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Apparatus for synthesizing and separating synthesis products e.g. gaseous and liquid phases on bed, maintains heavier liquid phase at lower portion of first meatus due to gravity and lighter liquid phase at upper portion of meatus
NOVELTY - The apparatus has header that is set to make the heavier and lighter liquid phases flow along outer side surface of a third tube (8) as far as first closure element (13). The third tube is provided with second side openings for directly connecting the first and second meatus. The heavier liquid phase is maintained at lower portion of the first meatus due to gravity and lighter liquid phase is maintained at upper portion of the first meatus until the liquid phases fall into a fourth tube (9). The heavier liquid phase is collectible through a collection hole (12).
USE - Apparatus e.g. reactor/separator for synthesizing and separating synthesis products e.g. gaseous phase and heavier and lighter liquid phases on catalytic bed, used in production of biodiesel.
ADVANTAGE - Since heavier liquid phase is maintained at lower portion of the first meatus due to gravity and lighter liquid phase is maintained at upper portion of the first meatus, sedimentation separation of the liquid phases is improved. The structure of the apparatus is simplified and the apparatus is constructed easily. The efficacy and use of catalyst are maximized.
DETAILED DESCRIPTION - The apparatus has synthesis module (M1) that is set with a first tube (1) which is provided with an opening at one end and closed at second end by a mesh (7). The first tube is adapted to contain a catalytic bed (6). A separation module (M2) is set to separate heavier and lighter liquid phases and gaseous phase originating from the synthesis module. A second tube (1') is arranged adjacent to second end of the first tube. A first closure element is provided with a through hole for sole passage of the second liquid and of the gaseous phase. A third tube is affixed to first end of second tube. A first meatus is set between second tube and the third tube. The fourth tube is set inside the third tube so as to define a second meatus between the third tube and the fourth tube. A separation zone is set between the heavier and lighter liquid phases. A collection hole is set in the second tube to collect the heavier liquid phase. The third tube is set with first side openings at first end, and is set with a header for collecting the liquid phases originating from the synthesis module. The first meatus is directly inserted into the third tube and subsequently into the fourth tube. A control system is set between the liquid phases, to check and maintain interface level below the upper end of the first side openings. The control system has interface level indicator that is connected to the second tube by second side holes envisaged in side surface of the second tube. One of the second side holes is arranged in proximity of the first closure element and other is positioned above the upper end of the first side openings. The protrusions are arranged along cylindrical side surface of the third tube, and are separated by spaces for passage of the liquid phases from the header to the first meatus. A redistribution module (M3) is set to redistribute the lighter liquid phase and gaseous phase originating from the fourth tube. A fifth tube (1") is arranged adjacent to second end of the second tube. The closure element is set with a central perforated area. A sixth tube (14) is set to descent and release of the gaseous phase. The central perforated area is provided with several holes for homogeneous distribution of lighter liquid phase downstream of the redistribution module. The sixth tube is affixed to a second closure element (15). The mesh is provided with a passage area. The synthesis module, separation module and redistribution module are vertically-stacked. An INDEPENDENT CLAIM is included for a method for synthesizing and separating synthesis products e.g. gaseous phase and heavier and lighter liquid phases on catalytic bed, involves synthesizing on a catalytic bed and producing the synthesis products. The liquid phases and gaseous phase are separated in the separation module
On the Optimum Long Baseline for the Next Generation Neutrino Oscillation Experiments
For high energy long baseline neutrino oscillation experiments, we propose a
Figure of Merit criterion to compare the statistical quality of experiments at
various oscillation distances under the condition of identical detectors and a
given neutrino beam. We take into account all possible experimental errors
under general consideration. In this way the Figure of Merit is closely related
to the usual statistical criterion of number of sigmas. We use a realistic
neutrino beam for an entry level neutrino factory and a possible superbeam from
a meson source and a 100 kt detector for the calculation. We considered in
detail four oscillation distances, 300 km, 700 km, 2100 km and 3000 km, in the
neutrino energy range of 0.5-20 GeV for a 20 GeV entry level neutrino factory
and a 50 GeV superbeam. We found that the very long baselines of 2100 km and
3000 km are preferred for the neutrino factory according to the figure of merit
criterion. Our results also show that, for a neutrino factory, lower primary
muon energies such as 20 GeV are preferred rather than higher ones such as 30
or 50 GeV. For the superbeam, the combination of a long baseline such as 300 km
and a very long baseline like 2100 km will form a complete measurement of the
oscillation parameters besides the CP phase. To measure the CP phase in a
superbeam, a larger detector (a factor 3 beyond what is considered in this
article) and/or a higher intensity beam will be needed to put some significant
constraints on the size of the CP angle.Comment: 21 LaTeX pages, 13 PS figures, typos corrected, references adde
Neutrino Oscillations in the Framework of Three-Generation Mixings with Mass Hierarchy
We have analyzed the results of reactor and accelerator neutrino oscillation
experiments in the framework of a general model with mixing of three neutrino
fields and a neutrino mass hierarchy that can accommodate the results of the
solar neutrino experiments. It is shown that
oscillations with and amplitude
larger than are not compatible with the existing limits on
neutrino oscillations if the non-diagonal elements of the mixing matrix and are small. Thus, if the
excess of electron events recently observed in the LSND experiment is due to oscillations, the mixing in the lepton sector
is basically different from the CKM mixing of quarks. If this type of mixing is
realized in nature, the observation of
oscillations would not influence
oscillations that are being searched for in the CHORUS and NOMAD experiments.Comment: Revtex file, 13 pages + 2 figures (included). The postscript file of
text and figures is available at
http://www.to.infn.it/teorici/giunti/papers.html or
ftp://ftp.to.infn.it/pub/giunti/1995/dftt-25-95/dftt-25-95.ps.
The CAST Time Projection Chamber
One of the three X-ray detectors of the CAST experiment searching for solar
axions is a Time Projection Chamber (TPC) with a multi-wire proportional
counter (MWPC) as a readout structure. Its design has been optimized to provide
high sensitivity to the detection of the low intensity X-ray signal expected in
the CAST experiment. A low hardware threshold of 0.8 keV is safely set during
normal data taking periods, and the overall efficiency for the detection of
photons coming from conversion of solar axions is 62 %. Shielding has been
installed around the detector, lowering the background level to 4.10 x 10^-5
counts/cm^2/s/keV between 1 and 10 keV. During phase I of the CAST experiment
the TPC has provided robust and stable operation, thus contributing with a
competitive result to the overall CAST limit on axion-photon coupling and mass.Comment: 19 pages, 11 figures and images, submitted to New Journal of Physic
Investigating serum and tissue expression identified a cytokine/chemokine signature as a highly effective melanoma marker
The identification of reliable and quantitative melanoma biomarkers may help an early diagnosis and may directly affect melanoma mortality and morbidity. The aim of the present study was to identify effective biomarkers by investigating the expression of 27 cytokines/chemokines in melanoma compared to healthy controls, both in serum and in tissue samples. Serum samples were from 232 patients recruited at the IDI-IRCCS hospital. Expression was quantified by xMAP technology, on 27 cytokines/chemokines, compared to the control sera. RNA expression data of the same 27 molecules were obtained from 511 melanoma-and healthy-tissue samples, from the GENT2 database. Statistical analysis involved a 3-step approach: analysis of the single-molecules by Mann–Whitney analysis; analysis of paired-molecules by Pearson correlation; and profile analysis by the machine learning algorithm Support Vector Machine (SVM). Single-molecule analysis of serum expression identified IL-1b, IL-6, IP-10, PDGF-BB, and RANTES differently expressed in melanoma (p < 0.05). Expression of IL-8, GM-CSF, MCP-1, and TNF-α was found to be significantly correlated with Breslow thickness. Eotaxin and MCP-1 were found differentially expressed in male vs. female patients. Tissue expression analysis identified very effective marker/predictor genes, namely, IL-1Ra, IL-7, MIP-1a, and MIP-1b, with individual AUC values of 0.88, 0.86, 0.93, 0.87, respectively. SVM analysis of the tissue expression data identified the combination of these four molecules as the most effective signature to discriminate melanoma patients (AUC = 0.98). Validation, using the GEPIA2 database on an additional 1019 independent samples, fully confirmed these observations. The present study demonstrates, for the first time, that the IL-1Ra, IL-7, MIP-1a, and MIP-1b gene signature discriminates melanoma from control tissues with extremely high efficacy. We therefore propose this 4-molecule combination as an effective melanoma marker
First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review
Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available antibiotics
Intracochlear schwannoma presenting as diffuse cochlear enhancement: diagnostic challenges of a rare cause of deafness
Intracochlear schwannoma is a rare, treatable, cause of unilateral hearing loss. Due to the small size, position, and variable clinical and imaging features, diagnosis presents a significant challenge and is often delayed. We present a case of a patient with an intracochlear schwannoma presenting as a diffuse enhancement of the cochlea, mimicking an infectious or inflammatory process. The absence of focal nodularity in this lesion on multiple high-resolution MRI examinations led to a delay of over 3 years from the patient’s initial presentation to surgical diagnosis. Clinical history and examination, imaging features, pathologic findings, and surgical management options are described
Search for solar Kaluza-Klein axions in theories of low-scale quantum gravity
We explore the physics potential of a terrestrial detector for observing
axionic Kaluza-Klein excitations coming from the Sun within the context of
higher-dimensional theories of low-scale quantum gravity. In these theories,
the heavier Kaluza-Klein axions are relatively short-lived and may be detected
by a coincidental triggering of their two-photon decay mode. Because of the
expected high multiplicity of the solar axionic excitations, we find
experimental sensitivity to a fundamental Peccei-Quinn axion mass up to
eV (corresponding to an effective axion-photon coupling GeV) in theories with 2 extra
dimensions and a fundamental quantum-gravity scale of order 100
TeV, and up to eV (corresponding to GeV) in theories with 3 extra dimensions and
TeV. For comparison, based on recent data obtained from lowest
level underground experiments, we derive the experimental limits: GeV and GeV in the
aforementioned theories with 2 and 3 large compact dimensions, respectively.Comment: 19 pages, extended version, as to appear in Physical Review
Search for solar axions using Li-7
We describe a novel approach to the search for solar, near-monochromatic
hadronic axions, the latter being suggested to be created in the solar core
during M1 transitions between the first excited level of Li-7, at 478 keV, and
the ground state. As a result of Doppler broadening, in principle these axions
can be detected via resonant absorption by the same nuclide on the Earth.
Excited nuclei of Li-7 are produced in the solar interior by Be-7 electron
capture and thus the axions are accompanied by emission of Be-7 solar neutrinos
of energy 384 keV. An experiment was made which has yielded an upper limit on
hadronic axion mass of 32 keV at the 95% confidence level.Comment: revtex, 4 pages with 2 figures, title revised, minor changes, matches
version to appear in Phys. Rev.
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