Pengaruh Pemanfaatan Teknologi Informasi, Penerapan Sistem Akuntansi Keuangan Daerah, dan Penerapan Standar Akuntansi Pemerintahan terhadap Kualitas Laporan Keuangan Daerah (Studi Empiris pada Skpd Provinsi Riau)

This research aim to analyze the impact of empirical utilization of information technology, the application of regions Financial Accounting System and application of the government accounting standards on the quality of regions financial reporting area in Riau province. Analysis method used in this research was multiple regression using SPSS Version 20. Population in this research is the all of Echelon III and IV Unit in the Riau provincial government amounting to 1063 people. Respondents of this research is some have maintained echelon III and IV in each SKPD (satuan kerja perangkat daerah) Riau Province. Echelon III and IV was chosen as respondents with the reason to look at managerial performance in the financial quality reporting area. Results of this research is the utilization of information technology, Implementation of Regions Financial Accounting System , Implementation of the Government Accounting Standards significantly positive affects the quality of the regions financial reporting that can be viewed by t> t table.Keywords: Information Technology, Accounting, Government, Quality and Reporting

Surgical Risk for Adult with Tetralogy of Fallot

Background. The beneficiaries of successful pediatric cardiac surgery and cardiology increases surgical treatment in the adult population with congenital heart disease. Adults patient with Tetralogy of Fallot (TOF) will need surgery either reoperative, palliative or more commonly reparative by the time they come. Many of them face the prospect of further operations, arrhythmias, complications and if managed inappropriately will increase risk of heart failure and premature death. This study presents the early surgical results of adult TOF. Methods and results.Data were reviewed retrospectively related to the hospital course of TOF adult patients (age > 17 years) from June 1, 1998 to December 30, 2006 who require surgical treatment in National Cardiac Center - Harapan Kita, Indonesia. Most of the operations were corrective procedures (20 patients, 66.7%), followed by palliative procedures (6 patients, 20%), and reoperations (4 patients, 13.3%). Mean age at surgery was 20.87+5.49 years. There were no hospital mortality in the primary corrective group, one death (16.7) in the palliative group related to poor left ventricular function, and one death (25%) in the reoperation group related to perioperative bleeding. Follow up data of 11.73+17.68 months duration were available in 28 of 30 patients (93%) who were discharged home. Overall survival probability is higher for corrective procedures than palliative and reoperative procedures. Conclusions. Surgical treatment of TOF in adult patients proved quite save and beneficial

Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain

Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m2, respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood–brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.Jana V. van Vliet-Ostaptchouk is supported by a Diabetes Funds Junior Fellowship from the Dutch Diabetes Research Foundation (project no. 2013.81.1673). This work was supported by the National Consortium for Healthy Ageing (NCHA) (NCHA NGI Grant 050-060-810), and the European Union’s Seventh Framework program (FP7/2007-2013) through the BioSHaRE-EU (Biobank Standardization and Harmonization for Research Excellence in the European Union) project, grant agreement 261433, and by the Danish Center on Endocrine Disrupters and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC)

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder that frequently results in renal fallure due to progressive cyst development. The major locus, PKD1, maps to 16p13.3. We identified a chromosome translocation associated with ADPKD that disrupts a gene (PBP) encoding a 14 kb transcript in the PKD1 candidate region. Further mutations of the PBP gene were found in PKD1 patients, two deletions (one a de novo event) and a splicing defect, confirming that PBP is the PKD1 gene. This gene is located adjacent to the TSC2 locus in a genomic region that is reiterated more proximally on 16p. The duplicate area encodes three transcripts substantially homologous to the PKD1 transcript. Partial sequence analysis of the PKD1 transcript shows that it encodes a novel protein whose function is at present unknown

Alterations in Epithelial and Mesenchymal Intestinal Gene Expression During Doxorubicin-Induced Mucositis in Mice

In the current study we aimed to gain insight into epithelial-mesenchymal cross-talk and progenitor compartment modulation during doxorubicin (DOX)-induced mucositis in mice. Intestinal segments were collected on various days after DOX treatment. DOX-induced damage at day 1–2 was characterized by increased epithelial proliferation and apoptosis and a decrease in the expression of epithelial differentiation markers. Concurrently, T-cell factor-4 (TCF4) levels increased and the epithelial differentiation enhancing factor, bone morphogenic protein-4 (BMP4), decreased. During severe damage (day 3), BMP4 levels were significantly increased, which inversely correlated with epithelial proliferation. At the same time, the expression of the epithelial differentiation markers was increasing again. At day 7, BMP4 levels were down-regulated, while the levels of the epithelial differentiation markers and TCF4 were normalized again. These data suggest that in response to DOX-induced damage, BMP4 and TCF4 are modulated in such a way that homeostasis of the progenitor compartment is partly preserved

Peran dan Kewenangan Profesi Penunjang Pasar Modal (Notaris) dalam Menghadapi Era Globalisasi

This study aims to examine the legal arrangements for the role and authority of the capital market supporting profession in the face of globalization, namely the notary public. Notary public is a public official who has the authority to make a contract deed or decision required by law to be made in confirmed documents. The position of a notary is regulated in Law No. 30 of 2004 which states that a notary public is the authorized official to make an authentic deed and other authorities. This study uses a normative juridical method that is analytical descriptive. The notary is authorized to make authentic deeds about all agreements, deeds, and stipulations that are required by legislation and / or that are desired by the parties concerned to be stated in the authentic deed. In addition, the notary must also ensure the certainty of the date of making the deed, keep the deed, give the grosse, copy and quote the deed, all of it as long as the making of the deeds are not also assigned or excluded to other officials

Analisis Karakteristik Followers dan Konten Iklan dalam Mengukur Efektivitas Instagram Stories Advertisement pada Produk Kosmetik Wardah

Penelitian ini bertujuan untuk menjelaskan dan menggambarkan apakah terdapat pengaruh karakteristik followers dan konten iklan terhadap efektivitas instagram stories advertisement. Penelitian ini menggunakan metode kuantitatif, dengan pendekatan deskriptif asosiatif. Teknik pemilihan sampel pada penelitian ini menggunakan teknik non probability sampling, yakni Purposive Sampling dimana peneliti hanya mengambil sampel yang menjadi kriteria dalam penelitian ini. Teknik pengumpulan data pada penelitian ini yaitu dengan melakukan penyebaran kuesioner online kepada 200 responden. Penelitian ini dilakukan pada akun media sosial instagram produk kosmetik wardah dengan id @wardahbeauty. Teori pemasaran digital merupakan teori utama yang digunakan dalam penelitian ini, dimana menurut teori ini pemasaran digital akan memberikan peluang bagi para pemasar untuk mempromosikan barang atau jasa melalui konten iklan dengan layanan yang cepat dan interaksi pemasaran yang lebih interaktif, real time, dan efektif. Teknik analisis yang digunakan pada penelitian ini adalah analisis regresi linear berganda. Berdasarkan hasil penelitian dapat disimpulkan bahwa hasil pengujian hipotesis memperlihatkan variabel karakteristik followers berpengaruh signifikan terhadap variabel efektivitas iklan dan variabel konten iklan berpengaruh signifikan terhadap variabel efektivitas iklan. Adapun hasil pengukuran efektivitas iklan dengan menggunakan AISAS model berada pada rentang skala efektif

Design and Development of Archive Management Application in East Java Lamongan Area of Service

Badan Kepegawaian Daerah is a government agency that has the task to make the formulation and implementation of policies and conduct education and training. Currently BKD has managed all employment documents. management is still done manually, the absence of recording of borrowing and return of documents. Problems - problems that arise from the condition of the company above is the loss of archival documents because the return is not returned properly due to lack of loan record. In addition, when searching documents will take a long time ranging from 30 to 60 minutes depending on the number of documents sought. It also happens to not get the document while searching, because when the document is completed lent is not returned properly or misplaced in the process of return. The next problem is the absence of recording while borrowing documents and also returning documents. The problem caused no history of the document whether it has been returned or has not been returned so that the impact when searching the document because there is no document information being borrowed or not.To solve the problem, the Archives Archive Management Dictionary will be created which can record all document management activitie