Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Rectal Dieulafoy Lesions: A Rare Etiology of Chronic Lower Gastrointestinal Bleeding

Dieulafoy lesion is rarely seen, yet it can be life-threatening. This lesion makes up to 1-2% of gastrointestinal bleedings and must definitely be considered in gastrointestinal bleedings whose source cannot be identified. In this case study, the 75-year-old woman was suffering from active, fresh, and massive rectal bleeding. Colonoscopy was applied in order to find out the source of bleeding. In the typical endoscopic appearance of the lesion a single round mucosal defect in the rectum and arterial bleeding were observed. To procure hemostasis, epinephrine was injected into the lesion and the bleeding vein was sutured

Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Case Report Rectal Dieulafoy Lesions: A Rare Etiology of Chronic Lower Gastrointestinal Bleeding

Dieulafoy lesion is rarely seen, yet it can be life-threatening. This lesion makes up to 1-2% of gastrointestinal bleedings and must definitely be considered in gastrointestinal bleedings whose source cannot be identified. In this case study, the 75-year-old woman was suffering from active, fresh, and massive rectal bleeding. Colonoscopy was applied in order to find out the source of bleeding. In the typical endoscopic appearance of the lesion a single round mucosal defect in the rectum and arterial bleeding were observed. To procure hemostasis, epinephrine was injected into the lesion and the bleeding vein was sutured

Isolated Small Bowel Transplantation in Turkey: A Single Center Experience Running Title: Isolated Small Bowel Transplantation in Turkey

Background SBTx has become a feasible therapeutic option for patients with irreversible intestinal failure. Increase in the number and in the improvement of the patient and graft survival in SBTx has a slow course when compared to other solid organ transplantation. Aim The aim of this study is to analyze 25 isolated SBTx performed since 2003 at a single center. It also aims to compare the patient and graft survivals rate during the early (before 2010) and late (after 2010) period. Materials and Methods Medical charts of 24 patients were analyzed retrospectively. To compare the center’s experience during a twelve year period, the results were divided into two groups (before (n:7) and after 2010 (n:18)). At the appropriate time, data were reported as mean± standard deviation, median, and range. Kaplan Meier method was used for the survival analysis of the graft and the patients. Results Median age of the patients was 39 (min 6 months, max: 56 yr). Six of them were in the pediatric age group. Compared to before 2010, graft survival rates increased from 28.1% to 53.8% in 3 months, from 28.6% to 35.9% in 6 months, and from 14.3% to 29.9% in one year after 2010. At the same period, patient survival rate increased from 57.1% to 72.2% in 3 months, from 28.6% to 38.9% in 6 months, and from 14.3% to 33.3% in one year. In the pediatric age group, patient and graft survival rates were 85.7% in 3 months, 71.4% in 6 months, and 71.4 % in 1 year. Conclusion SBTx is an effective treatment choice for selected patients with intestinal failure. Although patient and graft survival rates were improved after 2010 in our center, it was inferior. Patient and graft survival rates in pediatric SBTx are favourable and promising

Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202

Supplementary material for: [https://doi.org/10.1016/j.indcrop.2020.112202]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3882