Las revistas científico-técnicas españolas de las ciencias de la actividad física y el deporte: inventario y análisis de la calidad de contenido y difusión

En este artículo se presenta el primer inventario de publicaciones periódicas españolas de carácter científico-técnico del campo de las Ciencias de la Actividad Física y el Deporte. Se explica el proceso metodológico seguido para su elaboración y se comenta la problemática de algunas decisiones del grupo de investigación. También se analiza información básica y varios indicadores elementales de la calidad de contenido y difusión de dichas publicaciones periódicas que permite ofrecer un primer acercamiento a la situación en que se encuentran los principales órganos de difusión del mencionado campo.The first inventory of Spanish scientific journals of Physical Activity and Sport Sciences is developed in this article. Methodological process of inventory development is described and problems related to research group decisions are commented. Basic information and dissemination and content quality indicators of these journals are also analysed. This allows to present the first approach to the current situation of the periodicals in this field of study.Devis Devis, José, [email protected]. ; Valenciano Valcarcel, Francisco J., [email protected] ; Antolin Jimeno, Luis , [email protected] ; Villamon Herrera, Miguel, [email protected]

Las revistas científico-técnicas españolas de ciencias de la actividad física y el deporte: adecuación a las normas ISO y grado de normalización

The objective of this paper is to know the normalization grade and adjustment of Spanish scientific and technical journals of Physical Activity and Sport Sciences to various key epigraphs of the ISO 8-1977 and ISO 215-1986 norms. Also two indexes are made to calculate the General Normalization Grade (GGN) and the Fundamental Normalization Grade (GFN) of the journals. Results show that journals adjustment to ISO 8-1977 is equivalent to the journals of other Spanish fields as Economy and Technology, while it is less adjusted in relation to ISO 215- 1986. Most of the journals show an inferior GFN respective to its GGN. A considerable range of improvement in the journals studied, especially in the fundamental aspects of the ISO 215-1986 norm and some of the ISO 8-1977 norm, is the main conclusion of the study

Chronic Obstructive Lung Disease: Treatment Guidelines and Recommendations for Referral and Multidisciplinary Continuity of Care

Chronic obstructive pulmonary disease; Continuity of patient care; Referral and consultationMalaltia pulmonar obstructiva crònica; Continuïtat de l'atenció al pacient; Derivació i consultaEnfermedad pulmonar obstructiva crónica; Continuidad de la atención al paciente; Derivación y consultaChronic Obstructive Pulmonary Disease (COPD) constitutes a major public health problem, and it is anticipated that its prevalence will continue to increase in the future. Its progressive nature requires a continuous and well-coordinated care approach. The follow-up for COPD should primarily focus on disease screening and control, which includes monitoring of pulmonary function, prevention of exacerbations, identification of aggravating factors and comorbidities, as well as ensuring treatment adequacy and adherence. However, existing clinical practice guidelines and consensus documents offer limited recommendations for the follow-up. In this context, we undertake a review of COPD treatment and the continuity of care recommendations endorsed by several scientific societies. Moreover, we underscore the importance of the involvement of nursing and community pharmacy in this process, as well as the utilization of quality indicators in the provision of care for the disease

Fluoroquinolone photodegradation influences specific basophil activation

Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has proven to be useful for evaluating immunoglobulin E (IgE)-mediated hypersensitivity to FQs, with a higher percentage of positive responders with ciprofloxacin (CIP) than with moxifloxacin (MOX). We studied the effect of laboratory light on CIP and MOX degradation, and drug-protein conjugate formation, and its influence on the BAT for evaluating IgE-mediated hypersensitivity to FQs. The results showed an important decrease in fluorescence emission intensity under light compared to dark conditions for MOX, and that BAT positivity was lower in light (17.9%) than in dark (35.7%) conditions. No changes were found for CIP in either fluorescence emission intensity or BAT results (46.4% in both conditions). We can conclude that light exposure is a critical factor in BAT results when photolabile drugs like MOX are used. Therefore, light is important when interpreting in vitro results. Copyright (C) 2012 S. Karger AG, BaselWe thank Ian Johnstone for his help with the English language version of the manuscript, and Jose Luis Rodriguez-Bada and Lidia Melendez for their technical support. This study was funded by the FIS-Thematic Networks and Co-operative Research Centres: RIRAAF (RD07/0064) and the Spanish Health Ministry (FIS PS09/01768, PI11/01416 and M Servet contract CP11/00154 for I.A.), the Andalusia Health Ministry (PI-0545-2010), and the Andalusia Economic Innovation and Science Ministry (CTS 06603).Mayorga, C.; Andreu Ros, MI.; Aranda, A.; Doña, I.; Montañez, MI.; Blanca-López, N.; Ariza, A.... (2013). Fluoroquinolone photodegradation influences specific basophil activation. International Archives of Allergy and Immunology. 160(4):377-382. https://doi.org/10.1159/000343023S3773821604Albini, A., & Monti, S. (2003). Photophysics and photochemistry of fluoroquinolones. Chemical Society Reviews, 32(4), 238. doi:10.1039/b209220bBelvedere, A., Boscá, F., Cuquerella, M. C., de Guidi, G., & Miranda, M. A. (2002). Photoinduced N-Demethylation of Rufloxacin and its Methyl Ester Under Aerobic Conditions¶. Photochemistry and Photobiology, 76(3), 252. doi:10.1562/0031-8655(2002)0762.0.co;2Dawe, R. S., Ibbotson, S. H., Sanderson, J. B., Thomson, E. M., & Ferguson, J. (2003). A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity. British Journal of Dermatology, 149(6), 1232-1241. doi:10.1111/j.1365-2133.2003.05582.xHayashi, N., Nakata, Y., & Yazaki, A. (2004). New Findings on the Structure-Phototoxicity Relationship and Photostability of Fluoroquinolones with Various Substituents at Position 1. Antimicrobial Agents and Chemotherapy, 48(3), 799-803. doi:10.1128/aac.48.3.799-803.2004Van Bambeke, F., & Tulkens, P. M. (2009). Safety Profile of the Respiratory Fluoroquinolone Moxifloxacin. Drug Safety, 32(5), 359-378. doi:10.2165/00002018-200932050-00001Sachs, B., Riegel, S., Seebeck, J., Beier, R., Schichler, D., Barger, A., … Erdmann, S. (2006). Fluoroquinolone-Associated Anaphylaxis in Spontaneous Adverse Drug Reaction Reports in Germany. Drug Safety, 29(11), 1087-1100. doi:10.2165/00002018-200629110-00008Manfredi, M., Severino, M., Testi, S., Macchia, D., Ermini, G., Pichler, W. J., & Campi, P. (2004). Detection of specific IgE to quinolones. Journal of Allergy and Clinical Immunology, 113(1), 155-160. doi:10.1016/j.jaci.2003.09.035Aranda, A., Mayorga, C., Ariza, A., Doña, I., Rosado, A., Blanca-Lopez, N., … Torres, M. J. (2010). In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones. Allergy, 66(2), 247-254. doi:10.1111/j.1398-9995.2010.02460.xAndreu, I., Mayorga, C., & Miranda, M. A. (2010). Generation of reactive intermediates in photoallergic dermatitis. Current Opinion in Allergy and Clinical Immunology, 10(4), 303-308. doi:10.1097/aci.0b013e32833bc68cAntunez, C., Fernandez, T., Blanca-Lopez, N., Torres, M. J., Mayorga, C., Canto, G., … Blanca, M. (2006). IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response. Allergy, 61(8), 940-946. doi:10.1111/j.1398-9995.2006.01120.xTorres, M. J., Ariza, A., Mayorga, C., Doña, I., Blanca-Lopez, N., Rondon, C., & Blanca, M. (2010). Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions. Journal of Allergy and Clinical Immunology, 125(2), 502-505.e2. doi:10.1016/j.jaci.2009.11.032Torres, M. J., & Blanca, M. (2010). The Complex Clinical Picture of β-Lactam Hypersensitivity: Penicillins, Cephalosporins, Monobactams, Carbapenems, and Clavams. Medical Clinics of North America, 94(4), 805-820. doi:10.1016/j.mcna.2010.04.00

Las revistas científico-técnicas españolas de ciencias de la actividad física y el deporte: adecuación a las normas ISO y grado de normalización

Este artículo tiene por objeto conocer el grado de normalización y la adecuación de las revistas científico-técnicas españolas del campo de las Ciencias de la Actividad Física y el Deporte a diversos apartados clave de las normas ISO 8-1977 e ISO 215-1986. A partir de la observación directa de los fascículos, se han confeccionado dos índices para calcular el Grado General de Normalización (GGN) y el Grado Fundamental de Normalización (GFN). Los resultados indican que el ajuste de las publicaciones a la norma ISO 8-1977 es equivalente a la de otros campos españoles como el de Economía y el de Tecnología, mientras que es menor en la norma ISO 215-1986. La mayoría de las revistas presentan un GFN inferior a su respectivo GGN. Como principal conclusión se señala la existencia de un margen considerable de mejora en las revistas estudiadas, especialmente en los aspectos fundamentales de las normas

Las revistas científico-técnicas españolas de ciencias de la actividad física y el deporte: adecuación a las normas ISO y grado de normalización

The objective of this paper is to know the normalization grade and adjustment of Spanish scientific and technical journals of Physical Activity and Sport Sciences to various key epigraphs of the ISO 8-1977 and ISO 215-1986 norms. Also two indexes are made to calculate the General Normalization Grade (GGN) and the Fundamental Normalization Grade (GFN) of the journals. Results show that journals adjustment to ISO 8-1977 is equivalent to the journals of other Spanish fields as Economy and Technology, while it is less adjusted in relation to ISO 215- 1986. Most of the journals show an inferior GFN respective to its GGN. A considerable range of improvement in the journals studied, especially in the fundamental aspects of the ISO 215-1986 norm and some of the ISO 8-1977 norm, is the main conclusion of the study

Las revistas científicas-técnicas españolas de las ciencias de la Actividad Física y el Deporte: inventario y análisis de la calidad de contenido y difusión

The first inventory of Spanish scientific journals of Physical Activity and Sport Sciences is developed in this article. Methodological process of inventory development is described and problems related to research group decisions are commented. Basic information and dissemination and content quality indicators of these journals are also analysed. This allows to present the first approach to the current situation of the periodicals in this field of study.En este artículo se presenta el primer inventario de publicaciones periódicas españolas de carácter científico-técnico del campo de las Ciencias de la Actividad Física y el Deporte. Se explica el proceso metodológico seguido para su elaboración y se comenta la problemática de algunas decisiones del grupo de investigación. También se analiza información básica y varios indicadores elementales de la calidad de contenido y difusión de dichas publicaciones periódicas que permite ofrecer un primer acercamiento a la situación en que se encuentran los principales órganos de difusión del mencionado campo

Allergic Reactions to Metamizole: Immediate and Delayed Responses

[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole. Methods: Patients with suspicion of hypersensitivity to metamizole were evaluated. We verified acetylsalicylic acid tolerance and classified patients as immediate or delayed responders if they showed symptoms less or more than 24 h after metamizole administration. Skin tests were performed and if negative, a basophil activation test (BAT) was performed on immediate responders. If it was negative, we performed a drug provocation test (DPT) with metamizole. Results: A total of 137 patients were included: 132 reacted within 24 h (single NSAID-induced urticaria/angioedema/ anaphylaxis; SNIUAA) and 5 after 24 h (single NSAID-induced delayed hypersensitivity reaction; SNIDHR). Most SNIUAA patients developed anaphylaxis (60.60%); for SNIDHR, maculopapular exanthema was the most frequent entity (60%). Skin testing was positive in 62.04% of all cases and BAT in 28% of the SNIUAA patients with negative skin tests. In 5.1% of the cases, DPT with metamizole was needed to establish the diagnosis. In 22.62% of the cases, diagnosis was established by consistent and unequivocal history of repeated allergic episodes in spite of a negative skin test and BAT. Conclusions: SNIUAA to metamizole is the most frequent type of selective NSAID hypersensitivity, with anaphylaxis being the most common clinical entity. It may occur within 1 h after drug intake. SNIDHR occurs in a very low percentage of cases. The low sensitivity of diagnostic tests may be due to incomplete characterization of the chemical structures of metamizole and its metabolites.The present study has been supported by the Institute of Health ‘Carlos III’ of the Ministry of Economy and Competitiveness [grants cofounded by European Regional Development Fund (ERDF), Red de Reacciones Adversas a Alergenos y Farmacos (RD12/0013/0001 and PI15/01317)] and by Consejeria de Salud de la Junta de Andalucía (PI-0463-2013).Blanca-López, N.; Pérez-Sanchez, N.; Agúndez, JA.; García-Martín, E.; Torres, MJ.; Cornejo-Garcia, JA.; Perkins, JR.... (2016). Allergic Reactions to Metamizole: Immediate and Delayed Responses. International Archives of Allergy and Immunology. 169(4):223-230. https://doi.org/10.1159/000444798S223230169

Asthma and rhinitis induced by selective immediate reactions to paracetamol and non-steroidal anti-inflammatory drugs in aspirin tolerant subjects

En sujetos con anti-inflamatorios no esteroideos (AINES) se agravan las enfermedades respiratorias (ERNE) y los síntomas son desencadenados por el ácido acetilsalicílico (AAS) y otros potentes inhibidores COX-1 y, en algunos casos, por la debilidad de la COX-1 o los inhibidores selectivos de la COX-2. El mecanismo está relacionado con la prostaglandina vía inhibición y la liberación de leucotrienos. Los sujetos que reaccionan a un solo AINES y toleran otros se consideran respondedores selectivos, y a menudo presentan urticaria y/o angioedema y anafilaxia (SNIUAA). Un mecanismo inmunológico está implicado en estas reacciones. Sin embargo, la evidencia anecdótica sugiere que los respondedores selectivos que presentan síntomas de las vías respiratorias también pueden existir en los síntomas respiratorios. Nuestro objetivo fue determinar si los sujetos pueden desarrollar respuestas selectivas a los AINES/paracetamol que se manifiestan como vías respiratorias superiores/inferiores de los síntomas respiratorios. Para ello, estudiamos informes de pacientes con rinitis y/o asma inducida por el paracetamol o un único NSAID que tolera la ASA. Una evaluación alergológica plus reto, controlados con ASA, se llevó a cabo. Si la tolerancia ASA se encuentra, se procede a una provocación oral con el fármaco responsable. La aparición de los síntomas fue supervisada por un cuestionario clínico, midiendo el FEV1 y/o las vías respiratorias nasales y los cambios de volumen pre y post-desafío. De un total de 21 casos iniciales, hemos confirmado la aparición de problemas nasales y/o manifestaciones bronquiales en diez, caracterizados por una disminución significativa en el VEF1% y/o una disminución en el volumen de la cavidad nasal tras la administración del fármaco. Todos los casos tolerados cuentan con ASA. Esto demuestra que los sujetos con tolerante ASA presentan manifestaciones sistémicas de rinitis y/o asma inducida por el paracetamol o un único NSAID sin piel. Se requiere más investigación para saber si estos pacientes representan un nuevo fenotipo clínico para ser incluido dentro de la actual clasificación de las reacciones de hipersensibilidad a AINES.In subjects with non-steroidal anti-inflammatory drugs (NSAIDs)- exacerbated respiratory disease (NERD) symptoms are triggered by acetyl salicylic acid (ASA) and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors. The mechanism involved is related to prostaglandin pathway inhibition and leukotriene release. Subjects who react to a single NSAID and tolerate others are considered selective responders, and often present urticaria and/or angioedema and anaphylaxis (SNIUAA). An immunological mechanism is implicated in these reactions. However, anecdotal evidence suggests that selective responders who present respiratory airway symptoms may also exist. Our objective was to determine if subjects might develop selective responses to NSAIDs/paracetamol that manifest as upper/lower airways respiratory symptoms. For this purpose, we studied patients reporting asthma and/or rhinitis induced by paracetamol or a single NSAID that tolerated ASA. An allergological evaluation plus controlled challenge with ASA was carried out. If ASA tolerance was found, we proceeded with an oral challenge with the culprit drug. The appearance of symptoms was monitored by a clinical questionnaire and by measuring FEV1 and/or nasal airways volume changes pre and post challenge. From a total of 21 initial cases, we confirmed the appearance of nasal and/or bronchial manifestations in ten, characterized by a significant decrease in FEV1% and/or a decrease in nasal volume cavity after drug administration. All cases tolerated ASA. This shows that ASA tolerant subjects with asthma and/or rhinitis induced by paracetamol or a single NSAID without skin/systemic manifestations exist. Whether these patients represent a new clinical phenotype to be included within the current classification of hypersensitivity reactions to NSAIDs requires further investigation.Trabajo patrocinado por: Programa Miguel Servet. Ref CP14/00034, para José Antonio Cornejo García Ministerio de Economía y Competitividad y Instituto Nacional de Salud Carlos III y Fondos FEDER. Programa Sara Borrell. Ref. CD14/00242, para James R. Perkins Ministerio de Economía y Competitividad e Instituto Nacional de Salud Carlos III y Fondos FEDER. Becas FISPI12/02247, FISPI13/02598, FISPI15/00726 y FIS PI15/00303 Servicio Público de Salud de Andalucía. Becas PI-0279-2012 y PI-0463- 2013 Junta de Extremadura y Fondos FEDER. Beca GR15026peerReviewe