A 2.5MHz bandpass active complex filter With 2.4MHz bandwidth for wireless communications

Trabajo presentado al 23rd DCIS celebrado en grenoble del 12 al 14 de noviembre de 2008.This paper presents a fully differential 8th order transconductor-based active complex filter with 2.4MHz bandwidth and centered at 2.5MHz, designed in a 90nm 2.5V 7M and MIM capacitors CMOS process technology. The filter compliants with the requirements of the IEEE802.15.4 standard. Simulation results including mismatching and process variations over the extracted view of the circuit are shown. The filter has a nominal gain of 12dB, good selectivity (20dB@2MHz offset), high image rejection (51dB nominal) and low power consumption (3.6mA @2.5V).This work has been founded in part by the EC through the project A109-Medea+ WITNESS (Wireless technologies for small area networks with embedded security and safety), the Spanish Regional Government of Junta de Andalucía under project TIC-927 and the Spanish Government under project TEC2007-68072.Peer reviewe

The Role of Glycosyltransferases in Colorectal Cancer

Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Posttranslational modifications (PTMs) have been extensively studied in malignancies due to its relevance in tumor pathogenesis and therapy. This review is focused on the dysregulation of glycosyltransferase expression in CRC and its impact in cell function and in several biological pathways associated with CRC pathogenesis, prognosis and therapeutic approaches. Glycan structures act as interface molecules between cells and their environment and in several cases facilitate molecule function. CRC tissue shows alterations in glycan structures decorating molecules, such as annexin-1, mucins, heat shock protein 90 (Hsp90), 1 integrin, carcinoembryonic antigen (CEA), epidermal growth factor receptor (EGFR), insulin-like growth factor-binding protein 3 (IGFBP3), transforming growth factor beta (TGF- ) receptors, Fas (CD95), PD-L1, decorin, sorbin and SH3 domain-containing protein 1 (SORBS1), CD147 and glycosphingolipids. All of these are described as key molecules in oncogenesis and metastasis. Therefore, glycosylation in CRC can affect cell migration, cell–cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease. According to these findings, multiple strategies have been evaluated to alter oligosaccharide processing and to modify glycoconjugate structures in order to control CRC progression and prevent metastasis. Additionally, immunotherapy approaches have contemplated the use of neo-antigens, generated by altered glycosylation, as targets for tumor-specific T cells or engineered CAR (Chimeric antigen receptors) T cells

A 5 GHz LC-VCO with active common mode feedback circuit in sub-micrometer CMOS technology

Trabajo presentado al XXV DCIS celebrado en Lanzarote del 17 al 19 de noviembre de 2010.A 1.2V 5GHz low-cost voltage-controlled oscillator (VCO) with active common mode feedback has been implemented in a CMOS/RF 90nm technology for a robust I/Q generation using a frequency divider-by-2 (DIV2). As the input common mode of the DIV2 affects critically its performance, a calibration method to correct the output common mode of the VCO has been proposed and validated through post-layout simulations.This work has been partially supported by the Spanish TIC-927 Junta de Andalucía, FEDER and Ministerio de Educación y Ciencia TEC2007-68072 projects.Peer Reviewe

Inductor characterization in RF LC-VCOs

Comunicación presentada al "LASCAS 2013) celebrado en Cusco (Perú) del 27 de Febrero al 1 de MarzoThis paper analyzes the characterization of inductors in resonant radio frequency (RF) circuits, with emphasis in LC voltage-controlled oscillators (VCOs). We will demonstrate how inductor quality factor is often underestimated in the vicinity of self-resonance frequency, because its capacitive parasitic contribution is not properly considered. In consequence, some valid inductor geometries could be incorrectly discarded during the initial circuit optimization process. To overcome this design space limitation, the paper presents an alternative method to characterize inductors at the wanted resonant frequency. The comparison between the conventional and the proposed methods is illustrated with the characterization of a complete inductor library in a commercial 90nm CMOS RF technology.Peer Reviewe

On-chip biased voltage-controlled oscillator with temperature compensation of the oscillation amplitude for robust I/Q generation

Trabajo presentado al "International Symposium on Circuits and Systems (ISCAS)" celebrado del 30 de Mayo al 2 de Junio del 2010 en Paris (Francia).In this work a CMOS 1.2V 5GHz low-power voltage-controlled oscillator (VCO) is proposed. It uses an on-chip biased LC-tank topology and introduces a temperature compensation technique which stabilizes the oscillation amplitude for a robust I/Q generation using a frequency divider-by-2. Compared to a standard design with constant bias, it reduces the oscillation variation by almost two orders of magnitude between 0°C and 100°C with negligible impact on the phase noise. Worst case estimations of the VCO phase noise after layout parasitic extraction are -110.1dBc/Hz and -126.6dBc/Hz at 1MHz and 5MHz offsets from the carrier, respectively. Its nominal current consumption is 198μA (plus 22.5μA for biasing) and it occupies 370×530μm2.This work has been partially supported by the SR2- Short Range Ratio Catrene European Project and the Spanish TIC-927 Junta de Andalucía and TEC2007-68072 projects.Peer reviewe

photoarray 22psd

22 arrays de fotodiodos. Cada array se utiliza para la detección de la trayectoria de un foco luminosoThe main objective of the Optonanogen proposal is to develop a portable biosensor microsystem able to detect single nucleotide variations in human genes. The biosensor microsystem will consist of: i) an array of 20 microcantilevers produced by standar silicon micromechanical technology, ii) an optical detection system capable of measuring the cantilever movement (lasers and photodetectors). The array of lasers (VSCELs) will be fabricated by Molecular Beam Epitaxy of semiconductor compounds. The array of photodetectors will be integrated with their corresponding amplifier and signal processing circuits, after desing and fabrication of the CMOS circutry and iii) a polymer microfluidic system will be developed for reagents delivery to the biosensorProyecto OPTONANOGEN, Ref. 1ST-2001-37239, Unión EuropeaN

A first order incremental analog to digital converter based on continuous time circuits

Comunicación presentada al "XVII IMEKO World Congress: Metrology in the 3rd Millennium" celebrado en Dubrovnik (croacia) del 22 al 28 de Junio del 2003.In this paper, an incremental Analog-to- Digital Converter (ADC) designed as part of the signalconditioning circuitry for tissue impedance measurement system is presented. Continuous-time design techniques has been used and a modified implementation of the conversion algorithm, with respect to its discrete-time counterpart, has been developed. To reduce the influence of the no-idealities, analog and digital corrections have been also implemented. A prototype in 0.8μm CMOS technology has been fabricated and tested. Experimental results are reported.Peer reviewe