Combined frequency-amplitude nonlinear modulation: theory and applications

In this work we formulate a generalized theoretical model to describe the nonlinear dynamics observed in combined frequency-amplitude modulators whose characteristic parameters exhibit a nonlinear dependence on the input modulating signal. The derived analytical solution may give a satisfactory explanation of recent laboratory observations on magnetic spin-transfer oscillators and fully agrees with results of micromagnetic calculations. Since the theory has been developed independently of the mechanism causing the nonlinearities, it may encompass the description of modulation processes of any physical nature, a promising feature for potential applications in the field of communication systems.Comment: 8 pages, 4 figures, to be published on IEEE Transactions on Magnetic

Location Analytics in Information Systems: Innovative Applications & Research Opportunities

Some organizations have found competitive advantages through location analytics, yet such methods are rarely taught, applied, or researched within the information systems discipline. Instead, questions about location or analysis of location data are frequently treated as an afterthought or special case rather than an integral part of most business processes. Hence, organizations rarely adopt location analytics as a core enabler for remaining competitive or gaining a competitive advantage. Location analytics is an exciting opportunity for information systems programs to discover innovative industry applications, expand research approaches, and meet a critical workforce need through curricular enhancements. Many industries have yet to discover the capabilities of practical analyses of location-based data to drive decisions and inform strategy. Similarly, most information systems research (analytical, organizational, and behavioral) does not include spatial methodologies and theories. Finally, industries that hire information systems majors expect them to be able to work with a variety of data, including spatial data. Therefore, exposing information systems students to advanced spatial problem solving and analysis is critical. Our panel will share ideas for implementing innovative spatial analysis within industries, present examples of how spatial dimensions can inform richer and more rigorous research methodologies, and discuss how to best ensure that information systems students are exposed to spatial analysis. We invite those curious about bringing innovation to the IS curriculum to join us on an exploratory journey about location analytics in industry, research, and the classroom

High spatial resolution and high contrast optical speckle imaging with FASTCAM at the ORM

In this paper, we present an original observational approach, which combines, for the first time, traditional speckle imaging with image post-processing to obtain in the optical domain diffraction-limited images with high contrast (1e-5) within 0.5 to 2 arcseconds around a bright star. The post-processing step is based on wavelet filtering an has analogy with edge enhancement and high-pass filtering. Our I-band on-sky results with the 2.5-m Nordic Telescope (NOT) and the lucky imaging instrument FASTCAM show that we are able to detect L-type brown dwarf companions around a solar-type star with a contrast DI~12 at 2" and with no use of any coronographic capability, which greatly simplifies the instrumental and hardware approach. This object has been detected from the ground in J and H bands so far only with AO-assisted 8-10 m class telescopes (Gemini, Keck), although more recently detected with small-class telescopes in the K band. Discussing the advantage and disadvantage of the optical regime for the detection of faint intrinsic fluxes close to bright stars, we develop some perspectives for other fields, including the study of dense cores in globular clusters. To the best of our knowledge this is the first time that high contrast considerations are included in optical speckle imaging approach.Comment: Proceedings of SPIE conference - Ground-based and Airborne Instrumentation for Astronomy III (Conference 7735), San Diego 201

Cutaneous Biology: In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades

Pemphigus vulgaris (PV) is an autoimmune disease characterized by mucocutaneous intraepithelial blisters and pathogenic autoantibodies against desmoglein 3. The mechanism of blister formation in pemphigus has not been defined; however, in vitro data suggest a role for activation of intracellular signalling cascades. OBJECTIVES: To investigate the contribution of these signalling pathways to the mechanism of PV IgG-induced acantholysis in vivo. METHODS: We used the passive transfer mouse model. Mice were injected with IgG fractions of sera from a patient with PV, with or without pretreatment with inhibitors of proteins that mediate intracellular signalling cascades. RESULTS: Inhibitors of tyrosine kinases, phospholipase C, calmodulin and the serine/threonine kinase protein kinase C prevented PV IgG-induced acantholysis in vivo. CONCLUSIONS: These observations strongly support the role of intracellular signalling cascades in the molecular mechanism of PV IgG-induced acantholysi

Supersymmetric QCD flavor changing top quark decay

We present a detailed and complete calculation of the gluino and scalar quarks contribution to the flavour-changing top quark decay into a charm quark and a photon, gluon, or a Z boson within the minimal supersymmetric standard model including flavour changing gluino-quarks-scalar quarks couplings in the right-handed sector. We compare the results with the ones presented in an earlier paper where we considered flavour changing couplings only in the left-handed sector. We show that these new couplings have important consequences leading to a large enhancement when the mixing of the scalar partners of the left- and right-handed top quark is included. Furthermore CP violation in the flavour changing top quark decay will occur when a SUSY phase is taken into account.Comment: 14 pages, latex, 3 figure

Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population\u27s treatment response

Experimental aspects of SU(5)xU(1) supergravity

We study various aspects of $SU(5)\times U(1)$ supergravity as they relate to the experimental verification or falsification of this model. We consider two string-inspired, universal, one-parameter, no-scale soft-supersymmetry-breaking scenarios, driven by the $F$-terms of the moduli and dilaton fields. The model is described in terms of the supersymmetry mass scale (\ie, the chargino mass $m_{\chi^\pm_1}$), $\tan\beta$, and the top-quark mass. We first determine the combined effect on the parameter space of all presently available direct and indirect experimental constraints, including the LEP lower bounds on sparticle and Higgs-boson masses, the $b\to s\gamma$ rate, the anomalous magnetic moment of the muon, the high-precision electroweak parameters $\epsilon_1,\epsilon_b$ (which imply m_t\lsim180\GeV), and the muon fluxes in underground detectors (neutrino telescopes). For the still-allowed points in $(m_{\chi^\pm_1},\tan\beta)$ parameter space, we re-evaluate the experimental situation at the Tevatron, LEPII, and HERA. In the 1994 run, the Tevatron could probe chargino masses as high as 100 GeV. At LEPII the parameter space could be explored with probes of different resolutions: Higgs boson searches, selectron searches, and chargino searches. Moreover, for m_t\lsim150\GeV, these Higgs-boson searches could explore all of the allowed parameter space with \sqrt{s}\lsim210\GeV.Comment: latex, 36 pages, 25 figures (not included). Figures are available via anonymous ftp from hplaa02.cern.ch (/pub/lopez) as either 33 ps files (Easpects*.ps, 8.1MB) or one uuencoded file (AllFigures.uu, 3.7MB

A Shape-based Approach to Creativity and Connection Making

Creativity can be driven by cross-pollinating ideas, often from divergent disciplines, and synthesizing them into something ‘original’. This workshop presents a shape-based activity that uses polyhedra as an abstract external stimulus to inspire creative design responses. Concepts generated during a participatory community workshop are presented as example outcomes of this pedagogic approach