Overtime Violations

Overtime violations are especially prevalent in low wage jobs. Some of the industries with notably high instances of violations include the restaurant and hotel industries, retail, drug and grocery stores, private households and home health care. Within these industries, occupations with the most overtime violations include childcare workers, home health care workers, waiters and bartenders, cooks and food preparers, retail salespeople, cashiers and stock clerks. A quick glance at the national median hourly wages for these jobs shows that they all pay around just ten dollars an hour. This averages out to just 100 percent of the poverty level for a single person, which would make the worker eligible for various kinds of public assistance in New York State. Thus, the workers who are making the least amount of money are the ones who are most vulnerable to this exploitation

Youth Community Informatics: Engagement through Technology-Supported Inquiry into Community Issues

Youth Community Informatics (YCI) engages under-served youth as leaders in using cutting-edge technologies to address local community issues in semi-formal and informal education contexts. This poster gives an overview of program activities and goals, presents preliminary quantitative and qualitative data on the program's impact for participants and invites dialog with conference participants.published or submitted for publicatio

Effectiveness of an online homework system in a career college mathematics class

This study investigated the impact the online homework system MyLabsPlus (MLP) had on student success in Introductory Algebra at a career college. Seventy-four students from five classrooms at the same campus participated in this study. The participants??? beginning mathematics skills were assessed upon admission to the college. The results of the pre-assessment, grades and attendance were recorded for five Introductory Algebra classes. These classes were taught by four different instructors. Results demonstrated no statistical difference in final course grades between students using MLP homework and students using textbook homework even when controlling for beginning mathematics skills and attendance. Discussions of why MLP was not more effective and recommendations for further research are included

Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepan-cies in understanding the complex role of PPARβ/δ in disease, having both anti‐ and pro‐effects on inflammation. After ligand activation, PPARβ/δ regulates genes by two different mechanisms; induction and transrepression, the effects of which are difficult to differentiate directly. We studied the PPARβ/δ‐regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL‐6) of rat pulmonary artery, using different combinations of agonists (GW0742 or L−165402) and antagonists (GSK3787 or GSK0660). LPS induced release of NO and IL‐6 is not significantly reduced by incubation with PPARβ/δ ligands (either agonist or antagonist), however, co-incubation with an agonist and antagonist significantly reduces LPS‐induced nitrite production and Nos2 mRNA expression. In contrast, incubation with LPS and PPARβ/δ agonists leads to a significant increase in Pdk−4 and Angptl−4 mRNA expression, which is significantly decreased in the presence of PPARβ/δ antagonists. Docking using computational chemistry methods indicates that PPARβ/δ agonists form polar bonds with His287, His413 and Tyr437, while antagonists are more promiscuous about which amino acids they bind to, although they are very prone to bind Thr252 and Asn307. Dual binding in the PPARβ/δ binding pocket indicates the ligands retain similar binding energies, which suggests that co‐incubation with both agonist and antagonist does not prevent the specific binding of each other to the large PPARβ/δ binding pocket. To our knowledge, this is the first time that the possibility of binding two ligands simultaneously into the PPARβ/δ binding pocket has been explored. Agonist binding followed by antagonist simultaneously switches the PPARβ/δ mode of action from induction to transrepression, which is linked with an increase in Nos2 mRNA expression and nitrite production.Peer reviewedFinal Published versio

Civic Engagement Assessment: Linking Activities to Attitudes

In the March-April 2005 issue of Assessment Update, Trudy Banta issued a call to readers to provide information on individual campuses’ efforts to assess civic engagement. This call has prompted us to share the multifaceted approach that Tuffs University has taken to describe and assess this area of student endeavor. Specifically, we will describe an in-depth study designed to investigate undergraduates’ participation in and attitudes toward civic engagement

The non-genomic effects of the PPARβγ agonist GW0742 on streptozotocin treated rat aorta

Copyright© Bentham Science Publishers; For any queries, please email at [email protected]: The ubiquitous nuclear receptor PPARβ/δ is increasingly being studied in regards to numerous diseases including diabetes following on the finding that PPARβ/δ agonist GW0742 controls Type 1 Diabetes in rats. Studies have shown that GW0742 has off target, non- PPARβ/δ effects in the cell although there are some key questions that remain to be addressed in respect to the significance of this control on vascular tone. Methods: Using isometric organ baths, rat aorta rings were exposed to ROCK inhibitors and the changes in contraction and dilation measured. Results: Our data shows that the PPARβ/δ agonist GW0742 (10 -7M) inhibits contractile responses to U46619 and phenylephrine, and that these responses are similar in normal and Streptozotocin (STZ) diabetic rat aorta. ROCK inhibitors Fasudil and Y27632 significantly reduced GW0742 mediated dilation of naïve rat aorta, but Fasudil had no effect on GW0742 dilation in STZ diabetic rat aorta. In contrast, STZ diabetic rat aorta pre-contracted with high [K +] Krebs lacked a dilatory response to GW0742, which taken together indicates that the mechanism of action of GW0742 mediated dilation changes in the diabetic state compared to non-diabetic state. Conclusion: This is the first direct evidence demonstrating the non- PPARβ/δ effect of GW0742 on contraction is irrespective to the diabetic state, and that GW0742 has the potential to induce vasodilation via multiple off-target mechanisms.Peer reviewedFinal Accepted Versio

Civic Engagement: a Study of Changes in College

Using a mixed method longitudinal cohort design, the Tufts University study is examining student involvement in and attitudes towards civic engagement during the undergraduate years and beyond. It does this by using baseline data from students’ levels of community service in high school and then analyzes a variety of curricular and co-curricular experiences in college. This article focuses solely on the research design and some preliminary findings of students’ civic attitudes during their first two years of college