8,099 research outputs found

    Identifying mechanisms influencing the emergence and success of innovation within national economies: a realist approach

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    This paper uses data from recent OECD (OECD Science, technology and industry scoreboard. OECD Publishing, Paris, 2013b) and Cornell University et al. (The global innovation index 2014. World Intellectual Property Organization, Fontainebleau, 2014) national innovation reports to explain Australiaā€™s poor innovation performance. We adopt a realist approach and apply the technique of retroduction to identify potential causes. While our account is only preliminary, we contend that this technique provides the resources to uncover plausible causes for further, more detailed, causal analysis. We conclude that the retroductive method is one that can be applied to aggregated statistics more generally and could be used by analysts and policy makers in any jurisdiction

    Power-law carrier dynamics in semiconductor nanocrystals at nanosecond time scales

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    We report the observation of power law dynamics on nanosecond to microsecond time scales in the fluorescence decay from semiconductor nanocrystals, and draw a comparison between this behavior and power-law fluorescence blinking from single nanocrystals. The link is supported by comparison of blinking and lifetime data measured simultaneously from the same nanocrystal. Our results reveal that the power law coefficient changes little over the nine decades in time from 10 ns to 10 s, in contrast with the predictions of some diffusion based models of power law behavior.Comment: 3 pages, 2 figures, compressed for submission to Applied Physics Letter

    Towards operational measures of computer security

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    Ideally, a measure of the security of a system should capture quantitatively the intuitive notion of ā€˜the ability of the system to resist attackā€™. That is, it should be operational, reflecting the degree to which the system can be expected to remain free of security breaches under particular conditions of operation (including attack). Instead, current security levels at best merely reflect the extensiveness of safeguards introduced during the design and development of a system. Whilst we might expect a system developed to a higher level than another to exhibit ā€˜more secure behaviourā€™ in operation, this cannot be guaranteed; more particularly, we cannot infer what the actual security behaviour will be from knowledge of such a level. In the paper we discuss similarities between reliability and security with the intention of working towards measures of ā€˜operational securityā€™ similar to those that we have for reliability of systems. Very informally, these measures could involve expressions such as the rate of occurrence of security breaches (cf rate of occurrence of failures in reliability), or the probability that a specified ā€˜missionā€™ can be accomplished without a security breach (cf reliability function). This new approach is based on the analogy between system failure and security breach. A number of other analogies to support this view are introduced. We examine this duality critically, and have identified a number of important open questions that need to be answered before this quantitative approach can be taken further. The work described here is therefore somewhat tentative, and one of our major intentions is to invite discussion about the plausibility and feasibility of this new approach

    Maximum Mass-Radius Ratios for Charged Compact General Relativistic Objects

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    Upper limits for the mass-radius ratio and total charge are derived for stable charged general relativistic matter distributions. For charged compact objects the mass-radius ratio exceeds the value 4/9 corresponding to neutral stars. General restrictions for the redshift and total energy (including the gravitational contribution) are also obtained.Comment: 6 pages, 2 figures, RevTex. To appear in Europhys. Let

    Validation of Continuous Glucose Monitoring in Children and Adolescents With Cystic Fibrosis: A prospective cohort study

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    OBJECTIVE: To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis. RESEARCH DESIGN AND METHODS: Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability. RESULTS: CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias +/- 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference +/- 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively. CONCLUSIONS: In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable

    Plasma proteomic profiles of UK Biobank participants with multiple sclerosis.

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    OBJECTIVE: We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to explore protein biomarkers of disease severity using radiological outcome measures. METHODS: Multiple sclerosis cases and controls were identified in UK Biobank, a longitudinal cohort study of ~500,000 British adults. Plasma proteins were assayed in ~50,000 UK Biobank participants using the Olink proximity extension assay. We performed case-control association testing to examine the association between 2911 proteins and multiple sclerosis, using linear models adjusted for confounding covariates. Associations with radiological lesion burden and brain volume were determined in a subset of the cohort with available magnetic resonance imaging, using normalized T2-hyperintensity volume or whole brain volume as the outcome measure. RESULTS: In total, 407 prevalent multiple sclerosis cases and 39,979 healthy controls were included. We discovered 72 proteins associated with multiple sclerosis at a Bonferroni-adjusted p value of 0.05, including established markers such as neurofilament light chain and glial fibrillary acidic protein. We observed a decrease in plasma Granzyme A, a marker of T cell and NK cell degranulation, which was specific to multiple sclerosis. Higher levels of plasma proteins involved in coagulation were associated with lower T2 lesion burden and preserved brain volume. INTERPRETATION: We report the largest plasma proteomic screen of multiple sclerosis, replicating important known associations and suggesting novel markers, such as the reduction in granzyme A. While these findings require external validation, they demonstrate the power of biobank-scale datasets for discovering new biomarkers for multiple sclerosis

    Atomic environments in iron meteorites using EXAFS

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    Extended x ray absorption fine structure (EXAFS) is observed as a modulation on the high energy side of an x ray absorption edge. It occurs when the photo-ejected electron wave is scattered by neighboring atoms in a solid, and interference occurs between the outgoing and scattered waves. The result is that the absorption spectrum carries a signature that is characteristic of the identity and disposition of scattering atoms around the absorbing atom. Therefore, it may be shown that the Fourier transform of the normalized EXAFS can provide detailed information about the immediate environment of specific atoms in a solid and is ideally suited to the study of cosmic dusts. A study of cosmic dust was initiated using EXAFS and other techniques. The simplest type of cosmic material, namely iron meteorites, was investigated

    (Total) Vector Domination for Graphs with Bounded Branchwidth

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    Given a graph G=(V,E)G=(V,E) of order nn and an nn-dimensional non-negative vector d=(d(1),d(2),ā€¦,d(n))d=(d(1),d(2),\ldots,d(n)), called demand vector, the vector domination (resp., total vector domination) is the problem of finding a minimum SāŠ†VS\subseteq V such that every vertex vv in Vāˆ–SV\setminus S (resp., in VV) has at least d(v)d(v) neighbors in SS. The (total) vector domination is a generalization of many dominating set type problems, e.g., the dominating set problem, the kk-tuple dominating set problem (this kk is different from the solution size), and so on, and its approximability and inapproximability have been studied under this general framework. In this paper, we show that a (total) vector domination of graphs with bounded branchwidth can be solved in polynomial time. This implies that the problem is polynomially solvable also for graphs with bounded treewidth. Consequently, the (total) vector domination problem for a planar graph is subexponential fixed-parameter tractable with respectto kk, where kk is the size of solution.Comment: 16 page

    The blood acid base and gastrointestinal response to three different forms of sodium citrate encapsulation

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    Enterically coated (ENT) or delayed-release (DEL) capsules may lessen gastrointestinal symptoms (GIS) following acute sodium citrate (SC) ingestion, although the effects on blood acid-base balance are undetermined. Fourteen active males ingested 0.4Ā  g.kgāˆ’1 body mass (BM) SC, within gelatine (GEL), DEL and ENT capsules or 0.07 g.kgāˆ’1 BM sodium chloride control (CON). Blood acid-base balance and GIS were measured for 4 h. Ingestion form had no significant effect on total GIS experienced (GEL: 2 Ā± 7; DEL: 1Ā  Ā± 8; ENT: 1 Ā± 4 AU). Most (7/14) participants experienced zero symp-toms throughout. Peak GIS typically emerged ā‰¤100 min post- ingestion, with a similar time to reach peak GIS between ingestion form (GEL: 36 Ā± 70; DEL: 13 Ā± 28; ENT: 15 Ā± 33 AU). Blood [HCO3āˆ’] was significantly higher with ENT versus GEL (ENT: 29.0 Ā± 0.8; GEL: 28.5 Ā± 1.1 mmol.Lāˆ’1, P = 0.037). Acute ingestion of a reduced SC dose elicited minimal GIS, producing significant changes in blood [HCO3āˆ’] from rest, irrespective of ingestion form (GEL: 6.0 Ā± 0.9; DEL: 5.1 Ā± 1.0; ENT: 6.2 Ā± 0.8 mmol.Lāˆ’1). The necessity of individualized ingestion strategies is also challenged, with sustained increases in blood [HCO3āˆ’] of ā‰„4 mmol.Lāˆ’1 for up to 153 min highlighted. If commencing exercise at peak alkalosis augments subsequent per-formance above starting at a standardized time point where HCO3āˆ’ is still elevated remains unclear
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