Loss of Satb2 in the Cortex and Hippocampus Leads to Abnormal Behaviors in Mice

Satb2-associated syndrome (SAS) is a genetic disorder that results from the deletion or mutation of one allele within the Satb2 locus. Patients with SAS show behavioral abnormalities, including developmental delay/intellectual disability, hyperactivity, and symptoms of autism. To address the role of Satb2 in SAS-related behaviors and generate an SAS mouse model, Satb2 was deleted in the cortex and hippocampus of Emx1-Cre; Satb2flox/flox [Satb2 conditional knockout (CKO)] mice. Satb2 CKO mice showed hyperactivity, increased impulsivity, abnormal social novelty, and impaired spatial learning and memory. Furthermore, we also found that the development of neurons in cortical layer IV was defective in Satb2 CKO mice, as shown by the loss of layer-specific gene expression and abnormal thalamocortical projections. In summary, the abnormal behaviors revealed in Satb2 CKO mice may reflect the SAS symptoms associated with Satb2 mutation in human patients, possibly due to defective development of cortical neurons in multiple layers including alterations of their inputs/outputs

Generation of Coherent X-Ray Radiation Through Modulation Compression

In this paper, we propose a scheme to generate tunable coherent X-ray radiation for future light source applications. This scheme uses an energy chirped electron beam, a laser modulator, a laser chirper and two bunch compressors to generate a prebunched kilo-Ampere current electron beam from a few tens Ampere electron beam out of a linac. The initial modulation energy wavelength can be compressed by a factor of $1+h_b R_{56}^a$ in phase space, where $h_b$ is the energy bunch length chirp introduced by the laser chirper, $R_{56}^a$ is the momentum compaction factor of the first bunch compressor. As an illustration, we present an example to generate more than 400 MW, 170 attoseconds pulse, 1 nm coherent X-ray radiation using a 60 Ampere electron beam out of the linac and 200 nm laser seed. Both the final wavelength and the radiation pulse length in the proposed scheme are tunable by adjusting the compression factor and the laser parameters

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression

Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry. MP was funded by the Scottish Universities Life Science Alliance (SULSA) and the University of Aberdeen. Funding This work was supported by grants from British Council China (Sino-UK higher Education for PhD studies) to YD and CM, The Carnegie Trust for the Universities of Scotland (70190) and The NHS Grampian Endowment Funds (14/09) to BL, and National Natural Science Foundation of China (31528011) to BL and YD.Peer reviewedPostprin

Energy efficiency in energy harvesting cooperative networks with self-energy recycling

Cooperative communication has been identified as an important component in the 5G system. This paper considers a decode-and-forward (DF) relaying wireless cooperative network, in which the self-energy recycling relay is powered by radio-frequency (RF) signal from the source and its transmitted power from the loop-back channel. The harvested energy is used to support the relay transmissions. Based on a self-energy recycling relaying protocol, we study the optimization of energy efficiency in wireless cooperative networks. Although the formulated optimization problem is not convex, it can be re-constructed to a parametric problem in the convex form by using the non-linear fractional programming, to which closed form solutions can be found by using the Lagrange multiplier method. The simulation results are presented to verify the effectiveness of this solution proposed in this paper

Mars Atmospheric Entry Integrated Navigation with Partial Intermittent Measurements

Signal degradation suffered by the vehicle is a combination brownout and blackout during Mars atmospheric entry. The communications brownout means that signal fades and blackout means that the signal is lost completely. The communications brownout and blackout periods are analyzed and predicted with an altitude and velocity profiles. In the brownout period, the range measurements between the vehicle and the orbiters are modeled as intermittent measurements with the radio signal arrival probabilities, which are distributed as a Rayleigh distribution of the electron number density around the entry vehicle. A new integrated navigation strategy during the Mars atmospheric entry phase is proposed to consider the probabilities of the radio measurements in the communications brownout and blackout periods under the IMU/beacon scenario based on the information filter with intermittent measurements. Numerical navigation simulations are designed to show the performance of the proposed navigation strategy under the integrated navigation scenario