CHARLES NORRIS (1712-1766): PHILADELPHIA GENTLEMAN.

Abstract not availabl

Course Studies : Tracking Ontario's Thames : An Exploration of the River

Illustrated by period paintings, photographs, maps and historical documentation, Kapelos’ consideration of the Thames River in Ontario investigates the meaning of landscape, its cultural sedimentation, and how place is constituted by the vernacular manifestation of abstract concepts of order, time, and system. L. DiStefano contributes an essay on 19th century travel narratives and adventure tourism associated with the Thames. 36 recent photographs by Evans capture the diversity along the river. List of facts about the Thames with map of its watershed. Bibl. 3 p. 134 bibl. ref

Organomercurial Lyase and Mercuric Ion Reductase: Nature's Mercury Detoxification Catalysts

Concern over our increasingly polluted environment, with its potentially deleterious effects on organisms, including humans, has sparked considerable research into the strategies by which living systems contend with toxic compounds. One area of research that has been especially prolific in recent years deals with the mechanisms by which bacteria cope with increased heavy metal burdens. Heavy metals are prevalent throughout the biosphere, and while some (e.g., Co, Cu, Mo, Ni, and Zn) are required in trace amounts, elevated concentrations of most are deleterious by virtue of their avid ligation to cellular components, particularly proteins. Especially toxic to higher organisms are organometallics, whose lipophilic nature gives them a strong tendency toward bioaccumulation in the food chain

Organomercurial Lyase and Mercuric Ion Reductase: Nature's Mercury Detoxification Catalysts

Concern over our increasingly polluted environment, with its potentially deleterious effects on organisms, including humans, has sparked considerable research into the strategies by which living systems contend with toxic compounds. One area of research that has been especially prolific in recent years deals with the mechanisms by which bacteria cope with increased heavy metal burdens. Heavy metals are prevalent throughout the biosphere, and while some (e.g., Co, Cu, Mo, Ni, and Zn) are required in trace amounts, elevated concentrations of most are deleterious by virtue of their avid ligation to cellular components, particularly proteins. Especially toxic to higher organisms are organometallics, whose lipophilic nature gives them a strong tendency toward bioaccumulation in the food chain

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.

BACKGROUND & AIMS: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and to characterise its role in the regulation of related metabolic phenotypes through a meta-analysis. METHODS: We performed a meta-analysis of studies with data on the association between rs641738C>T genotype and liver fat, NAFLD histology, and serum alanine aminotransferase (ALT), lipids or insulin. These included directly genotyped studies and population-level data from genome-wide association studies (GWAS). We performed a random effects meta-analysis using recessive, additive and dominant genetic models. RESULTS: Data from 1,066,175 participants (9,688 with liver biopsies) across 42 studies were included in the meta-analysis. rs641738C>T was associated with higher liver fat on CT/MRI (+0.03 standard deviations [95% CI 0.02-0.05], pz = 4.8×10-5) and diagnosis of NAFLD (odds ratio [OR] 1.17 [95% CI 1.05-1.3], pz = 0.003) in Caucasian adults. The variant was also positively associated with presence of advanced fibrosis (OR 1.22 [95% CI 1.03-1.45], pz = 0.021) in Caucasian adults using a recessive model of inheritance (CC + CT vs. TT). Meta-analysis of data from previous GWAS found the variant to be associated with higher ALT (pz = 0.002) and lower serum triglycerides (pz = 1.5×10-4). rs641738C>T was not associated with fasting insulin and no effect was observed in children with NAFLD. CONCLUSIONS: Our study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent. LAY SUMMARY: Fatty liver disease is a common condition where fat builds up in the liver, which can cause liver inflammation and scarring (including 'cirrhosis'). It is closely linked to obesity and diabetes, but some genes are also thought to be important. We did this study to see whether one specific change ('variant') in one gene ('MBOAT7') was linked to fatty liver disease. We took data from over 40 published studies and found that this variant near MBOAT7 is linked to more severe fatty liver disease. This means that drugs designed to work on MBOAT7 could be useful for treating fatty liver disease.JPM is supported by a Wellcome Trust Fellowship (216329/Z/19/Z

rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD : a meta-analysis

Background & Aims: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and to characterise its role in the regulation of related metabolic phenotypes through a meta-analysis. Methods: We performed a meta-analysis of studies with data on the association between rs641738C>T genotype and liver fat, NAFLD histology, and serum alanine aminotransferase (ALT), lipids or insulin. These included directly genotyped studies and population-level data from genome-wide association studies (GWAS). We performed a random effects meta-analysis using recessive, additive and dominant genetic models. Results: Data from 1,066,175 participants (9,688 with liver biopsies) across 42 studies were included in the meta-analysis. rs641738C>T was associated with higher liver fat on CT/MRI (+0.03 standard deviations [95% CI 0.02\u20130.05], pz = 4.8 710\u20135) and diagnosis of NAFLD (odds ratio [OR] 1.17 [95% CI 1.05\u20131.3], pz = 0.003) in Caucasian adults. The variant was also positively associated with presence of advanced fibrosis (OR 1.22 [95% CI 1.03\u20131.45], pz = 0.021) in Caucasian adults using a recessive model of inheritance (CC + CT vs. TT). Meta-analysis of data from previous GWAS found the variant to be associated with higher ALT (pz = 0.002) and lower serum triglycerides (pz = 1.5 710\u20134). rs641738C>T was not associated with fasting insulin and no effect was observed in children with NAFLD. Conclusions: Our study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent. Lay summary: Fatty liver disease is a common condition where fat builds up in the liver, which can cause liver inflammation and scarring (including \u2018cirrhosis\u2019). It is closely linked to obesity and diabetes, but some genes are also thought to be important. We did this study to see whether one specific change (\u2018variant\u2019) in one gene (\u2018MBOAT7\u2019) was linked to fatty liver disease. We took data from over 40 published studies and found that this variant near MBOAT7 is linked to more severe fatty liver disease. This means that drugs designed to work on MBOAT7 could be useful for treating fatty liver disease