456 research outputs found
Project UPLIFT: A Distance Delivered Mindfulness-Based Intervention to Address Depression Among Diverse Populations
Building Workforce Capacity through a Community-Based System of Care Model: The Challenges of Balancing Fidelity and Adaptability
A Combine On-Line Acoustic Flowmeter and Fluorocarbon Coolant Mixture Analyzer for The ATLAS Silicon Tracker
An upgrade to the ATLAS silicon tracker cooling control system may require a
change from C3F8 (octafluoro-propane) to a blend containing 10-30% of C2F6
(hexafluoro-ethane) to reduce the evaporation temperature and better protect
the silicon from cumulative radiation damage with increasing LHC luminosity.
Central to this upgrade is a new acoustic instrument for the real-time
measurement of the C3F8/C2F6 mixture ratio and flow. The instrument and its
Supervisory, Control and Data Acquisition (SCADA) software are described in
this paper. The instrument has demonstrated a resolution of 3.10-3 for
C3F8/C2F6 mixtures with ~20%C2F6, and flow resolution of 2% of full scale for
mass flows up to 30gs-1. In mixtures of widely-differing molecular weight (mw),
higher mixture precision is possible: a sensitivity of < 5.10-4 to leaks of
C3F8 into the ATLAS pixel detector nitrogen envelope (mw difference 160) has
been seen. The instrument has many potential applications, including the
analysis of mixtures of hydrocarbons, vapours for semi-conductor manufacture
and anaesthesia
Development of a Multilayer MODIS IST-Albedo Product of Greenland
A new multilayer IST-albedo Moderate Resolution Imaging Spectroradiometer (MODIS) product of Greenland was developed to meet the needs of the ice sheet modeling community. The multiple layers of the product enable the relationship between IST and albedo to be evaluated easily. Surface temperature is a fundamental input for dynamical ice sheet models because it is a component of the ice sheet radiation budget and mass balance. Albedo influences absorption of incoming solar radiation. The daily product will combine the existing standard MODIS Collection-6 ice-surface temperature, derived melt maps, snow albedo and water vapor products. The new product is available in a polar stereographic projection in NetCDF format. The product will ultimately extend from March 2000 through the end of 2017
Development of a custom on-line ultrasonic vapour analyzer/flowmeter for the ATLAS inner detector, with application to gaseous tracking and Cherenkov detectors
Precision sound velocity measurements can simultaneously determine binary gas
composition and flow. We have developed an analyzer with custom electronics,
currently in use in the ATLAS inner detector, with numerous potential
applications. The instrument has demonstrated ~0.3% mixture precision for
C3F8/C2F6 mixtures and < 10-4 resolution for N2/C3F8 mixtures. Moderate and
high flow versions of the instrument have demonstrated flow resolutions of +/-
2% F.S. for flows up to 250 l.min-1, and +/- 1.9% F.S. for linear flow
velocities up to 15 ms-1; the latter flow approaching that expected in the
vapour return of the thermosiphon fluorocarbon coolant recirculator being built
for the ATLAS silicon tracker.Comment: Paper submitted to TWEPP2012; Topical Workshop on Electronics for
Particle Physics, Oxford, UK, September 17-21, 2012. KEYWORDS: Sonar;
Saturated fluorocarbons; Flowmetry; Sound velocity, Gas mixture analysis. 8
pages, 7 figure
Etiology of the membrane potential of rat white fat adipocytes
The plasma membrane potential (Vm) is key to many physiological processes, however its ionic aetiology in white fat adipocytes is poorly characterised. To address this question, we have employed the perforated patch current-clamp and cell-attached patch-clamp methods in isolated primary white fat adipocytes and their cellular model: 3T3-L1. The resting Vm of primary and 3T3-L1 adipocytes were -32.1±1.2mV (n=95) and -28.8±1.2mV (n=87), respectively. Vm was independent of cell size and fat content. Elevation of extracellular [K+] to 50mM by equimolar substitution of bath Na+ did not affect Vm, whereas substitution of bath Na+ with the membrane impermeant cation N-methyl-D-glucamine+ hyperpolarized Vm by 16mV, data indicative of a non-selective cation permeability. Substitution of 133mM extracellular Cl- with gluconate, depolarised Vm to +5.5, whereas Cl- substitution with I- caused a -9mV hyperpolarization. Isoprenaline (10µM) but not insulin (100nM) significantly depolarized Vm. Single-channel ion activity was voltage independent; currents were indicative for Cl- with an inward slope conductance of 16±1.3pS (n=11) and a reversal potential close to the Cl- equilibrium potential: -29±1.6mV. Reduction of extracellular Cl- elevated the intracellular Ca2+ of adipocytes.
In conclusion, the Vm of white fat adipocyte is well described by the Goldman-Hodgkin-Katz equation with a predominant permeability to Cl-. Consequently, changes in serum Cl- homeostasis or the adipocyte’s permeability to this anion via drugs will affect its Vm, intracellular Ca2+ and ultimately its function and its role in metabolic control
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