Three essays on social interactions and education : theory and application

L’objectif principal de cette thèse est de proposer des méthodes d’identification des effets qui découlent des interactions sociales dans le contexte éducatif. La pertinence de ma recherche se trouve à trois niveaux : 1) elle nous aide à mieux mesurer l’impact du réseau social sur les comportements individuels ; 2) elle améliore notre compréhension de phénomènes sociaux négatifs tels que l’obésité ou le décrochage scolaire ; 3) elle permet de proposer des politiques publiques adaptées, qui permettent d’exploiter au mieux les effets qui découlent de ces interactions sociales en milieu scolaire. L’atteinte de nos objectifs se fait à travers trois chapitres. Le premier chapitre propose une nouvelle stratégie d’estimation de l’influence du réseau social sur les décisions individuelles dans un contexte d’interactions en réseau à l’aide d’expériences randomisées. Le chapitre combine le modèle structurel d’interactions sociale développé par Bramoullé et al. [2009] avec une expérience randomisée. Des conditions d’identification sont fournies et le modèle est estimé et validé sur des données expérimentales recueillies pour l’évaluation d’un programme de bourses d’études en Colombie. De par sa conception, la randomisation est au niveau de l’élève. Les données sur réseaux d’amitié révèlent que les étudiants traités et non traités interagissent ensemble. En plus de fournir des preuves sur la présence d’effets de pairs dans la fréquentation scolaire, le chapitre conclut que la non prise en considération des interactions sociales de pairs conduit à une surestimation de l’impact réel du programme. L’objectif du deuxième chapitre est de proposer un modèle qui tient compte de l’hétérogénéité des effets de pairs entre les différentes catégories d’individus dans un cadre d’interactions en réseau. Les catégories peuvent se composer du genre ou de la race de l’individu, entre autres. Des conditions d’identification d’un modèle qui généralise celui proposé par Bramoullé et al. [2009] sont dérivées, et l’hétérogénéité des effets de pairs est permise à l’intérieur et entre les catégories. À l’aide des données Add Health, le chapitre explore l’hétérogénéité sur le poids des adolescents mesuré par leur indice de masse corporelle, utilisant à la fois le genre et une catégorisation basée sur leur groupe racial. Les résultats montrent que l’effet positif endogène trouvé en utilisant le modèle homogène présente de l’hétérogénéité lorsque l’on considère ces deux catégorisations. Alors que les deux premiers chapitres de cette thèse étudient les réseaux d’amitié dans une tentative d’identifier les effets qui résultent des interactions sociales, le troisième chapitre considère le réseau de partage de cours -course-overlap- fourni par les études Add Health et AHAA. Le modèle est agrégé au niveau local et a la particularité, contrairement à d’autres études sur les effets de pairs, que la matrice d’interactions sociales considère les marges extensive et intensive. De plus, les interactions de ce type sont meilleures dans la conception des politiques scolaires. L’estimation du modèle sur les résultats scolaires généraux, en mathématiques et en sciences révèle la présence d’effets d’interaction sociales positives et significatives en utilisant les techniques des moindres carrés à deux étapes et la méthode des moments généralisés.The aim of this thesis is to investigate identification of peer effects and their application on a large set of outcomes, going from school attendance to obesity. The relevance of this research relies on three main points: 1) it allows better measurrement of effects stemming from social interactions, thus providing some answer to the numerous econometric issues that make the study of peer effects a lot challenging; 2) it improves our comprehension of negative social phenomena, including the incidence of school dropouts and obesity; 3) it proposes better public policies aiming at fighting against such phenomena by exploiting social network effects that contribute to amplify them. The different objectives of this thesis are investigated in three different chapters. The first chapter proposes a new strategy for estimating the influence of the social network on individual decisions in a network context using randomized experiments. It combinates the structural social network model developed by Bramoullé et al. [2009] and randomized experiments. New identification conditions that mostly require balance in the characteristics of friends between treatment and control groups are provided. The model is estimated and validated on experimental data collected for the evaluation of a scholarship program in Colombia. By design, randomization is at the student-level. Friendship data reveals that treated and untreated students interact together. Besides providing evidence of peer effects in schooling, the chapter concludes that ignoring peer effects would have led to an overestimation of the program actual impact. The aim of the second chapter is to propose a model that accounts for heterogeneity in peer effects between individual categories in a network setting. Identification conditions of a network-based interactions model that generalizes the one proposed by Bramoullé et al. [2009] are derived, and heterogeneity of peer effects is allowed within and between categories of individuals. Using the Add-Health dataset, the study explores heterogeneity in adolescents weight using both gender and racial categorizations. The results show that the positive endogenous effect found using the homogeneous model is actually heterogeneous when considering both gender and racial categorizations, as for example, females seem to be more influenced by their female friends than by their male friends. While the first two chapters consider friendship networks in an attempt to identify the effects that result from social interactions, the third chapter considers the course-overlaps network. The model is local agregate and has the feature, unlike other studies of peer effects, that the interaction matrix accounts for the extensive and intensive margins. Interactions of this type are better to design school policies. The chapter then proceeds to estimation of peer effects in overall GPA and GPAs in both mathematics and science courses using the Add Heakth and AHAA datasets. The results reveal the presence of positive and significant social interaction effects using both 2SLS and GMM estimation techniques

Accounting for Peer Effects in Treatment Response

When one's treatment status affects the outcomes of others, experimental data are not sufficient to identify a treatment causal impact. In order to account for peer effects in program response, we use a social network model. We estimate and validate the model on experimental data collected for the evaluation of a scholarship program in Colombia. By design, randomization is at the student-level. Friendship data reveals that treated and untreated students interact together. Besides providing evidence of peer effects in schooling, we find that ignoring peer effects would have led us to overstate the program actual impact

Genetic contribution of breast cancer genes in women of black African origin

Breast cancer (BC) is an increasing public health issue worldwide. BC incidence and mortality rates are rising in transitioning countries in Africa, with the most rapid increase occurring in Sub-Saharan Africa (SSA). Female BC represents 25.8% of all cancer diagnosis in SSA. Early age at onset, high grade and triple negative tumors are hallmarks of BC in this region, associated with germline pathogenic variants in susceptibility genes. While several genes have been associated with genetic predisposition (BRCA1, BRCA2, PALB2, TP53, PTEN, CDH1, STK11, ATM, CHEK2, NBN, BARD1, BRIP1, RAD50, RAD51C, RAD51D, … ), most studies have reported contribution of BRCA1 and BRCA2 pathogenic variants. Genetic contribution of BRCA genes has been estimated at 27% in Caucasian women. Available data from population of African origin are scarce and have mainly focused on pathogenic variants of BRCA1 and BRCA2. Reports from main studies on large sample size highlighted that BRCA1 still the major gene associated with BC in SSA. In addition, BRCA2, PALB2, and P53, are also on the top major genes with high penetrance, associated with BC. Mutation spectrum of BC genes in black African women seems to be different from Caucasian with increasing number of founder mutations identified. We hypothesis that the genetic contribution of known BC genes may be different between women of black African origin compared to Caucasians. In this review we explore the genetic contribution of known breast cancer genes in women of African origin, and discuss perspectives for prevention and patients care strategies in the era of precision medicine

Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal

International audienceBACKGROUND:Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved in the severe form of the disease.METHODS:Blood transcriptional levels were assessed in patients with cerebral malaria, non-cerebral malaria, or mild malaria by using microarray technology to look for gene expression profiles associated with clinical status. Multi-way ANOVA was used to extract differentially expressed genes. Network and pathways analyses were used to detect enrichment for biological pathways.RESULTS:We identified a set of 443 genes that were differentially expressed in the three patient groups after applying a false discovery rate of 10%. Since the cerebral patients displayed a particular transcriptional pattern, we focused our analysis on the differences between cerebral malaria patients and mild malaria patients. We further found 842 differentially expressed genes after applying a false discovery rate of 10%. Unsupervised hierarchical clustering of cerebral malaria-informative genes led to clustering of the cerebral malaria patients. The support vector machine method allowed us to correctly classify five out of six cerebral malaria patients and six of six mild malaria patients. Furthermore, the products of the differentially expressed genes were mapped onto a human protein-protein network. This led to the identification of the proteins with the highest number of interactions, including GSK3B, RELA, and APP. The enrichment analysis of the gene functional annotation indicates that genes involved in immune signalling pathways play a role in the occurrence of cerebral malaria. These include BCR-, TCR-, TLR-, cytokine-, FcεRI-, and FCGR- signalling pathways and natural killer cell cytotoxicity pathways, which are involved in the activation of immune cells. In addition, our results revealed an enrichment of genes involved in Alzheimer's disease.CONCLUSIONS:In the present study, we examine a set of genes whose expression differed in cerebral malaria patients and mild malaria patients. Moreover, our results provide new insights into the potential effect of the dysregulation of gene expression in immune pathways. Host genetic variation may partly explain such alteration of gene expression. Further studies are required to investigate this in African populations

Étude in vitro de l’effet antifalcémiant des globules rouges et de l’activité antioxydante d’extraits de la poudre de racines de Maytenus senegalensis Lam (Celestraceae)

La drépanocytose est une hémoglobinopathie largement répandue chez les populations africaines noires. Actuellement, très peu de traitements conventionnels existent sur le marché, d’où le recours à la médecine traditionnelle. Maytenus senegalensis est une plante prescrite par les tradipraticiens dans la prise en charge de la drépanocytose. L’activité antifalcémiante des extraits de la poudre de racines de Maytenus senegalensis a été étudiée dans ce travail. Après obtention de l’extrait hexanique par extraction à l’aide d’un Soxhlet, le marc est macéré dans de l’acétate d’éthyle puis dans du méthanol pour donner les extraits correspondants. L’activité des fractions a été évaluée sur des drépanocytes de type SS. Les activités antifalcémiantes les plus importantes ont été observées pour les fractions polaires du méthanol et de l’acétate d’éthyle avec des taux d’inversion de la falciformation respectivement de 77% et de 65% à 10 mg/mL. Les activités antioxydantes de M. senegalensis (CI50 = 0,195 ± 0,004 mg/mL) et de l’acide ascorbique (CI50 = 0,078 ± 0,002 mg/mL) ont été déterminées. Les pouvoirs antioxydants (PA) montrent que l’activité antiradicalaire de l’acide ascorbique (PA = 12,85) est 2,5 fois meilleure que celle de M. senegalensis (PA = 5,14). Les résultats de l’étude justifient l’utilisation traditionnelle des racines de Maytenus senegalensis dans la prise en charge de la drépanocytose.Mots clés : Hémoglobine, drépanocytose, Maytenus senegalensis, activité antifalcémiante, stress oxydant, radicaux libres, activité antioxydante

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria. Methods Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed. Results We evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients. Conclusions Our results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes

Genetic Determination and Linkage Mapping of Plasmodium falciparum Malaria Related Traits in Senegal

Plasmodium falciparum malaria episodes may vary considerably in their severity and clinical manifestations. There is good evidence that host genetic factors contribute to this variability. To date, most genetic studies aiming at the identification of these genes have used a case/control study design for severe malaria, exploring specific candidate genes. Here, we performed a family-based genetic study of falciparum malaria related phenotypes in two independent longitudinal survey cohorts, as a first step towards the identification of genes and mechanisms involved in the outcome of infection. We studied two Senegalese villages, Dielmo and Ndiop that differ in ethnicity, malaria transmission and endemicity. We performed genome-scan linkage analysis of several malaria-related phenotypes both during clinical attacks and asymptomatic infection. We show evidence for a strong genetic contribution to both the number of clinical falciparum malaria attacks and the asymptomatic parasite density. The asymptomatic parasite density showed linkage to chromosome 5q31 (LOD = 2.26, empirical p = 0.0014, Dielmo), confirming previous findings in other studies. Suggestive linkage values were also obtained at three additional chromosome regions: the number of clinical malaria attacks on chromosome 5p15 (LOD = 2.57, empirical p = 0.001, Dielmo) and 13q13 (LOD = 2.37, empirical p = 0.0014 Dielmo), and the maximum parasite density during asymptomatic infection on chromosome 12q21 (LOD = 3.1, empirical p<10−4, Ndiop). While regions of linkage show little overlap with genes known to be involved in severe malaria, the four regions appear to overlap with regions linked to asthma or atopy related traits, suggesting that common immune related pathways may be involved

Susbsidies and cluster policy in French NUTS3 Regions. Direct and indirect effects through space and co-patenting networks

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Collaboration dynamics within clusters and impact analysis

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Financial market reaction to cyberattacks

International audienceDrawing upon an extensive dataset comprising 3,680 cyberattacks on firms listed in 5 stock markets, our main objective is to ascertain the financial market reaction based on a hybrid valuation inspired by the event study methodology and a counterfactual analysis. Analyses concern three dates that are specific to cyberattacks: 1) the accident date; 2) the first notice date; and 3) the original loss start date. Results indicate that there is a negative abnormal return for the NASDAQ after the accident date. The reactions of the NASDAQ and NYSE are similar, and negative for the first notice date but positive after the original loss start date. In the European context, cumulative abnormal returns are negative for French and German companies after the first notice date