ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ ТА ЙОГО КОМОРБІДНІСТЬ

Summary. Diabetes is a complex health problem that has caused international concern over the past few decades. The aim of the study – to analyze the literature sources  on comorbid pathologies that are combined with the type 2 diabetes mellitus (T2DM). Materials and Methods. Scientific publications for the last decade was examined in the study, which are available in the Internet, the key words were “type 2 diabetes mellitus”, “comorbidity”, “concurrent diseases”. Results. Multimorbidity, presence of two or more chronic diseases [8], is characteristic for patients with T2DM, which makes multimorbidity an important clini­cal priority in this population. Because of similar risk factors such as obesity, endothelial dysfunction, vascular inflammation and dyslipidemia, patients with T2DM have higher risk of cardiovascular complications, kidney disease and hypertension. Patients with T2DM have also higher risk of depression, gastrointestinal disease, thyroid disease, and chronic obstructive pulmonary di­sease. T2DM is closely associated with overweight and low physical activity. Another complication of T2DM is erectile dysfunction. Although most of the scientific lite­rature highlights development of T2DM in patients with pancreatitis, there is an inverse relations: exocrine insufficiency of the pancreas is found in 35 % of patients with T2DM. In addition, high level of vitamin D deficiency is another factor associated with both obesity and type 2 diabetes mellitus. Conclusions. Analysis of literature sources indicates significant prevalence of comorbidity in patients with type 2 diabetes mellitus, which justifies the necessity of more detailed and comprehensive study of the mechanisms of combined pathology, peculiarities of course, methods of precaution, treatment and prevention of complications.Резюме. Цукровий діабет є складною проблемою охорони здоров’я, яка за останні кілька десятиліть викликає занепокоєння міжнародного рівня. Мета дослідження – проаналізувати літературні джерела щодо коморбідних патологій, які поєднано перебігають з цукровим діабетом 2 типу (T2DM). Матеріали і методи. У дослідженні опрацьовано наукові публікації за останнє десятиліття, які доступні у мережі «Інтернет», ключовими словами були: «цукровий діабет 2 типу», «коморбідність», «супутні захворювання». Результати. Мультиморбідність, наявність двох або більше хронічних захворювань, є характерним для пацієнтів з T2DM, що робить мультиморбідність у цій популяції важливим клінічним пріоритетом. Через схожі фактори ризику, такі, як ожиріння, ендотеліальна дисфункція, запалення судин та дисліпідемія, хворі на T2DM мають більш високий ризик серцево-судинних ускладнень, хвороб нирок та гіпертензії. Також у пацієнтів із T2DM встановлено більш високий ризик депресії, захворювань шлунково-кишкового тракту, щитоподібної залози та хронічного обструктивного захворювання легень. T2DM тісно пов’язаний із надмірною масою тіла та низькою фізичною активністю. Ще одним ускладненням T2DM є еректильна дисфункція. Хоча більшість наукової літератури присвячена розвитку T2DM у хворих на панкреатит, існує й зворотна залежність: екзокринна недостатність підшлункової залози виявляється у 35 % хворих на T2DM. Крім того, високий рівень дефіциту вітаміну D є ще одним фактором, пов’язаним як із ожирінням, так і з діабетом 2 типу. Висновки. Аналіз літературних джерел свідчить про значну поширеність коморбідності у хворих на цукровий діабет 2 типу, що обґрунтовує необхідність детальнішого й всебічного дослідження механізмів розвитку поєднаної патології, особливостей перебігу, методів профілактики, лікування та попередження ускладнень

Results of Work of the Rospotrebnadzor SAET on the Provision of Sanitary Epidemiological Welfare of the Population during the Summer Health-Promotion Campaign, 2014 in the Crimean Federal District

Integration of the Crimean Federal District (CFD) into the Russian Federation in March, 2014 predetermined the necessity to organize preventive activities, aimed at the provision of sanitary epidemiological welfare in the region. The paper observes the results of work of the specialized anti-epidemic teams, affiliated to the Stavropol Research Anti-Plague Institute and Russian Research Anti-Plague Institute “Microbe”, on the provision of assistance to CFD Sanitary Epidemiological Service (SES) in operational etiological investigation of infectious diseases outbreaks. Performed is the laboratory analysis of 2407 clinical and environmental samples. 676 tests out of 11518 have showed positive (non-standard) results. Given are the recommendations concerning optimization of work of the CFD SES facilities

Equity Ownership Strategy in Greenfield Investments : Influences of Host Country Infrastructure and MNE Resources in Emerging Markets

This chapter addresses equity ownership strategy in greenfield investments by multinational enterprises (MNEs) in the emerging markets (EMs). It is one of the few studies to hypothesize and analyze influences of host EM physical infrastructure in relation to investment decisions of MNEs. We use resource dependence theory (RDT) as a theoretical basis and test the moderating effects of firm resources like size and host country investment experience. Moreover, the current study assumes a more nuanced approach to studying equity ownership by analyzing wholly owned subsidiaries versus joint ventures (JVs) and including majority versus minority JVs in the analysis as well. The empirical results based on greenfield investments undertaken by Nordic (Danish, Finnish, Norwegian, and Swedish) MNEs in EMs during 1990–2015 reveals the importance of host country physical infrastructure for high equity ownership strategy. Moreover, host country investment experience moderates the effect of physical infrastructure on equity ownership strategy. Finally, the analysis of a sub-sample of greenfield JVs reveals that determinants of equity ownership strategy differ somewhat between greenfield JV or greenfield wholly owned subsidiaries (WOS).© The Author(s) 2019.fi=vertaisarvioitu|en=peerReviewed

Performance of the SAET of the Stavropol Anti-Plague Institute of the Rospotrebnadzor during the XXII Olympic and XI Paralympic Winter Games in Sochi

Given is a general overview of the SAET performance during the XXII Olympic and XI Paralympic Winter Games, 2014 in Sochi. Discussed are the peculiarities of work management of the SAET diagnostic facilities; represented are the data on the structure and scope of laboratory investigations of clinical material and environmental samples. Analyzed is the experience of operation under major international mass event. Consequently, it is concluded that current SAET structure, its stuffing and equipping, the laid-up stock of preparations and test-systems have allowed for coping with a diverse task complex in the laboratory diagnostics of infectious diseases and indication of their agents

Moyamoya disease in the practice of a pediatric-infectiologist

Moyamoya disease is a rare chronic cerebrovascular disorder characterized by gradually progressive luminal stenosis of the intracranial segments of the internal carotid artery and the initial segments of the anterior and middle cerebral arteries, thus forming a network of minor vascular anastomoses. Impaired blood supply in the above vessels due to occlusion leads to the development of ischemic and hemorrhagic strokes in the respective beds, causing a variety of neurological and visual disorders.Activation of herpesvirus infection in a 2-year-old infant provoked the onset of moyamoya disease. An abnormal posterior right eye segment (bindweed syndrome) detected by an ophthalmic examination, which is commonly concurrent with various cerebrovascular disorders, allowed cliniciansto adequately interpret mild transient neurologicalsymptoms and to rapidly diagnose moyamoya disease, by applying radiodiagnostic methods.The treatment involved antibiotic and antiviral therapy, infusion of glucose-salt solutions and encephabol. The infant’s status improved; seizures were stopped; right muscle tone fully recovered; and right hand tone remained reduced. Revascularization of  the middle and anterior cerebral arteries were further performed

Entry Mode Strategies: Are SMEs Any Different?

Adopting a quantitative explorative research design, we employed a sample of 770 foreign market entries in the period 2005-2015 to investigate whether particular entry mode strategies such as joint venture or wholly owned subsidiary are differently chosen by SMEs and large firms. Various tests have been carried out revealing that SMEs show some different features compared to large firms when selecting their entry mode. SMEs react differently to economic downturns and the diversification level is a crucial determinant for SMEs entry choices while it is not for large firms. Moreover, we found for a set of other factors affecting the entry choice of large firms, not being significant for SMEs. Implications of these findings are discussed

Доклади от научната сесия 70 години Медицински колеж-Варна 5 Октомври 2012

Варненски медицински форум (Varna Medical Forum) V. 1, No 1 (2012

Different forms of agency and institutional influences within multinational enterprises

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