Intracranial Meningioma Diagnosed during Pregnancy Caused Maternal Death

Brain tumors are rarely diagnosed during pregnancy. Accelerated growth of intracranial meningiomas during pregnancy sometimes requires urgent surgical intervention. We describe a 41-year-old pregnant woman with severe neurological decompensation requiring immediate neurosurgery. Cesarean section resulted in maternal death. Meningioma diagnosed during a viable pregnancy should be managed according to the severity of maternal neurological symptoms and gestational age of pregnancy. Early intervention for intracranial tumors during pregnancy may save maternal and fetal lives

The impact of low molecular weight heparin on obstetric outcomes among unexplained recurrent miscarriages complicated with methylenetetrahydrofolate reductase gene polymorphism

Objectives: The association between methylenetetrahydrofolate reductase gene polymorphisms and unexplained recurrent miscarriage is elusive. The recommendations for improving pregnancy outcomes in these patients keep changing based on the available evidence. The aim of this study is to analyze the impact of low molecular weight heparin on obstetric outcomes of recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphism. Material and methods: We reviewed medical records of 121 patients with a history of recurrent miscarriage complicated by methylenetetrahydrofolate reductase gene polymorphisms, retrospectively. From among them, 68 patients were treated only with folic acid and iron. The remaining 53 patients were treated with folic acid, iron and prophylactic doses of low molecular weight heparin. The subsequent pregnancy outcomes of these patients were noted. Results: The live birth rate was higher in patients with anticoagulant therapy than in patients without anticoagulant therapy (48.5% vs. 69.8%, respectively, p: 0.015) and the congenital anomaly rate was lower in anticoagulant therapy group (17.6% vs. 3.8%, respectively, p: 0.022). The other obstetric outcomes were found to be similar between the two groups. Conclusions: The current study demonstrated that low molecular weight heparin improved the live birth rates among unex­plained recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphisms. How­ever, the routine use of low molecular weight heparin did not improve the late pregnancy complications in these selected patients in the eastern region of our country. Further studies are needed to discriminate the effect of anticoagulation on the live birth rate of each of methylenetetrahydrofolate reductase gene polymorphism type

Geochemistry of fluid inclusions in travertines from Western and Northern Turkey: inferences on the role of active faults in fluids circulation

The understanding of the relationship between the geochemistry of fluids circulating during travertine deposition and the presence of active faults is crucial for evaluating the seismogenetic potential of an area. Here we investigate travertines from Pamukkale and Reşadiye (Turkey), sited in seismic regions and next to thermal springs. These travertines formed ~24,500–50,000 (Pamukkale) and ~240–14,600 years (Reşadiye) BP. We characterize fluid inclusions (FIs) and studied concentration of H2O, CO2, O2 + N2, and 3He, 4He, 20Ne, and 40Ar, and bulk composition (trace elements and δ13C‐δ18O). FIs from both localities are mainly primary with low salinity and homogenization temperature around 136–140 °C. H2O is the major component followed by CO2, with the highest gas content measured in Pamukkale travertines. Concentrations of Ne‐Ar together with O2 + N2 indicate that travertines from both areas precipitated from atmosphere‐derived fluids. The 3He/4He is 0.5–1.3 Ra in Pamukkale and 0.9–4.4 Ra in Reşadiye. Samples with R/Ra > 1 are modified by cosmogenic 3He addition during exposure to cosmic rays. Excluding these data, FIs of Reşadiye are mostly atmosphere‐derived. This implies a shallow formation where the circulation was dominated by meteoric waters, which is consistent with their young age. Instead, FIs of Pamukkale show mixing of mantle‐, crustal‐, and atmosphere‐derived He, indicating that these travertines formed in lithospheric fractures. Based on the δ13CCO2 and δ18O of bulk rocks, we infer that travertines formed involving crustal‐ (mechanochemical rather than organic) and mantle‐derived CO2. Trace elements of Pamukkale and Reşadiye show comparable rare earth element patterns. We conclude that travertines formed in response of seismogenetic activity.Published5473-54982T. Deformazione crostale attiva7T. Variazioni delle caratteristiche crostali e precursori sismici6A. Geochimica per l'ambiente e geologia medicaJCR Journa

Ulusal Yazın Bağlamında İşten Ayrılma Niyetinin Öncüllerine İlişkin Bir Meta-Analiz Çalışması(A Meta-Analytic Review of Studies on the Antecedents of Intention to Leave in Turkish National Literature)

This study aims to make a systematic review of studies on the antecedents of “intention to leave” in the context of articles featuring samples from Turkey and published in national/international peer-reviewed journals, and hence to generate a comprehensive model of intention to leave antecedents. According to fifteen different meta-analyses based on correlation coefficients, the most frequently investigated antecedent of intention to leave is job satisfaction, and there is a medium to high level negative correlation (ES=-0,478, p<0,00). Organizational commitment meta-analyses reveal that the highest correlation occurs with affective commitment (ES=-0,462, p<0,00) and the smallest correlation occurs with continuance commitment (ES=- 0,082, p<0,00). The negative correlation between identification and intention to leave is quite small (ES=-0,278, p<0,00). Job stress and intention to leave are positively correlated at a medium-level (ES=0,395, p<0,00). However, there is a very small and negligible correlation between intention to leave and job performance, contrary to prevailing opinion (ES=-0,133, p<0,00). We expect this paper to make a modest contribution to the extant literature on the intention to leave by providing a comprehensive and up-to-date review of the empirical studies in the national contex

Psychological wellbeing of Turkish university students with physical impairments: An evaluation within the stress-vulnerability paradigm

Generally, universities in developing countries offer little in the way of provisions and support (material, emotional, etc.) for disabled students. Therefore, disabled students experience considerable burdens and barriers in their educational life. This study investigated the psychological wellbeing of disabled Turkish university students by examining influences on stress-related growth and psychological distress. Disability is defined within the framework of a social model. According to this view, impairment refers to the functional limitation(s) that affect(s) a person's body, whereas disability refers to the loss or limitation of opportunities owing to social, physical or psychological obstacles. Seventy disabled university students with physical impairments were administered a questionnaire package, including a sociodemographic information sheet, Ways of Coping Questionnaire, Stress-Related Growth Scale, Multidimensional Scale of Social Support, Life Events Inventory, and Brief Symptom Inventory. Snowball sampling was used and voluntary participation was essential. The results showed that disability burden, daily hassles, and helplessness coping were significant predictors of psychological symptoms. For stress-related growth the only variable that appeared significant was problem-solving coping. The results pointed out that there may be different pathways to distress and growth. In order to decrease psychological distress and enhance growth in disabled university students, disability awareness programs, changes in the barriers in the academic and physical environments of the university campuses, and coping skills training to increase problem-focused coping and to combat helplessness may prove to be effective. Reducing daily hassles for the disabled students is likely to contribute to their wellbeing by decreasing their burdens. Also, a more disability-friendly environment is likely to be empowering for disabled university students

The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1 year in the Marmara Region of Turkey

It is important to detect recent and new HIV/1 infections and to take preventative measures in order to prevent rapid disease progression in AIDS and to decrease the incidence of infection. We aimed to detect long standing or recent HIV infections by determining transmission times for the cases in which first-time HIV/1 seropositivity were detected. The serum samples of 323 cases which were found to be seropositive by ELISA and Western-blotting were included in this study. The discrimination between long-term and recent HIV/1 infection was made by determining transmission-time with the Aware BED-EIA, HIV-1 incidence test (IgG capture HIV-EIA) tests. Ninety-six healthy blood donors who did not have a positive anti-HIV test and a chronic infectious disease for at least 1 year were included in this study as a negative healthy control group. In the discrimination of long-term and recent HIV/1 infections, only in vitro ODn values were used. The cases with normalized optical density (OD) (ODspecimen/ODcalibrator) 1.2 were accepted as long-term HIV/1 infections (more than 155 days history or more than 6 months). The cases with ODn between 0.8 and 1.2 were accepted as "additional tests needed" cases. We detected recent HIV/1 infections (6 months) in 263 (81.5%) out of 323 cases. The most frequently encountered transmission route in long-term and recent HIV/1 infections was heterosexual sexual intercourse as 54(50%) and 257 (97%), respectively. 63.3% of newly infected patients were married females and 65.3% of recently infected patients were males