Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p< 0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p= 0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p= 0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture

Web-Based Android Malicious Software Detection and Classification System

Android is the most used operating system (OS) by mobile devices. Since applications uploaded to Google Play and other stores are not analyzed comprehensively, it is not known whether the applications are malicious software or not. Therefore, there is an urgent need to analyze these applications regarding malicious software. Moreover, mobile devices have limited resources to analyze the applications. In this study, a malicious detection system named ``Web-Based Android Malicious Software Detection and Classification System{''} was developed. The system is based on client-server architecture, static analysis and web-scraping methods. The proposed system overcomes the resource restriction issue, as well as providing third-party service support by means of client-server architecture. Based on the performance evaluation conducted in this research, the developed system's success rate is 97.62\% on benign and malicious datasets

Effect of Diurnal Blood Pressure on Endothelial Functions in Essential Hypertensive Patients

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEYWOS: 000329858400204…Turkish Soc Cardio

Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

ABSTRACT Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p<0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p=0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p=0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture

Effects of inguinal hernia repair on trunk muscle strength, quality of life, and neuropathic pain<bold> </bold>

WOS: 000470067100003BACKGROUND: The Lichtenstein's and Kugel's procedures for inguinal hernia repair have been compared in terms of immediate complications, including hematoma, testicular pain and wound infection, and long-term outcomes such as chronic pain. OBJECTIVE: The aim of the present study was to compare trunk muscle strength, quality of life (QoL), and neuropathic pain (NP) components using a prospective controlled study following the above two procedures. METHODS: Sixty consecutive patients underwent elective inguinal hernia repair from 2013 until 2014. Thirty patients were operated using standard Lichtenstein, while 30 were treated with a Kugel patch. Six months after initial surgery, trunk muscle strength and patient QoL were evaluated. Additionally, 40 healthy volunteers, matched for age and sex, were recruited for comparison. Trunk muscle strength was measured isokinetically, whereas QoL and pain level were assessed using the Short Form 36 (SF-36) and the PainDETECT questionnaire (PD-Q), respectively. RESULTS: Mean peak moment of trunk flexion and trunk flexor-extensor (agonist/antagonist) ratio were significantly lower in patients than in controls, while no differences were observed between the two surgery groups. In addition, trunk extension strength was mearly identical in all there (2 experimental, 1 control) groups. Only two patients in the Lichtenstein group and one patient in the Kugel group showed a PD-Q score over 19 and NP component. There was no difference in the PD-Q scores and SF-36 domains between the different surgery groups. CONCLUSIONS: Based on the outcome parameters evaluated in this study, none of the two surgical interventions is superior to the other. Therefore, the particular choice of surgical procedure should rely on other factors

Purification and characterization of polyphenol oxidase from purslane

Abstract The polyphenol oxidase (PPO) is an enzyme that is responsible for the enzymatic browning of fruits and vegetables. This is generally undesired process and need to be prevented in food technology. PPO from purslane was purified, characterised and the kinetic parameters for three substrates namely, catechol, L-Dopa and 4-methylcatechol were determined. The optimum pH and temperature values were found to be pH 7.0 and 50 °C, respectively using the catechol as substrate. The apparent molecular weight of the PPO from purslane was determined as high as 163 kDa by partially denaturing SDS-PAGE. Moreover, the inhibition kinetics of the purified PPO were determined, using both synthetic and natural inhibitors. Among inhibitors tested, ascorbic acid was the most effective inhibitor with the lowest Ki value of 0.36 mM. This is the first study on the purification and characterisation of PPO from purslane (Portulaca oleracea) that may provide new insight into how to overcome the enzymatic browning

Initial Management of Childhood Acute Immune Thrombocytopenia: Single-Center Experience of 32 Years

Immune thrombocytopenia (ITP) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti-RhD immunoglobulin. We reviewed our 32years' experience for first-line therapy of acute ITP. Five hundred forty-one children (mean age: 5.3years) diagnosed and treated for ITP were evaluated retrospectively. Among 491 acute ITP patients, IVIG was used in 27%, high-dose steroids in 27%, low-dose steroids in 20%, anti-D immunoglobulin G (IgG) in 2%, and no therapy in 22%. When the initial response (platelets >50 x 10(9)/L) to first-line treatment modalities were compared, 89%, 84%, and 78% patients treated by low-dose steroids, high-dose steroids, and IVIG responded to treatment, respectively (P > .05). Mean time to recovery of platelets was 16.8, 3.8, and 3.0days in patients treated with low-dose steroids, high-dose steroids, and IVIG, respectively (P < .0001). Thrombocytopenia recurred in 23% of low-dose steroid, 39% of high-dose steroid, and in 36% of IVIG (P < .0001) treatment groups. Of 108 patients who were observed alone, 4 (3%) had a recurrence on follow-up and only 2 of these required treatment subsequently. Recurrence was significantly less in no therapy group compared with children treated with 1 of the 3 options of pharmacotherapy (P < .0001). Response rates were similar between patients treated by IVIG and low- and high-dose steroids; however, time to response was slower in patients treated with low-dose steroids compared with IVIG and high-dose steroids