1 Year

A little over a year ago, Deane Kenny Stryker was taken from our community and the world too soon. Her memory remains close to our hearts and continues to inspire us

Using the Advantages of NOSQL: A Case Study on MongoDB

With such a big volume of data growing tremendously every day, the storage of information, support and maintenance have become difficult. A further level of difficulty is added by the variety of data being captured. The data stored and updated on daily bases is in the form of logs, audio, video, sensor data and so on, which is not easy to be stored and queried using relational database. The paper gives the overview of NOSQL databases which provide more scalability and efficiency in storage and access of the data. A case study on MongoDB is done as to show the representational format and querying process of NOSQL database. The concepts of MongoDB are compared to the relational databases

Certain subclasses of analytic function by Sălăgean q-differential operator

The theory of q-analysis has many applications in various sub-fields of mathematics and quantum physics. In the present article, we define the class Tn(α, λ; q) using the Sălăgean q-differential operator. For functions belonging to this class we obtain coefficient estimates, extreme points and integral preserving properties.Publisher's Versio

Certain subclasses of analytic function by Sǎlǎgean q-differential operator

The theory of q-analysis has many applications in various sub-fields of mathematics and quantum physics. In the present article, we define the class Tn(α, λ; q) using the Sǎlǎgean q-differential operator. For functions belonging to this class we obtain coefficient estimates, extreme points and integral preserving properties.Publisher's Versio

Formulation and In vitro Evaluation of Carvedilol Transdermal Delivery System

Purpose: To develop and optimize carvedilol transdermal delivery system.Methods: Solvent casting method was used to prepare patches using polymethyl methacrylate (PMMA) and Eudragit E100 (EE100) polymers, dimethylsulfoxide (DMSO) penetration enhancer, dibutylphthalate (DBP) plasticizer and Tween 80 surfactant. A 23 factorial design was used based on three variables (PMMA, EE100, DMSO). at two levels Second order polynomial equations indicating interplay of ingredients were obtained by factorial design using SigmaTech software for 1, 4, 8 and 20 h release data. so the design was extended to central composite design (CCD). The target formulation was obtained from contour plots and evaluated for various physicochemical parameters. including in-vitro dissolution studies.Results: Curvature effect was observed in F1 to F8 formulations, highlighting the interplay of ingredients. The interaction term (X2X3)exhibited highest Sum of Squares SS ratio at 1, 4, and 8 h data with positive coefficients indicating interaction; and so extended to CCD. From contour plots target formulation, F19, was identified and evaluated. The release data, were subjected to kinetic analysis, which followed Higuchi (diffusion) model (R2 = 0.9886).Conclusion: F19 yielded release profile nearer to the theoretical predictions with R2 of 0.9888 and followed Higuchi kinetics. Thus, a diffusion-mediated carvedilol matrix patch was successfully developed.Keywords: Carvedilol, Central composite design, Drug release, Transdermal patch

Pain management in Gridhrasi through Ayurveda - An Observational Study

Gridhrasi is a Shula Pradhana Vata Nanatmaja Vyadhi which is characterized by the Kramat Shula in the Prushtha Bhaaga of Sphik, Kati, Uru, Jaanu Jangha and Pada Pradesha. It is corelated with Sciatica based on the aetiology and symptomatology. This disease is mainly caused due the improper postures and the nature of the work. The main challenge is the management of pain. In Modern Science this condition is managed by the administration of Analgesics and in the later conditions Surgery will be advised with no definite relief. Shodhana, Siravyadha, Basti, Agni Karma are the treatment modalities have been mentioned in the classics. Here the study is conducted to evaluate the efficacy of Siravyadha in the management of the Shula in Gridhrasi with a successful outcome

A study on the effect of adenoidectomy with tonsillectomy in otitis media with effusion in children

Background: The aural symptoms attributed to adenoid hypertrophy are Eustachian tube block (ET) and otitis media with effusion (OME). It is thought that adenoid hypertrophy causes a block in air flow through the ET, thus creating a negative pressure in the middle ear leading to effusion which acts as a focus of infection. The role of hypertrophied tonsils in the aetiology of OME is controversial. Adenoid and tonsillar hypertrophy and associated inflammation continue to be a major problem in paediatric age group despite the advances in medicine. Otitis media with effusion is a treatable cause of deafness which may hamper the learning ability of a child. This study was undertaken to study the effect of adenoidectomy with tonsillectomy on established otitis media with effusion in children.Methods: 35 children presenting to the department of ENT, Government Medical College, Thrissur, Kerala, India over one and a half years with features suggestive of secretory otitis media, tonsillar and adenoid hypertrophy who underwent adenoidectomy with tonsillectomy in Government Medical College, Thrissur, Kerala, India were included in the study. A predesigned questionnaire was prepared which included details on clinical symptoms, relevant investigations and preoperative and postoperative evaluation of hearing after 6 weeks and 3 months. Data collected was analyzed using paired t-test and chi square test to determine the improvement in hearing after 6 weeks and 3 months following surgery.Results: Out of the 35 children included in the study, it was seen that 56% of cases, after 6 weeks showed complete resolution of OME which improved to 67% after 3 months. This was assessed by PTA and tympanometry. 33% showed partial improvement with Type C curve in tympanometry and improvement in PTA values.Conclusions: All cases of OME associated with adenoid and tonsillar hypertrophy responded to our treatment with 67% showing complete cure of the condition. It can be assumed that, in the 33% partial responders there may be other factors like allergy, anatomical deformities, immunological which prevented the complete resolution of symptoms in OME.

Prevalence of candidiasis, uremic stomatitis, uremic frost and colonization of candida subspecies in hemodialysis patients

BACKGROUND: With impaired renal function, decreased glomerular filtration rate and accumulation and retention of various products of renal failure the oral cavity may shows a variety of changes as the body progresses through an azotemic to uremic state. In 90% of hemodialysis patient oral manifestation are evident which may be due to disease process or as a result of treatment. Studies have been conducted regarding colonization of yeast in hemodialysis patients. However there is a gap in the knowledge regarding assessment of Candida subspecies and its correlation with oral lesions in hemodialysis patient which aid in prophylactic treatment. Prevalence of Candidiasis, Uremic Stomatitis, Uremic frost and colonization of Candida Subspecies will open eyes in this new research. AIM OF THE STUDY: 1. To assess the presence of candidiasis, uremic stomatitis, and uremic frost in patients undergoing hemodialysis. 2. To assess the presence of various subspecies of Candida in patients with chronic renal disease undergoing hemodialysis MATERIALS & METHODS: A comparative cross-sectional study to determine the presence of Candidiasis, Uremic Stomatitis, and Uremic frost and various subspecies of Candida in patients undergoing hemodialysis was carried out in the outpatient department and the study sample consisted of 50 chronic renal failure patients. The oral health status was assessed clinically for each patient and recorded. The data was analysed by Statistical Package for Social Sciences (SPSS 16.0). Chi square test was applied to find the statistical significance between the groups. RESULTS: The analysis demonstrated significant association between colonization by yeasts and patient’s age (P = 0.04), chief complaint (P = 0.004), duration of the diseases (P = 0.03), duration of dialysis treatment (P = 0.03) and oral hygiene status (P = 0.03). However, no significant association was observed with gender. The percentage of patients affected by the disease was found to be higher between the age group of 40 -60 years of age and the analysis demonstrated that the results in relation to the presence of oral lesion and age changed and were no longer significant for the presence of yeasts. Common dental problems associated with these patients are periodontitis and dental caries. Despite optimal dialysis, oral disease may be increased in these patients treated due to their lower uptake of public dental services, as well as increased malnutrition and inflammation. Nevertheless, chronic kidney disease patients undergoing hemodialysis treatment were more likely to carry yeasts and its prevalence is higher when lesions were present in the oral cavity. But our results demonstrated only 18 (36%) patients with CKD undergoing HT were colonized by yeasts, from which a total of 2 subspecies were only isolated and identified, all belonging to the genus Candida with the predominance of C. albicans (22%). Clinical assessment detected more than one type of lesion in one of the 18 patients with CKD undergoing HT with oral lesions. Candidiasis (acute pseudomembranous candidiasis, chronic atrophic candidiasis or angular cheilitis) was confirmed in 17 (34%) of the 18 lesions suggestive of the disease. Among the remaining lesion found, the diagnosis suggested uremic stomatits. Uremic frost was not reported in any patients. The only type of lesion to show positive association with the presence of yeasts was chronic erythematosus candidiasis, which is the kind of lesion typically resulting from the use of dental prosthesis. CONCLUSION: It is concluded that the oral cavity can reveal signs of undiagnosed renal failure, hence oral health care providers must be well aware of signs and symptoms to refer such patients to a physician for further investigation as well as manage and treat the oral health complications

Mapping the methodological quality of international primary-secondary transitions research literature : A systematic methodological review.

Funding Information This article is partly based on a study funded by the Scottish Government (PI Jindal-Snape; CI Cantali; CI MacGillivray; CI Hannah).Peer reviewe