΠΠ ΠΈ 25 ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ Ρ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΠΌ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΎΠΌ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π₯ΠΠ Π²ΡΡΠ²Π»Π΅Π½Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΡΠ΄Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² ΠΏΠ΅ΡΠΈΡ Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ. ΠΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Π·Π°Π²ΠΈΡΠ΅Π»Π° ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠ°. ΠΠ·Π°ΠΈΠΌΠΎΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΡΠΊΠ°Π½ΡΡ
ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠ° ΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ Π·Π²Π΅Π½ΡΡΡ
ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ²ΡΠ·ΡΡ
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