Cetacean Morbillivirus-Associated Pathology: Knowns and Unknowns

The present minireview deals with the pathology of Cetacean Morbillivirus (CeMV) infection in free-ranging cetaceans. In this respect, while "classical" CeMV-associated lesions were observed in the lung, brain, and lymphoid tissues from striped dolphins (Stenella coeruleoalba) and pilot whales (Globicephala melas) which were victims of the 1990-1992 and 2006-2008 epidemics in the Western Mediterranean, an apparent reduction in CeMV neurovirulence, along with a different viral antigen's tissue and cell distribution, were found during the 2010-2011 and the 2013 outbreaks in the same area. Of remarkable concern are also the documented CeMV ability to induce maternally acquired infections in wild cetaceans, coupled with the progressively expanding geographic and host range of the virus in both Hemispheres, as well as in conjunction with the intriguing forms of "brain-only" morbilliviral infection increasingly reported in Mediterranean-striped dolphins. Future research in this area should address the virus-host interaction dynamics, with particular emphasis on the cell receptors specifying viral tissue tropism in relation to the different cetacean species and to their susceptibility to infection, as well as to the CeMV strains circulating worldwide

Cetacean Host-Pathogen Interaction(s): Critical Knowledge Gaps

Within the broad range of viral and non-viral pathogens infecting cetaceans, Cetacean Morbillivirus (CeMV), Herpesvirus (HV), Brucella ceti, and Toxoplasma gondii are of special concern, due to their impact(s) on the health and conservation of free-ranging cetacean populations worldwide (1). The most \u201cparadigmatic\u201d example in this direction is represented by CeMV, which throughout the last 3 decades has caused more than 10 mass mortality outbreaks among different cetacean species and populations across the globe (2, 3)

PROGETTO E REALIZZAZIONE DI UN AMBIENTE HARDWARE PER LA SINTESI E L'ELABORAZIONE NUMERICA DI SEGNALI.

This work show how is possible to handle generic signal via a numerical system. In particular we create a complete software and hardware environment for signal treatment by digital signal processor (DSP). Digital signal processing allows a full and customizable control on signal, unlike the analog treatment of the information. Signals generated by analog or digital system are mostly indistinguishable. Moreover, we take the advantages of the numerical system like low cost, easy mass-production, error correction and no need of specific hardware. Simply by re-coding the algorithm executed by the DSP instead of by hardware modifications, is possible to create any type of telecomunication signal and hardware equivalent architecture we need

Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus).

Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-'92 and the 2006-'08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells

Coinfection by Ureaplasma spp., Photobacterium damselae and an Actinomyces-like microorganism in a bottlenose dolphin (Tursiops truncatus) with pleuropneumonia stranded along the Adriatic coast of Italy

A case of pleuropneumonia is reported in an adult male bottlenose dolphin (Tursiops truncatus) found stranded in 2014 along the Central Adriatic coast of Italy. A severe pyogranulomatous pneumonia and thoracic lymphadenopathy were present at necropsy. Numerous Splendore-Hoeppli bodies were found microscopically scattered throughout the lung. Histochemical evidence of Actinomyces-like organisms was obtained from the pulmonary parenchyma, with a strain of Photobacterium damselae subsp. piscicida and Ureaplasma spp. being also isolated from the same tissue. For the latter, a genome fragment of approximately 1400 bp from the 16s rDNA was amplified and sequenced. BLAST analysis revealed 100% identity with an uncultured Ureaplasma spp. (JQ193826.1)

Stability Analysis of Gravity Currents of a Power-Law Fluid in a Porous Medium

We analyse the linear stability of self-similar shallow, two-dimensional and axisymmetric gravity currents of a viscous power-law non-Newtonian fluid in a porous medium. The flow domain is initially saturated by a fluid lighter than the intruding fluid, whose volume varies with time astα. The transition between decelerated and accelerated currents occurs atα= 2 for two-dimensional and atα= 3 for axisymmetric geometry. Stability is investigated analytically for special values ofαand numerically in the remaining cases; axisymmetric currents are analysed only for radially varying perturbations. The two-dimensional currents are linearly stable forα 2 (two-dimensional accelerated currents) andα> 3 (axisymmetric accelerated currents) the linear stability analysis is of limited value since the hypotheses of the model will be violated

Near-field electrospinning of conjugated polymer light-emitting nanofibers

The authors report on the realization of ordered arrays of light-emitting conjugated polymer nanofibers by near-field electrospinning. The fibers, made by poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene], have diameters of few hundreds of nanometers and emission peaked at 560 nm. The observed blue-shift compared to the emission from reference films is attributed to different polymer packing in the nanostructures. Optical confinement in the fibers is also analyzed through self-waveguided emission. These results open interesting perspectives for realizing complex and ordered architectures by light-emitting nanofibers, such as photonic circuits, and for the precise positioning and integration of conjugated polymer fibers into light-emitting devices.Comment: 11 pages, 6 figures Nanoscale, 201