3 research outputs found
\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
- Author
- Abdelnabi Mai
- Abrams Marita K
- Abusheikh Tariq
- Ackerman Cheri M
- Adams Andrew
- Adams Stephanie J
- Agarwalla Anant
- Agbley Kwabea
- Aldrup Megan E
- Alldredge Justin
- Allen Alicia B
- Alvarez Consuelo J
- Alvendia Erica L
- Ament Caitlin
- Anderson John E
- Archambault Alexi
- Armistead Isaac O
- Armstrong Andrew R
- Armstrong William
- Aronhalt Todd
- Ashrawi Yara
- Asinof Sam
- Aso Soham
- Augustine LaJerald
- Baatenberg Lara
- Bahr Thomas J
- Bailey Robert J
- Baker Atlee
- Baker Morgan
- Baldassari Shane M
- Banker Roxanne
- Barberi Chelsea R
- Barnett Jason M
- Bartling Justina R
- Baumgardner Jordan S
- Beck Christopher
- Beck Lauren R
- Beckett Alissa
- Bedard James E J
- Bednarski April E
- Beken Levent H
- Belella Carissa
- Bellush James M
- Benitez Pedro
- Benson Jonathon M
- Bertolet Anne
- Bhalla Satish C
- Bhatiya Chinmoy I
- Blaker Amanda L
- Blunden Christopher E
- Bodenberg Jessica M
- Boham Sampson K
- Bor Matthew J
- Botsford Bobbi
- Boudoures Anna L
- Boudreaux Lauren R
- Bourland Megan
- Brand Jordan P
- Braverman John M
- Brinkley Briana
- Brock Ethan J
- Brooks Dana W
- Broomfield Daniel
- Brouwer Lindsay K
- Brown Adam D
- Brown Ashley S
- Brown Carter
- Brown Marie
- Bryant Ashley
- Bryant Julie
- Burg Martin G
- Burke Christa
- Burkhart Brandon J
- Bushhouse Kelsey T
- Butzler Sarah C
- Caesar Nicole M
- Campana Christopher
- Carney Jordan E
- Caronna Jason
- Carranza David
- Cassidy Daniel W
- Cesko Lejla
- Chamma Norma
- Chandrasekaran Vidya
- Chapman Julia
- Chapman Kayla
- Chase Ian O
- Chau Kim M
- Chavez Miranda
- Chavez Ramiro A
- Chen Maida
- Chiang Scott
- Chlebina Ben
- Choeying Tenzin
- Choi Tiffany Y Y
- Chong Insun
- Christgen Shelbi L
- Christiansen Lena
- Christie Jordan S
- Cifelli Alyssa
- Clark Eric M
- Clark Nicole B
- Clarke-Medley Nicole
- Clary Andrea N
- Cognetti Peter A
- Cohen Heather
- Cole Mara G
- Collins Ashley A
- Conn Michael A
- Conrad Turner
- Conturso Alaina C
- Cooper Kristen M
- Corrielus Maureen
- Cotteleer Rebecca J
- Coulson Kevin
- Cristostomo Michael C
- Cromwell Avery B
- Crowley Matt J
- Crowley Samuel T
- Cruz Samantha
- Cullimore Peterson R
- Custer Ashley F
- Cyranowski Olivia
- Damsteegt Amanda M
- Danner Benjamin L
- Darusz Jess M
- DaSilva Paolo A
- Dauphin Cory M
- Davis Kristen C
- Davis Yelena P
- Davis-Reyes Brionna
- Dawson Seth G
- Debow Calise
- DeFazio Steve
- DeJong Randall J
- Delacruz Noelle
- DeMichele Gabriella A
- Deranek Kelly M
- DeShetler Megan
- Deuschle Frederic J
- DiAngelo Justin R
- Diekema Emily J
- DiLorenzo Lauren A
- Dirkes William
- DiTommaso Tia M
- Dobbe Ali
- Dobbe Ian
- Docking Carter T
- Does Benjamin R
- Dorsett Sasha L
- dos Santos Vieira Carolina Marques
- Dothager Matthew
- Doty Jennifer S
- Dougherty Grace A
- Dow Brian A
- Dowd Rose M
- Downey Kaitlyn A
- Drake Andrew P
- Drewry Melissa
- Drumm Kelly
- Du Chunguang
- Dunbar David A
- Dunham Carrie A
- Earl Erica K
- Echendu Vivienne
- Eckardt Alexandra K
- Eckdahl Todd T
- Edwards Curtis R
- Ehret Sharon C
- Eisen Michelle E M
- Eisler Heather L
- El-Adaimi Jad
- Elder Darcie D
- Elliott GiNell
- Emerson Charlene
- Emerson Julia A
- Emiah Shadie
- English Johnathan D
- Enoch Erica
- Faber Hayley M
- Faber Katherine J
- Fadus Matthew C
- Falk I N
- Fanning John P
- Farek Jesse R
- Farrar Cassandra
- Fearnow Adam
- Feenstra Elizabeth
- Fefelova Nadezhda
- Felzer-Kim Isabella T
- Fese Jessica
- Fick Cameron N
- Fitzgibbons John D
- Flohr Sarah
- Flores Amanda H
- Floyd Trevor G
- Foret Don
- Forsyth Joshua D
- Fosselman Daniel S
- Foust Jonathan D
- Franchi Spencer L
- Freda Philip J
- Freeburg Trip
- French Kristin M
- Friedman Harrison
- Friedrichs Chelsey
- Fusco Zach
- Garibay Edgar
- Garrett Amanda D
- Gaur Shailly
- Geary James F
- Gier Chad
- Gill Ishwar S
- Gilman Hannah
- Glenn Omolara
- Goeller Katie L
- Gomez Carolina
- Gonzales Justin A
- Gooch John
- Goodman Anya L
- Goodwin Zane
- Goscinski Nora C
- Gosser Yuying
- Govind Shubha
- Grantham Alaina J
- Greenwell Alyson
- Grove Ryan A
- Guadron Leslie
- Gutierrez Nestor
- Haberman Adam
- Hales Jasmine
- Hammett Deborah
- Hammond Brandy L
- Hammond Maureen S
- Hanson Cynthia K
- Harding Taylor S
- Hare Amber N
- Hark Amy T
- Harker Katherine S
- Harnoto Raechel S
- Harrington William
- Harris Cameron B
- Hatfield Kristen R
- Hauke Jeanette
- Hauser Charles R
- Havill Jessen T
- Heckman Jonathan M
- Hedeen Heather
- Helmreich Eric
- Hendricksma Jesse
- Hennessy Bryan M
- Henry Tyneshia C P
- Herbstsomer Robert A
- Herrick Douglas A
- Herrold Milton R
- Heslop Michelle
- Hilbrands Julia A
- Hirsch Sarah
- Hockenberger Kelsey
- Holderness Heather L
- Hong Emily L
- Hoogenboom Lindsay
- Hoogewerf Arlene J
- Hoopes Laura L M
- Hoover Betsy
- Hopkins Barbara L
- Howell Emily J
- Howey Nicole A
- Huerta Vilma F
- Ibarra Sharon
- Ibrahem Marwan
- Ighile Osagie
- Intriago Stephanie
- Jacobs Dontae A
- Janssen Bridget M
- Jarrell Jenifer N
- Jelgerhuis Sarah A
- Jelsema Timothy R
- Jewell Elizabeth S
- Jimenez Luis A
- Jipp Jacob
- Johnson Ashlee G
- Johnson Benjamin K
- Johnson Cristen
- Johnson Diana E
- Johnson Jaelyn L
- Johnson Lauriaun
- Johnson Todd D
- Jones Christopher J
- Jones Jennifer K
- Jones Kelly K
- Jones Melissa
- Kabaso Rita
- Kaehler Marian M
- Kaisler Maria
- Kammrath Anna
- Kandahari Adrese
- Kappes Michelle L
- Karaska Elizabeth A
- Katz Brandon M
- Kaur Sukhjit
- Kehoe James L
- Kelley Colleen V
- Kelly Elisabeth A
- Kennedy Andre
- Kennedy William R
- Keny Lauren J
- Kerber John M
- Keysock Nicholas
- Khan Ambreen
- Khayrullina Guzal
- Khoshabian Colin
- Khoury Christopher B
- Kiernan Elizabeth
- Kiley John
- Kim Andrew J
- Kim Anna
- Kim Van
- King Jessica E
- Klett Bethany M
- Knepper John Mark
- Knob Christopher R
- Knouse Kristin A
- Knudsen Nelson H
- Koaches Hannah C
- Koehler Jessica
- Koenig Dana
- Kokan Nighat P
- Kolibas Kimberly S
- Kooienga Ross D
- Koplinsky Chad A
- Kraftmann Karen J
- Kubricky Cassandra
- Kufel Christina N
- Kujawski Alexander J
- Kuleck Gary A
- Kulich Danielle
- Kung Faith
- Kus Jordan E
- Kuschner Cyrus E
- Kusner Matt
- Kwan Wa Shum Yuki
- Ladzekpo Danielle
- LaForge Kristin M
- Lamb Travis
- Lambright Anthony K
- Lammers Jennifer A
- Lane Curtiss E
- Langner Christine
- Lau Dawn
- Lea Charlotte
- Leads Rachel R
- Leatherman Emily C
- LeBlanc Mark T
- Lee Cassidy T
- Lee Paul
- Lemmon Eric
- Leung Wilson
- Lewis Benjamin M
- Li Linghui
- Light Morgan R
- Limle Austin B
- Lin Devry
- Lindbeck Peter
- Lippert Rachel N
- Lopez Lenin
- Lopilato Jane E
- Louie Christopher A
- Lowell Shannon M
- Lu Alvin
- Lucas Gabi
- Luippold Erin K
- Lupey Lena N
- Lydon Anniken M
- Macchi Christopher R
- Machone Joshua F
- Macias Elizabeth
- Macias Jason S
- Maffa Amanda
- Mageeney Catherine M
- Malkowitz Lorraine
- Mammo Danny
- Maniaci Brian J
- Marra Jonathan
- Martinez Megan
- Martiniuc Daniela
- Martinov Tijana
- Mason Portia
- Matthews Jordan E
- May Francis J
- Mayorga Lissett
- Mazur Tammy
- Mazzeo Cheryl
- McCabe Nikie L
- McCartha Shannon R
- McCracken Marly R
- McDonald Mitchell
- McDonough Alexa M
- McFarland Darryl
- McLaughlin Christopher
- Mecoli Jonathan P
- Medina Joseph
- Meghdari Mariam
- Meier Anne C
- Melton Amy D
- Membreno Nelson
- Mendoza Carlos
- Menillo Daniella
- Menyes Erika E
- Mercer Amanda
- Merry Callie R
- Messenger Gregory S
- Messiah Shady
- Messler James
- Meyer Lauren R
- Miller Emily G
- Minnick Phillip J
- Minniti Carl J
- Minton Thomas F
- Misch Jonathan
- Mitchell Ryan D
- Monsma Nicholaus
- Moran Joseph V
- Morgan Abbie
- Morlock Elaine V
- Morris William M
- Morrow Adam T
- Mudumbi Krishna
- Mullen Gregory J
- Muller Sarah E
- Musick Adam E
- Musokotwane Sepo
- Myirski Kevin
- Naik Monal
- Naik Priyanka
- Neufeld Lacey
- Neutzling William
- Newcomb Victoria
- Newhart William H
- Newman Alyssa M
- Ng Chun Leung
- Ng Simon
- Nguyen San Francisco
- Nguyen Trung T
- Nichols Zachary
- Nicolas Daniel S
- Nietmann Jana
- Nikam Vinyak S
- Nollet Eric A
- Nordman Elizabeth C
- Norton Diana
- Noynaert Joseph W
- Nyabeta Onsarigo Eric
- O\u27Rouke Allison
- Obiorah Ifeanyi
- Ochoa Andrea
- Odisho George
- Ogden Bradley J
- Olson Nicole C
- Ortiz Carlos
- Ostby Kristine
- Osterloh Jeanette M
- Overvoorde Paul J
- Ovu Steven
- Paetkau Don W
- Palozola Katherine C
- Paluskievicz Christina
- Pamnani Brad
- Parrish Susan
- Parry Kesley
- Pasierb Brittany D
- Patao Melissa D
- Patao Shane M
- Patterson Seantay D
- Pattison Claire
- Penn Jessica
- Peoples Emily
- Perella Mallory
- Perez Marcos A
- Peterson Daymon
- Pfeil Jacob J
- Pham Philip
- Plante Olivia
- Plasman Haley J
- Plescher Brittany E
- Poet Jeffrey L
- Polk Jessica W
- Potocny Stephanie J
- Powers Michelle K
- Pozmanter Caitlin
- Prasad Shreya
- Presley Jonathan D
- Price Amber L
- Primus Shekerah
- Puetz William J
- Quach Michael
- Ragland Nicolas
- Raimey England
- Ramic Alen
- Ramirez Roman E, Jr.
- Ramsey Kimberley
- Ramthun Jennifer R
- Randazzo Matt J
- Rankin Helen
- Rathore Sunil
- Ratliff Camille D
- Rauf Sabya A
- Reed Emily
- Reem Rachel M
- Regan Melanie K
- Regisford E Gloria C
- Reilly Mary T
- Rekai Jade Lea
- Rempe Ryan Michael
- Rennhack Jonathan P
- Revie Dennis
- Reynolds Katherine R
- Reynolds Lyndsey A
- Reynolds Thomas J
- Reza Evangelina
- Rhee Dong K
- Rigby Nichole
- Rios Lindsay
- Rivard Allyson B
- Robertson Gregory M
- Robic Srebenka
- Robinett Deirdre
- Robinson Lauren M
- Rodela Laura
- Rodriguez Priscilla
- Rodriguez Vanessa
- Roecklein-Canfield Jennifer A
- Ronk Adam J
- Rooney Meghan B
- Rose Jenny L
- Rose Thomas J
- Rosenwald Anne G
- Rossi Franca G
- Rossi Nadine L
- Rubin Lainey S
- Ruiz Jorge
- Rupley Bryan J
- Sable Joseph E
- Sadovsky Griffin
- Safa Nadia
- Salbert Luke R
- Salgado Michael S
- Saluja Rasleen K
- Salzman Garrett
- Sandusky Michael W
- Sanusi Fareed
- Sassu Eric D
- Saville Kenneth
- Scala Victoria
- Schauder Taylor
- Schepers Allison J
- Schibler Jeanine
- Schiedermeyer Holly
- Schmidt Lasse
- Schmuecker Samantha M
- Schneiter Allison R
- Schottler Jennifer
- Schueler Mary Grace
- Schultz Darrin
- Schulz Robert W
- Schwartz Nicholas U
- Scoma Alexandra H
- Scott Geoff
- Scott Zachary W
- Sessions Bridget J
- Seydoux Marie-Isabelle B
- Shallman Devon
- Shantzer Lindsey
- Sharif Karim A
- Shaw Mary E
- Shelton Micah
- Sherrill Will
- Shevin Yakov
- Shipman Anna L
- Shoemaker Emma
- Shoop Elizabeth
- Shuen Jessica A
- Shuford Rebecca
- Silva Valeria
- Silver Key S Catherine
- Simon Matthew
- Simone Bisogno Laura
- Smith Anna L
- Smith Christopher D
- Smith Jonathan E
- Smith Joshua R
- Smith Karl E
- Smith Mary A
- Smith Melanie A
- Smith Samuel I
- Smith-Gee Maxwell T
- Snavely Michael
- Soliterman Eugenia A
- Song Roy
- Soos Mahdi
- Spaeder Lindsay A
- Spana Eric P
- Sparks Ciani J
- Sparks Jeri
- Spencer Eric
- Spencer Sarah
- Sreenivasan Aparna
- Stagaard Erica
- Starcher Justin R
- Starkey Kristin M
- Statton Geeta
- Sterling Allison M
- Svoronos Petros
- Swanson Bryant R
- Sweeney Edward P
- Tache Melissa A
- Tare Archana
- Tenney Jenna C
- Tewilliager Ashley A
- Thistle Katrina
- Thomas Jessica G
- Thompson Jeffrey S
- Thomsen Kristen M
- Tilot Amanda K
- Timko Ashley S
- Tirasawasdichai Tiara
- Tomkins Trisha
- Torchon Karvyn
- Townsend Ashley
- Tran Danny L
- Trieu Melissa
- Tuberty Sarah
- Tucci Jessica M
- Tumminello Richard A
- Turner Bryce A
- Tynon Marykathryn
- Uitvlugt Chris
- Undem Blair
- Unruh Anna K
- Unzicker Matthew R
- Urick Damian
- Valdez Isabel
- VanderVennen Marielle
- VanDyken Rachel E
- VanEck Eve
- Velasquez Vicente
- Verbofsky Evan M
- Vernon William B
- Vetor Ashley
- Villerot Matthew M
- Vondy Kayla
- Vrable Abby
- Vue Samantha
- Vuong Tam
- Vylonis Megan B
- Waggoner Andrew W
- Walji Tezin A
- Walker Chelsea A
- Wan Tiffany
- Wande Lucia
- Ward Alyssa
- Waters Mary
- Watson David T
- Wawersik Matthew
- Weaver Jennifer A
- Welker Anne A
- Wellinghoff Jules
- Wendland Pete
- Westphal Kyle
- White Jackie X
- Williams Charlotte
- Winkler Stacey
- Winn Wesley W
- Winters Jenifer
- Woehlke Sarah
- Wolski Matthew W
- Wolyniak Michael J
- Wong Jeanette
- Wong Jeremy N
- Woyski Dustin S
- Wurzler Juliana A
- Wylie Anna
- Wysocki Lauren M
- Xiong David
- Xu Amy
- Xu Thomas Q
- Yalamanchili Monica
- Yang Bib
- Yarrington Bryan
- Yemelyanova Anastasia K
- Youngblom Jim
- Yu Nicole S
- Yuan Han
- Zaborowicz Matthew A
- Zarrasola Stephanie
- Zhang Yi
- Zhu Xiao
- Zidan Ameer
- Zumkehr Joannee
- Publication venue
- ScholarWorks@GVSU
- Publication date
- 01/05/2015
- Field of study
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25â50%) than euchromatic reference regions (3â11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11â27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4â3.6 vs. 8.4â8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
- Aceituno A
- Acosta I
- Adams A
- Adatia S
- Aerden Leo A.m.
- Aeron-thomas John
- Aggour Mohamed
- Aghaebrahim A
- Agid R
- Aguettaz Pierre
- Ahle Guido
- Aja L
- Akhtar N
- Al Najjar-carpentier Amen-adam
- Al'boutros S
- Al-ajlan F
- Albers Gregory W
- Albers Gregory W.
- Alexandrou M
- Alhazzaa M
- Ali L
- Allen E
- Almekhlafi M
- Alseraya A
- Aly J
- Amar Arun
- Amaro S
- Amato-marzialli B
- Amerson L
- Amiri H
- Andersen G
- Andersen L
- Anderson A
- Andersson Tommy
- Ang Timothy
- Anton C
- Anxionnat René
- Apoil-brissard Marion
- Aram H
- Arenillas Lara Jf
- Arenillas J
- Ariño H
- Arkin S
- Armbruster K
- Armitage K
- Arquizan C
- Arquizan Caroline
- Arteaga Charles
- Ashforth Ra
- Ashok Vasdev
- Attia John
- Ayrignac X
- Azizi A
- Añon J
- Bach E
- Badve Monica
- Baillot Pierre-alexandre
- Bain M
- Bakchine Serge
- Baker C
- Balasa M
- Balgude A
- Bamford John
- Banaras Azra
- Bang Oh Young
- Bang Oy
- Barber P. Alan
- Barber Pa
- Barbier Charlotte
- Barbieux Marianne
- Barnwell S
- Baronnet-chauvet Flore
- Barral Francis-guy
- Barreau Xavier
- Barros Renan Sales
- Bartolini Mario Bruno
- Barton K
- Barton K
- Bartt R
- Basir G
- Bataille Mathieu
- Bauer A
- Baxendell L
- Baxendell L
- Baxter B
- Baxter Bw
- Beadell N
- Beauchamp B
- Beaujeux RĂ©my
- Beck C
- Beck P
- Becker M
- Beenen Ludo F.m.
- Bejot Yannick
- Belagaje Sr
- Belden J
- Bellew M
- Bellon R
- Bendszus M
- Bennett Patricia
- Berge JĂ©rĂŽme
- Berhoune Nadia-nawel
- Berkefeld J
- Berkhemer Olvert A
- Berkhemer Olvert A
- Bettinger I
- Beumer Debbie
- Bharatha A
- Bhatt A
- Biberacher V
- Biethahn S
- Billigan J
- Binder A
- Bintner Marc
- Biondi Alessandra
- Birchenall Julia
- Bitner A
- Blacquiere D
- Bladin Christopher F
- Blanc Raphael
- Blasco J
- Blayney S
- Blue-schaller A
- Bodenant Marie
- Bodiguel Eric
- Boeckh Behrens T
- Boers Merel
- Boiten Jelis
- Bonafé Alain
- Bonafé Alain
- Boned S
- Bonnet Anne-laure
- Bonneville Jean-françois
- Bonwit E
- Boo S
- Boodt Nikki
- Borst Jordi
- Bot Joseph C.j.
- Boubagra Kamel
- Bouhour Françoise
- Boulos M
- Boulton M
- Bounolleau Pierre
- Bourcier Romain
- Bourdain Frédéric
- Bourgois Nathalie
- Boutoleau-bretonniere Claire
- Boutwell C
- Boyle K
- Bozorgchami H
- Bracard S
- Bracard Serge
- Brant R
- Braun H
- Brekenfeld C
- Brennan P
- Brewer L
- Brick J
- Brion B
- Brooks C
- Brooks Mark
- Broussalis E
- Brouwer Patrick A.
- Brown B
- Brown Martin M
- Brown Martin M.
- Brown Scott
- Brunner F
- Buck B
- Budzik R
- Buffon Porcher Frédérique
- Buhk J-h
- Burg K
- Burns Pa
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- Butcher Ks
- Caceves D
- Cahagne Vincent
- Calderon Arnulphi M
- Calleja Sanz Ai
- Calvert J
- Calvet David
- Campbell Bruce C V
- Campbell Bruce Cv
- Campbell D
- Campbell D
- Campbell N
- Cano L
- Carandang R
- Cardona P
- Carelli Gabriela
- Caroff Jildaz
- Carpenter Jeffrey
- Carpenter Js
- Casaubon Lk
- Castaño C
- Cate C
- Caucheteux Nathalie
- Cayley A
- Celestino Sherisse
- Cerejo R
- Cervera A
- Cha J
- Chabert Emmanuel
- Chabriat Hugues
- Chamorro A
- Chan R
- Chandra Ronil V
- Chang H-w
- Chang I
- Chang V
- Charif M
- Charlin Cyril
- Chassin Olivier
- Chau Yves
- Chavent Adrien
- Chen M
- Cheng Ching E
- Cheng B
- Chiacchierini Richard
- Cho Tae-hee
- Choe H
- Choi P
- Chong Winston
- Churilov Leonid
- Clarencon Frédéric
- Clarençon Frédéric
- Clark D
- Clark W
- Clavelou Pierre
- Clement F
- Clifton Andrew
- Clifton Andy
- Cloud Geoffrey
- Cnyrim C
- Cobo E
- Codas J
- Cogez Julien
- Cognard Christophe
- Cohen David J.
- Collins R
- Connolly Ls
- Coote Skye
- Cordonnier Charlotte
- Cornut-chauvinc Catherine
- Cortes M
- Cortijo Garcia E
- Cortsen M
- Coscojuela P
- Coskun Oguzhan
- Costalat V
- Costalat Vincent
- Cotter P
- Coté Va
- Coughlan T
- Couillard P
- Coulthard Alan
- Coulton Bronwyn
- Courtheoux Patrick
- Coutts Sb
- Cowley Elise
- Crandall S
- Crann S
- Crespo Vallejo E
- Cronquist M
- Cross L
- Crowe M
- Crozier Sophie
- Csizmadia Marloes
- Cuadras P
- Cullen A
- Cunningham James
- Cunningham N
- D'este Cate
- Da Costa L
- Dahlgren R
- Dallinga René J.
- Daly T
- Daly T
- Damgaard D
- Dancer S
- Danch M-j
- Daneault N
- Darcel Françoise
- Das E
- Daumas-duport Benjamin
- Davis Stephen M
- Davis Stephen M
- Davis T
- Day J
- Day Susan
- De Bont-stikkelbroeck José
- De Bruijn Sebastiaan F.
- De Bustos Medeiros Elisabeth
- De Gaalon SolĂšne
- De Kort Paul L.m.
- De La Ossa Natalia PĂ©rez
- De Meris Joke
- De Miquel Ma
- De Ridder Ans
- De Villiers Laetitia
- De Vries Joost
- Debiais SĂ©verine
- Debruxelles Sabrina
- Decesare S
- Decroix Jean Pierre
- Dehkharghani S
- Del Campo Jm
- Dellinger C
- Dellinger C
- Deltour Sandrine
- Demaerschalk B
- Demchuk Am
- Demchuk Andrew M
- Den Hertog Heleen M.
- Denier Christian
- Deplanque Dominique
- Derdeyn C
- Derelle Anne-laure
- Derex Laurent
- Derkinderen Pascal
- Desai J
- Desal Hubert
- Deschaintre Y
- Deshaies E
- Deshmukh V
- Desousa K
- Detante Olivier
- Devlin T
- Devlin T
- Devlin Thomas G
- Dewey Helen M
- Dharia R
- Dharmadhikari S
- Di Maria Federico
- Diener Hans Christoph
- Diepers M
- Dietzold M
- Dippel Diederik W J
- Dippel Diederik W.j.
- Dixit Anand
- Dixit Anand
- Dobbe Roeland
- Dogan A
- Dolan E
- Domico J
- Domigo Valérie
- Dominger C
- Donegan C
- Donnan Geoffrey A
- Donnan Geoffrey A
- Dooley G
- Doppelheuer S
- Dorado L
- Dowlatshahi D
- Dowlatshahi D
- Dowling Richard
- Doyle R
- Drofa A
- Drouineau Jacques
- Drupals E
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- Vuillier Fabrice
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- Wardlaw Joanna
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- Wortmann G
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- Yassi Nawaf
- Yavagal D
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- Zavanone Chiara
- Zech M
- Zegarac V
- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09â2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75â3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14â2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
- Author
- A Aceituno
- A Adams
- A Aghaebrahim
- A Alseraya
- A Anderson
- A Azizi
- A Balgude
- A Bauer
- A Bharatha
- A Bhatt
- A Binder
- A Bitner
- A Blue-Schaller
- A Cayley
- A Cervera
- A Chamorro
- A Cullen
- A Dogan
- A Drofa
- A Ducruet
- A Ducruet
- A Durocher
- A DĂĄvalos
- A Farrag
- A Farrow-Schmidt
- A Flores
- A Fulton
- A Grande
- A Hassan
- A Hendrickson
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- Roberto Riva
- Roel J.J. Heijboer
- Roeland Dobbe
- Ronil V Chandra
- RĂ©my Beaujeux
- RĂŒdiger von Kummer
- S Adatia
- S Al-Boutros
- S Amaro
- S Arkin
- S Barnwell
- S Biethahn
- S Blayney
- S Boned
- S Boo
- S Bracard
- S Crandall
- S Crann
- S Dancer
- S Decesare
- S Dehkharghani
- S Dharmadhikari
- S Doppelheuer
- S Duff
- S Faro
- S Gallagher
- S Gelabert
- S Guggenberger
- S Göricke
- S Hall
- S Hasan
- S Hou
- S Jamieson
- S John
- S Karabegovich
- S Koch
- S Krieter
- S Lacusta
- S Lanthier
- S Lee
- S Lescher
- S Looby
- S Lownie
- S Man
- S Mishra
- S Murphy
- S Murphy
- S O'Leary
- S Onteddu
- S Ozark
- S Patel
- S Patil
- S Perez
- S Phillips
- S Prothmann
- S Quarfordt
- S Quarfordt
- S Rangaraju
- S Remollo
- S Renfrow
- S Rho
- S Robert
- S Rohde
- S Rudilosso
- S Ryoo
- S Sheth
- S Shine
- S Smyth
- S Starkman
- S Streib
- S Subramaniam
- S Tateshima
- S Taudorf
- S Wunderlich
- S Zaidi
- S-I Sohn
- Sabrina Debruxelles
- Sal Lamin
- Sandra Felix
- Sandrine Deltour
- Sandrine Wiertlewski
- Sanjeev Nayak
- Sarah Evain
- Saver
- Saver
- SB Coutts
- Scott Brown
- Scott Hamilton
- Sebastiaan F. de Bruijn
- Serge Bakchine
- Serge Bracard
- Serge Evrard
- Servane Mouton
- Sherisse Celestino
- Silvan Licher
- Silvia Pistocchi
- Simon Salinas
- SJ Kim
- SJ You
- Sjoerd F.M. Jenniskens
- Skye Coote
- SolĂšne De Gaalon
- Sophie Crozier
- Sophie Godard Ducceschi
- SR Belagaje
- SS Naik
- Stefan Vinken
- Stefanie Schipperen
- Steff Lewis
- Stephane Velasco
- Stephen M Davis
- Stephen M Davis
- Susan Day
- Sylvain Lachaud
- Sylvie Godon-Hardy
- SĂ©bastien Richard
- SĂ©bastien Richard
- SĂ©verine Debiais
- T Boeckh-Behrens
- T Coughlan
- T Daly
- T Daly
- T Davis
- T Devlin
- T Devlin
- T Galvin
- T Harbo
- T Hendrickson
- T Hyldal
- T Jeerakathil
- T Kahles
- T Krings
- T Larson
- T Lowenkopf
- T Lynch
- T Marotta
- T Meindl
- T Musuka
- T Nguyen
- T Reiff
- T Roberts
- T Sajobi
- T Sajobi
- T Scheibe-Mirek
- T Stavngaard
- T Stewart
- T Stewart
- T Stewart
- T Walsh
- TA Yeo
- Tae-Hee Cho
- Tanya Frost
- TB Kotylak
- Teddy Y Wu
- TG Jovin
- Thanh Phan
- Theo Stijnen
- Thibaud Lebouvier
- Thierry Moulin
- Thomas J Oxley
- Thomas Liebig
- Thomas Ritzenthaler
- Thomas Ronziere
- Thompson Robinson
- Tiemen van Boxtel
- Timo Krings
- Timothy Ang
- Timothy J Harrington
- Timothy J Kleinig
- Tiphaine Rouaud
- Tissa Wijeratne
- Tobien H.C.M.L. Schreuder
- Tommy Andersson
- Tony Goddard
- TS Field
- Tudor G Jovin
- Tudor G. Jovin
- TW Watson
- U Grzyska
- V Biberacher
- V Chang
- V Costalat
- V Deshmukh
- V Dubuc
- V Kalugdan
- V Nambiar
- V Obach
- V Pandey
- V Patel
- V Reddy
- V Snyder
- V Szeder
- V Totoraitis
- V Totoraitis
- V Yang
- V Zegarac
- VA Coté
- Valérie Domigo
- Valérie Wolff
- Vasdev Ashok
- Vincent Cahagne
- Vincent Costalat
- Vincent Guiraud
- Violaine Rouaud Jaffrenou
- Vitor Mendes Pereira
- VK Reddy
- W Clark
- W Holloway
- W Maloney
- W Montanera
- W Morgan
- W Pfeilschifer
- W Poon
- W Tekle
- Wade Smith
- Werner Hacke
- WF Morrish
- WF Morrish
- Willem Jan J. van Rooij
- Willy Struijk
- Wilma Pellikaan
- Wim H van Zwam
- Wim H. van Zwam
- Winston Chong
- Wintermark
- WJ Hicks
- WJ Montanera
- WJ Montanera
- Wouter J Schonewille
- X Ayrignac
- X Urra
- Xavier Barreau
- Xavier Ducrocq
- Xavier Leclerc
- Y Deschaintre
- Y Li
- Y Yu
- Yannick Bejot
- YD Kim
- Yince Loh
- Yves Chau
- Yves Samson
- Yvo B W E M Roos
- Yvo B.W.E.M. Roos
- Z El-Zammar
- Z Khawaja
- Zofia Ross
- Zoltan Szatmary
- Zwenneke Flach
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