ANALISIS STRATEGI PENGEMBANGAN MINUMAN HERBAL INSTAN (STUDI KASUS : UPPKS MADYA XI KARAWANG)

This research is a descriptive qualitative research on the analysis of the development of instant herbal beverage business at UPPKS Madya XI Karawang. The analysis method used is swot analysis method (Strength, Weakness, Opportunity, Threat) which aims to know how the strategy used by UPPKS Madya XI Karawang in its business development and QSPM which aims to establish the right alternative strategy for use by UPPKS XI Madya Karawang in better business development. The data used in this study comes from observations made directly on companies, interviews, and documentation. The results of this study were obtained from the calculation of IE matrix, IE matrix is obtained from the results of IFAS matrix with a value of 3,020 and EFAS with a value of 2,687 which based on the IE matrix of the company is in the cell or quadrant IV is a growth and development strategy consisting of intensive strategies such as the company's growth to product development in the market, market development and market penetration and integration from the front,  back and horizontally. in the QSPM matrix with a TAS value of 5,329 in the first place, namely maintaining the network and expanding the connection and increasing the number of distributors. These factors become one of the alternative strategies that can be used by companies

Determinan Perilaku Tes IVA di Puskesmas Sawangan Kota Depok Tahun 2022

Latar Belakang. Berdasarkan WHO tahun 2020, kanker terbanyak keempat adalah kanker serviks dan GLOBOCAN tahun 2018 menyatakan kanker serviks merupakan kanker terbanyak kedua di Indonesia. IVA merupakan salah satu program pemerintah untuk mendeteksi dini kanker serviks dan telah dijalankan di Indonesia. Namun cakupan IVA di Indonesia masih tergolong rendah.Tujuan. Identifikasi determinan perilaku tes IVA pada wanita di UPTD Puskesmas Sawangan Kota Depok yang berusia 30-50 tahun.Metode. Penelitian ini merupakan observasional analitik dengan desain potong lintang. Sampel penelitian yaitu wanita 30-50 tahun di Puskesmas Sawangan. Teknik pengumpulan data yang digunakan adalah con­secutive sampling. Instrumen penelitian berupa kuesioner. Analisis data dilakukan dengan uji Chi-square dan regresi logistik.Hasil. Mayoritas responden tidak bekerja, multipara, memiliki pengetahuan baik, sikap negatif, akses infor­masi kurang baik, tidak dapat dukungan keluarga, dan tidak tes IVA. Terdapat hubungan signifikan antara paritas (p-value = 0,005) dan akses informasi (p-value = 0,001) dengan perilaku tes IVA serta tidak ada hubungan signifikan antara pengetahuan, sikap, pekerjaan, dan dukungan keluarga dengan perilaku tes IVA (p-value > 0,05). Uji multivariat menunjukkan paritas adalah faktor yang berhubungan dominan dengan perilaku IVA (OR = 9,106).Kesimpulan. Paritas dan akses informasi berhubungan dengan perilaku IVA. Pengetahuan, sikap, pekerjaan, dan dukungan keluarga tidak berhubungan dengan perilaku IVA

Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets

Background: Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint molecular pathways related to platelet function. Plasma levels of Platelet factor 4 (PF4/CXCL4) and Von Willebrand factor (VWf), as well as in vitro PLTs—P. vivax infected erythrocytes (Pv-IEs) interactions were also evaluated to explore the PLT response and effect on parasite development. Methods: A cohort of 48 patients and 25 healthy controls were enrolled. PLTs were purified from 5 patients and 5 healthy controls for Liquid Chromatography–Mass spectrometry (LC–MS/MS) analysis. Plasma levels of PF4/CXCL4 and VWf were measured in all participants. Additionally, P. vivax isolates (n = 10) were co-cultured with PLTs to measure PLT activation by PF4/CXCL4 and Pv-IE schizonts formation by light microscopy. Results: The proteome from uncomplicated P. vivax patients showed 26 out of 215 proteins significantly decreased. PF4/CXCL4 was significantly decreased followed by other proteins involved in platelet activation, cytoskeletal remodeling, and endothelial adhesion, including glycoprotein V that was significantly decreased in thrombocytopenic patients. In contrast, acute phase proteins, including SERPINs and Amyloid Serum A1 were increased. High levels of VWf in plasma from patients suggested endothelial activation while PF4/CXCL4 plasma levels were similar between patients and controls. Interestingly, high levels of PF4/CXCL4 were released from PLTs—Pv-IEs co-cultures while Pv-IEs schizont formation was inhibited. Conclusions: The PLT proteome analyzed in this study suggests that PLTs actively respond to P. vivax infection. Altogether, our findings suggest important roles of PF4/CXCL4 during uncomplicated P. vivax infection through a possible intracellular localization. Our study shows that platelets are active responders to P. vivax infection, inhibiting intraerythrocytic parasite development. Future studies are needed to further investigate the molecular pathways of interaction between platelet proteins found in this study and host response, which could affect parasite control as well as disease progression

The impact of farmer partnerships on arabica coffee farming in Simalungun Regency, North Sumatra Province, Indonesia

Coffee is one of Indonesia's main economic activities for foreign exchange. An increase in exports of 8.11%, and a decline in imports of 58% in 2019, opened up export opportunities and large domestic markets. The government has implemented efforts to improve coffee farmers' welfare, one of which is agricultural business partnerships that can solve smallholder problems in developing countries and expand subsistence or traditional agriculture to high production value and export-oriented. This research aimed to analyze (1) the factors influencing coffee farmers' participation in agricultural partnerships and (2) the impact of the agricultural partnership on coffee farmers' performance in Simalungun Regency, North Sumatra Province. The Propensity Score Matching (PSM) technique analyzed the partnership's influence on coffee farming and agricultural income, productivity, and prices.  The results showed that number of dependents  household members and land area influence farmers' partnership participation. Participation increases coffee farming and agricultural income, productivity, and prices

Comparison of EfficientNet B5-B6 for Detection of 29 Diseases of Fruit Plants

In initiatives to meet food needs and enhance the wellbeing of farmers and society at large, crop production performance is essential. For early attempts to be made for quick handling to prevent crop failure, farmers must be able to readily and quickly receive information in order to detect plant illnesses. In this study, two Convolutional Neural Network (CNN) architectures namely, EfficientNet versions B5 and B6 are used to develop a classification model for plant disease using Deep Learning (DL). The 66,556 visuals in the dataset, which is from Kaggle.com, are used. To create a model, the training method uses 57,067 images data and 3,170 image data for validation. The EfficientNet architecture versions B5 and B6 received very good accuracy scores for the total test results, namely 0.9905 and 0.9927. The model testing phase was carried out through testing phases utilising 3.171 images data. Future analysis can compare CNN architectures and try it with different datasets

Diabetes Mellitus tipo 2 y puntuaciones de riesgo

La diabetes mellitus está emergiendo más rápidamente que cualquier otra enfermedad. Se ha demostrado que la prevención de la Diabetes tipo 2 es posible y requiere de acción inmediata basada en cambios del estilo de vida sostenidos en la dieta y en la actividad física, además de la identificación a nivel poblacional de los grupos con mayor riesgo de padecer la enfermedad. La presente investigación se realizó con el objetivo de caracterizar la diabetes mellitus así como las diferentes puntuaciones de riesgo existentes para la identificación de individuos con probabilidad de desarrollar diabetes mellitus tipo 2 sin alteraciones previas de la glucemia, para lo cual se consultaron un total de 46 referencias bibliográficas.ABSTRACTDiabetes mellitus is emerging more quickly than any other illness. It is not still possible to prevent the diabetes type 1 and this goal remains as an objective of the future. Has been demonstrated that the prevention of the Diabetes type 2 is possible and it requires of immediate action based on changes of the lifestyle sustained in the diet and in the physical activity, besides the identification at populational level of the groups with more risk of suffering the illness. The present investigation was carried out with the objective of characterizing the diabetes mellitus as well as the existent different punctuations of risk for the identification of individuals with probability of developing diabetes mellitus type 2 without previous alterations of the glycaemia, for that which a total of 46 bibliographical references were consulted

Assessment of Academic Resilience and its associated factors among Pharmacy Students in Twelve Countries

Objective Academic resilience, a critical determinant of academic achievement, is affected by various factors. There is a paucity of large-scale international assessments of academic resilience among pharmacy students. Therefore, this study aimed to assess academic resilience among pharmacy students in 12 countries and to evaluate factors associated with their academic resilience levels. Methods A cross-sectional online survey-based study was conducted among randomly selected pharmacy students in 12 countries: Egypt, Türkiye, Indonesia, Pakistan, Bangladesh, Iraq, Jordan, Nigeria, Malaysia, Saudi Arabia, Sudan, and the United Arab Emirates. After pilot testing, the validated 30-item academic resilience scale (ARS) was used for the assessment. The data were collected between November 1, 2022 and April 15, 2023. Descriptive and inferential statistics were performed, as appropriate. Results A total of 3950 were received from the 12 participating countries. The mean age was 21.68 ± 2.62 years. About two-thirds of the responses were from female participants and those studying for Bachelor of Pharmacy degrees. Overall, the findings show moderate academic resilience, which varied across countries. The median (IQR) of the total ARS-30 was 114 (103−124). Females exhibited lower negative affective and emotional response subscale levels than males. There were significant cross-country variations in the ARS-30 and all subscales. The highest overall levels were reported for Sudan, Pakistan, and Nigeria and the lowest were reported for Indonesia and Türkiye. Students in private universities tended to have higher overall ARS levels than public university students. Higher academic performance was significantly associated with ARS levels, whereas those with excellent performance exhibited the highest ARS levels. Students with exercise routines had higher ARS levels than those without exercise routines. Finally, students who were engaged in extracurricular activities had higher ARS levels than those who did not participate in these activities. Conclusion The study offers insights into the factors affecting academic resilience in pharmacy students across several countries. The findings could guide interventions and support activities to improve resilience and academic outcomes

Estimating global injuries morbidity and mortality : methods and data used in the Global Burden of Disease 2017 study

Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future