35 research outputs found

    Gapful electrons in a vortex core in granular superconductors

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    We calculate the quasiparticle density of states (DoS) inside the vortex core in a granular superconductor, generalizing the classical solution applicable for dirty superconductors. A discrete version of the Usadel equation for a vortex is derived and solved numerically for a broad range of parameters. Electron DoS is found to be gapful when the vortex size ΞΎ\xi becomes comparable to the distance between neighboring grains ll. Minigap magnitude EgE_g grows from zero at ΞΎβ‰ˆ1.4l\xi \approx 1.4 l to third of superconducting gap Ξ”0\Delta_0 at ΞΎβ‰ˆ0.5l\xi \approx 0.5 l. The absence of low-energy excitations is the main ingredient needed to understand strong suppression of microwave dissipation recently observed in a mixed state of granular Al

    Π₯роничСскиС Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡ сознания: клиничСскиС Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ ΠžΠ±Ρ‰Π΅Ρ€ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ общСствСнной ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ «ЀСдСрация анСстСзиологов ΠΈ Ρ€Π΅Π°Π½ΠΈΠΌΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΎΠ²Β»

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    Π₯роничСскиС Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡ сознания (Π₯НБ) ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡŽΡ‚ собой синдромы тяТСлого пораТСния Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмы, приводящиС ΠΊΒ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠ±ΠΎΠΉ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΈΒ Ρ‚Ρ€Π΅Π±ΡƒΡŽΡ‰ΠΈΠ΅ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… усилий ΠΏΠΎΒ Π»Π΅Ρ‡Π΅Π½ΠΈΡŽ ΠΈΒ Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΈ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ лоТатся на мСдицинскиС учрСТдСния ΠΈΒ Π½Π°Β ΠΏΠ»Π΅Ρ‡ΠΈ Π±Π»ΠΈΠ·ΠΊΠΈΡ… ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ². Π₯НБ Ρ€Π°Π·Π²ΠΈΠ²Π°ΡŽΡ‚ΡΡ ΡƒΒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² послС ΠΊΠΎΠΌΡ‹ ΠΈΒ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΡƒΡŽΡ‚ΡΡ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ΠΌ бодрствования ΠΏΡ€ΠΈ ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΈΠ»ΠΈ практичСски ΠΏΠΎΠ»Π½ΠΎΠΌ отсутствии ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² осознанного повСдСния. К Π₯НБ относятся Π²Π΅Π³Π΅Ρ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΠ΅ состояниС (Π’Π‘) и состояниС минимального сознания (БМБ). Π’Π°ΠΊΠΆΠ΅ для описания Π½Π°Ρ‡Π°Π»ΡŒΠ½Ρ‹Ρ… стадий этих состояний ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅Ρ‚ΡΡ Ρ‚Π΅Ρ€ΠΌΠΈΠ½ Β«ΠΏΡ€ΠΎΠ΄Π»Π΅Π½Π½ΠΎΠ΅ Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠ΅ сознания» (ПНБ). ΠžΡ‚Π΄Π΅Π»ΡŒΠ½ΠΎ Π²Ρ‹Π΄Π΅Π»ΡΡŽΡ‚ Π²Ρ‹Ρ…ΠΎΠ΄ ΠΈΠ·Β Π‘ΠœΠ‘Β β€” состояниС, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ формируСтся ΠΏΠΎΒ ΠΌΠ΅Ρ€Π΅ восстановлСния ΠΊΠΎΠ³Π½ΠΈΡ‚ΠΈΠ²Π½Ρ‹Ρ… Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ. Диагностика Π₯НБ основываСтся Π½Π°Β ΠΌΠ½ΠΎΠ³ΠΎΠΊΡ€Π°Ρ‚Π½ΠΎΠΌ структурированном клиничСском осмотрС с примСнСниСм спСциализированных шкал ΠΏΡ€ΠΈ условии ΠΈΡΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΡ ΠΎΠ±Ρ€Π°Ρ‚ΠΈΠΌΡ‹Ρ… ΠΏΡ€ΠΈΡ‡ΠΈΠ½ Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡ сознания. Π›Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π₯НБ Π²ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ в сСбя ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½Ρ‹Ρ… Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΉ, обСспСчСниС ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ питания ΠΈΒ Π±ΠΎΡ€ΡŒΠ±Ρƒ с типичными ослоТнСниями ΠΈΒ ΡΠΎΠΏΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌΠΈ состояниями (ΠΏΡ€ΠΎΠ»Π΅ΠΆΠ½ΠΈ, ΡΠΏΠ°ΡΡ‚ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ, боль, ΠΏΠ°Ρ€ΠΎΠΊΡΠΈΠ·ΠΌΠ°Π»ΡŒΠ½Π°Ρ симпатичСская Π³ΠΈΠΏΠ΅Ρ€Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈΒ Π΄Ρ€.). Π£Β ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π₯НБ Π΄ΠΎΠ»ΠΆΠ½Π° ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΡŒΡΡ рСабилитация с участиСм ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠ΄ΠΈΡΡ†ΠΈΠΏΠ»ΠΈΠ½Π°Ρ€Π½ΠΎΠΉ Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠΌΠ°Π½Π΄Ρ‹ в объСмС, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ опрСдСляСтся ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ и возмоТностями ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½ΠΎΠ³ΠΎ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°. НаиболСС эффСктивной рСабилитация являСтся ΠΏΡ€ΠΈ условии Π΅Π΅Β Ρ€Π°Π½Π½Π΅Π³ΠΎ Π½Π°Ρ‡Π°Π»Π°. На данный ΠΌΠΎΠΌΠ΅Π½Ρ‚ ΠΎΠ΄Π½ΠΎΠ·Π½Π°Ρ‡Π½Ρ‹Ρ… Π΄ΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒΡΡ‚Π² эффСктивности ΠΊΠ°ΠΊΠΈΡ…-Π»ΠΈΠ±ΠΎ спСцифичСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ², Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Ρ… на восстановлСниС сознания, Π½Π΅Β ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΎ; изучаСтся ряд ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… фармакологичСских и нСфармакологичСских Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π², ΠΎΠ±ΡΠ·Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌ условиСм примСнСния ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… являСтся максимально возмоТная коррСкция соматичСских ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°. Π’Π°ΠΆΠ½ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π²Β Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π₯НБ ΠΈΠ³Ρ€Π°Π΅Ρ‚ Π²ΠΎΠ²Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π±Π»ΠΈΠ·ΠΊΠΈΡ… ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅, в свою ΠΎΡ‡Π΅Ρ€Π΅Π΄ΡŒ, Π½ΡƒΠΆΠ΄Π°ΡŽΡ‚ΡΡ Π²Β ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠΈ ΠΎΠ±ΡŠΠ΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ практичСской ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ о состоянии своСго родствСнника и о направлСниях Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΈ, Π°Β Ρ‚Π°ΠΊΠΆΠ΅ в психологичСской ΠΏΠΎΠΌΠΎΡ‰ΠΈ

    A Study of Biofeedback Gait Training in Cerebral Stroke Patients in the Early Recovery Phase with Stance Phase as Target Parameter

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    Walking function disorders are typical for patients after cerebral stroke. Biofeedback technology (BFB) is currently considered effective and promising for training walking function, including in patients after cerebral stroke. Most studies recognize that BFB training is a promising tool for improving walking function; however, the data on the use of highly selective walking parameters for BFB training are very limited. The aim of our study was to investigate the feasibility of using BFB training targeting one of the basic parameters of gait symmetryβ€”stance phase durationβ€”in cerebral stroke patients in the early recovery period. The study included 20 hemiparetic patients in the early recovery period after the first hemispheric ischemic stroke. The control group included 20 healthy subjects. The BFB training and biomechanical analysis of walking (before and after all BFB sessions) were done using an inertial system. The mean number of BFB sessions was nine (from 8 to 11) during the three weeks in clinic. There was not a single negative response to BFB training among the study patients, either during the sessions or later. The spatiotemporal parameters of walking showed the whole syndrome complex of slow walking and typical asymmetry of temporal walking parameters, and did not change significantly as a result of the study therapy. The changes were more significant for the functioning of hip and knee joints. The contralateral hip amplitude returned to the normal range. For the knee joint, the amplitude of the first flexion increased and the value of the amplitude of hyperextension decreased in the middle of the stance phase. Concerning muscle function, the observed significant decrease in the function of m. Gastrocnemius and the hamstring muscles on the paretic side remained without change at the end of the treatment course. We obtained positive dynamics of the biomechanical parameters of walking in patients after the BFB training course. The feasibility and efficacy of their use for targeted correction need further research

    Wideband waveguide loading impedance matching on the basis of photonic crystals with nanometer metal layers

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    Theoretically shown and experimentally proven is the possibility of creating wideband matched loading on the basis of photonic crystals, composed of alternating nanometer metal and isolator layers with different electro-physical parameters

    Nucleophilic Ring Opening of Donor–Acceptor Cyclopropanes with the Cyanate Ion: Access to Spiro[pyrrolidone-3,3β€²-oxindoles]

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    The nucleophilic ring opening of donor–acceptor cyclopropanes with the cyanate ion is reported for the first time. Cyclopropanes, spiro-activated with oxindole fragments as acceptors, are shown to undergo transformations into biologically relevant spiroΒ­[pyrrolidone-3,3β€²-oxindoles] while being treated with potassium cyanate under microwave assistance

    Dispirooxindole-Ξ²-Lactams: Synthesis via Staudinger Ketene-Imine Cycloaddition and Biological Evaluation

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    In this work, we present the first synthesis of dispirooxindole-Ξ²-lactams employing optimized methodology of one-pot Staudinger ketene-imine cycloaddition with N-aryl-2-oxo-pyrrolidine-3-carboxylic acids as the ketene source. Spiroconjugation of indoline-2-one with Ξ²-lactams ring is considered to be able to provide stabilization and wide scope of functionalization to resulting scaffolds. The dispipooxindoles obtained demonstrated medium cytotoxicity in the MTT test on A549, MCF7, HEK293, and VA13 cell lines, and one of the compounds demonstrated antibacterial activity against E. coli strain LPTD
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