STATE TRADING IN AGRICULTURE: AN ANALYTICAL FRAMEWORK

This paper highlights some of the recent concerns regarding agricultural state trading enterprises (STEs) and proposes an analytical framework to examine the trade impacts of such entities. Issues associated with discriminatory pricing, exclusive rights to sell and purchase commodities, and unfair competitive advantage vis-a-vis private traders are expected to be major concerns on the export side, while on the import side, the relevance of tariffication in the presence of STEs is being questioned. Our paper proposes that, in most instances, tariff equivalents are the most relevant methodology to quantify the trade impacts of agricultural STEs. But, obtaining empirical information that would enable the calculation of such measures is not an easy task. To that end, a classification scheme that highlights the different types of STEs in terms of their ability to distort trade is proposed. Quantification can then focus on those most likely to impact trade.International Relations/Trade,

THE CURRENT WTO AGRICULTURAL NEGOTIATIONS: OPTIONS FOR PROGRESS; SYNTHESIS

World Trade Organization, International Relations/Trade,

Optimal Multi-Modes Switching Problem in Infinite Horizon

This paper studies the problem of the deterministic version of the Verification Theorem for the optimal m-states switching in infinite horizon under Markovian framework with arbitrary switching cost functions. The problem is formulated as an extended impulse control problem and solved by means of probabilistic tools such as the Snell envelop of processes and reflected backward stochastic differential equations. A viscosity solutions approach is employed to carry out a finne analysis on the associated system of m variational inequalities with inter-connected obstacles. We show that the vector of value functions of the optimal problem is the unique viscosity solution to the system. This problem is in relation with the valuation of firms in a financial market

Spatial Resolution of a Micromegas-TPC Using the Charge Dispersion Signal

The Time Projection Chamber (TPC) for the International Linear Collider will need to measure about 200 track points with a resolution close to 100 $\mu$m. A Micro Pattern Gas Detector (MPGD) readout TPC could achieve the desired resolution with existing techniques using sub-millimeter width pads at the expense of a large increase in the detector cost and complexity. We have recently applied a new MPGD readout concept of charge dispersion to a prototype GEM-TPC and demonstrated the feasibility of achieving good resolution with pads similar in width to the ones used for the proportional wire TPC. The charge dispersion studies were repeated with a Micromegas TPC amplification stage. We present here our first results on the Micromegas-TPC resolution with charge dispersion. The TPC resolution with the Micromegas readout is compared to our earlier GEM results and to the resolution expected from electron statistics and transverse diffusion in a gaseous TPC.Comment: 5 pages, 8 figures, to appar in the Proceedings of the 2005 International Linear Collider Workshop (LCWS05), Stanford, 18-22 March 200

Joubert syndrome diagnosed renally late

Joubert syndrome is a genetically heterogeneous multisystem disorder typically diagnosed in childhood. Nephronophthisis is the most common renal pathology in Joubert syndrome, and renal failure usually occurs in childhood or in young adults. We report a 61-year-old female diagnosed with AHI1-related oculorenal Joubert syndrome, who presented initially with decline in renal function in her 50s. Our report describes exceptionally late presentation of renal disease in Joubert syndrome and highlights the importance of continued renal function monitoring in older adults with Joubert syndrome

Heavy quark potential and quarkonia dissociation rates

Quenched lattice data for the quark-antiquark interaction (in terms of heavy quark free energies) in the color singlet channel at finite temperatures are fitted and used within the nonrelativistic Schroedinger equation formalism to obtain binding energies and scattering phase shifts for the lowest eigenstates in the charmonium and bottomonium systems in a hot gluon plasma. The partial dissociation rate due to the Bhanot-Peskin process is calculated using different assumptions for the gluon distribution function, including free massless gluons, massive gluons, and massive damped gluons. It is demonstrated that a temperature dependent gluon mass has an essential influence on the heavy quarkonia dissociation, but that this process alone is insufficient to describe the heavy quarkonia dissociation rates.Comment: 4 pages, 5 figures, contribution to the proceedings of the International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions, Ericeira, Portugal, Nov. 4-10, 200

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients.

BackgroundWe previously reported the results of a multicentric prospective randomized trial of chemo-refractory metastatic breast cancer patients testing the efficacy of two doses of TGFβ blockade during radiotherapy. Despite a lack of objective responses to the combination, patients who received a higher dose of TGFβ blocking antibody fresolimumab had a better overall survival when compared to those assigned to lower dose (hazard ratio of 2.73, p = 0.039). They also demonstrated an improved peripheral blood mononuclear cell (PBMC) counts and increase in the CD8 central memory pool. We performed additional analysis on residual PBMC using single cell network profiling (SCNP).MethodsThe original trial randomized metastatic breast cancer patients to either 1 or 10 mg/kg of fresolimumab, every 3 weeks for 5 cycles, combined with radiotherapy to a metastatic site at week 1 and 7 (22.5 Gy given in 3 doses of 7.5 Gy). Trial immune monitoring results were previously reported. In 15 patients with available residual blood samples, additional functional studies were performed, and compared with data obtained in parallel from seven healthy female donors (HD): SCNP was applied to analyze T cell receptor (TCR) modulated signaling via CD3 and CD28 crosslinking and measurement of evoked phosphorylation of AKT and ERK in CD4 and CD8 T cell subsets defined by PD-1 expression.ResultsAt baseline, a significantly higher level of expression (p < 0.05) of PD-L1 was identified in patient monocytes compared to HD. TCR modulation revealed dysfunction of circulating T-cells in patient baseline samples as compared to HD, and this was more pronounced in PD-1+ cells. Treatment with radiotherapy and fresolimumab did not resolve this dyfunctional signaling. However, in vitro PD-1 blockade enhanced TCR signaling in patient PD-1+ T cells and not in PD-1- T cells or in PD-1+ T cells from HD.ConclusionsFunctional T cell analysis suggests that baseline T cell functionality is hampered in metastatic breast cancer patients, at least in part mediated by the PD-1 signaling pathway. These preliminary data support the rationale for investigating the possible beneficial effects of adding PD-1 blockade to improve responses to TGFβ blockade and radiotherapy.Trial registrationNCT01401062

Adolescent Burmese Refugees Perspectives on Determinants of Health

Over 70,000 Burmese refugees have resettled in the United States in the past decade. While Burmese adolescents quickly acculturate into American society, their perspectives on health are not well-known. The purpose of this study was to identify adolescent Burmese refugee perspectives on determinants of health and health-related experiences after resettlement. In this qualitative study, Burmese adolescents took photographs depicting health-related experiences that were used as elicitation tools during focus groups. These discussions were recorded, transcribed, and analyzed for themes. Participants described positive determinants of health, including family and church. Rampant tobacco use was identified by the participants as a determinant of poor health within the Burmese community. Notably, the participants were proud to serve as liaisons within their community, despite the stressful nature of this role. Our results highlight the need to screen this population for anxiety, secondary to serving as a liaison for their community, as well as tobacco use

Measurement of electron screening in muonic lead

Energies of the transitions between high-lying (n≥6) states of muonic lead were accurately determined. The results are interpreted as a ∼2% test of the electron screening. The agreement between experiment and theory is good if it is assumed that the refilling of the electron K shell is fast. The present results furthermore severely restrict possible ionization of the electron L shell