Electrolytic Corrosion Resistant Plating for Connector Pins

This disclosure describes an electroplating configuration that is resistant to electrolytic corrosion. The configuration is a stack-up of different layers that include copper (Cu) layer surrounding the substrate, a nickel (Ni) layer, and a nickel-tungsten (NiW) layer. The configuration additionally includes a gold (Au) layer utilized as an interface layer between the NiW layer and an outer rhodium-ruthenium (RhRu) layer. To impart electrolytic corrosion resistance, a rhodium-ruthenium (RhRu) layer is electroplated as an outer layer. The electroplating stack-up described in this disclosure has significantly improved anti-electrochemical corrosion capability than prior techniques

Protecting Electrical Connectors From Corrosion

This publication describes techniques and apparatuses for protecting electrical connectors from corrosion. An electrical connector may include an electrolytic plating stack-up of layers configured to minimize electrolytic corrosion. The plating stack-ups described in this publication utilize various elements applied in multiple ways to create a cost-efficient and effective solution for minimizing electrolytic corrosion in electrical connectors, thereby improving efficiency and extending the life of electrical connectors

Chronic Voluntary Alcohol Drinking Causes Anxiety-Like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice

The central nervous system is vulnerable to chronic alcohol abuse, and alcohol dependence is a chronically relapsing disorder which causes a variety of physical and mental disorders. Appropriate animal models are important for investigating the underlying cellular and molecular mechanisms. The crossed High Alcohol Preferring mice prefer alcohol to water when given free access. In the present study, we used female cHAP mice as a model of chronic voluntary drinking to evaluate the effects of alcohol on neurobehavioral and neuropathological changes. The female cHAP mice had free-choice access to 10% ethanol and water, while control mice had access to water alone at the age of 60-day-old. The mice were exposed to alcohol for 7 months then subjected to neurobehavioral tests including open field (OF), elevated plus maze (EPM), and Morris water maze (MWM). Results from OF and EPM tests suggested that chronic voluntary drinking caused anxiety-like behaviors. After behavior tests, mice were sacrificed, and brain tissues were processed for biochemical analyses. Alcohol altered the levels of several neurotransmitters and neurotrophic factors in the brain including gamma-Aminobutyric acid (GABA), corticotropin-releasing factor, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor. Alcohol increased the expression of neuroinflammation markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor 2 (CCR2). Alcohol also induced cleaved caspase-3 and glial fibrillary acidic protein, indicative of neurodegeneration and gliosis. In addition, alcohol inhibited the expression of thiamine transporters in the brain and reduced thiamine levels in the blood. Alcohol also caused oxidative stress and endoplasmic reticulum (ER) stress, and stimulated neurogenesis

Research Note: Association of single nucleotide polymorphism of AKT3 with egg production traits in White Muscovy ducks (Cairina moschata).

Prior studies on transcriptomes of hypothalamus and ovary revealed that AKT3 is one of the candidate genes that might affect egg production in White Muscovy ducks. The role of AKT3 in the uterus during reproductive processes cannot be overemphasized. However, functional role of this gene in the tissues and on egg production traits of Muscovy ducks remains unknown. To identify the relationship between AKT3 and egg production traits in ducks, relative expression profile was first examined prior to identifying the variants within AKT3 that may underscore egg production traits [age at first egg (AFE), number of eggs at 300 d (N300D), and number of eggs at 59 wk (N59W)] in 549 ducks. The mRNA expression of AKT3 gene in high producing (HP) ducks was significantly higher than low producing (LP) ducks in the ovary, oviduct, and hypothalamus (P \u3c 0.05 or 0.001). Three variants in AKT3 (C-3631A, C-3766T, and C-3953T) and high linkage block between C-3766T and C-3953T which are significantly (P \u3c 0.05) associated with N300D and N59W were discovered. This study elucidates novel knowledge on the molecular mechanism of AKT3 that might be regulating egg production traits in Muscovy ducks

Compressive tracking via oversaturated sub‐region classifiers

This study proposed a tracking algorithm based on oversaturated sub‐region classifiers. Compared with the compressive tracking (CT), the tracker can reduce the influence of occlusion and improve the stability and accuracy of tracking result. First, the target region is divided into oversaturated sub‐regions randomly, and then some sub‐region classifiers are adaptively selected based on their confidence. Each selected classifier can find a candidate target position. At last, the place with the maximum candidate positions’ distribution density is the final location of the target. Experiments on different videos demonstrate that the proposed algorithm has stronger anti‐occlusion ability than the CT and is more robust and stable than the traditional sub‐region‐based tracking algorithm

Effects of task instructions and topic signaling on text processing among adult readers with different reading styles: An eye-tracking study

Effects of task instructions and topic signaling on text processing among adult readers with different reading styles were studied by eye-tracking. In Experiment 1, readers read two multiple-topic expository texts guided either by a summary or a verification task. In Experiment 2, readers read a text with or without the topic sentences underlined. Four types of readers emerged: topic structure processors (TSPs), fast linear readers (FLRs), slow linear readers (SLRs), and nonselective reviewers (NSRs). TSPs paid ample fixation time on topic sentences regardless of their signaling. FLRs were characterized by fast first-pass reading, little rereading of previous text, and some signs of structure processing. The common feature of SLRs and NSRs was their slow first-pass reading. They differed from each other in that NSRs were characterized by spending ample time also during second-pass reading. They only showed some signs of topic structure processing when cued by task instructions or topic signaling.</p

Changes in poly(ADP-ribosyl)ation patterns in workers exposed to BTX.

Occupational exposure to (benzene, toluene and xylene, BTX is common in the Chinese workplace. Chronic occupational exposure to benzene is associated with an increased risk of hematological malignancies such as acute myeloid leukemia (AML), but the underlying mechanisms are still unclear. This study investigates changes in poly(ADP-ribosyl)ation and DNA methylation in subjects occupationally exposed to a BTX. Blood DNA samples and exposure data were obtained from subjects with different levels of exposure, including 132 decorators, 129 painters, and 130 unexposed referents in a container-manufacturing factory in Shenzhen, China. Occupational exposure assessment included personal monitoring of airborne benzene, toluene and xylene. Hematological parameters were measured and the cytokinesis-block micronucleus (CBMN) assay was used to detect DNA damage in peripheral lymphocytes. Quantitative real-time PCR was used to detect the mRNA expression of poly(ADP-ribose) polymerase 1 (PARP1) and poly(ADP-ribose) glycohydrolase (PARG), DNA methyltransferases (DNMTs) including DNMT1, DNMT3a and DNMT3b, methyl-CpG-binding domain protein 2(MBD2). PARP1 assay was used to measure PARP activity. Airborne levels of benzene, toluene and xylene in the two exposed groups were significantly higher than those of controls (P<0.001). The two exposed groups (decorators, painters) showed decreased PARP1, DNMTs and MBD2 expression relative to controls (P<0.05), and PARP activity was also decreased (P<0.05). Decreased PARP1, DNMT1, DNMT3a, DNMT3b and MBD2 mRNA expression was correlated with increased airborne BTX (Pearson's r: -0.587, -0.314, -0.636, -0.567 and -0.592 respectively, P<0.001). No significant differences in hematological parameters and CBMN were found among the three groups. Together, these results suggest that decreased DNMTs, MBD2 and PARP1 might be involved in the global hypomethylation associated with BTX exposure, and the imbalance of PARP/PARG might participate in the down-regulation of DNMTs. This is the first human study to link altered poly(ADP-ribosyl)ation patterns, which reproduce the aberrant epigenetic patterns found in benzene-treated cells, to chronic occupational exposure to BTX