Governing Nanomedicine: Lessons from within, and for the EU medical technology regulatory framework.

Rapidly emerging technologies, such as nanotechnologies, are posing significant\ud challenges to regulatory governance due to the uncertainties of development\ud trajectories, product properties, and potential risk problems (Davies\ud 2009). While nanotechnology-based products and processes fall within the\ud scope of current regulatory instruments (European Commission 2008a;\ud Ludlow, Bowman, and Hodge 2007; van Calster 2006), there is increasing\ud concern that such frameworks may not be appropriate for adequately or\ud effectively regulating all dimensions of the technology (see, for example,\ud House of Lords Science and Technology Committee 2010; European Parliament\ud 2009a; Chaudhry et al. 2006; Taylor 2008, 2006; Royal Society and\ud Royal Academy of Engineering 2004). The traditional approach of evidencebased\ud regulation is not equipped to cope with myriad uncertainties surrounding\ud the development and commercialisation of nanotechnologies. This does\ud not mean that public policy can wait and see, however. Even in the case of\ud evidence deficiencies, public responsibility goes beyond a laissez-faire\ud approach to risk regulation. In the European Union and some other countries,\ud precautionary regulatory action is required when basic values like\ud human dignity, health, safety, environment, property, and privacy are at risk\ud (Fisher 2007; European Commission 2000)

Video Games as Time Machines: Video Game Nostalgia and the Success of Retro Gaming

This article conceptually integrates research on the experience of nostalgia—defined as a predominantly positive, social, and past-oriented emotion—into the fold of video game research. We emphasize the role of nostalgia as an explanation for contemporary retro gaming trends, and suggest that nostalgia towards gaming events is a necessary area of research. To those ends, we broadly review existing literature on nostalgia before specifically focusing on media-induced nostalgia, and demonstrate how theoretical and empirical observations from this work can be applied to understand video game nostalgia. In particular, we argue that engaging in older gaming experiences indirectly (via memories) and even directly (via replaying or recreating experiences) elicits nostalgia, which in turn contributes to players’ self-optimization and enhanced well-being. Moreover, as gamers and the medium mature together, nostalgic experiences with the medium are likely to become increasingly prevalent. The broad aim of this article is to offer future directions for research on video game nostalgia and provide a research agenda for research in this area

A Critical Analysis of the Environmental Dossiers from the OECD Sponsorship Programme for the Testing of Manufactured Nanomaterials

In 2015, the OECD finally published the findings of its seven year testing programme for manufactured nanomaterials.</p

The neural processing of moral sensitivity to issues of justice and care.

The empirical and theoretical consideration of ethical decision making has focused on the process of moral judgment; however, a precondition to judgment is moral sensitivity, the ability to detect and evaluate moral issues [Rest, J. R. (1984). The major components of morality. In W. Kurtines & J. Gewirtz (Eds.), Morality, moral behaviour, and moral development (pp. 24–38). New York, NY: Wiley]. Using functional magnetic resonance imaging (fMRI) and contextually standardized, real life moral issues, we demonstrate that sensitivity to moral issues is associated with activation of the polar medial prefrontal cortex, dorsal posterior cingulate cortex, and posterior superior temporal sulcus (STS). These activations suggest that moral sensitivity is related to access to knowledge unique to one\u27s self, supported by autobiographical memory retrieval and social perspective taking. We also assessed whether sensitivity to rule-based or “justice” moral issues versus social situational or “care” moral issues is associated with dissociable neural processing events. Sensitivity to justice issues was associated with greater activation of the left intraparietal sulcus, whereas sensitivity to care issues was associated with greater activation of the ventral posterior cingulate cortex, ventromedial and dorsolateral prefrontal cortex, and thalamus. These results suggest a role for access to self histories and identities and social perspectives in sensitivity to moral issues, provide neural representations of the subcomponent process of moral sensitivity originally proposed by Rest, and support differing neural information processing for the interpretive recognition of justice and care moral issues

High Volume Hydraulic Fracturing In Michigan Integrated Assessment Final Report

This report is part of the Hydraulic Fracturing in Michigan Integrated Assessment (IA) which has been underway since 2012. The guiding question of the IA is, “What are the best environmental, economic, social, and technological approaches for managing hydraulic fracturing in the State of Michigan?” The purpose of the IA is to present information that: • expands and clarifies the scope of policy options, and • allows a wide range of decision makers to make choices based on their preferences and values. As a result, the IA does not advocate for recommended courses of action. Rather, it presents information about the likely strengths, weaknesses, and outcomes of various options to support informed decision making. The project’s first phase involved the preparation of technical reports on key topics related to hydraulic fracturing in Michigan which were released by the University of Michigan’s Graham Sustainability Institute in September 2013. This document is the final report for the IA. The IA report has been informed by the technical reports, input from an Advisory Committee with representatives from corporate, governmental, and non-governmental organizations, a peer review panel, and numerous public comments received throughout this process. However, the report does not necessarily reflect the views of the Advisory Committee or any other group which has provided input. As with preparation of the technical reports, all decisions regarding content of project analyses and reports have been determined by the IA Report and Integration Teams. While the IA has attempted to provide a comprehensive review of the current status and trends of high volume hydraulic fracturing (HVHF), specifically, in Michigan (the technical reports) and an analysis of policy options (this report) there are certain limitations which must be recognized: • The assessment does not and was not intended to provide a quantitative assessment (human health or environmental) of the potential risks associated with HVHF. Completing such assessments is currently a key point of national discussion related to HVHF despite the challenges of uncertainty and limited available data–particularly baseline data. • The assessment does not provide an economic analysis or a cost-benefit analysis of the presented policy options. While economic strengths and/or weaknesses were identified for many of the options, these should not be viewed as full economic analyses. Additional study would be needed to fully assess the economic impact of various policy actions, including no change of current policy.U-M Graham Sustainability InstituteU-M Energy InstituteU-M Erb Institute for Global Sustainable EnterpriseU-M Risk Science CenterPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113663/1/HF-IA-Final-Report.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/113663/2/HF-IA-Final-Exec-Summary.pdf-1Description of HF-IA-Final-Report.pdf : Full ReportDescription of HF-IA-Final-Exec-Summary.pdf : Executive Summar

Assessing Addictions in a Spiritual World: Using Confirmatory Factor Analysis and Structural Equations Modeling to Develop the Life Interests Questionnaire

This study uses the thoughts and writings of Evagrius of Ponticus to provide a measure useful in assessing addictions in relation to spirituality. Evagrius (1972) theorizes that there are eight tempting thoughts that can form the basis of disordered attachments, and that these deadly thoughts could lead one to a life of addictions. These thoughts formed the foundation of the Life Interests Questionnaire (LIQ). This self-report survey consists of 170 items, all of which are scored on a Likert scale (1 = strongly agree and 5 = strongly disagree). The LIQ was paired with an interest survey containing 43 items taken from previously tested measures. These questions asked about one’s religious identification, locus of control, and beliefs about the world. In a pilot study, each attachment item group was examined through confirmatory factor analysis which allowed the substructure of the questionnaire to be examined and the overall fit of the model was found to be marginally adequate (GFI 0.8889). Reliability and validity of this measure were attained primarily through construct validity and it found both a valid and reliable measure of Evagrius’s underlying theory. Future plans include correlational studies between religious identification/practices and level of disordered attachments

Neighborhood-corrected interface discontinuity factors for multi-group pin-by-pin diffusion calculations for LWR

Performing three-dimensional pin-by-pin full core calculations based on an improved solution of the multi-group diffusion equation is an affordable option nowadays to compute accurate local safety parameters for light water reactors. Since a transport approximation is solved, appropriate correction factors, such as interface discontinuity factors, are required to nearly reproduce the fully heterogeneous transport solution. Calculating exact pin-by-pin discontinuity factors requires the knowledge of the heterogeneous neutron flux distribution, which depends on the boundary conditions of the pin-cell as well as the local variables along the nuclear reactor operation. As a consequence, it is impractical to compute them for each possible configuration; however, inaccurate correction factors are one major source of error in core analysis when using multi-group diffusion theory. An alternative to generate accurate pin-by-pin interface discontinuity factors is to build a functional-fitting that allows incorporating the environment dependence in the computed values. This paper suggests a methodology to consider the neighborhood effect based on the Analytic Coarse-Mesh Finite Difference method for the multi-group diffusion equation. It has been applied to both definitions of interface discontinuity factors, the one based on the Generalized Equivalence Theory and the one based on Black-Box Homogenization, and for different few energy groups structures. Conclusions are drawn over the optimal functional-fitting and demonstrative results are obtained with the multi-group pin-by-pin diffusion code COBAYA3 for representative PWR configurations

Running Head: Video Game Nostalgia and Retro Gaming

This article conceptually integrates research on the experience of nostalgia—defined as a predominantly positive, social, and past-oriented emotion—into the fold of video game research. We emphasize the role of nostalgia as an explanation for contemporary retro gaming trends, and suggest that nostalgia towards gaming events is a necessary area of research. To those ends, we broadly review existing literature on nostalgia before specifically focusing on media-induced nostalgia, and demonstrate how theoretical and empirical observations from this work can be applied to understand video game nostalgia. In particular, we argue that engaging in older gaming experiences indirectly (via memories) and even directly (via replaying or recreating experiences) elicits nostalgia, which in turn contributes to players' self-optimization and enhanced well-being. Moreover, as gamers and the medium mature together, nostalgic experiences with the medium are likely to become increasingly prevalent. The broad aim of this article is to offer future directions for research on video game nostalgia and provide a research agenda for research in this area