On the nonparametric inference of coefficients of self-exciting jump-diffusion

In this paper, we consider a one-dimensional diffusion process with jumps driven by a Hawkes process. We are interested in the estimations of the volatility function and of the jump function from discrete high-frequency observations in a long time horizon which remained an open question until now. First, we propose to estimate the volatility coefficient. For that, we introduce a truncation function in our estimation procedure that allows us to take into account the jumps of the process and estimate the volatility function on a linear subspace of L2(A) where A is a compact interval of R. We obtain a bound for the empirical risk of the volatility estimator, ensuring its consistency, and then we study an adaptive estimator w.r.t. the regularity. Then, we define an estimator of a sum between the volatility and the jump coefficient modified with the conditional expectation of the intensity of the jumps. We also establish a bound for the empirical risk for the non-adaptive estimators of this sum, the convergence rate up to the regularity of the true function, and an oracle inequality for the final adaptive estimator.Finally, we give a methodology to recover the jump function in some applications. We conduct a simulation study to measure our estimators' accuracy in practice and discuss the possibility of recovering the jump function from our estimation procedure

Rapid homeostatic modulation of transsynapticnanocolumn rings

Robust neural information transfer relies on a delicate molecular nano-architecture of chemical synapses. Neurotransmitter release is controlled by a specific arrangement of proteins within presynaptic active zones. How the specific presynaptic molecular architecture relates to postsynaptic organization and how synaptic nano-architecture is transsynaptically regulated to enable stable synaptic transmission remain enigmatic. Using time-gated stimulated emission-depletion microscopy at the Drosophila neuromuscular junction, we found that presynaptic nanorings formed by the active-zone scaffold Bruchpilot (Brp) align with postsynaptic glutamate receptor (GluR) rings. Individual rings harbor approximately four transsynaptically aligned Brp-GluR nanocolumns. Similar nanocolumn rings are formed by the presynaptic protein Unc13A and GluRs. Intriguingly, acute GluR impairment triggers transsynaptic nanocolumn formation on the minute timescale during homeostatic plasticity. We reveal distinct phases of structural transsynaptic homeostatic plasticity, with postsynaptic GluR reorganization preceding presynaptic Brp modulation. Finally, homeostatic control of transsynaptic nano-architecture and neurotransmitter release requires the auxiliary GluR subunit Neto. Thus, transsynaptic nanocolumn rings provide a substrate for rapid homeostatic stabilization of synaptic efficacy

Enumerating all bilocal Clifford distillation protocols through symmetry reduction

Entanglement distillation is an essential building block in quantum communication protocols. Here, we study the class of near-term implementable distillation protocols that use bilocal Clifford operations followed by a single round of communication. We introduce tools to enumerate and optimise over all protocols for up to $n=5$ (not necessarily equal) Bell-diagonal states using a commodity desktop computer. Furthermore, by exploiting the symmetries of the input states, we find all protocols for up to $n=8$ copies of a Werner state. For the latter case, we present circuits that achieve the highest fidelity. These circuits have modest depth and number of two-qubit gates. Our results are based on a correspondence between distillation protocols and double cosets of the symplectic group, and improve on previously known protocols.Comment: 13 pages main text, 5 pages appendices, 8 figure

Small Intestine Early Innate Immunity Response during Intestinal Colonization by Escherichia coli Depends on Its Extra-Intestinal Virulence Status

International audienceUropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in the digestive tract. Mice were orally challenged with UPEC strains 536 and CFT073, non-pathogenic strain K12 MG1655, and ΔPAI-536, an isogenic mutant of strain 536 lacking all 7 pathogenicity islands whose virulence is drastically attenuated. Intestinal colonization was measured, and cytokine expression was determined in various organs recovered from mice after oral challenge. UPEC strain 536 efficiently colonized the mouse digestive tract, and prior Enterobacteriaceae colonization was found to impact strain 536 colonization efficiency. An innate immune response, detected as the production of TNFα, IL-6 and IL-10 cytokines, was activated in the ileum 48 hours after oral challenge with strain 536, and returned to baseline within 8 days, without a drop in fecal pathogen load. Although inflammation was detected in the ileum, histology was normal at the time of cytokine peak. Comparison of cytokine secretion 48h after oral gavage with E. coli strain 536, CFT073, MG1655 or ΔPAI-536 showed that inflammation was more pronounced with UPECs than with non-pathogenic or attenuated strains. Pathogenicity islands also seemed to be involved in host detection, as IL-6 intestinal secretion was increased after administration of E. coli strain 536, but not after administration of ΔPAI-536. In conclusion, UPEC colonization of the mouse digestive tract activates acute phase inflammatory cytokine secretion but does not trigger any pathological changes, illustrating the opportunistic nature of UPECs. This digestive tract colonization model will be useful for studying the factors controlling the switch from commensalism to pathogenicity

THE READABILITY IN ENGLISH ZONE TEXTBOOK FOR THE TENTH GRADE STUDENTS OF SMA N 2 BANDAR

This study was carried out to find out the readability level of the reading texts in English Zone textbook by using Flesch Reading Ease Formula and Cloze Test at the tenth-grade students of SMA N 2 Bandar. The population of this research was the tenth-grade students of SMA N 2 Bandar. The textbook consists of 181 pages with 29 reading texts in it. The researcher took 5 reading texts from the English textbook entitled English Zone published by Penerbit Erlangga and the tenth-grade students of 30 students as the sample. The method used in this study was descriptive analysis using quantitative data. The instruments of the research were Flesch Reading Ease Formula and Cloze Test. The data were analyzed using Flesch Reading Ease Formula which is focused on the average number of the syllables per words. The result of the analysis by using Flesch Reading Ease Formula is grouped into three levels which are Very Easy, Easy, and Fairly Easy. The average readability score for all texts is 82.6 which implies that the texts are in Fairly Easy Level. The result of the analysis by using Cloze Test, the average readability score of the five texts is 51.20% (Independent Level), the texts are predicted to be of appropriate difficulty. Thus, it could be concluded that the reading texts were in the English Zone textbook were not suitable to be used by the students at the tenth-grade students of SMA N 2 Bandar

Endogenous IL-33 Accelerates Metacestode Growth during Late-Stage Alveolar Echinococcosis.

During the course of the infectious disease alveolar echinococcosis (AE), the larval stage of Echinococcus multilocularis develops in the liver, where an initial Th1/Th17 immune response may allow its elimination in resistant individuals. In patients susceptible to infection and disease, the Th2 response initiates later, inducing tolerance to the parasite. The role of interleukin 33 (IL-33), an alarmin released during necrosis and known to drive a Th2 immune response, has not yet been described during AE. Wild-type (WT) and IL-33-/- C57BL/6J mice were infected by peritoneal inoculation with E. multilocularis metacestodes and euthanized 4 months later, and their immune response were analyzed. Immunofluorescence staining and IL-33 enzyme-linked immunosorbent assay (ELISA) were also performed on liver samples from human patients with AE. Overall, metacestode lesions were smaller in IL-33-/- mice than in WT mice. IL-33 was detected in periparasitic tissues, but not in mouse or human serum. In infected mice, endogenous IL-33 modified peritoneal macrophage polarization and cytokine profiles. Th2 cytokine concentrations were positively correlated with parasite mass in WT mice, but not in IL-33-/- mice. In human AE patients, IL-33 concentrations were higher in parasitic tissues than in distant liver parenchyma. The main sources of IL-33 were CD31+ endothelial cells of the neovasculature, present within lymphoid periparasitic infiltrates together with FOXP3+ Tregs. In the murine model, periparasitic IL-33 correlated with accelerated parasite growth putatively through the polarization of M2-like macrophages and release of immunosuppressive cytokines IL-10 and transforming growth factor β1 (TGF-β1). We concluded that IL-33 is a key alarmin in AE that contributes to the tolerogenic effect of systemic Th2 cytokines. IMPORTANCE Infection with the metacestode stage of Echinococcus multilocularis, known as alveolar echinococcosis, is the most severe cestodosis worldwide. However, less than 1% of exposed individuals, in which the immune system is unable to control the parasite, develop the disease. The factors responsible for this interindividual variability are not fully understood. In this in vivo study comparing wild-type and IL-33-/- infected mice, together with data from human clinical samples, we determined that IL-33, an alarmin released following tissue injury and involved in the pathogenesis of cancer and asthma, accelerates the progression of the disease by modulating the periparasitic microenvironment. This suggests that targeting IL-33 could be of interest for the management of patients with AE, and that IL-33 polymorphisms could be responsible for increased susceptibility to AE

MLK Historic District: 493 Auburn Ave. NE

Prepared by the Fall 2010 Conservation of Historic Building Materials class. This Historic Structure Report contains the history of the three double-shotgun houses located at 493 Auburn Avenue built by Alexander Daniel Hamilton and his father, Alexander Hamilton, African-American father-and-son builders. The existing conditions of the interior, exterior, infrastructure, and grounds of the buildings are detailed, as well as a master plan of recommendations for the site. The purpose of this report is to provide a current assessment of the condition of the property, recommendations for needed repairs and options for future consideration.https://scholarworks.gsu.edu/history_heritagepreservation/1052/thumbnail.jp

Roswell, GA

Prepared by the Spring 2010 Preservation planning class. The Roswell Historic District Design Guidelines give an overview of the historic boundaries and their modern expansion. The guidelines illustrate appropriate structure styles for the district, both residential and commercial. Districts outlined in this design guidelines are the Mill Village and Town Square, Mimosa Boulevard Neighborhood, Uptown- Alpharetta Street Neighborhood, Uptown- Canton Street Neighborhood, and South Atlanta Street Neighborhood.https://scholarworks.gsu.edu/history_heritagepreservation/1037/thumbnail.jp

Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum

Disruption of the potassium/chloride cotransporter 3 (KCC3), encoded by the SLC12A6 gene, causes hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder affecting both the peripheral nervous system and CNS. However, the precise role of KCC3 in the maintenance of ion homeostasis in the nervous system and the pathogenic mechanisms leading to HMSN/ACC remain unclear. We established two Slc12a6 Cre/LoxP transgenic mouse lines expressing C-terminal truncated KCC3 in either a neuron-specific or ubiquitous fashion. Our results suggest that neuronal KCC3 expression is crucial for axon volume control. We also demonstrate that the neuropathic features of HMSN/ACC are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression. Furthermore, we demonstrate that KCC3 plays an essential role in inflammatory pain pathways. Finally, we observed hypoplasia of the corpus callosum in both mouse mutants and a marked decrease in axonal tracts serving the auditory cortex in only the general deletion mutant. Together, these results establish KCC3 as an important player in both central and peripheral nervous system maintenance

The Effectiveness of Passive Physical Modalities for the Management of Soft Tissue Injuries and Neuropathies of the Wrist and Hand: A Systematic Review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration

AbstractObjectiveThe purpose of this systematic review was to determine the effectiveness of passive physical modalities compared to other interventions, placebo/sham interventions, or no intervention in improving self-rated recovery, functional recovery, clinical outcomes and/or administrative outcomes (eg, time of disability benefits) in adults and/or children with soft tissue injuries and neuropathies of the wrist and hand.MethodsWe systematically searched MEDLINE, EMBASE, PsycINFO, and the Cochrane Central Register of Controlled Trials, accessed through Ovid Technologies, Inc, and CINAHL Plus with Full Text, accessed through EBSCO host, from 1990 to 2015. Our search strategies combined controlled vocabulary relevant to each database (eg, MeSH for MEDLINE) and text words relevant to our research question and the inclusion criteria. Randomized controlled trials, cohort studies, and case-control studies were eligible. Random pairs of independent reviewers screened studies for relevance and critically appraised relevant studies using the Scottish Intercollegiate Guidelines Network criteria. Studies with low risk of bias were synthesized following best evidence synthesis principles.ResultsWe screened 6618 articles and critically appraised 11 studies. Of those, 7 had low risk of bias: 5 addressed carpal tunnel syndrome (CTS) and 2 addressed de Quervain disease. We found evidence that various types of night splints lead to similar outcomes for the management of CTS. The evidence suggests that a night wrist splint is less effective than surgery in the short term but not in the long term. Furthermore, a night wrist splint and needle electroacupuncture lead to similar outcomes immediately postintervention. Finally, low-level laser therapy and placebo low-level laser therapy lead to similar outcomes. The evidence suggests that kinesio tape or a thumb spica cast offers short-term benefit for the management of de Quervain disease. Our search did not identify any low risk of bias studies examining the effectiveness of passive physical modalities for the management of other soft tissue injuries or neuropathies of the wrist and hand.ConclusionsDifferent night orthoses provided similar outcomes for CTS. Night orthoses offer similar outcomes to electroacupuncture but are less effective than surgery in the short term. This review suggests that kinesio tape or a thumb spica cast may offer short-term benefit for the management of de Quervain disease