Feasibility Study of an Airbag-Based Crew Impact Attenuation System for the Orion MPCV

Airbag-based methods for crew impact attenuation have been highlighted as a potential lightweight means of enabling safe land-landings for the Orion Multi-Purpose Crew Vehicle, and the next generation of ballistic shaped spacecraft. To investigate the performance feasibility of this concept during a nominal 7.62m/s Orion landing, a full-scale personal airbag system 24% lighter than the Orion baseline has been developed, and subjected to 38 drop tests on land. Through this effort, the system has demonstrated the ability to maintain the risk of injury to an occupant during a 7.85m/s, 0 deg. impact angle land-landing to within the NASA specified limit of 0.5%. In accomplishing this, the airbag-based crew impact attenuation concept has been proven to be feasible. Moreover, the obtained test results suggest that by implementing anti-bottoming airbags to prevent direct contact between the system and the landing surface, the system performance during landings with 0 deg impact angles can be further improved, by at least a factor of two. Additionally, a series of drop tests from the nominal Orion impact angle of 30 deg indicated that severe injury risk levels would be sustained beyond impact velocities of 5m/s. This is a result of the differential stroking of the airbags within the system causing a shearing effect between the occupant seat structure and the spacecraft floor, removing significant stroke from the airbags

An airbag-based crew impact attenuation system for the Orion Crew Exploration Vehicle

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 265-271).It is a well known fact that every capsule-shaped reentry vehicle developed by NASA was initially conceived to land on land, but was ultimately designed to land in water. In all cases, the primary factor contributing to this fundamental shift was related to difficulties with keeping the vehicle to within its mass allocation. In recognizing the recurrence of this scenario during the development of the Orion Crew Exploration Vehicle (CEV), the concept of airbag-based crew impact attenuation was identified as being a potential means for providing a low mass, reconfigurable alternative to the currently baselined pallet-strut design. This thesis presents the development effort undertaken to determine the feasibility of this concept in terms of protecting an astronaut from the impact loads incurred during the nominal 7.62m/s Orion CEV landing on land. Through the complete development and testing of an analog airbag system and an intermediate technology demonstrator, practical means for system implementation have been developed, and insights into the influence of the system configuration on its overall impact attenuation performance obtained. These findings have culminated in the design and implementation of a full-scale multi airbag system, which has been experimentally shown to be capable of maintaining the risk of injury to the occupant during a 7.85m/s, 0' impact angle land-landing to within the NASA specified limit of 0.5%. In accomplishing this, the airbag-based impact attenuation concept has been proven to be feasible. Moreover, the obtained test results suggest that by implementing anti-bottoming airbags to prevent direct contact between the system and the landing surface, the system performance during landings with 0' impact angles can be further improved, by at least a factor of two. Additionally, a series of drop tests from the nominal Orion impact angle of 30' indicated that severe injury risk levels would be sustained beyond impact velocities of 5m/s. This is due to the differential stroking of the airbags within the system causing a shearing effect between the occupant seat structure and the spacecraft floor, removing significant stroke from the airbags. These results combined indicate that with further detailed design in the context of the currently fixed Orion crew cabin design, and the enforcement of a flat impact angle during landing, airbag-based impact attenuation may prove to be the key to finally achieving the elusive goal of capsule-shaped vehicle reentry and land-landing.by Sydney Do.S.M

An Independent Assessment of the Technical Feasibility of the Mars One Mission Plan

In mid-2012, the Mars One program was announced, aiming to build the first human settlement on the surface of Mars. Following a series of precursor missions to develop and deploy key technologies, the first crewed mission would depart Earth in 2024, sending four people on a one-way journey to the surface of Mars. Additional four-person crews would be sent to Mars at every subsequent launch opportunity to further support and expand the Martian colony. While this program has been received with great fanfare, very little has been published in the technical literature on this mission architecture. As the Mars One mission plan represents a dramatic departure from more conservative exploration approaches, there are many uncertainties in the mission design. The establishment of a colony on Mars will rely on in-situ resource utilization (ISRU) and life support technologies that are more capable than the current state of the art. Moreover, resupply logistics and sparing will play a large role in the proposed colony, though the magnitude and behavior of these two effects is not well understood. In light of this, we develop a Mars settlement analysis tool that integrates a habitat simulation with an ISRU sizing model and a sparing analysis. A logistics model is utilized to predict the required number of launchers and provide a preliminary estimate of a portion of the program cost. We leverage this tool to perform an independent assessment of the technical feasibility of the Mars One mission architecture. Our assessment revealed a number of insights into architecture decisions for establishing a colony on the Martian surface. If crops are used as the sole food source, they will produce unsafe oxygen levels in the habitat. Furthermore, the ISRU system mass estimate is 8% of the mass of the resources it would produce over a two year period. That being said, the ISRU technology required to produce nitrogen, oxygen, and water on the surface of Mars is at a relatively low Technology Readiness Level (TRL), so such findings are preliminary at best. A spare parts analysis revealed that spare parts quickly come to dominate resupply mass as the settlement grows: after 130 months on the Martian surface, spare parts compose 62% of the mass brought from Earth to the Martian surface. The space logistics analysis revealed that, for the best scenario considered, establishing the first crew for a Mars settlement will require approximately 15 Falcon Heavy launchers and require $4.5 billion in funding, and these numbers will grow with additional crews. It is important to note that these numbers are derived only when considering the launch of life support and ISRU systems with spare parts. To capture a more realistic estimate of mission cost, future work should consider development and operations costs, as well as the integration of other key mission elements, such as communications and power systems. Technology development towards improving the reliability of life support systems, the TRL of ISRU systems, and the capability of Mars in-situ manufacturing will have a significant impact on reducing the mass and cost of Mars settlement architectures.United States. National Aeronautics and Space Administration (Grant NNX13AL76H)United States. National Aeronautics and Space Administration (Grant NNX14AM42H)Josephine De Karman Fellowship Trus

Role of SOCS3 in POMC Neurons in metabolic and cardiovascular regulation.

Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of leptin signaling. We previously showed that the chronic effects of leptin on blood pressure (BP) and glucose regulation are mediated by stimulation of pro-opiomelanocortin (POMC) neurons. In this study, we examined the importance of endogenous SOCS3 in POMC neurons in control of metabolic and cardiovascular function and potential sex differences. Male and female SOCS3flox/flox/POMC-Cre mice in which SOCS3 was selectively deleted in POMC neurons and control SOCS3flox/flox mice were studied during a control diet (CD) or high fat diet (HFD) and during chronic leptin infusion. On CD, male and female SOCS3flox/flox/POMC-Cre mice were lighter in body weight despite similar food intake compared to control mice. Male SOCS3flox/flox/POMC-Cre mice exhibited increased energy expenditure. BP and heart rate were similar in male and female SOCS3flox/flox/POMC-Cre and control mice on CD. On a HFD, male and female SOCS3flox/flox/POMC-Cre mice showed attenuated weight gain. Female SOCS3flox/flox/POMC-Cre mice exhibited greater HFD-induced elevations in baseline BP and BP responses to air jet stress test compared to control mice. Chronic leptin infusion produced similar responses in all groups for food intake, body weight, oxygen consumption, blood glucose, BP and heart rate. Thus, SOCS3 deficiency in POMC neurons influences body weight regulation in CD and HFD and differentially affects BP and energy balance in a sex specific manner, but does not amplify the dietary, glycemic or cardiovascular effects of leptin

SÍNDROME DE REITER E SUAS MANIFESTAÇÕES NA ARTICULAÇÃO TEMPOROMANDIBULAR, UM RELATO DE CASO.

A síndrome de Reiter (SR) é uma artrite reativa, asséptica, inflamatória, desenvolvida secundariamente por uma infecção extra-articular primária, mais tipicamente do trato gastrointestinal ou sistema urogenital que acomete preferencialmente indivíduos adultos do sexo masculino; as principais alterações inflamatórias são: articulares, mucocutâneas e oculares. O objetivo deste trabalho é relatar a conduta clínica do especialista em Disfunção Temporomandibular (DTM) e Dor Orofacial adotada para o tratamento de uma paciente de 21 anos com SR encaminhada por médico Reumatologista. A paciente apresentava dor grave na articulação temporomandibuar (ATM) direita, limitação de abertura e da função mandibular. O tratamento com dispositivo inter-oclusal e exercícios mandibulares pelo período de 4 meses foi eficaz na remissão total da dor e recuperação da função mandibular. Concluiu-se que essas modalidades de tratamento para DTM são eficientes no controle da dor articular provocada pela SR

Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, C

Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences

Pax6 is a developmental control gene essential for eye development throughout the animal kingdom. In addition, Pax6 plays key roles in other parts of the CNS, olfactory system, and pancreas. In mammals a single Pax6 gene encoding multiple isoforms delivers these pleiotropic functions. Here we provide evidence that the genomes of many other vertebrate species contain multiple Pax6 loci. We sequenced Pax6-containing BACs from the cartilaginous elephant shark (Callorhinchus milii) and found two distinct Pax6 loci. Pax6.1 is highly similar to mammalian Pax6, while Pax6.2 encodes a paired-less Pax6. Using synteny relationships, we identify homologs of this novel paired-less Pax6.2 gene in lizard and in frog, as well as in zebrafish and in other teleosts. In zebrafish two full-length Pax6 duplicates were known previously, originating from the fish-specific genome duplication (FSGD) and expressed in divergent patterns due to paralog-specific loss of cis-elements. We show that teleosts other than zebrafish also maintain duplicate full-length Pax6 loci, but differences in gene and regulatory domain structure suggest that these Pax6 paralogs originate from a more ancient duplication event and are hence renamed as Pax6.3. Sequence comparisons between mammalian and elephant shark Pax6.1 loci highlight the presence of short- and long-range conserved noncoding elements (CNEs). Functional analysis demonstrates the ancient role of long-range enhancers for Pax6 transcription. We show that the paired-less Pax6.2 ortholog in zebrafish is expressed specifically in the developing retina. Transgenic analysis of elephant shark and zebrafish Pax6.2 CNEs with homology to the mouse NRE/Pα internal promoter revealed highly specific retinal expression. Finally, morpholino depletion of zebrafish Pax6.2 resulted in a "small eye" phenotype, supporting a role in retinal development. In summary, our study reveals that the pleiotropic functions of Pax6 in vertebrates are served by a divergent family of Pax6 genes, forged by ancient duplication events and by independent, lineage-specific gene losses

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery