1,430 research outputs found
A comparison of microsatellite instability in early onset gastric carcinomas from relatively low and high incidence European populations.
We have investigated the genetic basis of gastric carcinomas occurring in patients aged under 40 years from a Portuguese population with a relatively high incidence of gastric cancer. We analysed a panel of 12 microsatellite loci in DNA extracted from gastric carcinomas arising in 16 patients aged 24-39 years from Braga, Portugal. Overall, microsatellite instability (MI) in at least 1 locus was detected in 44% (7 of 16) of carcinomas. A single patient demonstrated a mutator phenotype suggestive of the hereditary nonpolyposis colorectal cancer syndrome with instability in 82% of loci. This carcinoma showed loss of expression of the hMLH1 mismatch repair protein. In a previous study, we found no evidence of MI among 10 cases of early onset gastric carcinomas from an English population, which has a relatively low incidence of gastric cancer. Comparing the 2 series, we found that there was a significant difference (p = 0.04) in the prevalence of MI (at least 1 marker affected). This geographical difference in low-level MI may be related to a significantly higher prevalence of background chronic atrophic gastritis (8 of 16 vs. 0 of 8) and Helicobacter pylori infection (15 of 16 vs. 2 of 8) in Portuguese carcinomas compared with English cases. Genetic mechanisms underlying the hereditary non-polyposis colorectal cancer syndrome may play a role in a small number of early onset gastric carcinomas. The difference in prevalence of low-level MI between these relatively high and low incidence European populations requires further investigation
Differential equations for multi-loop integrals and two-dimensional kinematics
In this paper we consider multi-loop integrals appearing in MHV scattering
amplitudes of planar N=4 SYM. Through particular differential operators which
reduce the loop order by one, we present explicit equations for the two-loop
eight-point finite diagrams which relate them to massive hexagons. After the
reduction to two-dimensional kinematics, we solve them using symbol technology.
The terms invisible to the symbols are found through boundary conditions coming
from double soft limits. These equations are valid at all-loop order for double
pentaladders and allow to solve iteratively loop integrals given lower-loop
information. Comments are made about multi-leg and multi-loop integrals which
can appear in this special kinematics. The main motivation of this
investigation is to get a deeper understanding of these tools in this
configuration, as well as for their application in general four-dimensional
kinematics and to less supersymmetric theories.Comment: 25 pages, 7 figure
N=2 Instanton Effective Action in Omega-background and D3/D(-1)-brane System in R-R Background
We study the relation between the ADHM construction of instantons in the
Omega-background and the fractional D3/D(-1)-branes at the orbifold singularity
of C \times C^2/Z_2 in Ramond-Ramond (R-R) 3-form field strength background. We
calculate disk amplitudes of open strings connecting the D3/D(-1)-branes in
certain R-R background to obtain the D(-1)-brane effective action deformed by
the R-R background. We show that the deformed D(-1)-brane effective action
agrees with the instanton effective action in the Omega-background.Comment: 35 pages, no figures, references adde
Mellin Amplitudes for Dual Conformal Integrals
Motivated by recent work on the utility of Mellin space for representing
conformal correlators in /CFT, we study its suitability for representing
dual conformal integrals of the type which appear in perturbative scattering
amplitudes in super-Yang-Mills theory. We discuss Feynman-like rules for
writing Mellin amplitudes for a large class of integrals in any dimension, and
find explicit representations for several familiar toy integrals. However we
show that the power of Mellin space is that it provides simple representations
even for fully massive integrals, which except for the single case of the
4-mass box have not yet been computed by any available technology. Mellin space
is also useful for exhibiting differential relations between various multi-loop
integrals, and we show that certain higher-loop integrals may be written as
integral operators acting on the fully massive scalar -gon in
dimensions, whose Mellin amplitude is exactly 1. Our chief example is a very
simple formula expressing the 6-mass double box as a single integral of the
6-mass scalar hexagon in 6 dimensions.Comment: 29+7 page
Development of a taxonomy to describe massage treatments for musculoskeletal pain
BACKGROUND: One of the challenges in conducting research in the field of massage and bodywork is the lack of consistent terminology for describing the treatments given by massage therapists. The objective of this study was to develop a taxonomy to describe what massage therapists actually do when giving a massage to patients with musculoskeletal pain. METHODS: After conducting a review of the massage treatment literature for musculoskeletal pain, a list of candidate techniques was generated for possible inclusion in the taxonomy. This list was modified after discussions with a senior massage therapist educator and seven experienced massage therapists participating in a study of massage for neck pain. RESULTS: The taxonomy was conceptualized as a three level classification system, principal goals of treatment, styles, and techniques. Four categories described the principal goal of treatment (i.e., relaxation massage, clinical massage, movement re-education and energy work). Each principal goal of treatment could be met using a number of different styles, with each style consisting of a number of specific techniques. A total of 36 distinct techniques were identified and described, many of which could be included in multiple styles. CONCLUSION: A new classification system is presented whereby practitioners using different styles of massage can describe the techniques they employ using consistent terminology. This system could help facilitate standardized reporting of massage interventions
Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis
Background. Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease. However, the additional pathogenetic role of an impaired gallbladder function leading to an increased alkaline duodenogastric reflux is controversially discussed. Aim:To investigate the relation of gallbladder function and Hp infection to gastric mucosa inflammation in patients with symptomatic gallstones prior to cholecystectomy. Patients: Seventy-three patients with symptomatic gallstones were studied by endoscopy and Hp testing. Methods: Gastritis classification was performed according to the updated Sydney System and gallbladder function was determined by total lipid concentration of gallbladder bile collected during mainly laparoscopic cholecystectomy. Results: Fifteen patients revealed no, 39 patients mild, and 19 moderate to marked gastritis. No significant differences for bile salts, phospholipids, cholesterol, or total lipids in gallbladder bile were found between these three groups of patients. However, while only 1 out of 54 (< 2%) patients with mild or no gastritis was found histologically positive for Hp, this infection could be detected in 14 (74%) out of 19 patients with moderate to marked gastritis. Conclusion: Moderate to marked gastric mucosa inflammation in gallstone patients is mainly caused by Hp infection, whereas gallbladder function is not related to the degree of gastritis. Thus, an increased alkaline duodenogastric reflux in gallstone patients seems to be of limited pathophysiological relevance. Copyright (c) 2006 S. Karger AG, Basel
Identification of the factors associated with outcomes in a condition management programme
<p>Background: A requirement of the Governmentās Pathways to Work (PtW) agenda was to introduce a Condition Management Programme (CMP). The aim of the present study was to identify the differences between those who engaged and made progress in this telephone-based biopsychosocial intervention, in terms of their health, and those who did not and to determine the client and practitioner characteristics and programme elements associated with success in a programme aimed at improving health.</p>
<p>Methods: Data were obtained from the CMP electronic spreadsheets and clients paper-based case records. CMP
standard practice was that questionnaires were administered during the pre- and post-assessment phases over the
telephone. Each clientās record contains their socio-demographic data, their primary health condition, as well as the pre- and post-intervention scores of the health assessment tool administered. Univariate and multivariate statistical analysis was used to investigate the relationships between the database variables. Clients were included in the study if their records were available for analysis from July 2006 to December 2007.</p>
<p> Results: On average there were 112 referrals per month, totalling 2016 referrals during the evaluation period. The
majority (62.8%) of clients had a mental-health condition. Successful completion of the programme was 28.5% (575
ācompletersā; 144 ādischargesā). Several factors, such as age, health condition, mode of contact, and practitioner
characteristics, were significant determinants of participation and completion of the programme. The results
showed that completion of the CMP was associated with a better mental-health status, by reducing the number of
clients that were either anxious, depressed or both, before undertaking the programme, from 74% to 32.5%.</p>
<p>Conclusions: Our findings showed that an individual's characteristics are associated with success in the
programme, defined as completing the intervention and demonstrating an improved health status. This study
provides some evidence that the systematic evaluation of such programmes and interventions could identify ways
in which they could be improved.</p>
The use of abrasive polishing and laser processing for developing polyurethane surfaces for controlling fibroblast cell behaviour
Studies have shown that surfaces having micro and nano-scale features can be used to control cell behaviours including; cell proliferation, migration and adhesion. The aim of this work was to compare the use of laser processing and abrasive polishing to develop micro/nano-patterned polyurethane substrates for controlling fibroblast cell adhesion, migration and proliferation. Laser processing in a directional manner resulted in polyurethane surfaces having a ploughed field effect with micron-scale features. In contrast, abrasive polishing in a directional and random manner resulted in polyurethane surfaces having sub-micron scale features orientated in a linear or random manner. Results show that when compared with flat (non-patterned) polymer, both the laser processed and abrasive polished surface having randomly organised features, promoted significantly greater cell adhesion, while also enhancing cell proliferation after 72 h. In contrast, the abrasive polished surface having linear features did not enhance cell adhesion or proliferation when compared to the flat surface. For cell migration, the cells growing on the laser processed and abrasively polished random surface showed decreased levels of migration when compared to the flat surface. This study shows that both abrasive polishing and laser processing can be used to produce surfaces having features on the nano-scale and micron-scale, respectively. Surfaces produced using both techniques can be used to promote fibroblast cell adhesion and proliferation. Thus both methods offer a viable alternative to using lithographic techniques for developing patterned surfaces. In particular, abrasive polishing is an attractive method due to it being a simple, rapid and inexpensive method that can be used to produce surfaces having features on a comparable scale to more expensive, multi-step methods
Mapping Exoplanets
The varied surfaces and atmospheres of planets make them interesting places
to live, explore, and study from afar. Unfortunately, the great distance to
exoplanets makes it impossible to resolve their disk with current or near-term
technology. It is still possible, however, to deduce spatial inhomogeneities in
exoplanets provided that different regions are visible at different
times---this can be due to rotation, orbital motion, and occultations by a
star, planet, or moon. Astronomers have so far constructed maps of thermal
emission and albedo for short period giant planets. These maps constrain
atmospheric dynamics and cloud patterns in exotic atmospheres. In the future,
exo-cartography could yield surface maps of terrestrial planets, hinting at the
geophysical and geochemical processes that shape them.Comment: Updated chapter for Handbook of Exoplanets, eds. Deeg & Belmonte. 17
pages, including 6 figures and 4 pages of reference
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