1 research outputs found
COVID-19 vaccine failure
COVID-19 affects the population unequally with a higher impact on aged and
immunosuppressed people. Hence, we assessed the effect of SARS-CoV-2 vaccination
in immune compromised patients (older adults and oncohematologic patients),
compared with healthy counterparts. While the acquired humoral and cellular memory
did not predict subsequent infection 18 months after full immunization, spectral and
computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, NK
cells, monocytes and CD45RA+
CCR7- TγΎ cells differentially expressed in further
infected and non-infected individuals not just following immunization, but also prior to
that. Of note, up to 7 subsets were found within the CD45RA+
CCR7-
TγΎ population with
some of them being expanded and other decreased in subsequently infected individuals.
Moreover, some of these subsets also predicted COVID-induced hospitalization in
oncohematologic patients. Therefore, we hereby have identified several cellular subsets
that, even before vaccination, strongly related to COVID-19 vulnerability as opposed to
the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV2 mRNA vaccines.This study has been funded through Programa EstratĂ©gico Instituto de BiologĂa y
Genética Molecular (IBGM Junta de Castilla y León. Ref. CCVC8485), Junta de Castilla
y LeĂłn (Proyectos COVID 07.04.467B04.74011.0) and the European Commission â
NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform
(PTI Salud Global; SGL21-03-026 and SGL2021-03-038)N