Differences in education systems across OECD countries: the role of education policy preferences in a hierarchical system

The design of the educational system affects the degree of students’ equality of opportunities and the intergenerational social mobility. The topic is therefore of paramount importance. In this paper, we document differences in educational systems among OECD countries and argue that the system observed in a country is the result of a complex interaction between preferences for education and political competition. To analyse individual preferences over education funding, we build a model that allows us to study the effects of public funding on the welfare of agents, which are heterogeneous in terms of income and human capital. The model takes into account the hierarchical nature of the educational system and emphasises the role played by family background. Our theoretical results might help to explain why some OECD countries seem to remain stuck in “low education” traps

Final design and construction of the ERIS calibration unit

The Calibration Unit (CU) is a subsystem of the Enhanced Resolution Imager and Spectrograph (ERIS), the newgeneration instrument for the Cassegrain focus of the ESO UT4/VLT, aimed at performing AO-assisted imaging and medium resolution spectroscopy in the 1-5 micron wavelength range. The ERIS-CU is aimed to providing both focal plane artificial sources and uniform illumination over the 0.4 - 2.4 micron wavelengh range, for purposes of calibration and technical check of the SPIFFIER spectrograph, the NIX camera and the AO Module. Some challenging aspects emerged during the detailed design phase, mainly related to the need to cover such a broad wavelength range while ensuring adequate photon rates, excellent image quality and high Strehl. The technical solutions adopted to achieve the final design goals are presented and their implementation during the construction phase are shown and discussed

Design of the ERIS calibration unit

The Enhanced Resolution Imager and Spectrograph (ERIS) is a new-generation instrument for the Cassegrain focus of the ESO UT4/VLT, aimed at performing AO-assisted imaging and medium resolution spectroscopy in the 1-5 micron wavelength range. ERIS consists of the 1-5 micron imaging camera NIX, the 1-2.5 micron integral field spectrograph SPIFFIER (a modified version of SPIFFI, currently operating on SINFONI), the AO module and the internal Calibration Unit (ERIS CU). The purpose of this unit is to provide facilities to calibrate the scientific instruments in the 1-2.5 micron and to perform troubleshooting and periodic maintenance tests of the AO module (e.g. NGS and LGS WFS internal calibrations and functionalities, ERIS differential flexures) in the 0.5 - 1 μm range. The ERIS CU must therefore be designed in order to provide, over the full 0.5 - 2.5 μm range, the following capabilities: 1) illumination of both the telescope focal plane and the telescope pupil with a high-degree of uniformity; 2) artificial point-like and extended sources onto the telescope focal plane, with high accuracy in both positioning and FWHM; 3) wavelength calibration; 4) high stability of these characteristics. In this paper the design of the ERIS CU, and the solutions adopted to fulfill all these requirements, is described. The ERIS CU construction is foreseen to start at the end of 2016

A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band

The analysis of paired cerebrospinal fluid (CSF) and serum samples with isolectric focusing (IEF) can yield different patterns which can be of aid in the differential diagnosis of central nervous system (CNS) disorders. Rarely, a single CSF-restricted IgG band, which is not included within these patterns, can be detected in association with inflammatory disorders, multiple sclerosis (MS) above all. However, the diagnostic meaning of this abnormality is still uncertain. The main aim of our multicenter study was to establish the frequency and disease associations of single CSF IgG bands. Differences in the CSF profiles between MS and other diseases, and the follow-up patterns were also evaluated. Medical records of patients who underwent CSF analysis, which included IEF, over a 11.5-year period were retrospectively scrutinized at the participating centers, which used similar IEF techniques. One hundred and fifty-one of 9422 CSF reports (1.6%) showed single CSF-restricted IgG bands. Of the 129 patients with a definite diagnosis, 58.2% had CNS inflammatory-demyelinating diseases (the most frequent being MS: 21.7%), 6.2% tumours, 5.4% inflammatory peripheral nervous system diseases and 30.2% miscellaneous diseases. At follow-up, 3 out of the 10 patients with a repeated CSF analysis had developed an oligoclonal band pattern. Our findings indicate that single CSF IgG bands tend to associate with diseases characterized by the involvement of intrathecal humoral immune responses, and strongly support the notion that this abnormality should be regularly reported, thus alerting clinicians of possible inflammatory disorders of the CNS

ERIS: revitalising an adaptive optics instrument for the VLT

ERIS is an instrument that will both extend and enhance the fundamental diffraction limited imaging and spectroscopy capability for the VLT. It will replace two instruments that are now being maintained beyond their operational lifetimes, combine their functionality on a single focus, provide a new wavefront sensing module that makes use of the facility Adaptive Optics System, and considerably improve their performance. The instrument will be competitive with respect to JWST in several regimes, and has outstanding potential for studies of the Galactic Center, exoplanets, and high redshift galaxies. ERIS had its final design review in 2017, and is expected to be on sky in 2020. This contribution describes the instrument concept, outlines its expected performance, and highlights where it will most excel.Comment: 12 pages, Proc SPIE 10702 "Ground-Based and Airborne Instrumentation for Astronomy VII

The ERIS adaptive optics system: from design to hardware

ERIS is the new AO instrument for VLT-UT4 led by a Consortium of Max-Planck Institut fuer Extraterrestrische Physik, UK-ATC, ETH-Zurich, NOVA-Leiden, ESO and INAF. The ERIS AO system provides NGS mode to deliver high contrast correction and LGS mode to extend high Strehl performance to large sky coverage. The AO module includes NGS and LGS wavefront sensors and, with VLT-AOF Deformable Secondary Mirror and Laser Facility, will provide AO correction to the high resolution coronagraphic imager NIX (1-5um) and the IFU spectrograph SPIFFIER (1-2.5um). In this paper, we present the final design of the ERIS AO system and the status of the of current MAIV phase

Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF-platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage

Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that the rare complex allele [G576V;R668C] is associated with a milder disease via a gain-of-function mechanism. Conversely, CFTR ultra-rare alleles with reduced function are associated with disease severity either alone (dominant disorder) or with another hypomorphic allele in the second chromosome (recessive disorder) with a global residual CFTR activity between 50 to 91%. Furthermore, we characterized novel CFTR complex alleles, including [A238V;F508del], [R74W;D1270N;V201M], [I1027T;F508del], [I506V;D1168G], and simple alleles, including R347C, F1052V, Y625N, I328V, K68E, A309D, A252T, G542*, V562I, R1066H, I506V, I807M, which lead to a reduced CFTR function and thus, to more severe COVID-19. In conclusion, CFTR genetic analysis is an important tool in identifying patients at risk of severe COVID-19