Fronthaul evolution: From CPRI to Ethernet

It is proposed that using Ethernet in the fronthaul, between base station baseband unit (BBU) pools and remote radio heads (RRHs), can bring a number of advantages, from use of lower-cost equipment, shared use of infrastructure with fixed access networks, to obtaining statistical multiplexing and optimised performance through probe-based monitoring and software-defined networking. However, a number of challenges exist: ultra-high-bit-rate requirements from the transport of increased bandwidth radio streams for multiple antennas in future mobile networks, and low latency and jitter to meet delay requirements and the demands of joint processing. A new fronthaul functional division is proposed which can alleviate the most demanding bit-rate requirements by transport of baseband signals instead of sampled radio waveforms, and enable statistical multiplexing gains. Delay and synchronisation issues remain to be solved

DNA Damaged Induced Cell Death in Oocytes

The production of haploid gametes through meiosis is central to the principle of sexual reproduction. The genetic diversity is further enhanced by exchange of genetic material between homologous chromosomes by the crossover mechanism. This mechanism not only requires correct pairing of homologous chromosomes but also efficient repair of the induced DNA double-strand breaks. Oocytes have evolved a unique quality control system that eliminates cells if chromosomes do not correctly align or if DNA repair is not possible. Central to this monitoring system that is conserved from nematodes and fruit fly to humans is the p53 protein family, and in vertebrates in particular p63. In mammals, oocytes are stored for a long time in the prophase of meiosis I which, in humans, can last more than 50 years. During the entire time of this arrest phase, the DNA damage checkpoint remains active. The treatment of female cancer patients with DNA damaging irradiation or chemotherapeutics activates this checkpoint and results in elimination of the oocyte pool causing premature menopause and infertility. Here, we review the molecular mechanisms of this quality control system and discuss potential therapeutic intervention for the preservation of the oocyte pool during chemotherapy

DNA Damaged Induced Cell Death in Oocytes

The production of haploid gametes through meiosis is central to the principle of sexual reproduction. The genetic diversity is further enhanced by exchange of genetic material between homologous chromosomes by the crossover mechanism. This mechanism not only requires correct pairing of homologous chromosomes but also efficient repair of the induced DNA double-strand breaks. Oocytes have evolved a unique quality control system that eliminates cells if chromosomes do not correctly align or if DNA repair is not possible. Central to this monitoring system that is conserved from nematodes and fruit fly to humans is the p53 protein family, and in vertebrates in particular p63. In mammals, oocytes are stored for a long time in the prophase of meiosis I which, in humans, can last more than 50 years. During the entire time of this arrest phase, the DNA damage checkpoint remains active. The treatment of female cancer patients with DNA damaging irradiation or chemotherapeutics activates this checkpoint and results in elimination of the oocyte pool causing premature menopause and infertility. Here, we review the molecular mechanisms of this quality control system and discuss potential therapeutic intervention for the preservation of the oocyte pool during chemotherapy

Performance of HARQ with Reduced Size Retransmissions using Network Coding Principles

Abstract—This paper discusses retransmission approaches to improve the throughput performance of Hybrid-ARQ (HARQ) schemes in a point-to-point single user 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) uplink system. One goal of communication systems is to achieve a reliable transmission with a throughput performance as close as possible to channel capacity. For that, reducing the channel utilization will improve the throughput performance. Instead of sending two retransmission packets for two HARQ processes of one users, a previously published HARQ scheme uses the XOR combining of these packets to get only one retransmission packet with the same size. Similar to this idea, a new varied scheme performs XOR combining of parts of one conventional full retransmission to generate a smaller retransmission packet. Both approaches will reduce the channel utilization. They will be compared with a HARQ system in LTE uplink using a full size retransmission and a half size retransmission. The main focus of this work is the throughput performance evaluation of these schemes in an LTE link-level simulator. Index Terms—Network coding, HARQ, In-Packet, LTE uplink. I

Correlations Between High Level Sport-Climbing and the Development of Adolescents

Over the last years concerns have been raised about the health effects particulary on young climbers due to the observation of short stature with low body weight and body fat in sports climbers. The aim of this study was to investigate anthropometric and hormonal data for climbers of the German Junior national team. 16 climbers were compared with 14-age matched nonclimbers with respect to several anthropometric variables, leptin level, and climbing characteristics. Height, weight and body mass index (BMI) standard deviation scores (SDS) for boys were not significantly different from the controls, whereas girls had significantly lower SDS-values for weight and BMI. In comparison with the control group boys and girls had a lower skinfold thickness. The leptin values were lower than the calculated leptin levels but only reached significance for the girls. The young athletes of the GJNT were neither of short stature nor thin when compared with a physically active control group. The low body fat in boys and girls was within expected limits. The lower leptin levels might be attributed to a decrease in total body fat

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation

The covalent conjugation of ubiquitin-fold modifier 1 (UFM1) to proteins generates a signal that regulates transcription, response to cell stress, and differentiation. Ufmylation is initiated by ubiquitin-like modifier activating enzyme 5 (UBA5), which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1). The details of the interaction between UFM1 and UBA5 required for UFM1 activation and its downstream transfer are however unclear. In this study, we described and characterized a combined linear LC3-interacting region/UFM1-interacting motif (LIR/UFIM) within the C terminus of UBA5. This single motif ensures that UBA5 binds both UFM1 and light chain 3/γ-aminobutyric acid receptor-associated proteins (LC3/GABARAP), two ubiquitin (Ub)-like proteins. We demonstrated that LIR/UFIM is required for the full biological activity of UBA5 and for the effective transfer of UFM1 onto UFC1 and a downstream protein substrate both in vitro and in cells. Taken together, our study provides important structural and functional insights into the interaction between UBA5 and Ub-like modifiers, improving the understanding of the biology of the ufmylation pathway