Mindful medical practice and the therapeutic alliance

This review article focuses on how the therapeutic relationship is central to clinician-client/patient relationships in psychiatry as well as other medical and psychotherapeutic encounters.  Crucial to this relationship is the alliance formed between the caregiver and the person who seeks their care.  The threats to the therapeutic alliance in psychiatry are discussed as is the importance of facing them. How mindfulness enables clinicians to build such bonds and foster well-being in themselves and in those they treat is examined in the context of quantitative and qualitative studies

Projecting current and future location, quality, and connectivity of habitat for breeding birds in the Great Basin

We estimated the current location, quality, and connectivity of habitat for 50 species of breeding birds in four mountain ranges in the central Great Basin (Lander, Nye, and Eureka Counties, Nevada) and projected the future location, quality, and connectivity of habitat for these species given different scenarios of climate-induced land-cover change. In the United States, such models are relevant to federally mandated management of wild animals by state-level agencies. We sampled birds during the breeding seasons of 2001–2009 with fixed-radius point counts. For each species, we used boosted regression trees to model incidence (proportion of years a location was surveyed in which the species was present) as a function of topography and current land cover and climate. To assess model fit, we calculated the proportion of binomial deviance explained. We used cross-validation to estimate the predictive accuracy of the models. We applied the conservation planning program Zonation to identify locations where incidences of multiple species were maximized through time given current land cover and two scenarios of land-cover change, expansion of pinyon–juniper woodland into sagebrush shrubsteppe and contraction of riparian woodland. Models based on a set of 13 covariates derived from remotely sensed data had some predictive capacity for 41 of 50 species. Model outputs suggested substantial changes in amount of habitat for many species following projected expansion of pinyon–juniper woodland, but less pronounced changes following projected contraction of riparian woodland. Zonation analyses indicated that the spatial distribution of the highest-quality habitat for the avian assemblage was relatively consistent through time under both scenarios. Breeding birds in the Great Basin commonly are grouped in management plans on the basis of their general association with land-cover classes such as pinyon–juniper woodland, sagebrush shrubsteppe, and riparian woodland. However, even within these groups, the environmental attributes that explained a high proportion of variation in species' incidences and the projected responses to different scenarios of land-cover change varied considerably among species

Співвідношення категорій "добросовісність" та "моральні засади суспільства" у цивільному праві

Добкін, М. М. Співвідношення категорій "добросовісність" та "моральні засади суспільства" у цивільному праві / М. М. Добкін // Вісник Національного університету внутрішніх справ.- 2004.- Вип. 26.- С. 231 - 234Автор аналізує визначення меж поняття «моральні засади суспільства» та проводить співвідношення його з категорією «добросовісність». Пропонує звернутись до етимологічного походження слова «добросовісність» та похідних від нього. Автор анализирует определения границ понятия «моральные основы общества» и проводит соотношение его с категорией «добросовестность». Предлагает обратиться к этимологического происхождения слова «добросовестность» и производных от него. The author analyzes the definition of the boundaries of the concept of "moral principles of society" and correlates it with the category of "integrity". Suggests to refer to the etymological origin of the word "conscientiousness" and its derivatives

On chip interconnects for multiprocessor turbo decoding architectures

International audienc

The neuropsychiatry of Parkinson's disease: advances and challenges

In people with Parkinson's disease, neuropsychiatric signs and symptoms are common throughout the disease course. These symptoms can be disabling and as clinically relevant as motor symptoms, and their presentation can be similar to, or distinct from, their counterparts in the general population. Correlates and risk factors for developing neuropsychiatric signs and symptoms include demographic, clinical, and psychosocial characteristics. The underlying neurobiology of these presentations is complex and not well understood, with the strongest evidence for neuropathological changes associated with Parkinson's disease, mechanisms linked to dopaminergic therapy, and effects not specific to Parkinson's disease. Assessment instruments and formal diagnostic criteria exist, but there is little routine screening of these signs and symptoms in clinical practice. Mounting evidence supports a range of pharmacological and non-pharmacological interventions, but relatively few efficacious treatment options exist. Optimising the management of neuropsychiatric presentations in people with Parkinson's disease will require additional research, raised awareness, specialised training, and development of innovative models of care

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

<p>Abstract</p> <p>Background</p> <p>Although the cellular mechanisms responsible for the pathogenesis of autism are not understood, a growing number of studies have suggested that localized inflammation of the central nervous system (CNS) may contribute to the development of autism. Recent evidence shows that IL-6 has a crucial role in the development and plasticity of CNS.</p> <p>Methods</p> <p>Immunohistochemistry studies were employed to detect the IL-6 expression in the cerebellum of study subjects. <it>In vitro </it>adenoviral gene delivery approach was used to over-express IL-6 in cultured cerebellar granule cells. Cell adhesion and migration assays, DiI labeling, TO-PRO-3 staining and immunofluorescence were used to examine cell adhesion and migration, dendritic spine morphology, cell apoptosis and synaptic protein expression respectively.</p> <p>Results</p> <p>In this study, we found that IL-6 was significantly increased in the cerebellum of autistic subjects. We investigated how IL-6 affects neural cell development and function by transfecting cultured mouse cerebellar granule cells with an IL-6 viral expression vector. We demonstrated that IL-6 over-expression in granule cells caused impairments in granule cell adhesion and migration but had little effect on the formation of dendritic spines or granule cell apoptosis. However, IL-6 over-expression stimulated the formation of granule cell excitatory synapses, without affecting inhibitory synapses.</p> <p>Conclusions</p> <p>Our results provide further evidence that aberrant IL-6 may be associated with autism. In addition, our results suggest that the elevated IL-6 in the autistic brain could alter neural cell adhesion, migration and also cause an imbalance of excitatory and inhibitory circuits. Thus, increased IL-6 expression may be partially responsible for the pathogenesis of autism.</p

A waitlist-controlled trial of group cognitive behavioural therapy for depression and anxiety in Parkinson’s disease

Background: The aim of this study was to evaluate the efficacy of a group Cognitive Behavioural Therapy (CBT) treatment for depression and anxiety in Parkinson’s disease (PD). Methods: A waitlist-controlled trial design was used. Eighteen adults with PD and a comorbid DSM-IV-TR diagnosis of depression and/or anxiety were randomised to either Intervention (8-week group CBT treatment) or Waitlist (8-week clinical monitoring preceding treatment). The Depression, Anxiety, Stress Scale-21 (DASS-21) was the primary outcome. Assessments were completed at Time 1 (pretreatment), Time 2 (posttreatment/post-waitlist) and 1-month and 6-month follow-ups. Results: At Time 2, participants who received CBT reported greater reductions in depression (Mchange = -2.45) than Waitlist participants (Mchange = .29) and this effect was large, d = 1.12, p = .011. Large secondary effects on anxiety were also observed for CBT participants, d = .89, p = .025. All treatment gains were maintained and continued to improve during the follow-up period. At 6-month follow-up, significant and large effects were observed for both depression (d = 2.07) and anxiety (d = 2.26). Conclusions: Group CBT appears to be an efficacious treatment approach for depression and anxiety in PD however further controlled trials with larger numbers of participants are required