2,065 research outputs found
Properties of charmonium in lattice QCD with 2+1 flavors of improved staggered sea quarks
We use the dynamical gluon configurations provided by the MILC collaboration
in a study of the charmonium spectrum and psi leptonic width. We examine sea
quark effects on mass splitting and on the leptonic decay matrix element for
light masses as low as m_s/5, while keeping the strange quark mass fixed and
the lattice spacing nearly constant.Comment: Lattice2003(heavy
Barrier effect of Esoxx® on esophageal mucosal damage: experimental study on ex-vivo swine model
The aim of the present study was to assess the potential barrier effect of Esoxx®, a new nonprescription medication under development for the relief of gastroesophageal reflux symptoms. Esoxx is based on a mixture of hyaluronic acid and chondroitin sulfate in a bioadhesive suspension of Lutrol® F 127 polymer (poloxamer 407) which facilitates the product adhesion on the esophageal mucosa. The mucosal damage was induced by 15 to 90 minutes of perfusion with an acidic solution (HCl, pH 1.47) with or without pepsin (2000 U/mL, acidified to pH 2; Sigma-Aldrich). Mucosal esophageal specimens were histologically evaluated and Evans blue dye solution was used to assess the permeability of the swine mucosa after the chemical injury. The results show that: (1) esophageal mucosal damage is related to the perfusion time and to the presence of pepsin, (2) mucosal damage is associated with an increased permeability, documented by an evident Evans blue staining, (3) perfusion with Esoxx is able to reduce the permeability of the injured mucosa, even after saline washing of the swine esophagus. These preliminary results support further clinical studies of Esoxx in the topical treatment of gastroesophageal reflux symptoms
D_s spectrum and leptonic decays with Fermilab heavy quarks and improved staggered light quarks
We present preliminary results for the D_s meson spectrum and decay constants
in unquenched lattice QCD. Simulations are carried out with 2+1 dynamical
quarks using gauge configurations generated by the MILC collaboration. We use
the ``asqtad'' a^2 improved staggered action for the light quarks, and the
clover heavy quark action with the Fermilab interpretation. We compare our
spectrum results with the newly discovered 0+ and 1+ states in the D_s system.Comment: 3pp. Presented at 21st International Symposium on Lattice Field
Theory (LATTICE 2003), Tsukuba, Ibaraki, Japan, 15-19 Jul 200
Semileptonic decays of mesons in unquenched lattice QCD
We present our preliminary results for semileptonic form factors of
mesons in unquenched lattice QCD. Simulations are carried out with
dynamical quarks using gauge configurations generated by the MILC
collaboration. For the valence quarks, we adopt an improved staggered light
quark action and the clover heavy quark action. Our results for and
form factors at are in agreement with the experimental
values.Comment: Lattice2003(heavy), 3 page
Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results
AIMS: To test whether canrenone, an aldosterone receptor antagonist, improves left ventricular (LV) remodelling in NYHA class II heart failure (HF). Aldosterone receptor antagonists improve outcome in severe HF, but no information is available in NYHA class II. METHODS AND RESULTS: AREA IN-CHF is a randomized, double-blind, placebo-controlled study testing canrenone on top of optimal treatment in NYHA class II HF with low ejection fraction (EF) to assess 12-month changes in LV end-diastolic volume (LVEDV). Brain natriuretic peptide (BNP) was also measured. Information was available for 188 subjects on canrenone and 194 on placebo. Left ventricular end-diastolic volume was similarly reduced (-18%) in both arms, but EF increased more (P = 0.04) in the canrenone (from 40% to 45%) than in the placebo arm (from 40-43%). Brain natriuretic peptide (n = 331) decreased more in the canrenone (-37%) than in the placebo arm (-8%; P < 0.0001), paralleling a significant reduction in left atrial dimensions (-4% vs. 0.2%; P = 0.02). The composite endpoint of cardiac death and hospitalization was significantly lower in the canrenone arm (8% vs. 15%; P = 0.02). CONCLUSION: Canrenone on top of optimal treatment for HF did not have additional effects on LVEDV, but it increased EF, and reduced left atrial size and circulating BNP, with potential beneficial effects on outcome. A large-scale randomized study should be implemented to confirm benefits on cardiovascular outcomes in patients with HF in NYHA class I
Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults
The SSDC Role in the LICIACube Mission: Data Management and the MATISSE Tool
Light Italian Cubesat for Imaging of Asteroids (LICIACube) is an Italian mission managed by the Italian Space
Agency (ASI) and part of the NASA Double Asteroid Redirection Test (DART) planetary defense mission. Its
main goals are to document the effects of the DART impact on Dimorphos, the secondary member of the (65803)
Didymos binary asteroid system, characterizing the shape of the target body and performing dedicated scientific
investigations on it. Within this framework, the mission Science Operations Center will be managed by the Space
Science Data Center (ASI-SSDC), which will have the responsibility of processing, archiving, and disseminating
the data acquired by the two LICIACube onboard cameras. In order to better accomplish this task, SSDC also plans
to use and modify its scientific webtool Multi-purpose Advanced Tool for Instruments for the solar system
Exploration (MATISSE), making it the primary tool for the LICIACube data analysis, thanks to its advanced
capabilities for searching and visualizing data, particularly useful for the irregular shapes common to several small
bodies
The acute phase management of spinal cord injury affecting polytrauma patients : the ASAP study
Publisher Copyright: © 2022, The Author(s).Background: Few data on the management of acute phase of traumatic spinal cord injury (tSCI) in patients suffering polytrauma are available. As the therapeutic choices in the first hours may have a deep impact on outcome of tSCI patients, we conducted an international survey investigating this topic. Methods: The survey was composed of 29 items. The main endpoints of the survey were to examine: (1) the hemodynamic and respiratory management, (2) the coagulation management, (3) the timing of magnetic resonance imaging (MRI) and spinal surgery, (4) the use of corticosteroid therapy, (5) the role of intraspinal pressure (ISP)/spinal cord perfusion pressure (SCPP) monitoring and (6) the utilization of therapeutic hypothermia. Results: There were 171 respondents from 139 centers worldwide. A target mean arterial pressure (MAP) target of 80–90 mmHg was chosen in almost half of the cases [n = 84 (49.1%)]. A temporary reduction in the target MAP, for the time strictly necessary to achieve bleeding control in polytrauma, was accepted by most respondents [n = 100 (58.5%)]. Sixty-one respondents (35.7%) considered acceptable a hemoglobin (Hb) level of 7 g/dl in tSCI polytraumatized patients. An arterial partial pressure of oxygen (PaO2) of 80–100 mmHg [n = 94 (55%)] and an arterial partial pressure of carbon dioxide (PaCO2) of 35–40 mmHg [n = 130 (76%)] were chosen in most cases. A little more than half of respondents considered safe a platelet (PLT) count > 100.000/mm3 [n = 99 (57.9%)] and prothrombin time (PT)/activated partial thromboplastin time (aPTT) < 1.5 times the normal control [n = 85 (49.7%)] in patients needing spinal surgery. MRI [n = 160 (93.6%)] and spinal surgery [n = 158 (92.4%)] should be performed after intracranial, hemodynamic, and respiratory stabilization by most respondents. Corticosteroids [n = 103 (60.2%)], ISP/SCPP monitoring [n = 148 (86.5%)], and therapeutic hypothermia [n = 137 (80%)] were not utilized by most respondents. Conclusions: Our survey has shown a great worldwide variability in clinical practices for acute phase management of tSCI patients with polytrauma. These findings can be helpful to define future research in order to optimize the care of patients suffering tSCI.Peer reviewe
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