9 research outputs found
Phyllosticta citricarpa and sister species of global importance to Citrus.
- Author
- Aa H.A.
- Aa H.A.
- Alexopoulos C.
- Barr M.E.
- Benson A.H.
- Brodrick H.T.
- Calavan E.C.
- Cobb N.A.
- Crous P.W.
- de Almeida T.F.
- Dewdney M.M.
- Doidge E.M.
- Dummel D.M.
- EFSA
- Er H.L.
- European Union
- FAO
- Fogliata G.M.
- Guarnaccia V.
- Hennings P.
- Huang C.S.
- Kellerman C.R.
- Kiely T.B.
- Kiely T.B.
- Kiely T.B.
- Korf H.J.G.
- Kotzé J.M.
- Kotzé J.M.
- Kotzé J.M.
- Lee Y.S.
- Marchionatto J.B.
- McOnie K.C.
- McOnie K.C.
- McOnie K.C.
- McOnie K.C.
- Moran Lemir A.
- Moyo P.
- Noronha M.D.A.
- Petrak F.
- Robbs C.F.
- Schutte G.C.
- Schutte G.C.
- Silva‐Junior G.J.
- Truter M.
- USDA APHIS (United States Department of Agriculture Animal and Plant Health Inspection Service)
- Viala P.
- Wager V.A.
- Wang N.
- Wang N.‐Y.
- Whiteside J.O.
- Wulandari N.F.
- Zhang K.
- Zheng X.M.
- Publication venue
- eScholarship, University of California
- Publication date
- 01/12/2019
- Field of study
Several Phyllosticta species are known as pathogens of Citrus spp., and are responsible for various disease symptoms including leaf and fruit spots. One of the most important species is P. citricarpa, which causes a foliar and fruit disease called citrus black spot. The Phyllosticta species occurring on citrus can most effectively be distinguished from P. citricarpa by means of multilocus DNA sequence data. Recent studies also demonstrated P. citricarpa to be heterothallic, and reported successful mating in the laboratory. Since the domestication of citrus, different clones of P. citricarpa have escaped Asia to other continents via trade routes, with obvious disease management consequences. This pathogen profile represents a comprehensive literature review of this pathogen and allied taxa associated with citrus, focusing on identification, distribution, genomics, epidemiology and disease management. This review also considers the knowledge emerging from seven genomes of Phyllosticta spp., demonstrating unknown aspects of these species, including their mating behaviour.TaxonomyPhyllosticta citricarpa (McAlpine) Aa, 1973. Kingdom Fungi, Phylum Ascomycota, Class Dothideomycetes, Order Botryosphaeriales, Family Phyllostictaceae, Genus Phyllosticta, Species citricarpa.Host rangeConfirmed on more than 12 Citrus species, Phyllosticta citricarpa has only been found on plant species in the Rutaceae.Disease symptomsP. citricarpa causes diverse symptoms such as hard spot, virulent spot, false melanose and freckle spot on fruit, and necrotic lesions on leaves and twigs.Useful websitesDOE Joint Genome Institute MycoCosm portals for the Phyllosticta capitalensis (https://genome.jgi.doe.gov/Phycap1), P. citriasiana (https://genome.jgi.doe.gov/Phycit1), P. citribraziliensis (https://genome.jgi.doe.gov/Phcit1), P. citrichinaensis (https://genome.jgi.doe.gov/Phcitr1), P. citricarpa (https://genome.jgi.doe.gov/Phycitr1, https://genome.jgi.doe.gov/Phycpc1), P. paracitricarpa (https://genome.jgi.doe.gov/Phy27169) genomes. All available Phyllosticta genomes on MycoCosm can be viewed at https://genome.jgi.doe.gov/Phyllosticta
A Global Perspective on the Population Structure and Reproductive System of Phyllosticta citricarpa
- Author
- Publication venue
- 'Scientific Societies'
- Publication date
- 23/11/2020
- Field of study
The citrus pathogen Phyllosticta citricarpa was first described 117 years ago in Australia, and subsequently from the summer rainfall citrus-growing regions in China, Africa, South America and recently the United States of America (USA). Limited information is available on the pathogen's population structure, mode of reproduction and introduction pathways, which were investigated by genotyping 383 isolates representing 12 populations from South Africa, USA, Australia, China and Brazil. Populations were genotyped using seven published and eight newly developed polymorphic simple sequence repeat (SSR) markers. The Chinese and Australian populations had the highest genetic diversities, whereas populations from Brazil, USA and South Africa exhibited characteristics of founder populations. The USA population was clonal. Based on principal coordinate and minimum spanning network analyses the Chinese populations were distinct from the other populations. Population differentiation and clustering analyses revealed high connectivity and possibly linked introduction pathways between South Africa, Australia and Brazil. With the exception of the clonal USA populations that only contained one mating type, all the other populations contained both mating types in a ratio that did not deviate significantly from 1:1. Whilst most populations exhibited sexual reproduction, linkage disequilibrium analyses indicated that asexual reproduction is important in the pathogen's life cycle.This work was financially supported by Citrus Research International
and The Technology and Human Resources for Industry Programme.
We thank CenGen (Pty.) Ltd., and S. Langenhoven and A. Pretorius
(Department of Plant Pathology, Stellenbosch University), for assistance in
the laboratory and technical support; and S. Maduna and A. van der Merwe
(Department of Genetics, Stellenbosch University) for assistance with
analyses in R
Repeated measurement of spontaneous and clastogen-induced sister-chromatid exchange
- Author
- A.P. Budacz
- Ardito
- Arlett
- Balakrishna Murthy
- Bender
- Carrano
- Carrano
- Carrano
- Cohen
- Cohen
- Cone
- Conover
- Crossen
- Crossen
- D'Souza
- Dewdney
- Evans
- Fornace
- Fujiwara
- German
- German
- Haidle
- Hedner
- Hollander
- Husum
- Ikewage
- J.A. Astemborski
- J.A. Boughman
- Lambert
- Lambert
- Latt
- Latt
- Latt
- Lin
- Lukusa
- Lundberg
- M.M. Cohen
- Moorehead
- Morgan
- Muller
- Natarajan
- Perry
- Perry
- Popescu
- S. Schwartz
- S.S. Wasserman
- Sokal
- Soper
- Speit
- Tada
- Taylor
- Tucker
- Tucker
- Waksvik
- Wolff
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Phyllosticta citricarpa
- Author
- Aa H.A.
- Aa H.A.
- Alexopoulos C.
- Barr M.E.
- Benson A.H.
- Brodrick H.T.
- Calavan E.C.
- Cobb N.A.
- Crous P.W.
- de Almeida T.F.
- Dewdney M.M.
- Doidge E.M.
- Dummel D.M.
- EFSA
- Er H.L.
- European Union
- FAO
- Fogliata G.M.
- Guarnaccia V.
- Hennings P.
- Huang C.S.
- Kellerman C.R.
- Kiely T.B.
- Kiely T.B.
- Kiely T.B.
- Korf H.J.G.
- Kotzé J.M.
- Kotzé J.M.
- Kotzé J.M.
- Lee Y.S.
- Marchionatto J.B.
- McOnie K.C.
- McOnie K.C.
- McOnie K.C.
- McOnie K.C.
- Moran Lemir A.
- Moyo P.
- Noronha M.D.A.
- Petrak F.
- Robbs C.F.
- Schutte G.C.
- Schutte G.C.
- Silva‐Junior G.J.
- Truter M.
- USDA APHIS (United States Department of Agriculture Animal and Plant Health Inspection Service)
- Viala P.
- Wager V.A.
- Wang N.
- Wang N.‐Y.
- Whiteside J.O.
- Wulandari N.F.
- Zhang K.
- Zheng X.M.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study
- Author
- Abdelhadi M.
- Abid H.
- Abul M.H.
- Acres M.
- Adams R.
- Adebayo A.A.
- Ahern N.
- Ahmad K.
- Ahmed H.
- Ahmed M.
- Ahn J.S.
- Akhtar S.
- Al-Robeye A.
- Ali A.
- Ali S.
- Allen J.L.Y.
- Amin H.
- Amin O.
- Amphlett A.H.
- Anderson L.
- Anderson L.B.
- Antoniou I.
- Asbjoernsen C.A.
- Ashton A.J.
- Asmadi A.
- Assadullah S.
- Attalla M.
- Auyoung E.
- Aziz N.
- Baker A.N.
- Bakhsh A.
- Balaji S.
- Barai I.
- Barrow T.R.
- Barton E.C.
- Bassett J.
- Bath M.F.
- Batho A.
- Batt E.
- Behar N.
- Bell L.
- Bell N.
- Bhangu A.
- Bhatt N.
- Blessed R.
- Bolton W.
- Boon Xuan J.L.
- Borakati A.
- Botchey S.
- Brathwaite-Shirley C.
- Brennan C.
- Brennan K.
- Brent G.
- Bright M.
- Brooks T.M.
- Brown D.
- Brown E.
- Buakuma P.
- Bullman L.M.
- Bullock N.P.
- Burke D.
- Burke J.
- Callan R.
- Canning N.
- Carr L.
- Chan N.
- Chang H.M.
- Chapman S.J.
- Charalambos M.A.
- Charavanamuttu V.
- Chaudhry F.I.
- Chen J.H.
- Chen X.
- Cheng K.
- Chew L.S.
- Chhabra A.
- Chilvers N.J.
- Chisholm E.G.
- Chitnis A.R.
- Chiu S.M.
- Choi S.M.
- Chong B.F.
- Choo K.P.
- Claireaux H.A.
- Clement K.D.
- Coates A.
- Cody N.
- Coffin J.
- Collins A.
- Copley H.C.
- Cotton A.
- Craig-McQuaide A.
- Crewdson J.A.
- Crozier L.
- Culleton G.
- Cumber E.
- Das M.
- Davies J.
- Davies J.E.
- Davies K.
- Davies N.
- Davis-Hall M.
- Dawson P.M.
- Dean R.
- Dean S.
- Dean W.
- Debenham R.
- Demetri A.M.
- Devlin E.
- Dewdney C.J.
- Dickson J.
- Doan L.
- Dogra T.
- Dolaghan M.
- Dorman C.
- Drake T.M.
- Duke K.
- Duncumb J.W.
- Dyal A.R.
- Dynes K.
- Egerton C.
- Elf D.
- Empey J.
- Eragat M.
- Esteve L.
- Favero N.
- Fitzgerald J.E.
- Fleck R.
- Francescon C.T.
- Frank A.L.
- Gabriel J.
- Gaffney S.
- Galloway E.
- Gatfield W.A.
- Gauntlett L.
- Ghaffar M.K.A.
- Gilbert H.
- Giles J.E.
- Gillies M.A.
- Girling C.
- Glasbey J.C.
- Goldsmith T.
- Goodier R.
- Goodson R.
- Gouda P.
- Gouldthrope C.
- Govinden S.
- Gratton R.
- Gray L.
- Griffin E.J.
- Grossart C.M.
- Gundogan B.
- Hanrahan M.
- Haq H.
- Hardie J.
- Harris R.T.
- Harrison E.M.
- Hayes J.D.B.
- Heminway R.
- Henderson I.
- Henson A.D.
- Heppenstall-Harris G.
- Hibberd A.
- Hill A.
- Hirani S.
- Ho S.
- Ho W.
- Hoban K.A.
- Holloway C.
- Holmes C.
- Hu L.
- Huang H.C.
- Hughes B.A.
- Hughes F.
- Hulley K.
- Hung G.
- Ingram E.
- Jhala H.
- Jindal A.
- Johnstone M.
- Jordan H.E.M.
- Joshi K.R.
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- Kane T.
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- Kim S.
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- Kong Chia Yew
- Koumpa F.
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- Lees D.M.
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- Liu S.
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- Lunawat S.
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- Mackin S.
- Maclennan D.
- Mah J.
- Malik A.
- Mallick S.
- Mansoor S.
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- Martin A.L.
- Maru D.
- Matthews B.W.
- McAleer S.
- McCance E.
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- Tahmina A.
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- Ungcharoen N.
- Valli A.
- Vanniasegaram D.
- Varma R.K.
- Vithanage N.A.
- Vivekanantham S.
- Wan J.C.
- Ward N.
- Weaver R.
- Wells M.
- Whacha C.
- Whewell H.
- Wijesekera M.
- Wild J.R.L.
- Wilkinson D.
- Williams M.
- Wills J.
- Wilson H.C.P.
- Winarski A.
- Wing V.C.
- Winslow F.
- Woin E.
- Woodcock N.
- Woodward H.
- Woon E.
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- Xiao C.
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- Yener A.
- Yong C.S.
- Zhao J.
- Ziff O.
- Zuhair M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery.
Methods:
This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy.
Results:
Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51–19.97) than planned admissions (OR: 2.32, 95% CI: 1.43–3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8–51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI.
Conclusions:
After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies
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- R. Formanek
- R. Harré
- R. Harré
- R. Hayes
- R. Houston
- R. Ikoja-Odongo
- R. Ikoja-Odongo D.N. Ocholla
- R. Ikoja-Odongo D.N. Ocholla
- R. Ikoja-Odongo J. Mostert
- R. Krueger M.A. Casey
- R. Kubey M. Csikszentmihalyi
- R. Kubey R. Larson, M. Csikszentmihalyi
- R. Lachman J.L. Lachman, E.C. Butterfield
- R. Lion R.M. Meertens
- R. Little C. Williams, J. Yost
- R. Losee
- R. Marcella G. Baxter
- R. Marcella G. Baxter
- R. Marcella G. Baxter
- R. Mata L. Nunes
- R. Meier
- R. Merton
- R. Noble C. Coughlin
- R. Orr
- R. Perttilä S. Ek
- R. Rubin
- R. Savolainen
- R. Savolainen
- R. Savolainen
- R. Savolainen
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- R. Savolainen
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- R. Savolainen
- R. Savolainen J. Kari
- R. Savolainen J. Kari
- R. Savolainen J. Kari
- R. Schutt
- R. Schwarzer
- R. Stooke
- R. Thompson B. Croft
- R. Watson-Boone
- R. Wurman
- R. Yin
- R.A. Palmquist
- R.A. Stebbins
- R.A. Stebbins
- R.D. Daft J. Sormunen, D. Parks
- R.D. Daft R.H. Lengel
- R.D. Robertson
- R.E. Parks
- R.E. Rice C. Atkin
- R.E. Rice C.L. Borgman
- R.F. Carey L. McKechnie, P. McKenzie
- R.J. Gerrig D.A. Prentice
- R.J. Griffin S. Dunwoody, K. Neuwirth
- R.J. Todd
- R.J. Todd S. Edwards
- R.K. Merton
- R.K. Merton
- R.K. Merton M. Fiske, P. Kendall
- R.L. Derr
- R.L. Derr
- R.M. Harris
- R.M. Harris P. Dewdney
- R.M. Harris T.C. Veinot, L. Bella
- R.M. Roberts
- R.M. Sorrentino C.J.R. Roney
- R.S. Owen
- R.S. Taylor
- R.S. Taylor
- R.S. Taylor
- R.W. Belk
- R.W. Belk
- R.W. Belk J Sherry, M. Wallendorf
- R.W. Tardy C. Hale
- S. Allard K.J. Levine, C. Tenopir
- S. Apted
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- S. Attfield A. Blandford, J. Dowell
- S. Attfield J. Dowell
- S. Baker
- S. Beer
- S. Borgatti A. Mehra, D. Brass, G. Labianca
- S. Bowler T. Donovan, J. Snipp
- S. Braman
- S. Braman
- S. Brier
- S. Chaffee
- S. Chang R. Rice
- S. Cobbledick
- S. Corcoran-Perry J. Graves
- S. Cowan
- S. Crawford
- S. Ek G. Widén-Wulff
- S. Ek J. Heinström
- S. Erdelez
- S. Erdelez
- S. Erdelez
- S. Erdelez
- S. Finn
- S. Finn
- S. Fish
- S. Folkman
- S. Fox
- S. Freud
- S. Hampshire
- S. Hayter
- S. Herner
- S. Herner M. Herner
- S. Hirsh
- S. Hirsh J. Dinkelacker
- S. Joyce
- S. Kiesler L. Sproull
- S. Livingstone
- S. Majid M. Anwar, T. Eisenschitz
- S. Makri C. Warwick
- S. Massey A. Druin, A. Weeks
- S. Massey A. Weeks, A. Druin
- S. Miller
- S. Mizzaro
- S. Neill
- S. Shugan
- S. Stone
- S. Sutton
- S. Talja
- S. Talja
- S. Talja
- S. Talja H. Keso, T. Pietiläinen
- S. Talja H. Maula
- S. Talja K. Tuominen, R. Savolainen
- S. Talja P. Hansen
- S. Thompson H. O’Hair
- S. Turk-Charles B. Meyerowitz, M. Gatz
- S. Whittaker
- S.-C. Sin
- S.-J.L. Chang
- S.-J.L. Chang
- S.-J.L. Chang
- S.D. Lambert C.G. Loiselle
- S.E. Wiberley W.G. Jones
- S.E. Wiberley W.G. Jones
- S.E. Wiberley W.G. Jones
- S.H. Stocking P.H. Gross
- S.J. Tannenbaum
- S.L. Popkin
- S.M. Noar C.N. Benac, M.S. Harris
- S.P. Harter
- S.S. Adams
- S.S. Layne
- S.W. Littlejohn
- T. Ainslie
- T. Asla K. Williamson, J. Mills
- T. Childers J. Post
- T. Cook D. Campbell
- T. Cook L. Leviton
- T. Kuhn
- T. Nørretranders
- T. Park
- T. Pysczynski J. Greenberg, S. Solomon
- T. Rose
- T. Stonier
- T. Timpka E. Arborelius
- T.A. Finholt
- T.A. van Dijk W. Kintsch
- T.C. Veinot
- T.C. Veinot
- T.D. Afifi W.A. Afifi
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson
- T.D. Wilson D.R. Streatfield
- T.D. Wilson N. Ford, D. Ellis, A. Foster, A. Spink
- T.E. Pinelli
- T.E. Ruggiero
- T.J. Allen
- T.J. Allen
- T.J. Allen S.I. Cohen
- T.J. Froehlich
- T.J. Tidline
- T.J. Waldhart E.S. Waldhart
- T.L. Baker
- T.L. Mays
- T.L. von Thaden
- U. Josefsson
- V. Box M. Hepworth, J. Harrison
- V. Freimuth
- V. Freimuth T. Edgar, M. Fitzpatrick
- V. Jiyane D.N. Ocholla
- V. Palmour P. Rathbun, W. Brown, B. Dervin, P. Dowd
- V. Pifalo S. Hollander, C. Henderson, P. DeSalvo, G. Gill
- V. Rosenberg
- V.A. Walter
- V.D. Miller F.M. Jablin
- V.J. Janesick
- V.S. Freimuth J.A. Stein, T.J. Kean
- W. Beautyman A. Shenton
- W. Donnelly
- W. Gantz M. Fitzmaurice, E. Fink
- W. Hemmig
- W. Iser
- W. Jeong
- W. Schramm
- W. Shim
- W. Trochim J. Donnelly
- W. Weaver
- W.A. Afifi J.L. Weiner
- W.A. Afifi J.L. Weiner
- W.D. Garvey
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.J. Paisley
- W.M. Duff C.A. Johnson
- W.M. Duff C.A. Johnson
- W.M. Goldstein R.M. Hogarth
- W.R. Garner
- X. Lan
- Y. Zhang
- Y. Zhao R. Zhang, K.K. Klein
- Y.B. Kafai M.J. Bates
- Y.J. Xu C.Y. Tan, L. Yang
- Y.L. Lu
- Y.L. Lu
- Y.S. Lincoln E.G. Guba
- Z. Correia T.D. Wilson
- Z. Stavri
- Publication venue
- 'Emerald'
- Publication date
- 01/01/2012
- Field of study
Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study
- Author
- Abbas Z.
- Abburu S.
- Abdelhadi M.
- Abdikadir H.R.
- Abdulmajid A.
- Abid A.
- Abid H.
- Abuhussein N.
- Abul M.H.
- Acquaah F.
- Acres M.
- Adams R.
- Adams R.D.
- Adebayo A.A.
- Adeleja I.
- Adjei H.
- Afzal Z.
- Agarwal V.
- Ahern N.
- Ahmad K.
- Ahmad S.
- Ahmed F.
- Ahmed H.
- Ahmed M.
- Ahmed N.
- Ahmed S.
- Ahn J.S.
- Aidoo-Micah G.E.
- Aildasani L.
- Aithie J.M.
- Akhtar S.
- Al-Mousawi A.
- Al-Obaedi O.
- Al-Robeye A.
- Ali A.
- Ali B.
- Ali H.
- Ali M.
- Ali S.
- Alizadeh M.
- Allan C.
- Allen J.L.Y.
- Allot R.
- Amajuoyi A.
- Amin H.
- Amin O.
- Amphlett A.H.
- Anandarajah C.
- Anderson L.
- Anderson L.B.
- Anderson S.M.
- Ang A.
- Angelov S.
- Anilkumar A.
- Anim-Addo N.
- Ansari N.
- Antoniou I.
- Archer C.H.
- Arif T.
- Asbjoernsen C.A.
- Ashfaq U.
- Ashken L.
- Ashraf S.
- Ashraf S.F.
- Ashton A.J.
- Ashwood J.
- Aslanyan A.
- Asmadi A.
- Assadullah S.
- Atayi A.
- Atraszkiewicz B.A.
- Attalla M.
- Austreng L.
- Auyoung E.
- Avery P.
- Axelson T.
- Aziz H.
- Aziz N.
- Baker A.N.
- Bakewell Z.R.
- Bakhsh A.
- Balaji S.
- Balian V.
- Bamgbose F.A.
- Barai I.
- Barnes J.
- Barrow T.R.
- Barthorpe A.E.
- Bartlett J.
- Bartlett R.D.
- Barton E.C.
- Bassam N.
- Bassett J.
- Bassiony S.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background
Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery.
Methods
This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy.
Results
Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51–19.97) than planned admissions (OR: 2.32, 95% CI: 1.43–3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8–51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI.
Conclusions
After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
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- Publication venue
- Publication date
- 01/08/2018
- Field of study
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study
- Author
- A. Abdulmajid
- A. Abid
- A. Al-Mousawi
- A. Al-Robeye
- A. Ali
- A. Amajuoyi
- A. Ang
- A. Anilkumar
- A. Aslanyan
- A. Asmadi
- A. Atayi
- A. Bakhsh
- A. Batho
- A. Bell
- A. Bhangu
- A. Borakati
- A. Broyd
- A. Burgess
- A. Charania
- A. Chhabra
- A. Chung
- A. Coates
- A. Cody
- A. Collins
- A. Cotton
- A. Craig-McQuaide
- A. Croall
- A. Curran
- A. Daoub
- A. Delport
- A. Dhanji
- A. Duffy
- A. Durr
- A. Ghaffar
- A. Hague
- A. He
- A. Hibberd
- A. Higgins
- A. Hill
- A. Ibrahim
- A. Iqbal
- A. Isaac
- A. Jaitley
- A. Jindal
- A. Johnston
- A. Kahar
- A. Kaushal
- A. Kerai
- A. Khajuria
- A. Khan
- A. Kishore
- A. Kreibich
- A. Ledsam
- A. Linton
- A. Livesey
- A. Lotfallah
- A. Luhishi
- A. MacAskill
- A. Malik
- A. Marsh
- A. Mastan
- A. McBride
- A. McGrath
- A. Mehdi
- A. Menon
- A. Mian
- A. Mishra
- A. Mohite
- A. Mortimer
- A. Murtaza
- A. Narain
- A. O'Connor
- A. O'Kane
- A. Odeleye
- A. Omar
- A. Pandey
- A. Pericleous
- A. Piquet
- A. Pizzolato
- A. Ponweera
- A. Prabhudesai
- A. Qureshi
- A. Radotra
- A. Ramnarine
- A. Rangedara
- A. Reed
- A. Sahathevan
- A. Shah
- A. Sheldon
- A. Shukla
- A. Simpson
- A. Sreh
- A. Szczap
- A. Tahmina
- A. Tai
- A. Thacoor
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- A. Valli
- A. Wali
- A. Wang
- A. White
- A. Winarski
- A. Wright
- A. Yan
- A. Yener
- A. Yousif
- A.A. Adebayo
- A.A. Khetarpal
- A.A. Thevathasan
- A.C.D. Smith
- A.D. Greenhalgh
- A.D. Henson
- A.D. Semana
- A.D. Wood
- A.E. Barthorpe
- A.E. Cardwell
- A.E. Lim
- A.E. Logan
- A.E. Salih
- A.E. Ward
- A.F. Carroll
- A.H. Amphlett
- A.H.Y. Lee
- A.J. Ashton
- A.J. Boulton
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- A.J. Trist
- A.K. Clarke
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- A.L. Frank
- A.L. Kerr
- A.L. Martin
- A.M. Buchan
- A.M. Bucko
- A.M. Demetri
- A.M. Gwozdz
- A.M.A. Shafi
- A.N. Baker
- A.N. Kumar
- A.N. Street
- A.R. Chitnis
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- A.R. Dyal
- A.S. Fawaz
- A.S. Jawad
- A.S. Lynch
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- A.S. Rocke
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- A.Y. Tay
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- B. Forte
- B. Goh
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- B.H. Miranda
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- B.P. Traynor
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- D.N.E. Smith
- D.R. McCormack
- D.T. Robertson
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- E. Heathcote
- E. Hester
- E. Ingram
- E. Lim
- E. Mazumdar
- E. McAleer
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- E. Mckean
- E. Palkhi
- E. Prakash
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- E. Strange
- E. Sun
- E. Toner
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- E. Webb
- E. Woin
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- E.C. Barton
- E.D. Kennedy
- E.D. Mills
- E.G. Chisholm
- E.G. Heywood
- E.J. Brown
- E.J. Griffin
- E.J. Roberts
- E.J. Stone
- E.J.H. Turner
- E.M. Cumber
- E.M. Harrison
- E.M. O'Neill
- E.M. Ruiz
- E.S.M. Tan
- E.T. Tan
- E.V. Wright
- E.Y. Chua
- F. Acquaah
- F. Ahmed
- F. Bulley
- F. Cheung
- F. Edozie
- F. Harding
- F. Hirst
- F. Hughes
- F. Koumpa
- F. Long
- F. Morgan
- F. Morris
- F. Tongo
- F. Winslow
- F.A. Bamgbose
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- Sawyer
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- Symons
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- T. Khan
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- T. Rangan
- T. Reakes
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- T. Spencer
- T. Tharmachandirar
- T. Ward
- T. Yang
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- T.M. Schulz
- T.M.P. Fung
- T.P. Bemand
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- T.W. Tilston
- U. Ashfaq
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- U. White
- V. Agarwal
- V. Balian
- V. Charavanamuttu
- V. Elangovan
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